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31. 发明授权

US5190687A Liquid-crystalline polymers and copolymers 失效
标题翻译：液晶聚合物和共聚物
公开(公告)号：US5190687A
公开(公告)日：1993-03-02
申请号：US413625
申请日：1989-09-28
申请人： Satoshi Hachiya , Hiroyuki Endo , Shunji Uchida
发明人： Satoshi Hachiya , Hiroyuki Endo , Shunji Uchida
IPC分类号： C07D301/14 , C07C69/773 , C07C69/92 , C07C69/94 , C07D303/20 , C07D303/22 , C08G65/02 , C08G65/08 , C08G65/22 , C09K19/12 , C09K19/20 , C09K19/38
CPC分类号： C07D303/22 , C08G65/22 , C09K19/126 , C09K19/2021 , C09K19/388
摘要： A liquid-crystalline polymer having the repeating units represented by the following general formula (II): ##STR1## wherein R.sup.1 is ##STR2## wherein a is an integer having a value of 1 to 10,b is an integer having a value of 0 or 1,c is an integer having a value of 1 to 30,X.sup.1 is --COO--, --O-- or a single bond,M.sup.1 is ##STR3## d is an integer having a value of 1 to 5. The liquid-crystalline polymer exhibits ferroelectricity in a wide temperature range including room temperature and has a high speed of response to electric field.

32. 发明授权

US4897107A 1-hydroxyethyl-azole compounds and agricultural compositions 失效
标题翻译： 1-羟乙基 - 唑类化合物和农业组合物
公开(公告)号：US4897107A
公开(公告)日：1990-01-30
申请号：US549867
申请日：1983-11-08
申请人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
发明人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
IPC分类号： A01N20060101 , A01N43/20 , A01N43/50 , A01N43/64 , A01N43/653 , C07D20060101 , C07D233/60 , C07D249/08 , C07D301/00 , C07D301/02 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/20 , C07D303/22 , C07D521/00
CPC分类号： A01N43/50 , A01N43/653 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/22
摘要： New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.
摘要翻译：式（II）的环氧乙烷化合物，其中R代表叔丁基，异丙基，环丙基，取代的环丙基，环戊基或取代的环戊基，环己基或取代的环己基，在各种情况下，取代基选自甲基或苯基，其任选被选自氟，氯，甲基和三氟甲基的相同或不同的取代基单取代或二取代，Y表示分组-OCH 2 - ，各Z独立地选自氟，氯或溴原子，甲基，叔丁基，环己基，甲氧基，甲硫基，三氟甲基，三氟甲氧基，三氟甲硫基，苯基，苯氧基，苄基和苄氧基，所述苯基，苯氧基，苄基和苄氧基任选被相同或不同的选自氟，氯和甲基，m为0,1,2或3; 这些化合物特别可用作农业组合物中用作植物生长调节剂的化合物的中间体。

33. 发明授权

US4871390A 1-hydroxyethyl-azole compounds and agricultural compositions 失效
标题翻译： 1-羟乙基 - 唑类化合物和农业组合物
公开(公告)号：US4871390A
公开(公告)日：1989-10-03
申请号：US732193
申请日：1985-05-08
申请人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
发明人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
IPC分类号： A01N20060101 , A01N43/20 , A01N43/50 , A01N43/64 , A01N43/653 , C07D20060101 , C07D233/60 , C07D249/08 , C07D301/00 , C07D301/02 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/20 , C07D303/22 , C07D521/00
CPC分类号： A01N43/50 , A01N43/653 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/22
摘要： A 1-Hydroxyethyl-azole compound of the formula ##STR1## wherein R is an alkyl radical with 1 to 4 carbon atoms; a cycloalkyl radical which has 3 to 7 carbon atoms and is optionally substituted by alkyl with 1 or 2 carbon atoms or a phenyl radical which is optionally substituted by halogen, alkyl with 1 to 4 carbon atoms or haloalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms; or else is phenyl which is optionally mono- or di-substituted by identical or different substituents selected form fluorine, chlorine, methyl and trifluoromethylX is --CH--;Y is a grouping --OCH.sub.2 --;Z is a halogen atom an alkyl radical with 1 to 4 carbon atoms; a cycloalkyl radical with 5 to 7 carbon atoms, an alkoxy radical with 1 to 4 carbon atoms, an alkylthio radical with 1 to 4 carbon atoms, a haloalkyl radical 1 or 2 carbon atoms and 1 to 5 halogen atoms, a haloalkoxy radical with 1 or 2 carbon atoms and 1 to 5 halogen atoms, a haloalkylthio radical with 1 or 2 carbon atoms and 1 to 5 halogen atoms, a phenyl radical which is optionally substituted by halogen or alkyl with 1 to 4 carbon atoms, a phenoxy radical which is optionally substituted by halogen or alkyl with 1 to 4 carbon atoms, a phenylalkyl radical which has 1 or 2 carbon atoms in the alkyl part and is optionally substituted by halogen or alkyl with 1 to 4 carbon atoms, or a phenylalkoxy radical which has 1 or 2 carbon atoms in the alkoxy part and is optionally substituted by halogen or alkyl with 1 to 4 carbon atoms; andm is 0, 1, 2 or 3and physiologically acceptable acid addition salts thereof or metal salt complexes thereof. Such compound being useful as a plant growth regulant and a fungicide.
摘要翻译：式（I）的1-羟基乙基 - 唑化合物，其中R是具有1至4个碳原子的烷基; 具有3至7个碳原子并且任选被具有1或2个碳原子的烷基取代的环烷基或任选被卤素取代的苯基，具有1至4个碳原子的烷基或具有1或2个碳原子的卤代烷基和1 至5个卤素原子; 或者是任选地被选自氟，氯，甲基和三氟甲基的相同或不同取代基单取代或二取代的苯基，是-CH-; Y是一个分组-OCH2-; Z是卤原子，具有1至4个碳原子的烷基; 具有5至7个碳原子的环烷基，具有1至4个碳原子的烷氧基，具有1至4个碳原子的烷硫基，1或2个碳原子的卤代烷基，1至5个卤原子，卤代烷氧基与1 或2个碳原子和1至5个卤素原子，具有1或2个碳原子和1至5个卤素原子的卤代烷硫基，任选被卤素或具有1至4个碳原子的烷基取代的苯基，苯氧基是任选地被卤素或具有1至4个碳原子的烷基取代，在烷基部分中具有1或2个碳原子并且任选被卤素或具有1至4个碳原子的烷基取代的苯基烷基或具有1或4个碳原子的苯基烷氧基，烷氧基部分中的2个碳原子，任选被卤素或具有1至4个碳原子的烷基取代; 和m为0,1,2或3及其生理学上可接受的酸加成盐或其金属盐络合物。这种化合物可用作植物生长调节剂和杀真菌剂。

34. 发明授权

US4762648A Monofunctional and bisfunctional anthraquinone-(oxy-2,3-oxidopropanes), processes for their preparation, and their use as drugs 失效
标题翻译：单功能和双功能蒽醌 - （氧-2,3-氧丙烷），其制备方法及其作为药物的用途
公开(公告)号：US4762648A
公开(公告)日：1988-08-09
申请号：US645266
申请日：1984-08-29
申请人： Ulrich Stache , Hans P. Kraemer , Hans-Harald Sedlacek
发明人： Ulrich Stache , Hans P. Kraemer , Hans-Harald Sedlacek
IPC分类号： C07D303/20 , A61K31/335 , A61K31/336 , A61P35/00 , C07D303/22 , C07D303/24 , C07D303/27 , C07C50/34 , C07D303/12
CPC分类号： C07D303/22 , C07D303/24
摘要： The present invention relates to a novel mono-functional and bis-functional anthraquinone-(oxy-2,3-oxido-propanes) and to a process for their preparation. The compounds according to the invention are useful as intermediates in the preparation of drugs possessing a .beta.-receptor blocker action and as crosslinking agents in the preparation of polymers, and moreover exhibit cytostatic activity.
摘要翻译：本发明涉及一种新的单官能和双官能蒽醌 - （氧-2,3-氧基丙烷）及其制备方法。根据本发明的化合物可用作制备具有β-受体阻滞剂作用的药物和作为聚合物制备中的交联剂的中间体，并且还表现出细胞抑制活性。

35. 发明授权

US4626595A Oxirane intermediates of 1-hydroxyethyl azole compounds 失效
标题翻译： 1-羟乙基唑化合物的环氧乙烷中间体
公开(公告)号：US4626595A
公开(公告)日：1986-12-02
申请号：US695610
申请日：1985-01-28
申请人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
发明人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
IPC分类号： A01N20060101 , A01N43/20 , A01N43/50 , A01N43/64 , A01N43/653 , C07D20060101 , C07D233/60 , C07D249/08 , C07D301/00 , C07D301/02 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/20 , C07D303/22 , C07D521/00
CPC分类号： A01N43/50 , A01N43/653 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/22
摘要： According to the present invention 1-hydroxyethyl azole compounds are provided for in a process characterized by reacting an oxirane of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3, with an azole of the general formula ##STR2## in which X represents a nitrogen atom or a CH group.
摘要翻译：根据本发明，提供1-羟乙基唑化合物，其特征在于使通式为“IMAGE”的环氧乙烷与其中R表示烷基，任选取代的环烷基或任选取代的苯基反应，分组-OCH 2 - ， - CH 2 CH 2 - 或-CH = CH-，Z表示卤素原子，烷基，环烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基或卤代烷硫基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基或任选取代的苯基烷氧基，m为0,1,2或3，其中X表示氮原子或CH基团，通式为“IMAGE”的唑类。

36. 发明申请

US20200054766A1 Inclusion Compounds of Fumagillol Derivative or its Salt, and Pharmaceutical Compositions Comprising the Same 审中-公开
公开(公告)号：US20200054766A1
公开(公告)日：2020-02-20
申请号：US16366408
申请日：2019-03-27
申请人： Chong Kun Dang Pharmaceutical Corporation
发明人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
IPC分类号： A61K47/69 , A61K47/02 , A61K9/00 , A61K31/336 , B82Y5/00 , C08L5/16 , C08B37/16 , C07D407/14 , C07D303/28 , C07D303/20 , C07D303/16
摘要： The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.

37. 发明授权

US08921584B2 Composition containing intermediate for water-soluble monomer and process for production thereof, composition containing water-soluble monomer, intermediate for water-soluble monomer, and water-soluble monomer and process for production thereof 有权
标题翻译：含有水溶性单体的中间体的组合物及其制造方法，含有水溶性单体的组合物，水溶性单体的中间体和水溶性单体及其制造方法
公开(公告)号：US08921584B2
公开(公告)日：2014-12-30
申请号：US13512845
申请日：2010-12-03
申请人： Atsuro Yoneda , Makoto Saito , Aki Tsukajima , Daisuke Michitaka , Mitsuaki Makino
发明人： Atsuro Yoneda , Makoto Saito , Aki Tsukajima , Daisuke Michitaka , Mitsuaki Makino
IPC分类号： C07C43/188 , C07C43/178 , C11D3/37 , C08F216/14 , C07C217/28 , C08F216/12 , C08F290/06 , C07D303/24 , C07D303/22 , C07D303/20 , C02F1/28
CPC分类号： C07C43/178 , C02F1/285 , C07C43/188 , C07C217/28 , C07D303/20 , C07D303/22 , C07D303/24 , C08F216/125 , C08F216/1416 , C08F290/062 , C11D3/3746 , C11D3/3757
摘要： A composition is provided that contains an intermediate for a water-soluble monomer, wherein this intermediate is suitable for producing a water-soluble polyalkylene glycol-type monomer that has a polymerizable terminal double bond, and suitable for the production of water-soluble polymer, and moreover allows the high-yield production of water-soluble polymer. A process of producing this composition and a water-soluble monomer-containing composition obtained therefrom are also provided. A water-soluble monomer is also provided that can be used as a starting material for a water-soluble polymer that even at high hardnesses exhibits an excellent capacity to capture metal ions such as the calcium ion and magnesium ion, an excellent anti-gelation performance, an excellent anti-soil redeposition performance, a better anti-dye transfer performance than in the past, and also an excellent compatibility with surfactants. A production process is also provided that can produce such a water-soluble monomer at higher yields and higher selectivities (higher purities) than in the past. A composition containing an intermediate for a water-soluble monomer, that contains a compound (A) having a specified structure and that contains a specified amount of a compound (B) having a specified structure. Also, a water-soluble monomer having a specified structure is provided.
摘要翻译：提供了含有水溶性单体中间体的组合物，其中该中间体适用于生产具有可聚合端基双键的水溶性聚亚烷基二醇型单体，适用于生产水溶性聚合物，而且允许高产量生产水溶性聚合物。还提供了制备该组合物的方法和由其获得的含水溶性单体的组合物。还提供了可用作水溶性聚合物的起始材料的水溶性单体，即使在高硬度下也显示出优异的俘获金属离子的能力，例如钙离子和镁离子，优异的抗胶凝性能，优异的抗土壤再沉积性能，比过去更好的抗染料转移性能，以及与表面活性剂的优异相容性。还提供了一种生产方法，其可以以比过去更高的产率和更高的选择性（更高的纯度）生产这种水溶性单体。含有水溶性单体中间体的组合物，其含有具有规定结构且含有规定量的具有规定结构的化合物（B）的化合物（A）。另外，提供具有特定结构的水溶性单体。

38. 发明授权

US5623025A Epoxy-functional hydroxy esters 失效
标题翻译：环氧官能羟基酯
公开(公告)号：US5623025A
公开(公告)日：1997-04-22
申请号：US643196
申请日：1996-05-06
申请人： Jimmy D. Elmore
发明人： Jimmy D. Elmore
IPC分类号： C07D303/20 , B01F17/00 , C07D303/24 , C08F4/42 , C08F4/72 , C08G59/14 , C08G59/16 , C08G59/62
CPC分类号： B01F17/0021 , C07D303/24 , C08G59/1438 , C08G59/625
摘要： A novel epoxy-functional hydroxy ester composition is produced by reacting (a) dimethylolpropionic acid and (b) an aliphatic or cycloaliphatic glycidyl ether, an epoxy novolac or a cycloaliphatic epoxy having a functionality of at least about 1.5 epoxide group per molecule.
摘要翻译：通过使（a）二羟甲基丙酸和（b）每分子具有至少约1.5个环氧基官能度的脂族或脂环族缩水甘油醚，环氧酚醛树脂或脂环族环氧化物反应来制备新的环氧官能羟基酯组合物。

39. 发明授权

US5446205A Functionalized fluoropolyethers 失效
标题翻译：官能化含氟聚醚
公开(公告)号：US5446205A
公开(公告)日：1995-08-29
申请号：US209497
申请日：1994-02-24
申请人： Giuseppe Marchionni , Piero Gavezotti , Ezio Strepparola
发明人： Giuseppe Marchionni , Piero Gavezotti , Ezio Strepparola
IPC分类号： C07D209/48 , C07C43/11 , C07C43/12 , C07C43/13 , C07C43/315 , C07C49/84 , C07C59/315 , C07C69/708 , C07C217/26 , C07C233/18 , C07C235/06 , C07C235/10 , C07C235/12 , C07C255/13 , C07C257/14 , C07D235/12 , C07D251/24 , C07D263/56 , C07D277/64 , C07D303/20 , C07D317/54 , C07F7/18 , C08G65/00 , C08G65/22 , C08G65/32 , C08G65/328 , C08G65/329 , C08G65/48 , C08K5/06 , C07C45/00
CPC分类号： C08G65/329 , C08G65/007 , C08G65/226 , C08G65/32
摘要： Fluoropolyethers having functional groups, consisting of randomly distributed sequences of perfluoropolyoxyalkylene units selected from: ##STR1## and included in one of the following formulas: ##STR2## where X is F or CF.sub.3 T, T', T"=a perfluoroalkyl group containing from 1 to 3 carbon atoms and one or two atoms of Cl, Br or I;R, R'=halogen atoms;Y=a functional group;o, q=numbers, zero included, such that o+q=1-20;n=a number ranging from 1 to 15;m/n=a number ranging from 0.01 to 0.5;p=a number ranging from 1 to 20;s/p=a number ranging from 0.5 to 2; andz/o+p=a number ranging from 0.01 to 0.05.
摘要翻译：具有官能团的含氟聚醚，由选自以下的全氟聚氧化烯单元的随机分布序列组成：图像（I）T'O（CF 2 CF 2 O）p（CF 2 O）s CR R'Y（II）（III）其中 X是F或CF 3 T，T'，T“=含有1至3个碳原子和1或2个Cl，Br或I原子的全氟烷基; R，R'=卤素原子; Y =官能团; o，q =数字，包括零，使得o + q = 1-20; n = 1到15之间的数字; m / n = 0.01〜0.5的数; p = 1到20之间的数字; s / p =从0.5到2的数字; z + o + p = 0.01〜0.05的数。

40. 发明授权

US4723984A 1-hydroxyethyl-azole compounds and agricultural compositions 失效
标题翻译： 1-羟乙基 - 唑类化合物和农业组合物
公开(公告)号：US4723984A
公开(公告)日：1988-02-09
申请号：US621968
申请日：1984-06-18
申请人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
发明人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
IPC分类号： A01N20060101 , A01N43/20 , A01N43/50 , A01N43/64 , A01N43/653 , C07D20060101 , C07D233/60 , C07D249/08 , C07D301/00 , C07D301/02 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/20 , C07D303/22 , C07D521/00 , A61K31/41
CPC分类号： A01N43/50 , A01N43/653 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/22
摘要： New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, -- CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.
摘要翻译：其中R表示烷基，任选取代的环烷基或任选取代的苯基的新的1-羟乙基 - 唑衍生物，其中R表示氮原子或CH基团，Y表示分组-OCH 2 - ， - CH 2 CH 2 - 或-CH = CH-，Z表示卤素原子，烷基，环烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基或卤代烷硫基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基或任选取代的苯基烷氧基，m为0,1,2或3，其制备方法及其用作植物生长调节剂和杀真菌剂。

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