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31. 发明申请

WO2013021057A2 METHOD OF NEONATAL SEROLOGICAL DIAGNOSIS 审中-公开
标题翻译：新生儿血清学诊断方法
公开(公告)号：WO2013021057A2
公开(公告)日：2013-02-14
申请号：PCT/EP2012065737
申请日：2012-08-10
申请人： INST RECH DEVELOPPEMENT IRD , MIGOT-NABIAS FLORENCE , DECHAVANNE CELIA , GUILLONNEAU FRANCOIS , DUGOUJON JEAN-MICHEL , LEFRANC MARIE-PAULE
发明人： MIGOT-NABIAS FLORENCE , DECHAVANNE CELIA , GUILLONNEAU FRANCOIS , DUGOUJON JEAN-MICHEL , LEFRANC MARIE-PAULE
IPC分类号： G01N33/68
CPC分类号： C12Q1/37 , G01N33/6851 , G01N33/6857 , G01N2333/445 , G01N2333/45
摘要： The present invention provides a method for determining the amino acid polymorphisms of heavy gamma chain of immunoglobulins G by a proteomic approach. This method distinguishes the immunoglobulins of the mother and those of the newborn in a blood sample obtained during the first months of the child's life. The invention also relates to the use of this method in the early diagnosis of vertically transmitted diseases in the neonate. The invention also provides peptides distinctive of G3m and IGHG3 alleles, and a kit comprising said peptides.
摘要翻译：本发明提供了通过蛋白质组学方法确定免疫球蛋白G重链γ氨基酸多态性的方法。该方法区分母亲的免疫球蛋白和新生儿的免疫球蛋白在儿童生命的最初几个月期间获得的血液样品中。本发明还涉及该方法在新生儿垂直传播疾病的早期诊断中的用途。本发明还提供了与G3m和IGHG3等位基因不同的肽，以及包含所述肽的试剂盒。

32. 发明申请

WO2005088301A1 METHOD FOR DETECTION OF MALARIA AND OTHER PARASITE INFECTIONS 审中-公开
标题翻译：检测疟疾和其他寄生虫感染的方法
公开(公告)号：WO2005088301A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/005402
申请日：2005-02-18
申请人： BECKMAN COULTER, INC.
发明人： SIMON-LOPEZ, Ramon
IPC分类号： G01N33/48
CPC分类号： G01N33/56905 , G01N2333/45 , Y02A50/55 , Y02A50/58 , Y10T436/10 , Y10T436/101666 , Y10T436/107497
摘要： A method of detecting parasite infection, particularly malaria, includes mixing a blood sample with a lytic reagent system to lyse red blood cells, and to form a sample mixture; performing a differential analysis of white blood cells of the sample mixture on a blood analyzer, and obtaining a cell volume distribution of a white blood cell subpopulation from a cell volume measurement used in the differential analysis; obtaining a cell volume parameter from the cell volume distribution of the white blood cell subpopulation; evaluating the cell volume parameter against a predetermined criterion, and reporting an indication of the parasite infection if the cell volume parameter meets the predetermined criterion. The method also uses a discriminant obtained from cell volume parameters of two different white blood cell subpopulations against a predetermined criterion. The method further use a cell distribution parameter of a cell distribution obtained using a RF impedance measurement.
摘要翻译：检测寄生虫感染，特别是疟疾的方法包括将血液样品与裂解试剂系统混合以溶解红细胞，并形成样品混合物; 对血液分析仪上的样品混合物的白细胞进行差异分析，从用于差异分析的细胞体积测定中获得白细胞亚群的细胞体积分布; 从白细胞亚群的细胞体积分布获得细胞体积参数; 根据预定标准评估细胞体积参数，并且如果细胞体积参数满足预定标准，则报告寄生虫感染的指示。该方法还根据预定标准使用从两个不同白细胞亚群的细胞体积参数获得的判别式。该方法还使用使用RF阻抗测量获得的小区分布的小区分布参数。

33. 发明授权

EP2890703B1 SYNTHESIS OF DIVERSE GLYCOSYLPHOSPHATIDYLINOSITOL GLYCANS FROM TOXOPLASMA GONDII AND THEIR APPLICATION AS VACCINES AND DIAGNOSTICS 有权
公开(公告)号：EP2890703B1
公开(公告)日：2018-09-12
申请号：EP13739727.9
申请日：2013-07-23
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften
发明人： AZZOUZ, Nahid , GÖTZE, Sebastian , SEEBERGER, Peter H. , SILVA, Daniel Varon , TSAI, Yu-Hsuan
IPC分类号： C07H15/207 , C07H1/02 , C08B37/00 , A61K39/002 , A61P33/02 , A61K39/012 , A61K39/00 , A61K47/64 , G01N33/569
CPC分类号： C07H15/207 , A61K39/002 , A61K39/012 , A61K47/6415 , A61K2039/55544 , A61K2039/64 , C07H1/02 , C08B37/006 , G01N33/56905 , G01N2333/45
摘要： The present invention relates to the synthesis of GPI-related surface antigens of the parasite Toxoplasma gondii ( T. gondii ) and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis as well as a vaccine against toxoplasmosis, a diseases caused by infection with T. gondii. The compounds are of general formula (I).

34. 发明公开

EP2909630A1 ANTIGENES GRA RECOMBINANTS ET LEUR APPLICATION POUR LE DIAGNOSTIC PRECOCE DE LA TOXOPLASMOSE 审中-公开
标题翻译：重组GRA抗原和它弓形虫病的早期诊断中的应用
公开(公告)号：EP2909630A1
公开(公告)日：2015-08-26
申请号：EP13777058.2
申请日：2013-10-16
申请人： Université Joseph Fourier-Grenoble 1 , Centre Hospitalier Universitaire Grenoble
发明人： MERCIER, Corinne , DELAUW, Marie-France , PELLOUX, Hervé , FRICKER-HIDALGO, Hélène
IPC分类号： G01N33/569
CPC分类号： G01N33/56905 , G01N2333/45 , G01N2469/20
摘要： The present invention relates to a method for identifying the presence or absence of anti
-Toxoplasma gondii antibodies in a human or animal serum, including placing said previously drawn serum in contact with antigens capable of binding with said anti
-Toxoplasma gondii antibodies, and the observation of a bond or of an absence of a bond of antibodies with said antigens, the method being characterized in that said antigens include the combination of two recombinant GRA2 and GRA6 proteins. In particular, the antigens are attached to a support, in particular an ELISA plate. This test is preferably carried out as a supplement to another test for diagnosing toxoplasmosis.

35. 发明授权

EP2067783B1 Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof 有权
标题翻译：基因工程P30抗原，抗原增强鸡尾酒及其使用
公开(公告)号：EP2067783B1
公开(公告)日：2011-06-15
申请号：EP08171374.5
申请日：2003-10-02
申请人： ABBOTT LABORATORIES
发明人： Maine, Gregory T. , Patel, Chandu B. , Ginsburg, Sanford R. , Bliese, Timothy R.
IPC分类号： C07H21/04 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74
CPC分类号： C07K14/45 , A61K39/00 , G01N33/56905 , G01N2333/45 , G01N2469/20 , Y10S435/975

36. 发明公开

EP1556404A4 GENETICALLY ENGINEERED P30 ANTIGEN, IMPROVED ANTIGEN COCKTAIL, AND USES THEREOF 有权
标题翻译： Sa基因MADE P30抗原，改善的抗原鸡尾酒及其应用
公开(公告)号：EP1556404A4
公开(公告)日：2006-07-26
申请号：EP03781303
申请日：2003-10-02
申请人： ABBOTT LAB
发明人： MAINE GREGORY T , PATEL CHANDU B , GINSBURG SANFORD R , BLIESE TIMOTHY R
IPC分类号： A61K39/00 , C07K14/45 , G01N33/569 , C07H21/04 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74
CPC分类号： C07K14/45 , A61K39/00 , G01N33/56905 , G01N2333/45 , G01N2469/20 , Y10S435/975

37. 发明授权

EP1212451B1 CYCLIC GMP DEPENDENT PROTEIN KINASE AS A CHEMOTHERAPEUTIC TARGET FOR ANTIPROTOZOAL AGENTS 有权
标题翻译： ZYLKLISCHEM GMP依赖性蛋白激酶AS CHEMO的治疗目标，以查找与原虫展望代理
公开(公告)号：EP1212451B1
公开(公告)日：2006-06-28
申请号：EP00922040.1
申请日：2000-04-10
申请人： Merck & Co., Inc.
发明人： GURNETT, Anne , LIBERATOR, Paul, A. , DONALD, Robert , SCHMATZ, Dennis , HARRIS, Georgianna , RATTRAY, Sandra, J.
IPC分类号： C12P21/06 , C12N9/12
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/485 , G01N2333/45
摘要： Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents.

38. 发明公开

KR1020040053224A 네오스포라 카니눔에 대한 혈청학적 분석법 无效
标题翻译：新孢子虫的血清学分析
公开(公告)号：KR1020040053224A
公开(公告)日：2004-06-23
申请号：KR1020047006397
申请日：2002-10-08
申请人： 화이자 프로덕츠 인코포레이티드
发明人： 브레이크데이비드앨런 , 리터다이안마리
IPC分类号： G01N33/569
CPC分类号： G01N33/56905 , G01N2333/44 , G01N2333/45 , G01N2469/20
摘要： 본 발명은 피검 혈청을 네오스포라 카니눔(
Neospora caninum )과 반응성인 단백질과 반응시킴에 의한 네오스포라 카니눔 백신접종된 동물의 혈청학적 검출 방법에 관한 것이다. 이 단백질은 전체 길이의 본래의 또는 재조합 네오스포라 카니눔 또는 톡소플라즈마 곤디 느린분열소체 융합 단백질 또는 절단된 융합 단백질, 또는 이들의 단편이다. 이 단백질은 효소-연결된 면역흡수 분석법(ELISA), 방사면역분석법(RIA), 웨스턴 블롯(Western blot) 및 기타 적당한 형태의 면역분석법를 포함하는 다수의 분석법중 임의의 방법에서 사용될 수 있다.

39. 发明公开

US20240069020A1 FERROFLUID-BASED ASSAY METHODS, AND SYSTEMS FOR PARASITE EGGS OR OOCYSTS DETECTION 审中-公开
公开(公告)号：US20240069020A1
公开(公告)日：2024-02-29
申请号：US18275594
申请日：2022-02-02
申请人： Ancera Inc.
发明人： Mary K.H. SMITH , Arjun GANESAN , John C. VOYTA
IPC分类号： G01N33/569 , B01L3/00 , G01N33/543
CPC分类号： G01N33/56905 , B01L3/502761 , G01N33/54386 , B01L2200/0647 , B01L2200/16 , G01N2333/45 , G01N2333/455
摘要： Embodiments of the present disclosure are directed to ferrofluid-based assay methods, systems and device for detecting one or more parasite oocyst or egg, and more specifically, to detecting parasite oocysts or eggs in fecal matter of livestock, so as to determine parasitic infections within such livestock. Such embodiments are configured to help in the ability to maintain healthy livestock for human consumption.

40. 发明申请

US20180017557A1 Antibodies to the Surface of Toxoplasma Gondii Oocysts and Methods of Use Thereof 审中-公开
公开(公告)号：US20180017557A1
公开(公告)日：2018-01-18
申请号：US15548062
申请日：2016-03-08
申请人： The Regents of the University of California
发明人： Heather Fritz , Patricia Conrad
IPC分类号： G01N33/569 , C07K16/20
CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/33 , G01N2333/45 , G01N2469/10
摘要： The present disclosure provides antibodies that bind the surface of Toxoplasma gondii oocysts, methods for using such antibodies and kits and devices for practicing such methods. Such antibodies, methods, kits and devices find use in detection of T. gondii oocysts and the isolation of such oocysts from samples including environmental samples, food-based samples, diagnostic samples, and the like.

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