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31. 发明申请

WO2009039181A3 SULFONAMIDE-BASED ORGANOCATALYSTS AND METHOD FOR THEIR USE 审中-公开
标题翻译：基于磺酰胺的有机化合物及其使用方法
公开(公告)号：WO2009039181A3
公开(公告)日：2009-07-16
申请号：PCT/US2008076688
申请日：2008-09-17
申请人： STATE OF OREGON ACTING BY & TH , CARTER RICH GARRETT , YANG HUA
发明人： CARTER RICH GARRETT , YANG HUA
IPC分类号： B01J31/00 , C07C311/18 , C07C313/00
CPC分类号： B01J31/0237 , B01J31/0222 , B01J31/0247 , B01J31/0271 , B01J2231/32 , B01J2231/341 , B01J2231/346 , B01J2231/4283 , B01J2231/46
摘要： Organocatalysts, particularly proline sulfonamide organocatalysts, having a first general formula as follows are disclosed. Embodiments of a method for using these organocatalysts also are disclosed. The method comprises providing a disclosed organocatalyst, and performing a reaction, often an enantioselective or diastereoselective reaction, using the organocatalyst. Solely by way of example, disclosed catalysts can be used to perform aldol reactions, conjugate additions, Michael additions, Robinson annulations, Mannich reactions, a-aminooxylations, a-hydroxyaminations, a-aminations and alkylation reactions. Certain of such reactions are intramolecular cyclizations used to form cyclic compounds, such as 5- or 6-membered rings, having one or more chiral centers. Disclosed organocatalysts generally are much more soluble in typical solvents used for organic synthesis than are known compounds. Moreover, the reaction yield is generally quite good with disclosed compounds, as is their enantioselective and diastereoselective effectiveness.
摘要翻译：公开了具有如下第一通式的有机催化剂，特别是脯氨酸磺酰胺有机催化剂。也公开了使用这些有机催化剂的方法的实施方式。该方法包括提供公开的有机催化剂，并使用有机催化剂进行反应，通常是对映选择性或非对映选择性反应。仅举例而言，公开的催化剂可用于进行醛醇缩合反应，缀合物加成，迈克尔加成，罗宾逊环，曼尼希反应，α-氨氧基化，α-羟胺化，α-胺化和烷基化反应。某些这样的反应是用于形成具有一个或多个手性中心的环状化合物例如5元或6元环的分子内环化。披露的有机催化剂通常比已知化合物更易溶于用于有机合成的典型溶剂。此外，所公开的化合物的反应收率通常相当好，它们的对映选择性和非对映选择性效果也是如此。

32. 发明申请

WO2007095383A3 PRODRUGS 审中-公开
标题翻译：前体药物
公开(公告)号：WO2007095383A3
公开(公告)日：2008-09-25
申请号：PCT/US2007004189
申请日：2007-02-15
申请人： MYRIAD GENETICS INC , WALTON RUTH J , SLADE RACHEL M , WILLARDSEN J ADAM , WEINER WARREN S , ANDERSON MARK B
发明人： WALTON RUTH J , SLADE RACHEL M , WILLARDSEN J ADAM , WEINER WARREN S , ANDERSON MARK B
IPC分类号： C07C49/00 , A61K31/12 , A61K31/27 , C07C237/00 , C07C313/00
CPC分类号： A61K31/24 , C07C69/65 , C07C217/08 , C07C219/32 , C07C233/07 , C07C233/11 , C07C233/15 , C07C233/22 , C07C233/40 , C07C233/44 , C07C307/04 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D207/09 , C07D209/08 , C07D211/58 , C07D213/70 , C07D213/75 , C07D231/56 , C07D233/61 , C07D257/06 , C07D277/04 , C07D295/18
摘要： The invention relates prodrugs of phenyl alkanoic acids. The prodrugs of the invention can enhance and/or improve delivery of the phenyl alkanoic acid moiety to a desired target tissue.
摘要翻译：本发明涉及苯基链烷酸的前药。本发明的前药可以增强和/或改善苯基链烷酸部分向期望的靶组织的递送。

33. 发明申请

WO00001389A1 BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：联苯磺隆作为双血管内皮素受体拮抗剂
公开(公告)号：WO00001389A1
公开(公告)日：2000-01-13
申请号：PCT/US1999/015063
申请日：1999-07-01
IPC分类号： C07D233/70 , A61K31/18 , A61K31/415 , A61K31/4162 , A61K31/4178 , A61K31/4184 , A61K31/42 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/437 , A61K31/4418 , A61K31/4427 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/517 , A61P3/00 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P15/08 , A61P15/10 , A61P25/06 , A61P35/00 , A61P43/00 , C07D211/72 , C07D213/68 , C07D215/16 , C07D233/28 , C07D235/02 , C07D235/26 , C07D239/72 , C07D261/16 , C07D401/12 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/505 , C07C313/00 , C07D249/08 , C07D261/04 , C07D413/00 , C07D471/02
CPC分类号： C07D403/14 , C07D261/16 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutical compositions containing such compounds.
摘要翻译：联合血管紧张素和内皮素受体拮抗剂的新型联苯磺酰胺化合物以及使用这些化合物治疗诸如高血压和其它疾病的病症的方法以及含有这些化合物的药物组合物。

34. 发明申请

WO98050030A1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES 审中-公开
标题翻译：蛋白质异丙基转移酶抑制剂
公开(公告)号：WO98050030A1
公开(公告)日：1998-11-12
申请号：PCT/US1998/009297
申请日：1998-05-07
IPC分类号： C07D295/12 , A61K31/198 , A61K31/223 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/4152 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/4458 , A61K31/472 , A61K31/4965 , A61K31/4985 , A61K31/505 , A61K31/5375 , A61K31/7028 , A61P9/10 , A61P35/00 , A61P43/00 , C07C237/36 , C07C239/20 , C07C271/22 , C07C317/50 , C07C323/16 , C07C323/59 , C07C323/60 , C07C327/42 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/267 , C07D209/14 , C07D209/40 , C07D209/48 , C07D211/14 , C07D211/22 , C07D211/42 , C07D211/52 , C07D211/58 , C07D211/60 , C07D211/90 , C07D213/30 , C07D213/32 , C07D213/36 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/74 , C07D213/75 , C07D213/76 , C07D217/26 , C07D231/38 , C07D231/48 , C07D233/54 , C07D233/64 , C07D235/06 , C07D235/08 , C07D237/14 , C07D237/20 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D241/20 , C07D241/24 , C07D253/06 , C07D257/04 , C07D261/02 , C07D261/14 , C07D263/22 , C07D263/24 , C07D263/32 , C07D265/30 , C07D275/02 , C07D277/04 , C07D277/06 , C07D277/20 , C07D277/22 , C07D277/26 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/50 , C07D277/66 , C07D279/12 , C07D285/12 , C07D285/135 , C07D295/084 , C07D295/13 , C07D295/155 , C07D295/185 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/81 , C07D309/04 , C07D309/14 , C07D317/30 , C07D317/58 , C07D317/60 , C07D317/66 , C07D319/06 , C07D319/08 , C07D319/18 , C07D333/18 , C07D333/20 , C07D333/24 , C07D335/04 , C07D471/04 , C07D487/08 , C07F9/53 , C07H15/18 , A61K31/38 , A61K31/095 , A61K31/18 , A61K31/39 , A61K31/425 , A61K31/44 , A61K31/495 , C07C303/00 , C07C307/00 , C07C309/00 , C07C313/00 , C07D209/10 , C07D239/24 , C07D263/02 , C07D307/00 , C07D333/00
CPC分类号： C07D207/08 , C07B2200/07 , C07C237/36 , C07C239/20 , C07C271/22 , C07C317/50 , C07C323/59 , C07C323/60 , C07C327/42 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07C2603/18 , C07C2603/24 , C07C2603/74 , C07D205/04 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/267 , C07D209/48 , C07D211/14 , C07D211/42 , C07D211/52 , C07D211/58 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/74 , C07D213/75 , C07D213/76 , C07D233/64 , C07D235/06 , C07D237/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D253/06 , C07D257/04 , C07D261/02 , C07D263/22 , C07D263/32 , C07D265/30 , C07D277/30 , C07D277/36 , C07D277/48 , C07D277/50 , C07D277/587 , C07D279/12 , C07D295/084 , C07D295/13 , C07D295/155 , C07D295/185 , C07D307/54 , C07D307/81 , C07D317/30 , C07D317/60 , C07D333/18 , C07D333/20 , C07D333/24 , C07D487/08 , C07F9/5333
摘要： Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2-, and (i) heterocyclic-L2-; R2 is selected from (a) (Ia), (b) -C(O)NH-CH(R14)-C(O)OR15, (c) (Ib), (d) -C(O)NH-CH(R14)-C(O)NHSO2R16, (e) -C(O)NH-CH(R14)-tetrazolyl, (f) -C(O)NH-heterocyclic, and (g) -C(O)NH-CH(R14)-C(O)NR17R18; R3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, (Ic), and -P(W)R R ; R4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L1 is absent or is selected from (a) -L4-N(R5)-L5-, (b) -L4-O-L5-, (c) -L4-S(O)n-L5-, (d) -L4-L6-C(W)-N(R5)-L5-, (e) -L4-L6-S(O)m-N(R5)-L5-, (f) -L4-N(R5)-C(W)-L7-L5-, (g) -L4-N(R5)-S(O)p -L7-L5-, (h) optionally substituted alkylene, (i) optionally substituted alkenylene, (j) optionally substituted alkynylene, (k) a covalent bond, (l) (Id), and (m) (Ie) are inhibitors of protein isoprenyl transferases. Also disclosed are protein isoprenyl transferase inhibiting compositions and a method of inhibiting protein isoprenyl transferases.
摘要翻译：具有式（I）化合物或其药学上可接受的盐，其中R 1是（a）氢，（b）低级烷基，（c）烯基，（d）烷氧基，（e）硫代烷氧基，（f）卤素，（g）卤代烷基，（h）芳基-L2-和（i）杂环-L2-; R2选自（a）（Ia），（b）-C（O）NH-CH（R14）-C（O）OR15，（c）（Ib），（d）-C（O）NH-CH （R 14）-C（O）NHSO 2 R 16，（e）-C（O）NH-CH（R 14） - 四唑基，（f）-C（O）NH-杂环，和（g）-C（O） CH（R 14）-C（O）NR 17 R 18; R 3是取代或未取代的杂环或芳基，取代或未取代的环烷基或环烯基，（Ic）和-P（W）R R3是R3。 R4是氢，低级烷基，卤代烷基，卤素，芳基，芳基烷基，杂环或（杂环）烷基; （a）-L4-N（R5）-L5-，（b）-L4-O-L5-，（c）-L4-S（O）n-L5-，（d） -L4-L6-C（W）-N（R5）-L5-，（e）-L4-L6-S（O）mN（R5）-L5-，（f）-L4-N（R5）-C （W）-L7-L5-，（g）-L4-N（R5）-S（O）p -L7-L5-，（h）任选取代的亚烷基，（i）任选取代的亚烯基，（j）亚烷基，（k）共价键，（1）（Id）和（m）（Ie）是蛋白质异戊二烯基转移酶的抑制剂。还公开了蛋白质异戊二烯转移酶抑制组合物和抑制蛋白质异戊二烯转移酶的方法。

35. 发明申请

WO8701701A3 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：含氮杂质化合物
公开(公告)号：WO8701701A3
公开(公告)日：1987-06-18
申请号：PCT/EP8600530
申请日：1986-09-15
申请人： MERCK PATENT GMBH , WAECHTLER ANDREAS , EIDENSCHINK RUDOLF , KRAUSE JOACHIM , SCHEUBLE BERNHARD
发明人： WAECHTLER ANDREAS , EIDENSCHINK RUDOLF , KRAUSE JOACHIM , SCHEUBLE BERNHARD
IPC分类号： C09K19/20 , C07C45/00 , C07C49/00 , C07C49/788 , C07C49/792 , C07C67/00 , C07C253/00 , C07C313/00 , C07C323/16 , C07D213/00 , C07D213/30 , C07D213/55 , C07D213/57 , C07D213/65 , C07D213/79 , C07D237/00 , C07D237/08 , C07D239/00 , C07D239/26 , C07D241/12 , C07D265/00 , C07D265/08 , C07D319/06 , C07D339/08 , C09K19/00 , C09K19/22 , C09K19/30 , C09K19/32 , C09K19/34 , C09K19/42 , G02F1/13 , C07D237/14 , C07D241/18
CPC分类号： C09K19/3441 , C09K19/3068 , C09K19/322 , C09K19/3444 , C09K19/3452 , C09K19/3455 , C09K19/3458 , C09K19/42 , C09K2019/325 , C09K2019/326
摘要： Nitrogen-containing heterocyclic compounds of formula (II) wherein R1 and R2 which signifie an alkyl group with 1 to 15 C atoms, wherein also one or several CH2-groups can be replaced by a grouping selected on the group -O-, -S-, -CO-, -O-CO-, -O-COO-, -CO-O-, -CH=CH-, -CH-halogen and -CHCN- or also by a combination of two suited groups, whereby two heteroatoms are not directly linked with one another, m is 0 or 1, Ar is 1,4-phenylen, 4,4'-bi-phenyl or 2,6-naphthylen, in each of which one or several CH-groups are replaced by an N, Z signifies -CO-O-, -O-CO-, -CH2O-, -OCH2-, CH2CH2-, -CH2CHCN-, -CHCNCH2-, -CH=CH or a single bond and A is 1, 4-cyclohexylen, unsubstituted or substituted and the 1- or 4- position, with the condition that in the case where A=unsubstituted 1,4 cyclohexil Z is -CHCNCH2- or -CH2CHCN and/or an at least one of the residues R1 and R2 at least one CH2-group is replaced by -CHCN-, such compounds being suitable for use as components of smectic liquid crystal phases.

36. 发明申请

WO8700521A3 NEW CARBOXYLIC ACID DERIVATIVES,THEIR MANUFACTURING PROCESS,USE AND MEDICINES CONTAINING THESE COMPOUNDS 审中-公开
标题翻译：新型羧酸衍生物及其制备方法，使用和含有这些化合物的药物
公开(公告)号：WO8700521A3
公开(公告)日：1987-03-12
申请号：PCT/EP8600406
申请日：1986-07-10
申请人： BOEHRINGER MANNHEIM GMBH , WOLFF HANS PETER , WITTE ERNST CHRISTIAN , KUEHNLE HANS FRIEDER
发明人： WOLFF HANS PETER , WITTE ERNST-CHRISTIAN , KUEHNLE HANS-FRIEDER
IPC分类号： C07C69/736 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , A61K31/49 , C07C20060101 , C07C51/00 , C07C59/125 , C07C59/215 , C07C59/64 , C07C59/68 , C07C59/76 , C07C59/88 , C07C67/00 , C07C69/65 , C07C69/708 , C07C69/738 , C07C227/00 , C07C227/08 , C07C227/16 , C07C229/22 , C07C229/30 , C07C229/36 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/45 , C07C233/47 , C07C233/51 , C07C233/63 , C07C233/65 , C07C233/81 , C07C235/20 , C07C237/06 , C07C237/22 , C07C253/00 , C07C255/32 , C07C309/29 , C07C309/63 , C07C309/65 , C07C309/77 , C07C311/00 , C07C311/02 , C07C311/03 , C07C311/06 , C07C311/15 , C07C311/19 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/14 , C07C317/44 , C07C317/46 , C07C323/52 , C07C323/56
CPC分类号： C07C317/00 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , C07C59/64 , C07C59/68 , C07C59/88 , C07C309/00 , C07C323/00
摘要： New carboxylic acide derivatives having general formula (I) in which R1 is a possibly substituted aryl or aryloxy residue; R2 is hydrogen, a lower alkyl residue or the group R1-A-, as well as in the case where X represents the cyano group, an acylamino or amino group; A is a group of straight-chain or branched-chain, saturated or unsaturated alkyl group with 3 to 8 carbon atoms, which has a chain length of at least 3 carbon atoms; X represents the cyano group or a group of the formula -B-R3 or -D-NR4R5, in which B is O, S, SO, SO2, O(CO), OSO2, NHCO, NHSO2 or CO; D represents a valency dash, SO2 or CO; R3 is an alkyl, trifluoromethyl, cycloalkyl, aralkyl-, aralkenyl- or aryl group, in which the respective aryl residue can possibly be substituted; R4 is hydrogen, a lower alkyl residue, a possibly substituted aryl or aralkyl residue; R5 is hydrogen, a lower alkyl residue or R4 and R5 together are an alkyl chain with 4 to 6 carbon atoms which may be interrupted by O, S or NR6, and R6 is hydrogen, a lower alkyl residue or possibly a substituted phenyl or benzyl residue. Also described are their physiologically neutral salts, esters, amides and nitriles provided that in the case where: a) A is an alkyl group with 3 carbon atoms; a1) in all cases the aryl residue of the group R1 is not the unsubstituted phenyl residue and a2) X may not represent the groups -CN, NHCOR3 and NR4R5; b) where X is a residue of the formula -SCH3, R2 may not represent methyl; c) where X is the -NH2 or -NHCOCH3 group R1A- may not represent 4-phenylbutyl or 4-(4-methoxyphenyl)butyl; d) where X is the 2,4-dinitrophenyl group, R1A may not represent 4-phenylbutyl or 5-phenylpentyl; e) where X is the -COCH3 group, R1A may not represent 3-(2-chlorphenyl)propyl or 5-(4-methoxyphenyl)-pentyl. These compounds are used as medicines for lowering the sugar-level in the blood.

37. 发明申请

WO8604234A3 THROMBOXANE ANTAGONISTS IN THE TREATMENT OF HORMONE-DEPENDENT NEOPLASIAS 审中-公开
标题翻译：治疗依赖于雌激素的血栓素拮抗剂
公开(公告)号：WO8604234A3
公开(公告)日：1986-09-12
申请号：PCT/GB8600028
申请日：1986-01-16
申请人： NAT RES DEV , SENIOR JUDITH , TROUGHTON KAY MARIE
发明人： SENIOR JUDITH , TROUGHTON KAY MARIE
IPC分类号： C07C281/06 , A61K31/175 , A61K31/557 , C07C67/00 , C07C239/00 , C07C313/00 , C07C323/44 , C07C325/00 , C07C337/06 , C07C405/00 , C07D493/00
CPC分类号： C07C405/0091 , A61K31/175 , A61K31/557
摘要： Compounds having thromboxane antagonist activity are of use in the treatment of hormone-dependent neoplasias for example oestrogen-dependent neoplasias. Thromboxane antagonists of particular value are compounds of formula (I) wherein formula (II) represents one of the divalent cyclic groups (III). The letters a and b indicating in each case the points of attachment of the substituents R1 and CV(R2)-NV'R, respectively; R1 is a 6-carboxyhex-2-enyl group or a modification thereof in which the group is altered by one, or an appropriate combination of two or more, of the following: (a) alteration of the position of the double bond, (b) reduction of the double bond, (c) alteration of the chain length through a decrease of one or two methylene groups or an increase of one to six methylene groups, (d) replacement of one or two methylene groups each separately by an oxygen or sulphur atom with the proviso that in the modified group no oxygen or sulphur atom is in an alpha position relative to either a doubly bonded carbon atom or to the carboxy group or a derivative thereof and that at least 2 carbon atoms separate any pair of oxygen and/or sulphur atoms; and (e) formation of an amide, ester or salt derivative of the carboxy groups; V and V' either each separately is hydrogen or together are the second bond of a carbon-nitrogen double bond; R2 is hydrogen, an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R is a group -NH.CO.NH-R3 or -NH.CS.NH-R3 wherein R3 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by one or more aromatic groups directly or through an oxygen or sulphur atom.

38. 发明授权

EP1094816B1 BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS 有权
标题翻译：血管紧张素和内皮素的BIPHENYLSULFONAMIDE一倍以上ACTIVE受体拮抗剂
公开(公告)号：EP1094816B1
公开(公告)日：2008-12-10
申请号：EP99935406.1
申请日：1999-07-01
申请人： Bristol-Myers Squibb Company
发明人： MURUGESAN, Natesan , TELLEW, John, E. , MACOR, John, E. , GU, Zhengxiang
IPC分类号： A61K31/505 , A61K31/415 , C07C313/00 , C07D211/72 , C07D215/16 , C07D233/28 , C07D239/72 , C07D249/08 , C07D261/04 , C07D413/00 , C07D261/16 , C07D401/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , A61P9/12
CPC分类号： C07D403/14 , C07D261/16 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutical compositions containing such compounds.

39. 发明授权

EP0896533B1 PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS 失效
标题翻译： PENTAFLUOROBENZENSULFONAMIDEN和模拟
公开(公告)号：EP0896533B1
公开(公告)日：2003-09-10
申请号：EP97907843.3
申请日：1997-02-22
申请人： TULARIK, INC.
发明人： CLARK, David , FLYGARE, John , MEDINA, Julio, C. , ROSEN, Terry , SHAN, Bei
IPC分类号： A61K31/18 , A61K31/275 , C07C303/00 , C07C307/00 , C07C309/00 , C07C313/00 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/5375 , A61K31/44 , A61P3/08
CPC分类号： C07D319/18 , A61K31/18 , A61K31/275 , A61K31/357 , A61K31/404 , A61K31/416 , A61K31/44 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C323/49 , C07D209/08 , C07D213/75 , C07D231/56 , C07D317/66
摘要： The invention provides methods and compositions relating to novel pentafluorobenzenesulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of general formula (I).

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