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31. 发明申请

US20040265956A1 Method for producing target substance by fermentation 审中-公开
标题翻译：通过发酵生产目标物质的方法
公开(公告)号：US20040265956A1
公开(公告)日：2004-12-30
申请号：US10701923
申请日：2003-11-06
发明人： Rie Takikawa , Akira Imaizumi , Kazuhiko Matsui , Hiroyuki Kojima
IPC分类号： C12P013/04 , C12P013/08 , C12Q001/68 , C07H021/04 , C12N015/74
CPC分类号： C12P13/08
摘要： The present invention describes a method for producing a target substance using a microorganism comprising culturing an Escherichia bacterium in a medium to produce and accumulate the target substance in the medium or the bacterium, and collecting the target substance. More specifically, the bacterium of the present invention can be a strain in which the fis gene on bacterial chromosome is disrupted so that the FIS protein does not function normally in the bacterium.
摘要翻译：本发明描述了使用微生物制备目标物质的方法，所述微生物包括在培养基中培养大肠杆菌细菌以在培养基或细菌中产生和积累目标物质，并收集目标物质。更具体地说，本发明的细菌可以是细菌染色体上的fis基因被破坏，使得FIS蛋白在细菌中不起作用的菌株。

32. 发明申请

US20040265910A1 Peptides for use in culture media 失效
标题翻译：用于培养基的肽
公开(公告)号：US20040265910A1
公开(公告)日：2004-12-30
申请号：US10841056
申请日：2004-05-07
发明人： Perry D. Haaland , Douglas B. Sherman , Robert L. Campbell , Walter William Stewart , Sheila A. Lloyd , Bruce Wayne Erickson , Ann Hart Erickson
IPC分类号： G01N033/53 , C07H021/04 , C07K014/47 , C12N009/00
CPC分类号： C07K7/06 , C07K1/047 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C40B30/06
摘要： The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods.

33. 发明申请

US20040265852A1 Diangnosis and treatment of AUR1 and/or AUR2 related disorders 有权
标题翻译： AUR1和/或AUR2相关疾病的症状和治疗
公开(公告)号：US20040265852A1
公开(公告)日：2004-12-30
申请号：US10734126
申请日：2003-12-15
申请人： SUGEN, INC.
发明人： Gregory Plowman , James Bischof
IPC分类号： C12Q001/68 , C07H021/04 , C07K014/705
CPC分类号： C12Q1/485 , G01N2333/9121 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR1 and/or AUR2 related diseases or conditions characterized by an abnormal interaction between a AUR1 and/or AUR2 polypeptide and a AUR1 and/or AUR2 binding partner.
摘要翻译：本发明涉及AUR1和/或AUR2多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，此类多肽的抗体，利用此类多肽的测定法以及与上述所有相关的方法。 AUR1和/或AUR2相关疾病或特征为AUR1和/或AUR2多肽与AUR1和/或AUR2结合配偶体之间异常相互作用的病症的治疗，诊断和筛选方法。

34. 发明申请

US20040265839A1 RNA interference pathway genes as tools for targeted genetic interference 有权
标题翻译： RNA干扰途径基因作为靶向遗传干扰的工具
公开(公告)号：US20040265839A1
公开(公告)日：2004-12-30
申请号：US10645746
申请日：2003-08-20
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL
发明人： Craig C. Mello , Andrew Fire , Hiroaki Tabara , Alla Grishok
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/22 , C12N015/85
CPC分类号： C12N15/67 , C07K14/43545
摘要： Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.
摘要翻译：鉴定涉及双链RNA干扰基因（RNAi途径基因）并用于研究RNAi途径。基因及其产物也可用于调节RNAi通路活性。

35. 发明申请

US20040265837A1 Test system for the development of therapeutic agents, in particular active compounds for the treatment of osteoporosis 失效
标题翻译：用于开发治疗剂的试验系统，特别是治疗骨质疏松症的活性化合物
公开(公告)号：US20040265837A1
公开(公告)日：2004-12-30
申请号：US10622377
申请日：2003-07-18
发明人： Thomas J. Jentsch
IPC分类号： C12Q001/68 , A01K067/00 , C07H021/04 , C07K014/705
CPC分类号： C07K14/705 , A01K2217/075
摘要： The present invention relates to a test system for the identification and testing of active compounds which act on synapic transmission (active compounds for treatment of neuronal diseases), which influence endo/exocytosis, which influence processing of proteins and in particular of active compounds which can be used for treatment of osteoporosis or Paget's disease, for treatment of neurological and neuromuscular diseases and other nerve diseases or as psychotropic pharmaceuticals. The invention furthermore relates to a genetically modified non-human mammal, in which one or more chloride channels from the group consisting of CIC-3. CIC-4, CIC-6 and CIC-7 are not expressed or are expressed non-functionally, and somatic cell lines which are derived from such an animal, and the use thereof for the identification and testing of substances which are suitable for inhibiting chloride channels, in particular CIC-3, CIC-4, CIC-5, CIC-6 and/or CIC-7.
摘要翻译：本发明涉及一种用于鉴定和检测影响内吞/胞吐作用的活化化合物的作用于突触传递的活性化合物（用于治疗神经元疾病的活性化合物），其影响蛋白质，特别是活性化合物的加工，其可以用于治疗骨质疏松症或佩吉特氏病，用于治疗神经和神经肌肉疾病和其他神经疾病或作为精神药物。本发明还涉及一种遗传修饰的非人哺乳动物，其中一个或多个来自CIC-3的氯化物通道。 CIC-4，CIC-6和CIC-7不表达或非功能表达，并且衍生自这种动物的体细胞系及其用于鉴定和测试适于抑制氯化物的物质的用途通道，特别是CIC-3，CIC-4，CIC-5，CIC-6和/或CIC-7。

36. 发明申请

US20040265835A1 Method of sorting vesicle-entrapped, coupled nucleic acid-protein displays 审中-公开
标题翻译：分离囊泡夹带的偶联核酸蛋白质显示器的方法
公开(公告)号：US20040265835A1
公开(公告)日：2004-12-30
申请号：US10610024
申请日：2003-06-30
发明人： David M. Lemaster , James H. Jett
IPC分类号： C12Q001/68 , C07H021/04 , C12P021/04 , C12N009/00 , C12N001/18
CPC分类号： C40B40/02 , C07H21/04 , C12N15/1037
摘要： A method for identifying and sorting variants of a chosen enzyme is disclosed. Enzyme variants of a chosen enzyme are obtained and then linked to their corresponding genetic code through any of a family of suitable surface display methods. The enzyme variants, now displayed on the surface of a biological particle such as a phage, virus, yeast, or bacterium are then encapsulated in a vesicle containing an enzyme activity-sensitive assay reagent. The enzyme variant is thus exposed to the assay reagent, and displays a signal using the enzyme activity-sensitive assay reagent in a manner proportionate to the levels of activity of the enzyme, thus rendering the vesicles suitable for mechanical sorting based on these levels. The vesicles are then sorted using methods known in the art to isolate those variants exhibiting possibly beneficial variations in enzyme function.
摘要翻译：公开了用于鉴定和分选所选酶的变体的方法。获得选择的酶的酶变体，然后通过任何一种合适的表面显示方法与其相应的遗传密码连接。然后将现在显示在诸如噬菌体，病毒，酵母或细菌的生物颗粒的表面上的酶变体包封在含有酶活性敏感性测定试剂的囊泡中。因此，酶变体暴露于测定试剂，并且以与酶的活性水平成比例的方式使用酶活性敏感的测定试剂显示信号，从而使得囊泡适合于基于这些水平的机械分选。然后使用本领域已知的方法分选囊泡，以分离显示可能有益的酶功能变化的那些变体。

37. 发明申请

US20040265834A1 Human interleukin-17 receptor like molecule 失效
标题翻译：人白细胞介素-17受体样分子
公开(公告)号：US20040265834A1
公开(公告)日：2004-12-30
申请号：US10608449
申请日：2003-06-30
申请人： TSINGHUA UNIVERSITY
发明人： Shiqin Xiong , Zhijie Chang , Fu Xinyuan
IPC分类号： C12Q001/68 , C07H021/04 , C07K014/715
CPC分类号： C07K14/7155 , C07H21/04
摘要： The application relates to a newly identified polynucleotide, polypeptide encoded by such polynucleotide, the use of such polynucleotide and polypeptide, as well as the production of such polynucleotide and polypeptide. More particularly, the polypeptide of the present invention is human interleukin-17 receptor like molecule (IL-17RLM).
摘要翻译：本申请涉及新鉴定的多核苷酸，由该多核苷酸编码的多肽，这种多核苷酸和多肽的用途以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是人白细胞介素-17受体样分子（IL-17RLM）。

38. 发明申请

US20040265818A1 Histidine phosphatase interacting protein with 180kd 失效
标题翻译：组氨酸磷酸酶相互作用蛋白与180kd
公开(公告)号：US20040265818A1
公开(公告)日：2004-12-30
申请号：US10483679
申请日：2004-01-13
发明人： Roland Kellner , Bjoern Hock
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/16
CPC分类号： C07K14/47 , C07K2319/00
摘要： PHPIP-180 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PHPIP-180 polypeptides and polynucleotides in diagnostic assays.

39. 发明申请

US20040265806A1 Position-independent and tissue specific expression of a transgene in milk of transgenic animals 失效
标题翻译：在转基因动物牛奶中转基因的位置无关和组织特异性表达
公开(公告)号：US20040265806A1
公开(公告)日：2004-12-30
申请号：US10451503
申请日：2003-06-23
发明人： Sylvie Rival , Celine Viglietta , Joe Attal , Louis-Marie Houdebine
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/20
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/052 , A01K2217/206 , A01K2227/105 , A01K2267/01 , C07K14/47 , C12N15/63 , C12N15/8509 , C12N2800/204 , C12N2830/40 , C12N2830/85
摘要： The present invention relates to an isolated insulator DNA molecule consisting of the 5null and 3null regions of the porcine wrap gene locus and a method for insulating the expression of an introduced heterologous gene from silencing and variegation effect in chromatin into which the gene has integrated. The invention is also directed to mammalian cells comprising said insulator DNA molecule and non human animals obtained therefrom, which are preferably able to express a polypeptide of interest in milk.
摘要翻译：本发明涉及由猪包裹基因座的5'和3'区域组成的分离的绝缘子DNA分子，以及将引入的异源基因的表达与基因整合到染色质中的沉默和杂色效应绝缘的方法。本发明还涉及包含所述绝缘体DNA分子和由其获得的非人动物的哺乳动物细胞，其优选能够在牛奶中表达感兴趣的多肽。

40. 发明申请

US20040265330A1 Novel compounds 失效
标题翻译：新型化合物
公开(公告)号：US20040265330A1
公开(公告)日：2004-12-30
申请号：US10889335
申请日：2004-07-12
申请人： SmithKline Beecham Biologicals S.A.
发明人： Jean-Louis Ruelle
IPC分类号： C12Q001/68 , C07H021/04 , A61K039/02 , C07K014/195 , C12N001/21 , C12N015/74
CPC分类号： C07K14/22
摘要： The invention provides BASB047, BASB054, BASB068 and BASB069 polypeptides, and polynucleotides encoding BASB047, BASB054, BASB068 and BASB069 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
摘要翻译：本发明提供了BASB047，BASB054，BASB068和BASB069多肽，以及编码BASB047，BASB054，BASB068和BASB069多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供诊断，预防和治疗用途。

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