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31. 发明申请

WO00056320A1 TREATMENT OF MENSTRUAL FUNCTION 审中-公开
标题翻译：治疗器官功能
公开(公告)号：WO00056320A1
公开(公告)日：2000-09-28
申请号：PCT/US2000/007242
申请日：2000-03-17
IPC分类号： A61K31/135 , A61K31/137
CPC分类号： A61K31/135 , A61K31/137 , Y10S514/899
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N , N -dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for treating menstrual function and infertility.
摘要翻译：式（I）化合物或其药学上可接受的盐，其中R 1和R 2独立地为H或甲基（例如N，N'-二甲基-1- [1 - （4-氯苯基）环丁基] -3-甲基丁基胺盐酸盐，任选以其一水合物的形式）用于治疗月经功能和不育症。

32. 发明申请

WO9635453A3 ENDOTHELIN ANTAGONISTS AND ENDOTHELIN SYNTHASE INHIBITORS FOR THE PREVENTION AND TREATMENT OF UTERINE CONTRACTILITY DISORDERS, PREECLAMPSIA, ATHEROSCLEROTIC VASCULAR DISEASE, HYPERTENSION AND FOR HORMONE REPLACEMENT THERAPY 审中-公开
标题翻译：内皮素拮抗剂和内皮素合成酶抑制剂，用于预防和治疗子宫内膜异位症，前列腺炎，血管性血管疾病，高血压和霍尔米尔替代治疗
公开(公告)号：WO9635453A3
公开(公告)日：1997-03-13
申请号：PCT/US9515220
申请日：1995-11-30
申请人： CHWAKISZ KRISTOF , GARFIELD ROBERT E
发明人： CHWAKISZ KRISTOF , GARFIELD ROBERT E
IPC分类号： A61K31/00 , A61K31/223 , A61K31/42 , A61K31/565 , A61K31/57 , A61K31/60 , A61K38/12 , A61K45/06 , A61K31/22
CPC分类号： A61K45/06 , A61K31/00 , A61K31/223 , A61K31/42 , A61K31/565 , A61K31/57 , A61K31/60 , A61K38/12 , Y10S514/899 , A61K2300/00
摘要： A pharmaceutical composition for and methods of treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal, treatment of atherosclerotic vascular disease and hypertension in males as well as females, and for hormone replacement therapy in peri- and post-menopausal females, comprising administering effective amounts of an endothelin antagonist and/or an endothelin synthase inhibitor or both, in combination with (a) a progestin, and/or and estrogen, and/or (b) a cyclooxygenase inhibitor, and/or (c) a nitric oxide donor and/or nitric substrate, to prevent and/or ameliorate said conditions, are disclosed. In the method aspects, the endothelin antagonist and/or endothelin synthase inhibitor can be administered alone for treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal. Further, methods for screening compounds for such treatments are disclosed.

33. 发明申请

WO1995004535A1 ESTROGENIC COMPOUNDS AS ANTI-MITOTIC AGENTS 审中-公开
标题翻译：雌激素化合物作为抗菌剂
公开(公告)号：WO1995004535A1
公开(公告)日：1995-02-16
申请号：PCT/US1994008767
申请日：1994-08-02
申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION
发明人： THE CHILDREN'S MEDICAL CENTER CORPORATION , D'AMATO, Robert, John , FOLKMAN, Moses, Judah
IPC分类号： A61K31/56
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The application discloses methods of making medicaments for treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of general formulae found above in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
摘要翻译：本申请公开了通过以足以抑制细胞有丝分裂的剂量施用包括秋水仙碱或考布司他汀A-4结构基序的雌二醇衍生物，其特征在于治疗以异常细胞有丝分裂为特征的哺乳动物疾病的药物的方法。本申请公开了该方法中使用的新化合物。

34. 发明申请

WO1994023716A1 METHOD FOR TREATMENT OF MENOPAUSAL AND PREMENSTRUAL SYMPTOMS 审中-公开
标题翻译：治疗男性和母亲症状的方法
公开(公告)号：WO1994023716A1
公开(公告)日：1994-10-27
申请号：PCT/US1994004189
申请日：1994-04-15
申请人： TUFTS UNIVERSITY SCHOOL OF MEDICINE
发明人： TUFTS UNIVERSITY SCHOOL OF MEDICINE , GORBACH, Sherwood, L. , GOLDIN, Barry, R. , ADLERCREUTZ, Herman
IPC分类号： A61K31/35
CPC分类号： A61K31/35 , A23L33/11 , A61K31/12 , Y10S514/899
摘要： A method is provided for preventing or treating symptoms of menopause, premenstrual syndrome, or a condition resulting from reduced levels of endogenous estrogen, by administering to the woman an effective amount of an isoflavonoid. The invention also features a therapeutic dietary product, containing isoflavonoids, for preventing or treating symptoms of conditions resulting from reduced or altered levels of endogenous estrogen.
摘要翻译：通过向女性施用有效量的异黄酮提供了一种预防或治疗更年期症状，经前期症状或由内源性雌激素水平降低引起的病症的方法。本发明还具有含有异黄酮的治疗性饮食产品，用于预防或治疗由内源雌激素水平降低或改变引起的病症的症状。

35. 发明申请

WO2006107745A3 COMPOSITION FOR TREATMENT OF MENOPAUSE 审中-公开
标题翻译：用于治疗男性的组合物
公开(公告)号：WO2006107745A3
公开(公告)日：2008-12-31
申请号：PCT/US2006011862
申请日：2006-03-30
申请人： BIONOVO INC , COHEN ISAAC
发明人： COHEN ISAAC
IPC分类号： A61K49/00 , A01N65/00 , A61K36/00
CPC分类号： A61K36/488 , A61K36/076 , A61K36/21 , A61K36/284 , A61K36/296 , A61K36/40 , A61K36/48 , A61K36/481 , A61K36/484 , A61K36/489 , A61K36/539 , A61K36/62 , A61K36/638 , A61K36/65 , A61K36/708 , A61K36/725 , A61K36/884 , A61K36/8964 , A61K36/8965 , A61K36/899 , Y10S514/899 , A61K2300/00
摘要： A novel herbal extract, MFl0l, is effective in the treatment of symptoms of menopause.
摘要翻译：一种新颖的草药提取物MF101可有效治疗更年期症状。

36. 发明申请

WO99006057A1 SOYA EXTRACT, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：大豆提取物，其制备方法和药物组合物
公开(公告)号：WO99006057A1
公开(公告)日：1999-02-11
申请号：PCT/EP1998/004770
申请日：1998-07-30
IPC分类号： A61K31/704 , A61K20060101 , A61K9/64 , A61K31/7048 , A61K36/00 , A61K36/48 , A61K131/00 , A61P20060101 , A61P5/00 , A61P13/08 , A61P15/00 , A61P15/12 , A61P25/32 , A61P31/00 , A61P35/00 , A61P35/02 , B01D11/02 , C07D311/04 , C07G11/00 , C07H15/00 , C07H17/07 , C07J1/00 , C07K1/14 , A61K35/78
CPC分类号： A61K36/48 , Y10S514/811 , Y10S514/899
摘要： A description is given of novel soya extracts having a defined ratio of soya saponins to glucoside isoflavones; processes for their production; and pharmaceutical compositions containing these extracts.
摘要翻译：给出了具有确定的大豆皂苷与葡萄糖苷异黄酮的比例的新型大豆提取物的描述; 生产过程; 和含有这些提取物的药物组合物。

37. 发明申请

WO98050026A1 TREATMENT OR PREVENTION OF MENOPAUSAL SYMPTOMS AND OSTEOPOROSIS 审中-公开
标题翻译：治疗或预防男性症状和OSTEOPOROSIS
公开(公告)号：WO98050026A1
公开(公告)日：1998-11-12
申请号：PCT/AU1998/000313
申请日：1998-05-01
IPC分类号： A61K31/35 , A61K31/352 , A61K31/353 , A61P15/12 , A61P19/10
CPC分类号： A61K31/353 , A61K31/35 , A61K31/352 , Y10S514/899 , A61K2300/00
摘要： There is described a method for the treatment or prevention of menopausal symptoms or osteoporosis wherein there is administered to a subject in need of such treatment a therapeutically effective amount of the isoflavone formononetin, or a method for the treatment or prevention of menopausal symptoms wherein there is administered to a subject in need of such treatment a therapeutically effective amount of the isoflavone daidzein, the isoflavone being optionally administered with one or more pharmaceutically aceptable adjuvants, carriers and/or excipients. Therapeutic uses and compositions/foods are also described, comprising daidzein or formononetin optionally in association with one or more pharmaceutically acceptable adjuvants, carriers, food components and/or excipients.
摘要翻译：描述了治疗或预防绝经症状或骨质疏松症的方法，其中向需要这种治疗的受试者施用治疗有效量的异黄酮异黄酮酮，或用于治疗或预防绝经症状的方法，其中存在向需要这种治疗的受试者施用治疗有效量的异黄酮黄豆苷原，所述异黄酮任选地与一种或多种药学上可接受的佐剂，载体和/或赋形剂一起施用。还描述了治疗用途和组合物/食物，其包含任选地与一种或多种药学上可接受的佐剂，载体，食物组分和/或赋形剂结合的黄豆苷原或海参素。

38. 发明申请

WO1996035453A2 ENDOTHELIN ANTAGONISTS AND ENDOTHELIN SYNTHASE INHIBITORS FOR THE PREVENTION AND TREATMENT OF UTERINE CONTRACTILITY DISORDERS, PREECLAMPSIA, ATHEROSCLEROTIC VASCULAR DISEASE, HYPERTENSION AND FOR HORMONE REPLACEMENT THERAPY 审中-公开
标题翻译：内皮素拮抗剂和内皮素合成酶抑制剂，用于预防和治疗子宫内膜异位症，前列腺炎，血管性血管疾病，高血压和霍尔米尔替代治疗
公开(公告)号：WO1996035453A2
公开(公告)日：1996-11-14
申请号：PCT/US1995015220
申请日：1995-11-30
申请人： CHWAKISZ, Kristof , GARFIELD, Robert, E.
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K31/00 , A61K31/223 , A61K31/42 , A61K31/565 , A61K31/57 , A61K31/60 , A61K38/12 , Y10S514/899 , A61K2300/00
摘要： A pharmaceutical composition for and methods of treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal, treatment of atherosclerotic vascular disease and hypertension in males as well as females, and for hormone replacement therapy in peri- and post-menopausal females, comprising administering effective amounts of an endothelin antagonist and/or an endothelin synthase inhibitor or both, in combination with (a) a progestin, and/or and estrogen, and/or (b) a cyclooxygenase inhibitor, and/or (c) a nitric oxide donor and/or nitric substrate, to prevent and/or ameliorate said conditions, are disclosed. In the method aspects, the endothelin antagonist and/or endothelin synthase inhibitor can be administered alone for treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal. Further, methods for screening compounds for such treatments are disclosed.
摘要翻译：怀孕女性哺乳动物中的非怀孕女性，早产妇，子痫前期和/或胎儿生长迟缓期间的月经失调，例如痛经，治疗动脉粥样硬化性血管疾病和雄性高血压的药物组合物和方法包括施用有效量的内皮素拮抗剂和/或内皮素合成酶抑制剂或两者，与（a）孕激素和/或雌激素组合施用，作为雌性，以及在绝经后和绝经后雌激素替代疗法中，和/或（b）环氧合酶抑制剂和/或（c）一氧化氮供体和/或硝酸底物，以防止和/或改善所述条件。在方法方面，内皮素拮抗剂和/或内皮素合成酶抑制剂可以单独施用以治疗怀孕雌性哺乳动物中的非怀孕女性，早产，先兆子痫和/或胎儿生长迟缓中的月经失调，例如痛经。此外，公开了用于筛选用于这种处理的化合物的方法。

39. 发明申请

WO1995017411A1 NOVEL THERAPEUTIC CARBOHYDRATE BLENDS USEFUL FOR AIDING PREMENSTRUAL SYNDROME 审中-公开
标题翻译：新的治疗性碳水化合物有助于辅助预后综合征
公开(公告)号：WO1995017411A1
公开(公告)日：1995-06-29
申请号：PCT/US1994014733
申请日：1994-12-21
申请人： WALDEN LABORATORIES, INC.
发明人： WALDEN LABORATORIES, INC. , WURTMAN, Judith, J. , SHEAR, Jeff, L. , KERSHMAN, Alvin
IPC分类号： C07H01/00
CPC分类号： A61K31/718 , A61K31/715 , Y10S514/899 , A61K31/7004 , A61K31/375 , A61K31/19 , A61K2300/00
摘要： Novel therapeutic compositions comprising carbohydrate blends and methods of using the compositions for the treatment of premenstrual syndrome (PMS).
摘要翻译：包含碳水化合物掺合物的新型治疗组合物和使用该组合物治疗经前期综合征（PMS）的方法。

40. 发明申请

WO1986003674A1 MOUTH RINSING SOLUTION 审中-公开
标题翻译： MOUTH RINSING解决方案
公开(公告)号：WO1986003674A1
公开(公告)日：1986-07-03
申请号：PCT/FI1985000095
申请日：1985-11-28
申请人： LILIUS, Kaj, Rainer , TIKKANEN, Matti, Haakon, August
发明人： LILIUS, Kaj, Rainer
IPC分类号： A61K07/22
CPC分类号： A61K8/44 , A61K2800/51 , A61Q11/00 , Y10S514/899 , Y10S514/901
摘要： Mouth rinsing solution, which is intended for preventing the formation of tartar, as well as the use of the active compound contained in the mouth rinsing solution. According to the invention, mineralization of the plaque, i.e. formation of tartar, can be eliminated by rinsing the tooth faces with a solution which contains a suitable compound that complexes calcium ions. Such a compound is, for example, such a sodium salt of ethylenediaminetetraacetic acid (EDTA) whose rinsing solution has a pH within the range of 5.5 to 9.0. The quantity of EDTA in the rinsing solution may be 1 to 20 %. The solution may also be made of a concentration of the said compound, or the said compound can be used as an additive in tooth paste.
摘要翻译：旨在防止形成牙垢的口腔冲洗液，以及使用包含在口腔清洗溶液中的活性化合物。根据本发明，通过用含有合成钙离子的合适化合物的溶液冲洗牙面可以消除斑块的矿化，即形成牙垢。这种化合物是例如其洗涤溶液的pH在5.5至9.0范围内的乙二胺四乙酸（EDTA）的钠盐。冲洗溶液中的EDTA的量可以为1〜20％。溶液也可以由所述化合物的浓度制成，或者所述化合物可以用作牙膏中的添加剂。

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