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41. 发明专利

DE69939607D1 未知
公开(公告)号：DE69939607D1
公开(公告)日：2008-10-30
申请号：DE69939607
申请日：1999-02-19
申请人： BRACCO INT BV
发明人： ROPIAK IRENE K , NIEDOSPIAL JOHN J JR , ROBINSON MICHELLE L
IPC分类号： A61J1/00 , A61J1/14 , A61J1/05 , A61J1/10 , A61J1/16 , B32B27/08 , B65D65/18 , B65D65/40 , B65D81/24
摘要： Flexible medical container (12) containing a light-sensitive medical fluid packaged in an overwrap (30) having UV rays barrier properties to prevent degradation of the light-sensitive fluid but allowing observation of the content of the medical fluid and identifying inscription printed on the medical container.

42. 发明专利

IS2430B Aðferð til framleiðslu á 1,4,7,10-tetraasasýklódódekani 未知
公开(公告)号：IS2430B
公开(公告)日：2008-10-15
申请号：IS6058
申请日：2001-08-21
申请人： BRACCO INT BV
发明人： ARGESE MARIA , MANFREDI GIUSEPPE , REBASTI FABRIZIO , RIPA GIORGIO
IPC分类号： C07B61/00 , C07C20060101 , C07D20060101 , C07D257/02 , C07D487/16 , C07D487/22

43. 发明专利

DK0862979T3 未知
公开(公告)号：DK0862979T3
公开(公告)日：2008-09-08
申请号：DK98108141
申请日：1994-10-20
申请人： BRACCO INT BV
发明人： HEFFERNAN GAYLE , WELSHER ALLEN
IPC分类号： B29C45/17 , A61M5/00 , A61M5/178 , A61M5/28 , A61M5/31 , B29C67/00 , B29D22/00 , B65B3/00
摘要： A novel method for the preparation of a pre-filled plastic syringe, and preferably the preparation of a plastic syringe pre-filled with a diagnostic contrast agent wherein said syringe comprises as components a barrel, a tip seal capable of sealing the nozzle of the barrel and a piston capable of sliding in the barrel and sealing the open end of the barrel opposite the nozzle, comprising the steps of: (a) providing at least one component of said syringe which is molded under conditions which are substantially free of pyrogens and viable and non-viable particulates; and (b) filling and assembling said syringe.

44. 发明专利

NO325570B1 未知
公开(公告)号：NO325570B1
公开(公告)日：2008-06-23
申请号：NO993851
申请日：1999-08-10
申请人： BRACCO INT BV
发明人： DESANTIS NICOLA
IPC分类号： A61K49/04 , C07C231/24 , A61K51/00 , C07C231/22 , C07C237/46
摘要： Disclosed is a new process for the crystallization of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (I), using a linear or branched (C5-C6) alcohol or their mixtures.

45. 发明专利

DE69934827T2 未知
公开(公告)号：DE69934827T2
公开(公告)日：2007-10-31
申请号：DE69934827
申请日：1999-11-25
申请人： BRACCO INT BV
发明人： ANELLI PIER LUCIO , LATTUADA LUCIANO , UGGERI FULVIO , LUX GIOVANNA , SERLETI MICHELE , GABELLINI MILENA , TOURNIER HERVE
IPC分类号： C07F9/09 , A61K49/00 , A61K49/06 , A61K49/18 , C07C229/16 , C07C229/76 , C07C233/47 , C07C237/08 , C07C237/10 , C07C237/12 , C07D257/02 , C07J41/00
摘要： Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metal complexes for generating responses in the field of magnetic resonance imaging (MRI). The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.

46. 发明专利

CA2575730A1 METHODS FOR PREPARING MULTIVALENT CONSTRUCTS FOR THERAPEUTICAND DIAGNOSTIC APPLICATIONS 未知
公开(公告)号：CA2575730A1
公开(公告)日：2006-09-14
申请号：CA2575730
申请日：2005-08-09
申请人： BRACCO INT BV
发明人： FAN HONG , SWENSON ROLF E , MARINELLI EDMUND , NANJAPPAN PALANIAPPA , PILLAI RADHAKRISHNA
IPC分类号： A61K51/00 , A61K47/48 , A61K49/00 , C07K7/08 , C07K7/64

47. 发明专利

AT334704T 未知
公开(公告)号：AT334704T
公开(公告)日：2006-08-15
申请号：AT95900587
申请日：1994-11-16
申请人： BRACCO INT BV
发明人： POLLAK ALFRED , DUNN-DUFAULT ROBERT
IPC分类号： A61K47/48 , A61K49/00 , A61K51/00 , A61K51/08 , A61K51/12 , A61K103/10
摘要： PCT No. PCT/CA94/00637 Sec. 371 Date Feb. 8, 1996 Sec. 102(e) Date Feb. 8, 1996 PCT Filed Nov. 16, 1994 PCT Pub. No. WO95/13832 PCT Pub. Date May 26, 1995Described is a process for labelling ligands with metals comprising the steps of covalently coupling the ligand to a solid support via a metal-cleavable linker; introducing a complex-forming metal to the support; and collecting the metal-ligand complex released from the support. The metal catalyzes cleavage of the ligand from the support upon complex formation resulting in a solution substantially free of unlabelled ligand.

48. 发明专利

DE69925461T2 未知
公开(公告)号：DE69925461T2
公开(公告)日：2006-04-27
申请号：DE69925461
申请日：1999-02-02
申请人： BRACCO INT BV
发明人： SCHNEIDER MICHEL , YAN FENG , HIVER AGNES
IPC分类号： A61K41/00 , A61K9/00 , A61K9/127 , A61K9/50 , A61K45/00 , A61K47/04 , A61K47/24 , A61K48/00 , A61K49/00
摘要： The invention concerns a method for administering bioactive substances to patients at selected sites in the body and remotely promoting delivery of said media to selected organs or tissues in the body. The method comprises providing an administrable formulation comprising, dispersed in an aqueous carrier liquid, liposomes filled with bioactive substances and gas-filled microspheres, injecting said formulation into the circulation of a patient so that it is directed to a site of interest, and applying ultrasound pulses to said site so as to make the gas-filled microbodies explode and the gas confined therein to expand in the carrier liquid, the energy of expansion of said confined gas causing the liposome vesicles to open and release the trapped substances at said site. Also disclosed are formulations for delivery of biologically active substances to selected target sites in the organism, the formulations comprising an aqueous suspension of gas-filled microvesicles and liposomes filled with active susbstances such as drugs or diagnostic agents. The formulations are available in a kit form in which the kit comprises sterile precursor components.

49. 发明专利

DE69434384T2 未知
公开(公告)号：DE69434384T2
公开(公告)日：2006-03-23
申请号：DE69434384
申请日：1994-12-22
申请人： BRACCO INT BV
发明人： POLLAK ALFRED , GOODBODY ANNE
IPC分类号： A61K38/00 , C07K5/097 , A61K51/00 , A61K51/02 , A61K51/08 , C07K5/06 , C07K5/08 , C07K5/117 , C07K7/06
摘要： Radionuclide chelating compounds are provided for conjugation to targetting molecules such as proteins, peptides or antibodies. The resulting labelled targetting molecules may be used in diagnosis and therapy.

50. 发明专利

ES2243350T3 AGENTE DE CONTRASTE LIOFIZABLE QUE COMPRENDE MICROBURBUJAS DE GAS. 未知
公开(公告)号：ES2243350T3
公开(公告)日：2005-12-01
申请号：ES01102223
申请日：2001-01-31
申请人： BRACCO INT BV
发明人： SCHNEIDER MICHEL , FENG YAN , BROCHOT JEAN , LAZARUS DAVID
IPC分类号： A61K49/00
摘要： ¿ Un agente de contraste utilizable en la obtención de imágenes de diagnóstico que comprende microburbujas de un gas o una mezcla de gases obtenidas por reconstitución en un vehículo líquido acuoso fisiológicamente aceptable de material liofilizable que puede obtenerse por el proceso consistente en liofilizar un material liofilizable contenido en un recipiente, comprendiendo dicho material liofilizable al menos un agente tensioactivo formador de película de fosfolípido, efectuar el cierre de sellado de dicho recipiente, caracterizado porque, antes de efectuar el sellado de dicho recipiente, se aplica un vacío a dicho recipiente y se introduce en dicho recipiente una presión reducida comprendida entre 900 y 100 mbar de dicho gas o mezcla de gases.

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