专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明公开

EP4372772A1 HIGH-TEMPERATURE SUPERCONDUCTING FLUX PUMP SYSTEM 审中-实审
公开(公告)号：EP4372772A1
公开(公告)日：2024-05-22
申请号：EP22841210.2
申请日：2022-07-04
申请人： Sichuan University
发明人： WANG, Wei , YE, Hanxin , YANG, Chao , LI, Hong , WEI, Jiafu , ZHANG, Yuntian
IPC分类号： H01F36/00
CPC分类号： Y02E40/60
摘要： The invention belongs to the technical field of superconducting magnet excitation systems, and particularly relates to a high-temperature superconducting flux pump system, which comprises a flux pump body, a superconducting load and a stator group. A double-pancake coil group comprises at least one double-pancake coil. The stator group comprises at least one stator. The flux pump body has an air gap for receiving the stator group. The superconducting load and the stator group are connected to form a closed circuit. The high-temperature superconducting flux pump system has a simpler structure, solves the problem of low charging rate of magnets, and greatly reduces the power cost without changing the magnet structure and winding cost.

32. 发明公开

EP4357369A1 PREPARATION AND APPLICATION OF CHIMERIC ANTIGEN RECEPTOR IMMUNE CELL CONSTRUCTED ON BASIS OF GRANZYME B 审中-实审
公开(公告)号：EP4357369A1
公开(公告)日：2024-04-24
申请号：EP22824241.8
申请日：2022-06-15
申请人： West China Hospital, Sichuan University
发明人： ZHAO, Xudong , SUN, Bin
IPC分类号： C07K19/00 , C12N5/10 , C12N15/867 , A61K39/00 , A61P35/00
CPC分类号： A61K39/00 , A61P35/00 , A61P35/02 , C07K19/00 , C12N5/10 , C12N15/867
摘要： A preparation and an application of a chimeric antigen receptor immune cell constructed on the basis of granzyme B. Specifically, a granzyme B (GrB)-based modified chimeric antigen receptor (CAR), the CAR containing an extracellular binding domain, and the extracellular binding domain being capable of specifically targeting heat shock proteins. The CAR immune cell acts by means of binding of a ligand and a receptor, and has relatively high targeting specificity and relatively safety.

33. 发明授权

EP3587403B1 N-SUBSTITUTED IMIDAZOLE CARBOXYLATE COMPOUND, PREPARATION METHOD AND USE 有权
公开(公告)号：EP3587403B1
公开(公告)日：2023-08-23
申请号：EP18757664.0
申请日：2018-01-31
发明人： LIU, Jin , YANG, Jun , ZHANG, Wensheng , KE, Bowen , TANG, Lei , WANG, Bin
IPC分类号： C07D233/90 , A61P23/00 , A61P25/20

34. 发明授权

EP3546826B1 VAPOR HEAT PUMP AND METHOD FOR UTILIZING LOW PRESSURE VAPOR THROUGH SUPPLEMENTING ENTHALPY AND PRESSURE BOOST 有权
公开(公告)号：EP3546826B1
公开(公告)日：2021-04-28
申请号：EP17878307.2
申请日：2017-11-24
发明人： LI, Sai , FU, Hao , FU, Chaoqing
IPC分类号： F04F5/16 , F25B30/00 , F01K3/26 , F22G1/00 , F25B1/06 , F04F5/42

35. 发明公开

EP3581927A1 ELECTRONIC INTEGRATED MULTI-ELECTRODE DETECTION SYSTEM BASED ON POTENTIAL MEASUREMENT 审中-实审
公开(公告)号：EP3581927A1
公开(公告)日：2019-12-18
申请号：EP18754212.1
申请日：2018-02-11
申请人： Sichuan University
发明人： XIAO, Dan , WANG, Chunling , YUAN, Hongyan , DUAN, Zhijuan
IPC分类号： G01N27/49 , G01N27/00
摘要： The present invention discloses an electronic integrated multi-electrode detection system of a potential determination. The detection system comprises a multi-electrode array (10), a circuit unit (20) and a total signal output and acquisition unit (30). The circuit unit mainly comprises a multi-electrode array signal input end (21), a high input impedance voltage follower (22), a phase shifting filter circuit (23), an extension module input end (24), a summing circuit (25) and a total output signal end (26). The detection system disclosed by the present invention can obviously promote the detection sensitivity and increase the accuracy and precision of detection results. The detection system can be used for monitoring the change in trace ion concentration in a sample, analyzing a constant conventional sample and analyzing a sample with higher error requirement. The detection system can be widely applied to various analysis detection fields, including life sciences, environmental sciences, medicine clinics, and the like. The electronic integrated multi-electrode detection system of the potential determination of the present invention is applicable to all universal multi-electrode detection systems of potential determinations.

36. 发明公开

EP3546826A1 STEAM HEAT PUMP AND LOW-PRESSURE STEAM ENTHALPY SUPPLEMENTING AND PRESSURIZING UTILIZATION METHOD 有权
公开(公告)号：EP3546826A1
公开(公告)日：2019-10-02
申请号：EP17878307.2
申请日：2017-11-24
申请人： Sichuan University
发明人： LI, Sai , FU, Hao , FU, Chaoqing
IPC分类号： F22G1/00
摘要： The invention discloses an efficient vapor heat pump (VHP) and a method for utilizing low pressure vapor through enthalpy supplement and pressure boost, comprising the following steps: the low pressure vapor is heated into superheated vapor for enthalpy supplement; when a material is heated on a material heater, the pressure boosted and quantity increased saturated vapor will be condensed and sharply shrink in volume to generate a strong suction force so that the superheated vapor is sucked for spraying liquid boost pressure(SLBP), so as to utilize the pressure boosted and quantity increased saturated vapor; further, an artificial tornado is generated from vapor in relevant equipment by reference to the formation theory of tornado in nature and the strong suction force thereof, so as to enhance the suction force and improve thermal efficiency and compression ratio. The vapor heat pump, especially the tornado vapor heat pump(TVHP), has the advantages of high efficiency, low energy consumption, low cost and environmental protection due to small enthalpy difference between low pressure vapor and pressure boosted and quantity increased saturated vapor, less enthalpy supplement of superheated vapor ,and high pressure ratio for spraying liquid boost pressure(SLBP). Besides, the low carbon technology is used as a green energy source and thus the TVHP is widely applied to many fields.

37. 发明授权

EP2924021B1 ANTI-HIV COMPOUND AND PREPARATION METHOD AND USE THEREOF 有权
公开(公告)号：EP2924021B1
公开(公告)日：2019-08-28
申请号：EP13857626.9
申请日：2013-12-13
申请人： Sichuan University
发明人： LI, Rui , WEI, Yuquan
IPC分类号： C07C319/20 , C07C323/62 , A61K31/167 , A61P31/18 , C07C317/48 , C07C317/50 , C07C323/63 , C07C237/44 , C07D295/155 , C07F9/40

38. 发明授权

EP2578603B1 B CELL ACTIVATING FACTOR ANTAGONIST AND PREPARATION METHOD AND USE THEREOF 有权
公开(公告)号：EP2578603B1
公开(公告)日：2018-11-14
申请号：EP11786092.4
申请日：2011-05-26
申请人： CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. , Sichuan University
发明人： YANG, Li , WEI, Yuquan
IPC分类号： C07K19/00 , C12N15/11 , C12N15/63 , A61K38/16 , A61K48/00 , A61K31/7088 , A61P19/02 , A61P19/04 , A61P29/00 , A61P37/02
CPC分类号： C07K19/00 , A61K31/7088 , A61K38/00 , A61K48/005 , C07K14/4703 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to the field of genetic engineering drugs, particularly to a novel B cell activating factor (BAFF) antagonist and use thereof. The technical problem to be solved by the invention is to find a new and effective selection for the prevention and treatment of autoimmune diseases. The B cell activating factor receptor antagonist is mainly obtained by the fusion of the domain 2 binding BAFF in TACI receptor and the domain binding BAFF in Br3 receptor, and it also can be fused with a Fc segment of IgG1 to obtain a new fusion protein molecule. Experiments indicate that said new fusion protein molecule has the function of BAFF antagonist, which can treat the autoimmune diseases, and supply a new and effective selection for the prevention and treatment of the autoimmune diseases.

39. 发明授权

EP2586768B1 HYDROXY ACID ESTER OF PROPOFOL, PREPARATION METHOD AND MEDICAL USE 有权
公开(公告)号：EP2586768B1
公开(公告)日：2018-06-27
申请号：EP10853411.6
申请日：2010-10-13
申请人： West China Hospital Sichuan University
发明人： ZHANG, Wensheng , YANG, Jun , LIU, Jin
IPC分类号： C07C69/675 , C07C67/317 , A61K31/222 , A61P25/20 , A61P23/00
CPC分类号： C07C59/48 , C07C67/31 , C07C67/32 , C07C69/675
摘要： Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y = C 1-4 straight carbon chain. The compound can release 2, 6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.

40. 发明公开

EP3088394A1 N-SUBSTITUTED IMIDAZOLE CARBOXYLIC ESTER CHIRAL COMPOUND CONTAINING ETHER SIDE CHAIN, PREPARATION METHOD AND APPLICATION 有权转让
标题翻译：用醚侧链方法及应用的N-取代的手咪唑羧基酯CONNECTION
公开(公告)号：EP3088394A1
公开(公告)日：2016-11-02
申请号：EP14873468.4
申请日：2014-10-30
申请人： West China Hospital, Sichuan University
发明人： ZHANG, Wensheng , YANG, Jun , LIU, Jin , TANG, Lei , KE, Bowen
IPC分类号： C07D233/90 , A61P25/20 , A61P23/00
CPC分类号： C07D233/90 , C07B2200/07
摘要： The present invention relates to an N-substituted imidazole carboxylic ester chiral compound containing an ether side chain and to its preparation and application. The structure of this compound is represented by Formula (I). This compound can induce a rapid and reversible general anesthesia effect. Animal experiments show that this compound has rapid and short-acting pharmacological characteristics, so that it can be used as a rapid and short-acting general anesthesia medicine. Compared with etomidate, this compound can reduce the inhibition on the synthesis of adrenal cortical hormone, with an advantage of rapid and full recovery of the post-operative patient. The only chiral carbon in the compound structure belongs to the R form. This imidazole ring in the compound structure has acidifiable N atoms, so that this compound or its related pharmaceutically-acceptable salts can be used in preparation of the central inhibitory medicines, which can produce sedative, hypnotic and/or anesthetic effects on animals or human beings via their intravenous or non-intravenous administration.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式