专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明专利

DE60133394T2 未知
公开(公告)号：DE60133394T2
公开(公告)日：2009-04-23
申请号：DE60133394
申请日：2001-06-22
申请人： CERAMOPTEC GMBH
发明人： MOSER JOERG G
IPC分类号： A61K31/5415 , A61K31/724 , A61K41/00 , A61K47/48 , A61P35/00
摘要： The present invention provides a drug delivery system wherein a "parachute" structure is coupled to a therapeutic compound. The "parachute" structure comprises hydrophilic branched molecules with a defined action diameter. The complex (a parachute structure coupled with a therapeutic compound) is either fixed at a cell membrane or delivered to a defined distance from the membrane within the cell. The membrane-anchoring/localizing effect of the parachute is achieved by hydrophilic structures linked with a branching unit of desired therapeutic compounds. Furthermore, the parachute structures can be connected by a spacer (e.g. beta-amino acids, gamma-amino butyric acid, or poly-amino acids) instead of directly binding to the therapeutic compound, so that the therapeutic compounds can be localized within the cells at a defined distance from the cell membrane. A spacer containing a breaking point can determine the time span, during which the drug exhibits its therapeutic activity. The hydrophilic residues can also carry signals for targeting the parachute-therapeutic complex to a defined tissue type. This can be mediated by an antibody which is specific for a tumor marker. Alternatively, a Biotin can be attached at C6 position of the sugar and then react with an Avidin-labeled tumor-specific antibody. The parachute function may also be achieved by other, more bulky hydrophilic structures such as oligosaccharides connected to the branching unit. Such sugar oligomers have specific attachment points to cell selectins, and therefore do not need additional molecular structures to target a specific tumor tissue. The use of the parachute structure gives the advantages of being able to localize a photosensitizer or chemotherapeutic drug at the site within a cell where it can destroy the tumor cell most effectively. This reduces the level of necessary systemic doses of the drugs, promotes drug excretion, and therefore considerably reduces side effects of the therapy.

42. 发明专利

ITTO20080032U1 SISTEMA E METODO PER IL TRATTAMENTO DELLE EMORROIDI 未知
公开(公告)号：ITTO20080032U1
公开(公告)日：2008-09-12
申请号：ITTO20080032
申请日：2008-03-10
申请人： CERAMOPTEC GMBH
发明人： NEUBERGER WOLFGANG , SALFI RAFFAELE

43. 发明专利

DE60032637T2 未知
公开(公告)号：DE60032637T2
公开(公告)日：2007-11-15
申请号：DE60032637
申请日：2000-07-27
申请人： CERAMOPTEC GMBH
发明人： NEUBERGER WOLFGANG
IPC分类号： A61B18/18 , A61B18/20 , A61B18/22

44. 发明专利

ES2279767T3 SISTEMA DE LASER DE DIODO MEDICO DE DOBLE LONGITUD DE ONDA. 未知
公开(公告)号：ES2279767T3
公开(公告)日：2007-09-01
申请号：ES00953703
申请日：2000-07-27
申请人： CERAMOPTEC GMBH
发明人： NEUBERGER WOLFGANG
IPC分类号： A61B18/18 , A61B18/20 , A61B18/22
摘要： Sistema de láser de diodo médico que presenta una única fibra de emisión óptica (18), en el que dicha fibra de emisión presenta por lo menos dos secciones de núcleo (15, 16) de área en sección transversal diferente para transmitir la radiación de por lo menos dos fuentes de láser, en el que el área en sección transversal de cada núcleo es seleccionada independientemente, un área más pequeña para la densidad de potencia superior, con el fin de alcanzar por separado un haz de emisión de luz láser (12) para cortar tejido, y un área más grande para una densidad de potencia inferior, con el fin de alcanzar por separado una emisión de luz láser (13) para coagular o bioestimular el tejido que es cortado.

45. 发明专利

DE60213996D1 未知
公开(公告)号：DE60213996D1
公开(公告)日：2006-09-28
申请号：DE60213996
申请日：2002-05-31
申请人： CERAMOPTEC GMBH
发明人： NIFANTIEV E , YASHUNSKY V
IPC分类号： C07D487/22 , A61K31/409 , A61K41/00 , A61P31/00 , A61P35/00
摘要： The invention relates to the chemistry of biologically active compounds, namely, to a new method to prepare water-soluble porphyrin derivatives, particularly chlorin derivatives having general formulae (1). The compounds of the present invention are useful as photosensitizers, as drug substances and optionally in suitable drug products, for the photodynamic therapy of cancer, of infectious and other diseases, as well as for light irradiation treatments in other cases. B is a ring having the structure: where: R1=-CH=CH2, -CH(OAlk)CH3, -CHO, -C(O)CH3; -CH2CH3; -CH(Alk)CH(COAlk)2, -CH2CH(COAlk)2, -CH(Alk)CH2COAlk, -CH(Alk)CH2CH(OH)CH3, -CH2CH2CH(OH)CH3 R2=-CH3, -CHO, -CH(OH)Alk, -CH=CHAlk, CH2OH, CH2OAlk; R3=H or lower alkyl; G=hydrophilic organic amine (f.ex. N-methyl-D-glucamine and other amino-group containing carbohydrate derivatives, TRIS, aminoacids, oligopeptides). Alk=alkyl substituent.

46. 发明专利

DE69334047D1 未知
公开(公告)号：DE69334047D1
公开(公告)日：2006-08-24
申请号：DE69334047
申请日：1993-11-23
申请人： CERAMOPTEC GMBH
发明人： NABATOV ALEXEY , KUZIN EUGENY , ARTJUSHENKO VJACHESLAV DR , NEUBERGER WOLFGANG DR
IPC分类号： C03C13/04 , C30B33/00 , G02B6/10

47. 发明专利

DE20311002U1 未知
公开(公告)号：DE20311002U1
公开(公告)日：2003-09-18
申请号：DE20311002
申请日：2003-07-17
申请人： CERAMOPTEC GMBH
IPC分类号： G02B6/42 , G02B6/36 , A61N5/00
摘要： A safe connection system for coupling radiation from radiation sources, such as lasers, into optical fibers is provided. The system prevents the accidental use of standard optical fibers with radiation sources that require fibers capable of transmitting high power or other radiation with unique characteristics. Because often the fibers for use with high power lasers, for example, may also be used with standard lasers, the system preserves the interchangeability of standard connection systems such as SMA by providing connectors that can properly fit both in standard receptacles and in the receptacles of the present invention. Thus, this connection system preserves the advantages of a standard laser-fiber connection system while increasing the safety of such systems, where it is necessary.

48. 发明专利

DE69622324T2 未知
公开(公告)号：DE69622324T2
公开(公告)日：2003-03-13
申请号：DE69622324
申请日：1996-04-24
申请人： CERAMOPTEC GMBH
发明人： NEUBERGER WOLFGANG , CECHETTI WALTER
IPC分类号： A46B15/00 , A61C1/00 , A61C19/06 , A61N5/06 , A61N5/067 , A46B11/06 , A46B5/00
摘要： The invention is an oral cleaning device incorporating a low power laser radiation source and means for producing pulsed or continuous wave delivery of low power radiation to teeth, gums and oral tissue. The device is used alone or in conjunction with a liquid jet or jets and/or with photosensitizer dental paste or liquid. The device destroys bacteria and viruses in the mouth and on surrounding tissue. It increases oral blood circulation and enhances the body's immune system response to oral infection. The device may be operated by a trained professional at three different repetition rate frequencies, selected by the operator to threat different dental conditions. The specific photosensitizer liquid or paste which is activated at a certain wavelength is chosen by the operator to treat different dental conditions. The device is also intended for home dental hygiene at low power.

49. 发明专利

DE69622324D1 未知
公开(公告)号：DE69622324D1
公开(公告)日：2002-08-22
申请号：DE69622324
申请日：1996-04-24
申请人： CERAMOPTEC GMBH
发明人： NEUBERGER WOLFGANG , CECHETTI WALTER
IPC分类号： A46B15/00 , A61C1/00 , A61C19/06 , A61N5/06 , A61N5/067 , A46B11/06 , A46B5/00
摘要： The invention is an oral cleaning device incorporating a low power laser radiation source and means for producing pulsed or continuous wave delivery of low power radiation to teeth, gums and oral tissue. The device is used alone or in conjunction with a liquid jet or jets and/or with photosensitizer dental paste or liquid. The device destroys bacteria and viruses in the mouth and on surrounding tissue. It increases oral blood circulation and enhances the body's immune system response to oral infection. The device may be operated by a trained professional at three different repetition rate frequencies, selected by the operator to threat different dental conditions. The specific photosensitizer liquid or paste which is activated at a certain wavelength is chosen by the operator to treat different dental conditions. The device is also intended for home dental hygiene at low power.

50. 发明专利

DE69523094T2 未知
公开(公告)号：DE69523094T2
公开(公告)日：2002-07-11
申请号：DE69523094
申请日：1995-06-08
申请人： CERAMOPTEC GMBH
发明人： KRIVOSHLYKOV SERGEJ G
IPC分类号： G02F1/01 , G02F1/095
摘要： The present invention is directed at an all-fiber in line isolator. The basic isolator includes a single-mode optical fiber, a multimode waveguide, a coil or other traditional means to generate a magnetic field, and a fiber block or other traditional means to couple the fiber to the waveguide. In one embodiment, the fiber has a core and a cladding, and maintains a circular state of light polarization. The fiber has a coupling region where the cladding is partially removed. The waveguide evanescently couples to the fiber along the coupling region. The waveguide has magneto-optical properties such that applying a magnetic field along it causes backward propagating light to transfer to the waveguide with minimal disturbance to forward propagating light. Other embodiments using birefringent optical fibers are disclosed as well.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式