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    • 32. 发明申请
    • IR SPECTROGRAPHIC APPARATUS AND METHOD FOR DIAGNOSIS OF DISEASE
    • 红外光谱仪和疾病诊断方法
    • US20090118601A1
    • 2009-05-07
    • US11576229
    • 2005-09-29
    • John F. RaboltMei-Wei Tsao
    • John F. RaboltMei-Wei Tsao
    • A61B5/1455
    • A61B3/10A61B5/0059A61B5/14546G01J3/02G01J3/0208G01J3/021G01J3/0218G01J3/0294G01J3/04G01J3/108G01J3/14G01J3/2803G01J2003/2813G01N21/35G01N21/3504
    • A method for detecting disease in a patient includes providing infrared (IR) light and coupling the IR light through direct lens coupling or through a first group of one or more optical fibers. IR light is reflected from a portion of the patient and collected by a lens arrangement or a second group of one or more optical fibers. The reflected IR light is dispersed into its spectrum which is detected and analyzed. An apparatus suitable for diagnosing a disease in a patient includes an IR light source and optical fiber or direct lens coupling of IR light onto a body part or fluid of the patient. Reflected light from the patient is optically dispersed using a prism or grating. An IR focal plane array receives the optically dispersed light. The spectrum of the reflected IR light is used to provide a diagnosis of disease in the patient by identifying various disease markers or chemical fingerprints. The method and apparatus are capable of non-invasively detecting disease markers in a patient.
    • 用于检测患者疾病的方法包括提供红外(IR)光并通过直接透镜耦合或通过第一组一根或多根光纤耦合IR光。 IR光从患者的一部分反射并由透镜装置或第二组一根或多根光纤收集。 反射的红外光被分散到其光谱中,该光谱被检测和分析。 适用于诊断患者疾病的装置包括IR光源和光纤或将IR光直接连接到患者的身体部位或液体上的直接透镜。 来自患者的反射光使用棱镜或光栅进行光学分散。 IR焦平面阵列接收光学分散的光。 反射红外光的光谱用于通过识别各种疾病标志物或化学指纹来提供患者疾病的诊断。 该方法和装置能够非侵入性地检测患者中的疾病标志物。
    • 35. 发明公开
    • IMAGE CAPTURING DEVICE AND IMAGE CAPTURING METHOD
    • 图像捕捉装置和图像捕捉方法
    • EP2469860A1
    • 2012-06-27
    • EP10804511.3
    • 2010-07-29
    • Nagamune, Yasushi
    • Nagamune, Yasushi
    • H04N9/04H04N7/18
    • H04N5/33G01J3/2803G01J3/32G01J3/36G01J3/51G01J2003/2806G01J2003/2813H04N5/2256H04N5/332H04N9/045
    • Disclosed is an image capturing device which is provided with an irradiation unit, an image capturing unit, and a color representation setting unit, wherein the irradiation unit irradiates a subject with infrared rays having different wavelength intensity distributions, the image capturing unit captures images of the subject by the respective infrared rays having different wavelength distributions which are reflected by the subject, and forms image information indicating the respective images, and the color representation setting unit sets, in the image information, color representation information for representing the respective images, which are indicated by the formed image information, by different plain colors. Also disclosed is an image capturing method characterized by separating infrared rays from a subject into infrared rays having different wavelength intensity distributions, capturing images of the subject by the respective infrared rays having different wavelength intensity distributions, forming image information indicating the respective images, and representing the respective images, which are indicated by the formed image information, by different plain colors.
    • 公开了一种图像拍摄装置,其具有照射单元,图像拍摄单元和颜色表示设置单元,其中,照射单元用具有不同波长强度分布的红外线照射对象,图像拍摄单元拍摄 通过由被摄体反射的波长分布不同的各个红外线对被摄体进行成像,并且形成表示各个图像的图像信息,并且颜色表示设置单元在图像信息中设置用于表示各个图像的颜色表示信息, 由所形成的图像信息指示,通过不同的原色。 还公开了一种图像捕获方法,其特征在于,将来自对象的红外线分离成具有不同波长强度分布的红外线,通过具有不同波长强度分布的各个红外线捕获对象的图像,形成指示各个图像的图像信息, 由形成的图像信息指示的各个图像通过不同的素色。
    • 37. 发明公开
    • High sensitive multi-wavelength spectral analyzer
    • 高灵敏度多波长光谱分析仪
    • EP0498644A1
    • 1992-08-12
    • EP92300991.4
    • 1992-02-06
    • RESEARCH DEVELOPMENT CORPORATION OF JAPANIchimura, TsutomuNagoshi, Toshiyuki
    • Ichimura, TsutomuNagoshi, ToshiyukiInaba, Fumio
    • G01J3/28
    • G01J3/2803G01J3/0208G01J3/0256G01J3/0291G01J3/18G01J3/24G01J2003/2813
    • A compact, high sensitive, multi-wavelength spectral analyzer capable of simultaneously obtaining a spectral distribution of extremely weak radiation such as bio-luminescence, chemiluminescence, extremely weak fluorescence caused by excitation light, Raman scattered light, etc., with extremely high luminosity and without wavelength scanning, is disclosed. The spectral analyzer comprises a spectroscope (1) and a high sensitive, one-or two-dimensional photodetector (6). The spectroscope includes an entrance slit (2), a collimator lens (3) of high luminosity disposed such that a focal point of the collimator lens is coincident with the entrance slit to convert light emerging therefrom into parallel rays, a reflection diffraction grating (4) that diffracts the parallel rays from the collimator lens to produce spectra, and an imaging lens (5) that focuses the parallel rays diffracted by the reflection diffraction grating (4) on an image plane (P) thereof to form a spectral image. The photodetector (6) is disposed on the image plane (P) of the imaging lens (5).
    • 一种紧凑,高灵敏度,多波长的光谱分析仪,能够同时获得非常弱的辐射光谱分布,如生物发光,化学发光,由激发光引起的非常微弱的荧光,拉曼散射光等,具有极高的亮度和 没有波长扫描,被披露。 光谱分析仪包括分光镜(1)和高灵敏度的一维或二维光电探测器(6)。 该分光器包括入射狭缝(2),高亮度准直透镜(3),该准直透镜(3)被布置为使得准直透镜的焦点与入射狭缝重合以将从其出射的光转换成平行光线,反射衍射光栅(4 ),其将来自准直透镜的平行光线衍射以产生光谱;以及成像透镜(5),其将由反射衍射光栅(4)衍射的平行光聚焦在其像平面(P)上以形成光谱图像。 光电探测器(6)设置在成像透镜(5)的像平面(P)上。
    • 40. 发明公开
    • Flourescence correlation spectroscopy analyser
    • Fluoreszenzkorrelationsspektroskopie-Analysegerät
    • EP1925930A1
    • 2008-05-28
    • EP08002238.7
    • 2004-02-13
    • Hamamatsu Photonics K.K.
    • Inoue, TakayukiMaruno, TadashiIwase, Fumio
    • G01N21/64G01J3/44H04N3/15
    • G01N21/6456G01J3/2803G01J3/2823G01J3/2889G01J3/4406G01J2003/2813G01J2003/282G01N21/645G01N2021/6417G01N2021/6423H04N5/3454H04N5/372
    • A fluorescence correlation spectroscopy analyzer 1 is equipped with an excitation light illuminating optical system 21, a fluorescence imaging optical system 22, a CCD camera 15, and a data analyzer 16. The excitation light illuminating optical system 21 illuminates excitation light onto a predetermined region of a measured sample S. The fluorescence imaging optical system 22 images the fluorescence generated at the measured sample S onto the photodetection surface of the CCD camera 15. The CCD camera 15 performs photoelectric conversion of the fluorescence made incident onto the photodetection surface in accordance with the respective pixels and outputs the charges generated by the photoelectric conversion as detection signals from an output terminal. The data analyzer 16 inputs the detection signals based on the charges generated at the pixels, among the pixels of the CCD camera 15, that belong to an analyzed pixel set and computes autocorrelation functions of the input detection signals according to each pixel. A fluorescence correlation spectroscopy analyzer, which is enabled to perform fluorescence correlation spectroscopy analysis on multiple points of a measured sample simultaneously and at high speed, is thus provided.
    • 荧光相关光谱分析仪1配备有激发光照射光学系统21,荧光成像光学系统22,CCD照相机15和数据分析器16.激发光照射光学系统21将激发光照射到 测量样品S.荧光成像光学系统22将在测量样品S处产生的荧光图像成像到CCD照相机15的光电检测表面上。CCD照相机15对入射到光检测表面上的荧光进行光电转换, 并输出由光电转换产生的电荷作为来自输出端子的检测信号。 数据分析器16基于在CCD摄像机15的像素中产生的属于分析像素组的像素产生的电荷输入检测信号,并根据每个像素计算输入检测信号的自相关函数。 因此,能够同时进行高速度地对被测量样品的多个点进行荧光相关光谱分析的荧光相关光谱分析装置。