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31. 发明公开

EP1282411A4 METHOD OF TREATING CANCER 审中-公开
标题翻译：方法治疗癌症的
公开(公告)号：EP1282411A4
公开(公告)日：2008-05-21
申请号：EP01927380
申请日：2001-03-02
申请人： CHARLOTTE MECKLENBURG HOSPITAL
发明人： KENNEDY THOMAS P
IPC分类号： A61K31/05 , A61K31/122 , A61K31/198 , A61K31/221 , A61K31/28 , A61K31/366 , A61K31/37 , A61K31/41 , A61K31/44 , A61K31/452 , A61K31/66 , A61K38/44 , A61K45/06 , A61P35/00
CPC分类号： A61K45/06 , A61K31/05 , A61K31/122 , A61K31/198 , A61K31/221 , A61K31/28 , A61K31/366 , A61K31/37 , A61K31/41 , A61K31/452 , A61K31/66 , A61K38/44 , C12Y111/01006 , C12Y111/01009 , A61K2300/00

32. 发明公开

EP1545590A1 ENZYMATIC TREATMENT OF RETINITIS PIGMENTOSA AND RELEVANT PHARMACEUTICAL COMPOSITION IN FORM OF A KIT 有权
标题翻译：酶处理和色素性视网膜炎药物组合物在试剂盒形式的
公开(公告)号：EP1545590A1
公开(公告)日：2005-06-29
申请号：EP02785892.7
申请日：2002-10-01
申请人： Ammannati, Paola , Giordani, Roberto
发明人： Ammannati, Paola , Giordani, Roberto
IPC分类号： A61K38/54
CPC分类号： A61K38/44 , A61K38/443 , A61K38/4813 , C12Y101/01021 , C12Y101/01049 , C12Y111/01009 , C12Y304/13009 , A61K2300/00
摘要： A kit for the treatment of retinitis pigmentosa containing the enzymes glutathione peroxidase, prolidase, glucose-6-phosphate dehydrogenase and, optionally, aldose reductase in aliquot parts and interactive quantities appropriate for administering said enzymes in accordance with a predetermined time sequence.

33. 发明申请

US20180161459A1 Methods of Screening for Drugs to Prevent Noise-Induced Hearing Loss 审中-公开
公开(公告)号：US20180161459A1
公开(公告)日：2018-06-14
申请号：US15507738
申请日：2015-09-02
申请人： Sound Pharmaceuticals Incorporated
发明人： Jonathan Kil , Eric D. Lynch
IPC分类号： A61K49/00 , A61B5/12
CPC分类号： A61K49/0004 , A61B5/12 , A61B5/123 , A61B5/125 , A61B5/4848 , A61B2503/42 , A61K31/145 , A61K31/198 , A61K31/41 , A61K31/7076 , A61K38/063 , A61K38/44 , A61K49/0008 , C12Y111/01009 , A61K2300/00
摘要： The invention relates to methods of identifying a composition useful for the prevention or treatment of noise-induced hearing loss. The method includes exposing a mammalian test subject to a candidate composition and a calibrated sound or noise challenge. Next, a temporary threshold shift (TTS) is monitored in the test subject over a period of time. The monitored TTS is compared with a TTS of a control subject exposed to a control composition. The presence or absence is determined by clinically relevant and statistically significant differences between the monitored TTS in the test subject and the TTS of the control subject, and the presence of a statistically significant difference identifies the candidate composition as useful for prevention or treatment of noise-induced hearing loss.

34. 发明申请

US20150297564A1 METHOD OF ENHANCING GLUCOSE-STIMULATED INSULIN SECRETION AND OF TREATING TYPE 2 DIABETES OR HYPOGLYCEMIA 审中-公开
标题翻译：增强葡萄糖刺激胰岛素分泌和治疗2型糖尿病或高血糖症的方法
公开(公告)号：US20150297564A1
公开(公告)日：2015-10-22
申请号：US14691213
申请日：2015-04-20
申请人： Xingen Lei
发明人： Xingen Lei
IPC分类号： A61K31/41 , A61K38/44
CPC分类号： A61K31/41 , A61K31/425 , A61K38/44 , C12Y111/01009
摘要： The present invention is directed to a method of enhancing glucose-stimulated insulin secretion in a subject. The method involves selecting a subject with: (1) an antioxidant deficiency and (2) a need for enhanced glucose-stimulated insulin secretion, and administering to the selected subject an agent selected from the group consisting of (1) a compound according to Formula I or a pharmaceutically acceptable salt thereof: wherein the substituents R1-R3, X, Y, and n are as described herein, (2) glutathione peroxidase, or (3) activators of PGC-1α antioxidant response element, under conditions effective to enhance glucose-stimulated insulin secretion in the subject. The present invention also relates to methods of treating a subject with Type 2 diabetes and treating a subject with hypoglycemia by administering these agents.
摘要翻译：本发明涉及增加受试者中葡萄糖刺激的胰岛素分泌的方法。该方法包括选择受试者：（1）抗氧化剂缺乏症和（2）需要增强的葡萄糖刺激的胰岛素分泌，以及向所选择的受试者施用选自以下的药剂：（1）根据式 I或其药学上可接受的盐：其中取代基R 1 -R 3，X，Y和n如本文所述，（2）谷胱甘肽过氧化物酶或（3）PGC-1α抗氧化反应元件的活化剂，在有效增强的条件下葡萄糖刺激的胰岛素分泌。本发明还涉及用2型糖尿病治疗受试者的方法，并通过施用这些药物治疗患有低血糖症的受试者。

35. 发明申请

US20050043258A1 Methods of treating xerostomia and xerophthalmia 审中-公开
标题翻译：治疗口干燥和干眼症的方法
公开(公告)号：US20050043258A1
公开(公告)日：2005-02-24
申请号：US10811028
申请日：2004-03-25
申请人： Michael Bennett , Yen-Ju Chen
发明人： Michael Bennett , Yen-Ju Chen
IPC分类号： A61K38/18 , A61K38/20 , A61K38/21 , A61K38/44 , A61K38/45 , A61K48/00 , C12N20060101
CPC分类号： A61K48/005 , A61K38/1709 , A61K38/212 , A61K38/44 , A61K38/446 , A61K38/45 , C12Y111/01006 , C12Y111/01009 , C12Y115/01001 , C12Y203/02002 , A61K2300/00
摘要： The present invention provides methods for protecting or treating a tissue from a condition that elicits xerostomia or xerophthalmia.
摘要翻译：本发明提供了用于保护或治疗组织免受口腔干燥症或干眼症的病症的方法。

36. 发明申请

US20030118577A1 Use of analogues of superoxide dismutase for treating hepatocellular insufficiencies 审中-公开
标题翻译：使用超氧化物歧化酶类似物治疗肝细胞不足
公开(公告)号：US20030118577A1
公开(公告)日：2003-06-26
申请号：US10240270
申请日：2003-02-03
发明人： Bernard Weill , Frederic Batteux , Pierre-Jacques Ferret
IPC分类号： A61K038/44 , A61K031/555
CPC分类号： A61K38/44 , A61K38/00 , A61K38/446 , C12Y111/01006 , C12Y111/01009 , C12Y115/01001
摘要： The invention concerns the use of a compound having a superoxide dismustase activity, in particular a non-peptide analogue of the superoxide dismutase to obtain a medicine for preventive or curative treatment of hepatocellular insufficiency. Said medicine can be used in particular for treating hepatocellular insufficiencies of toxic or viral origin.
摘要翻译：本发明涉及具有超氧化物歧化酶活性的化合物，特别是超氧化物歧化酶的非肽类似物的用途，以获得预防或治疗肝细胞功能不全的药物。所述药物可特别用于治疗有毒或病毒来源的肝细胞不足。

37. 发明申请

US20020156040A1 Reduction of antioxidant enzyme levels in tumor cells using antisense oligonucleotides 审中-公开
标题翻译：使用反义寡核苷酸降低肿瘤细胞中的抗氧化酶水平
公开(公告)号：US20020156040A1
公开(公告)日：2002-10-24
申请号：US09993333
申请日：2001-11-14
发明人： Larry Wayne Oberley , Christine J. Weydert , Benjamin Barnes Smith
IPC分类号： A61K048/00 , C07H021/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12Y111/01006 , C12Y111/01009 , C12Y115/01001
摘要： The present invention provides an antisense oligonucleotide that specifically binds to an antioxidant enzyme start codon so as to inhibit the level of antioxidant enzymes in a cell. The present invention further provides methods of treating an antioxidant enzyme malfunction disorder in a mammal by reducing antioxidant enzyme levels in a cell with the administration of the antisense oligonucleotide.
摘要翻译：本发明提供了与抗氧化酶起始密码子特异性结合以抑制细胞中抗氧化酶水平的反义寡核苷酸。本发明还提供了通过在反应寡核苷酸的施用中减少细胞中的抗氧化酶水平来治疗哺乳动物抗氧化酶失活症状的方法。

38. 发明申请

US20020031506A1 Human glutathione peroxidase-6 审中-公开
标题翻译：人类谷胱甘肽过氧化物酶-6
公开(公告)号：US20020031506A1
公开(公告)日：2002-03-14
申请号：US09811118
申请日：2001-03-16
申请人： Incyte Pharmaceuticals, Inc.
发明人： Jennifer L. Hillman , Neil C. Corley , Chandra Patterson
IPC分类号： A61K038/44 , C12Q001/68 , G01N033/574 , C07H021/04 , C12N009/02 , C12P021/02 , C12N005/06
CPC分类号： C12N9/0065 , A61K38/00 , C12Y111/01009
摘要： The invention provides a human glutathione peroxidase (GPx6) and polynucleotides which identify and encode GPx6. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of GPx6.
摘要翻译：本发明提供人谷胱甘肽过氧化物酶（GPx6）和识别和编码GPx6的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与GPx6表达相关的疾病的方法。

39. 发明申请

US20160369285A1 TERMITE SUPEROXIDE DISMUTASES AND GLUTATHIONE PEROXIDASES FOR BIOMASS CONVERSION 审中-公开
标题翻译：用于生物质转化的超氧化物歧化酶和谷胱甘肽过氧化物
公开(公告)号：US20160369285A1
公开(公告)日：2016-12-22
申请号：US15036055
申请日：2014-11-12
申请人： Michael E. Scharg , Amit Sethi
发明人： Michael E. Scharf , Amit Sethi
IPC分类号： C12N15/52 , C12N15/86 , C12N9/42 , C12N7/00 , C12N9/02 , C12N9/08
CPC分类号： C12N15/52 , C07K2319/21 , C12N7/00 , C12N9/00 , C12N9/0061 , C12N9/0065 , C12N9/0089 , C12N9/2437 , C12N15/86 , C12N2710/14043 , C12P19/02 , C12P19/14 , C12Y110/03002 , C12Y111/01009 , C12Y115/01001 , C12Y302/01004
摘要： The present disclosure is generally related to enzymes, and to recombinant nucleic acid molecules encoding and/or expressing said enzymes, of the gut of the termite Reticulitermes flavipes. The disclosure further relates to a system combining said enzymes for substantially converting a plant lignocellulose to a fermentable sugar-based product.
摘要翻译：本公开通常涉及酶，以及编码和/或表达所述酶的重组核酸分子，其为白蚁Reticulitermes flavipes的肠。本公开还涉及将所述酶组合以将植物木质纤维素基本上转化为可发酵的糖基产物的系统。

40. 发明申请

US20150202187A1 COMPOSITIONS AND METHODS FOR TREATMENT OF VITILIGO 审中-公开
标题翻译：用于治疗VITILIGO的组合物和方法
公开(公告)号：US20150202187A1
公开(公告)日：2015-07-23
申请号：US14414874
申请日：2013-06-26
申请人： Sarah BACUS , Diarmuid MORAN
发明人： Sarah Bacus , Diarmuid Moran
IPC分类号： A61K31/436 , A61K31/352 , A61K38/34 , A61K38/44 , A61K31/355 , A61K38/18 , A61K31/198
CPC分类号： A61K31/436 , A61K31/198 , A61K31/352 , A61K31/355 , A61K38/1825 , A61K38/2285 , A61K38/34 , A61K38/44 , A61K45/06 , C07K14/50 , C12Y111/01006 , C12Y111/01009 , A61K2300/00
摘要： Compositions and methods are disclosed for treating hypomelanotic conditions such as vitiligo and promoting melanogenesis.
摘要翻译：公开了用于治疗低血糖症状如白癜风和促进黑素生成的组合物和方法。

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