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31. 发明授权

US08291901B2 Dose delivery device for inhalation 有权
标题翻译：用于吸入的剂量输送装置
公开(公告)号：US08291901B2
公开(公告)日：2012-10-23
申请号：US12168445
申请日：2008-07-07
申请人： Andrew Jones , Richard L. Miller
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M11/002 , A61M11/008 , A61M11/02 , A61M11/06 , A61M15/0008 , A61M15/0013 , A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/004 , A61M15/0041 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/005 , A61M15/0061 , A61M15/0068 , A61M15/0075 , A61M15/0081 , A61M15/0086 , A61M15/0088 , A61M15/009 , A61M16/0495 , A61M2202/064 , A61M2205/071 , A61M2205/075 , A61M2205/6045 , A61M2205/6081 , A61M2205/8225 , A61M2206/16 , A61M2209/06
摘要： Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.
摘要翻译：用于递送剂量的方法和装置，例如用于吸入的药物。剂量可以通过递送装置储存并以计量方式分散并递送到受试者，例如通过经由输送装置的吸口吸入的受试者。该装置的一个或多个腔室可以具有环形形状并且可以被布置成选择性地打开以便与输送装置的流动路径流体连通，例如通过相对于流动路径的一部分滑动腔室。流动路径可以包括允许空气绕过室的限制，和/或可以设置室，使得进入室的流体与离开室的流体相互作用，以增强剂量的分散。

32. 发明授权

US12128176B2 Inhalation device 有权
公开(公告)号：US12128176B2
公开(公告)日：2024-10-29
申请号：US18142894
申请日：2023-05-03
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00 , A61M11/02
CPC分类号： A61M15/0043 , A61M15/0003 , A61M15/0005 , A61M15/001 , A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0038 , A61M15/0045 , A61M15/0048 , A61M15/0065 , A61M15/0075 , A61M15/0085 , A61M11/02 , A61M2202/064 , A61M2205/07
摘要： The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another. The drug seal system can also provide a method of tightly containing the drug until the package is opened, of directing airflow through the package and of managing and containing the drug during the package/device manufacturing process.

33. 发明申请

US20210369988A1 Inhalation Device 有权
公开(公告)号：US20210369988A1
公开(公告)日：2021-12-02
申请号：US17402436
申请日：2021-08-13
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00
摘要： The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another. The drug seal system can also provide a method of tightly containing the drug until the package is opened, of directing airflow through the package and of managing and containing the drug during the package/device manufacturing process.

34. 发明授权

US09919115B2 Dose delivery device for inhalation with first and second portions to open a dose chamber 有权
公开(公告)号：US09919115B2
公开(公告)日：2018-03-20
申请号：US14249409
申请日：2014-04-10
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00 , A61M11/00 , A61M16/04 , A61M11/02 , A61M11/06
CPC分类号： A61M11/002 , A61M11/008 , A61M11/02 , A61M11/06 , A61M15/0008 , A61M15/0013 , A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/004 , A61M15/0041 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/005 , A61M15/0061 , A61M15/0068 , A61M15/0075 , A61M15/0081 , A61M15/0086 , A61M15/0088 , A61M15/009 , A61M16/0495 , A61M2202/064 , A61M2205/071 , A61M2205/075 , A61M2205/6045 , A61M2205/6081 , A61M2205/8225 , A61M2206/16 , A61M2209/06
摘要： Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

35. 发明授权

US09283336B2 Delivery device and related methods 有权
标题翻译：配送装置及相关方法
公开(公告)号：US09283336B2
公开(公告)日：2016-03-15
申请号：US13622122
申请日：2012-09-18
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M15/0028 , A61M15/0035 , A61M15/0038 , A61M15/0045 , A61M15/0048 , A61M15/0075 , A61M15/0081 , A61M2202/064 , A61M2206/16 , B65D83/06
摘要： A dose delivery device with a mouthpiece having an inlet, an outlet, and an air path extending between the inlet and the outlet. A dose chamber having an opening may hold a dose, e.g., for inhalation by a user. A disc element may be arranged to move between a closed position in which the disc element closes the opening of the dose chamber, and an open position in which the disc opens the dose chamber to permit introduction of the dose into the air path of the device. Movement of the disc element from the closed position to the open position may be in a direction away from the dose chamber (e.g., a puller may engage the disc element and pull the element away from the chamber) and may leave a substantial portion of the dose in the dose chamber.
摘要翻译：具有口部的剂量递送装置，其具有在入口和出口之间延伸的入口，出口和空气路径。具有开口的剂量室可以保持剂量，例如用于用户的吸入。盘元件可以被布置成在盘元件关闭剂量室的开口的闭合位置和打开位置之间移动，在该打开位置，盘打开剂量室以允许将剂量引入到装置的空气路径中。盘元件从关闭位置到打开位置的移动可以是远离剂量室的方向（例如，拉拔器可以接合盘元件并将元件拉离腔室），并且可以留下大部分的剂量剂量。

36. 发明授权

US09004064B2 Delivery device and related methods 有权
标题翻译：配送装置及相关方法
公开(公告)号：US09004064B2
公开(公告)日：2015-04-14
申请号：US14047369
申请日：2013-10-07
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M16/00 , A61M15/00
CPC分类号： A61M15/0028 , A61M15/0041 , A61M15/0043 , A61M15/0045 , A61M15/0061 , A61M15/0075 , A61M2206/16
摘要： A delivery device that includes a cutter for opening a barrier layer to provide fluid access to a dose chamber, and a diverting structure for direct air flow toward the dose chamber.
摘要翻译：一种输送装置，包括用于打开阻挡层以提供流体进入剂量室的切割器，以及用于直接空气流向剂量室的转向结构。

37. 发明申请

US20140216457A1 INHALATION DEVICE 审中-公开
标题翻译：吸入装置
公开(公告)号：US20140216457A1
公开(公告)日：2014-08-07
申请号：US14248628
申请日：2014-04-09
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M11/02 , A61M15/0003 , A61M15/0005 , A61M15/001 , A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0038 , A61M15/0043 , A61M15/0048 , A61M15/0065 , A61M15/0075 , A61M15/0085 , A61M2202/064 , A61M2205/07
摘要： The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another. The drug seal system can also provide a method of tightly containing the drug until the package is opened, of directing airflow through the package and of managing and containing the drug during the package/device manufacturing process.
摘要翻译：本发明提供将药物分散方法整合到药物或药物递送系统中。使用的药物分散方法包括剪切（例如，具有或不具有气体辅助的药物的空气），毛细管流动或文丘里效应，诸如旋转，振动或冲击的机械手段和湍流（例如，使用筛网，或限制在空中路径）。这些药物分散方法允许释放系统中的所有药物，从而控制剂量大小。这些方法还提供了药物计量，流化，夹带，解聚和解聚。本发明还提供了将药物密封系统整合到装置中。药物密封系统提供了阻止药物从包装的一个区域迁移到另一个区域的方式。药物密封系统还可以提供紧密包含药物的方法，直到包装打开为止，在包装/装置制造过程中引导气流通过包装并管理和容纳药物。

38. 发明申请

US20140216454A1 DOSE DELIVERY DEVICE FOR INHALATION 有权
标题翻译：用于吸入的剂量递送装置
公开(公告)号：US20140216454A1
公开(公告)日：2014-08-07
申请号：US14249409
申请日：2014-04-10
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00
CPC分类号： A61M11/002 , A61M11/008 , A61M11/02 , A61M11/06 , A61M15/0008 , A61M15/0013 , A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/004 , A61M15/0041 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/005 , A61M15/0061 , A61M15/0068 , A61M15/0075 , A61M15/0081 , A61M15/0086 , A61M15/0088 , A61M15/009 , A61M16/0495 , A61M2202/064 , A61M2205/071 , A61M2205/075 , A61M2205/6045 , A61M2205/6081 , A61M2205/8225 , A61M2206/16 , A61M2209/06
摘要： Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.
摘要翻译：用于递送剂量的方法和装置，例如用于吸入的药物。剂量可以通过递送装置储存并以计量方式分散并递送到受试者，例如通过经由输送装置的吸口吸入的受试者。该装置的一个或多个腔室可以具有环形形状并且可以被布置成选择性地打开以便与输送装置的流动路径流体连通，例如通过相对于流动路径的一部分滑动腔室。流动路径可以包括允许空气绕过室的限制，和/或可以布置室，使得进入室的流体与离开室的流体相互作用，以增强剂量的分散。

39. 发明授权

US08607787B2 Dose delivery device for inhalation 有权
标题翻译：用于吸入的剂量输送装置
公开(公告)号：US08607787B2
公开(公告)日：2013-12-17
申请号：US13647881
申请日：2012-10-09
申请人： Andrew Jones , Richard L. Miller
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M11/002 , A61M11/008 , A61M11/02 , A61M11/06 , A61M15/0008 , A61M15/0013 , A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/004 , A61M15/0041 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/005 , A61M15/0061 , A61M15/0068 , A61M15/0075 , A61M15/0081 , A61M15/0086 , A61M15/0088 , A61M15/009 , A61M16/0495 , A61M2202/064 , A61M2205/071 , A61M2205/075 , A61M2205/6045 , A61M2205/6081 , A61M2205/8225 , A61M2206/16 , A61M2209/06
摘要： Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.
摘要翻译：用于递送剂量的方法和装置，例如用于吸入的药物。剂量可以通过递送装置储存并以计量方式分散并递送到受试者，例如通过经由输送装置的吸口吸入的受试者。该装置的一个或多个腔室可以具有环形形状并且可以被布置成选择性地打开以便与输送装置的流动路径流体连通，例如通过相对于流动路径的一部分滑动腔室。流动路径可以包括允许空气绕过室的限制，和/或可以设置室，使得进入室的流体与离开室的流体相互作用，以增强剂量的分散。

40. 发明授权

US11672927B2 Inhalation device 有权
公开(公告)号：US11672927B2
公开(公告)日：2023-06-13
申请号：US16859683
申请日：2020-04-27
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00 , A61M11/02
CPC分类号： A61M15/0043 , A61M15/001 , A61M15/002 , A61M15/0003 , A61M15/0005 , A61M15/0021 , A61M15/0028 , A61M15/0038 , A61M15/0045 , A61M15/0048 , A61M15/0065 , A61M15/0075 , A61M15/0085 , A61M11/02 , A61M2202/064 , A61M2205/07
摘要： The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another. The drug seal system can also provide a method of tightly containing the drug until the package is opened, of directing airflow through the package and of managing and containing the drug during the package/device manufacturing process.

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