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31. 发明授权

EP3658625B1 CONDUCTIVE BENZOIC ACID BASED POLYMER CONTAINING BIOMATERIAL FOR ENHANCEMENT OF TISSUE CONDUCTION IN VITRO AND IN VIVO 有权
公开(公告)号：EP3658625B1
公开(公告)日：2024-06-12
申请号：EP18838499.4
申请日：2018-07-27
IPC分类号： C08L77/00 , A61K47/30 , A61K47/42 , A61K50/00 , A61N1/05 , A61P9/00 , C08L89/06 , C08H1/06
CPC分类号： A61K47/42 , C08L89/06 , A61P9/00 , A61K9/0019 , A61K9/06 , A61K47/34 , A61K47/36 , C08G69/48 , A61N1/056 , A61N1/37512 , C08H1/06

32. 发明公开

EP3389773A1 DISPOSITIF D'AMPLIFICATION DE COMMUNICATION COMPRENANT DES ÉLÉMENTS DE MAINTIEN POUR UNE CAPSULE IMPLANTABLE 有权
公开(公告)号：EP3389773A1
公开(公告)日：2018-10-24
申请号：EP16809092.6
申请日：2016-12-14
申请人： Sorin CRM SAS
发明人： REGNIER, Willy , DEBROUX, Jean-François
IPC分类号： A61N1/372 , A61N1/375
CPC分类号： A61N1/37229 , A61N1/057 , A61N1/37205 , A61N1/37512 , A61N1/37518 , A61N1/3756
摘要： The application relates to a communication amplification device (30) for an implantable capsule (10), in particular for an autonomous cardiac stimulation capsule, the capsule comprising, on its distal end, a distal electrode that is able to come into contact with a tissue of a wall of an organ of a patient. The amplification device comprises a first retention element (32) and a second retention element (34) for the implantable capsule, the distal end of the capsule being able to be inserted into the first retention element, and the proximal end being able to be inserted into the second retention element, said first retention element comprising a communication amplification antenna (36), said communication amplification antenna being able to be coupled to the distal electrode of the capsule.

33. 发明公开

EP3345651A1 SYSTEM AND METHODS FOR CAPTURE VERIFICATION IN IMPLANTABLE LEADLESS PACEMAKERS 有权
公开(公告)号：EP3345651A1
公开(公告)日：2018-07-11
申请号：EP17152973.8
申请日：2017-01-25
申请人： BIOTRONIK SE & Co. KG
发明人： Baru, Marcelo , Vijayagopal, Ramprasad , Fryer, Alan
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3702 , A61N1/3714 , A61N1/3716 , A61N1/37512 , A61N1/3756
摘要： A pacing system, which is particularly suitable for implantable leadless pacemakers, applies passively-balanced voltage-based pacing pulses, and periodically performs capture verification (evoked response detection) by following a pacing pulse with a current-based active balancing pulse, and then measuring any evoked response provoked by the pacing pulse. The active balancing pulse reduces residual charge on the electrodes used for pulsing, and thereby reduces polarization artifacts that could obscure measurement of the evoked response at the electrodes. The amplitude and pulse width of the active balancing current pulse are defined by measurements made in a few preceding pulses. The pacemaker preferably detects indicia of cardiac contractility, and performs capture verification only when contractility indicates that the patient is physically inactive and emotionally stable.

34. 发明公开

EP3311883A1 ANSCHLUSSSTIFT UND DURCHFÜHRUNG 有权
标题翻译：连接PIN和实施
公开(公告)号：EP3311883A1
公开(公告)日：2018-04-25
申请号：EP16195002.7
申请日：2016-10-21
申请人： BIOTRONIK SE & Co. KG
发明人： Eigenbrod, Hella , Fries, Lilli
IPC分类号： A61N1/375
CPC分类号： A61N1/3754 , A61N1/37512 , B23K1/0016 , B23K1/008 , B23K1/203 , B23K2101/32 , B23K2101/38 , B23K2103/08 , B23K2103/12 , H01B1/02 , H01R4/02 , H01R4/58 , H01R12/57 , H01R13/03 , H01R2201/12
摘要： Anschlussstift zum elektrischen Anschluss eines Leitungsträgers, wobei der Anschlussstift zur stoffschlüssigen Anbindung an eine Leiterfläche des Leitungsträgers ein verdicktes Ende hat und mindestens ein Teil der Oberfläche des verdickten Endes eine weichlötbare Beschichtung mit mindestens zwei übereinanderliegenden funktional differenzierten Teilschichten aufweist, von denen eine eine Lötverbindungsschicht ist und über der Lötverbindungsschicht eine Oxidationsschutzschicht und/oder unter der Lötverbindungsschicht eine Haftvermittlerschicht vorgesehen ist.
摘要翻译：销，用于电连接的引线框架，其中，所述端子销至到导体支撑件的导体表面的材料锁定连接具有加厚端和至少加厚端部的表面的一部分具有一个weichlötbare涂层具有至少两个叠加的功能上有区别的子层，其中之一是一个Lötverbindungsschicht和在焊料接合层上设置氧化保护层和/或在焊料接合层下设置助粘剂层。

35. 发明公开

EP3292884A1 A MODIFIED IMPLANTATION TOOL TIP CONFIGURATION FOR THE IMPROVED INSTALLATION OF LEADLESS PACEMAKERS WITH SHORT TINE-BASED ANCHORS 有权
标题翻译：一种改进的注入工具尖端配置，用于改进安装短尖端锚杆的无桩起重机
公开(公告)号：EP3292884A1
公开(公告)日：2018-03-14
申请号：EP16202108.3
申请日：2016-12-05
申请人： BIOTRONIK SE & Co. KG
发明人： Taff, Brian M. , Müssig, Dirk , von Arx, Jeffrey A. , Suwito, Wantjinarjo , Stotts, Larry , Kibler, Andrew B. , Austin, Eric
IPC分类号： A61N1/05 , A61B17/34
CPC分类号： A61N1/37518 , A61B5/0408 , A61B5/6869 , A61B2560/066 , A61B2562/14 , A61B2562/162 , A61M25/0023 , A61M25/0068 , A61M25/008 , A61M25/0138 , A61M2025/0081 , A61N1/057 , A61N1/0573 , A61N1/059 , A61N1/37512 , A61N1/3756 , A61N2001/058 , A61N2001/0582
摘要： A system and method for installing/implanting a leadless implant can include a leadless implant with shortened tine-based anchors and an implantation tool with a modified tip. The tines can extend from a surface of the leadless implant and may include a preformed curve or other shape to enable the tine to hook into or grapple tissue. The implantation tool may be provided with a modified tip to assist with proper alignment, insertion, and anchoring of the shortened tines. A tip of the implantation tool can have a reduced inner diameter to cause the tine tips to be approximately normal to the surface of the tissue to which the implant is being anchored. Upon deployment of the leadless implant, the tines of the anchoring mechanism are appropriately aligned for proper insertion so that robust anchoring is achieved.
摘要翻译：用于安装/植入无引线植入物的系统和方法可以包括具有缩短的齿基锚定件的无引线植入物和具有改进尖端的植入工具。尖齿可以从无引线植入物的表面延伸，并且可以包括预先形成的曲线或其他形状以使尖齿能够钩入或抓住组织。植入工具可以具有改进的尖端以帮助缩短的尖齿的正确对准，插入和锚定。植入工具的尖端可以具有减小的内径以使得尖端与植入物被锚定到的组织的表面大致垂直。在部署无引线植入物时，锚定机构的尖齿适当对齐以便适当插入，从而实现牢固的锚定。

36. 发明公开

EP3290081A1 IMPLANTABLE LEADLESS PACEMAKER WITH CAPACITIVE ELECTRODE 审中-公开
标题翻译：可植入无电极电容器
公开(公告)号：EP3290081A1
公开(公告)日：2018-03-07
申请号：EP16202110.9
申请日：2016-12-05
申请人： BIOTRONIK SE & Co. KG
发明人： Baru, Marcelo
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/3756 , A61N1/0573 , A61N1/37512
摘要： An implantable leadless cardiac pacemaker with at least one capacitive electrode and an embedded anti-parallel Schottky junction. The leadless pacemaker can include a bonded semiconductor die, depositing a metal layer, an oxide layer, an insulating layer, and/or a conductive layer over at least a portion of the leadless pacemaker case. Some embodiments can include attaching an n-type silicon ("Si") die to a portion of the pacemaker case. With the various configurations, a Schottky junction can be formed with the n-type Si die, which can be used to limit current flow in one direction and provide protection from external defibrillation pulses.
摘要翻译：一种植入式无引线心脏起搏器，至少有一个电容电极和一个嵌入式反并联肖特基结。无引线起搏器可以包括接合的半导体管芯，在无引线起搏器外壳的至少一部分上沉积金属层，氧化物层，绝缘层和/或导电层。一些实施例可以包括将n型硅（“Si”）管芯附接到起搏器壳体的一部分。通过各种配置，肖特基结可与n型硅片形成，可用于限制一个方向的电流，并提供外部除颤脉冲的保护。

37. 发明授权

EP4188523B1 SEPTAL PERFORATING VEIN PACING 有权
公开(公告)号：EP4188523B1
公开(公告)日：2024-08-28
申请号：EP21756169.5
申请日：2021-07-27
IPC分类号： A61N1/05 , A61M31/00 , A61M25/10
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/37512 , A61N2001/058520130101 , A61N1/372 , A61M2025/105220130101 , A61M25/1011

38. 发明公开

EP4385559A2 BIOSTIMULATOR FEEDTHROUGH HAVING INTEGRATED ELECTRODE CUP 审中-实审
公开(公告)号：EP4385559A2
公开(公告)日：2024-06-19
申请号：EP24171970.7
申请日：2019-10-24
申请人： Pacesetter, Inc.
发明人： Paspa, Paul , Eby, Thomas B , Fishler, Matthew G , Boling, Carl Lance , Luhrs, Thomas Robert , Klehn, Russell , Strang, Tyler J , Garabed, Arees , Sahabi, Kavous , Villavicencio, Brett , Alleman, Wes , Soriano, Alex , Malone, Matthew R , Foley, Conor P
IPC分类号： A61N1/375
CPC分类号： A61N1/37205 , A61N1/37512 , A61N1/3754 , A61N1/3756 , A61N1/0568 , A61N1/0575
摘要： A leadless biostimulator including an electrical feedthrough assembly (100) mounted on a housing (110) is described. An electronics compartment (202) of the housing (102) can contain an electronics assembly (202), and the electrical feedthrough assembly (100) can include an electrode body (302, 700, 800,1302, 1402, 1502, 1602, 1802) including an electrode wall (502, 1310, 1410, 1510, 1610, 1810) extending distally from an electrode base (504, 1312, 1412, 1512, 1612, 1812) around an electrode cavity (506, 1314, 1414, 1514, 1614, 1814), an electrode tip (304, 1304, 1404, 1504, 1604, 1704, 1804) mounted on a distal end of the electrode body (302, 700, 800, 1302, 1402, 1502, 1602, 1802), a filler (416, 1316, 1416, 1516, 1616, 1816) including a therapeutic agent in the electrode cavity (506,1314,1414,1514,1614,1814) between the electrode base (504,1312,1412, 1512, 1612, 1812) and the electrode tip (304, 1304, 1404, 1504, 1604, 1704, 1804), and one or more holes (418, 1002) in at least one of the electrode body (302) or the electrode tip (304, 1304, 1404, 1504, 1604, 1704, 1804). The one or more holes (418, 1002) are configured to deliver the therapeutic agent to the target tissue when the therapeutic agent elutes from the filler (416, 1316, 1416, 1516, 1616, 1816) and passes through the one or more holes (418, 1002).

39. 发明授权

EP4087644B1 TEMPORARY PACEMAKER 有权
公开(公告)号：EP4087644B1
公开(公告)日：2024-06-19
申请号：EP20839488.2
申请日：2020-12-15
IPC分类号： A61N1/362 , A61N1/375 , A61N1/378
CPC分类号： A61N1/3625 , A61N1/3752 , A61N1/3758 , A61N1/37512 , A61N1/378

40. 发明授权

EP3870267B1 BIOSTIMULATOR FEEDTHROUGH HAVING INTEGRATED ELECTRODE CUP 有权
公开(公告)号：EP3870267B1
公开(公告)日：2024-06-19
申请号：EP19802449.9
申请日：2019-10-24
IPC分类号： A61N1/05 , A61N1/372 , A61N1/375
CPC分类号： A61N1/37205 , A61N1/37512 , A61N1/3754 , A61N1/3756 , A61N1/0568 , A61N1/0575

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