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    • 37. 发明申请
    • Laboratory scale milling process
    • 实验室规模铣削加工
    • US20020119200A1
    • 2002-08-29
    • US10007515
    • 2001-12-05
    • Royal J. Haskell
    • A61K009/14B02C023/24
    • A61K9/146A61K9/14A61K9/145B02C17/005B02C17/163B02C17/20G09B5/14G09B9/08
    • There is provided a process for reducing particle size of a drug, the process comprising (a) a step of dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension; (b) a step of bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension; (c) a step of magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 nullm; and (d) a step of separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.
    • 提供了一种减少药物粒径的方法,该方法包括(a)将约10g或更少的药物分散在合适体积的液体分散介质中以形成悬浮液的步骤; (b)将容器研磨介质,用于搅拌和悬浮液的可磁化活化装置结合在一起的步骤; (c)磁力激活用于搅拌的装置以使悬浮液的研磨达到不大于约1μm的重均粒径的步骤; 和(d)将磨碎的悬浮液与研磨介质和可磁激活的装置分离以进行搅拌的步骤。