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31. 发明专利

SG11201906973TA MULTIPLE TRANSGENE RECOMBINANT ADENOVIRUS 未知
公开(公告)号：SG11201906973TA
公开(公告)日：2019-08-27
申请号：SG11201906973T
申请日：2018-01-30
申请人： EPICENTRX INC
发明人： REID TONY R , ORONSKY BRYAN T , LARSON CHRISTOPHER
IPC分类号： C12N7/01 , A61K35/761 , A61P35/00 , C12N15/861
摘要： INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIPO I PCT (51) International Patent Classification: Cl 2N 7/01 (2006.01) A61K 35/761 (2015.01) Cl 2N 15/861 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/016032 (22) International Filing Date: 30 January 2018 (30.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/452,342 30 January 2017 (30.01.2017) US 62/520,945 16 June 2017 (16.06.2017) US (71) Applicant: EPICENTRX, INC. [US/US]; 4445 Eastgate Mall, Suite 200, San Diego, CA 92121 (US). (72) Inventors: REID, Tony R.; 5517 Carriage Court, San Diego, CA 92130 (US). ORONSKY, Bryan T.; 28540 Matadero Creek Lane, Los Altos Hills, CA 94022 (US). LARSON, Christopher; 3815 Lebon Dr. Apt. 335, San Diego, CA 92122 (US). (74) Agent: DAVENPORT, Andrew M. et al.; Goodwin Proc- ter LLP, 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 1-1 O \" (57) : The invention provides a recombinant adenovirus comprising two (or more) therapeutic transgenes, e.g., CD80 and 0 CD137L. The transgenes are preferably inserted into an Elb-19K insertion site and/or an E3 insertion site. omit VIII °nolo 010 Holimo Ill ono mil (10) International Publication Number WO 2018/140973 Al (54) Title: MULTIPLE TRANSGENE RECOMBINANT ADENOVIRUS

32. 发明专利

IL265657D0 Immunomodulatory fusion proteins 未知
公开(公告)号：IL265657D0
公开(公告)日：2019-05-30
申请号：IL26565719
申请日：2019-03-27
申请人： EPICENTRX INC
IPC分类号： C07K20060101
摘要： Provided is a fusion protein, e.g., a cytokine receptor fusion protein, e.g., a TGFβ trap, with a novel linker sequence to permit the fusion protein to functionally optimally, e.g., to permit a cytokine receptor portion of a cytokine receptor fusion protein to bind optimally to its target cytokine. The fusion proteins, or expression vectors encoding for the fusion proteins, e.g., oncolytic adenoviral expression vectors, can be used to treat cell proliferative diseases and disorders, including certain forms of cancer and inflammatory disorders.

33. 发明专利

CA3077223A1 IMMUNOMODULATORY FUSION PROTEINS 未知
公开(公告)号：CA3077223A1
公开(公告)日：2019-04-04
申请号：CA3077223
申请日：2018-09-27
申请人： EPICENTRX INC
发明人： LARSON CHRISTOPHER , REID TONY R , ORONSKY BRYAN T
IPC分类号： C07K19/00 , A61K38/16 , A61P35/00 , C07K14/715
摘要： Provided is a fusion protein, e.g., a cytokine receptor fusion protein, e.g., an IL-10 trap, with a novel linker sequence to permit the fusion protein to functionally optimally, e.g., to permit a cytokine receptor portion of a cytokine receptor fusion protein to bind optimally to its target cytokine. The fusion protein, or an expression vector encoding for the fusion proteins, can be used to treat cell proliferative diseases and disorders, including certain forms of cancer and inflammatory disorders.

34. 发明专利

CA3069004A1 COMPOSITIONS FOR PARENTERAL ADMINISTRATION OF THERAPEUTIC AGENTS 未知
公开(公告)号：CA3069004A1
公开(公告)日：2019-01-10
申请号：CA3069004
申请日：2018-07-06
申请人： EPICENTRX INC
发明人： ORONSKY BRYAN T
IPC分类号： A61K9/08 , A61K31/337 , A61K31/407 , A61K31/4745 , A61K31/555 , A61K31/704 , A61K33/24 , A61K47/46 , A61P35/00
摘要： The invention provides compositions and methods for administering a therapeutic agent to a patient, such as pharmaceutical compositions containing a blood product and a therapeutic agent selected from an anthracycline anti-cancer agent (e.g., doxorubicin), a topoisomerase inhibitor, an oxazaphosphinanyl anti-cancer agent, a nitro-aryl anti-cancer agent, a thiol-reactive functional -group agent, a nitric oxide modulator, a platinum-based antineoplastic compound, acrylamide, acrylonitrile, bis(4-fluorobenzyl)trisulfide, a cardiac glycoside, an anti-mitotic agent (e.g., paclitaxel), a nucleoside analog, an EGFR inhibitor, or an anti-microbial agent.

35. 发明专利

ES2532457T3 Compuestos nitro cíclicos, composiciones farmacéuticas de éstos y usos de éstos 未知
公开(公告)号：ES2532457T3
公开(公告)日：2015-03-27
申请号：ES06801575
申请日：2006-08-14
申请人： ORBITAL ATK INC , EPICENTRX INC
发明人： KNOX SUSAN , CANNIZZO LOUIS , WARNER KIRSTIN , WARDLE ROBERT , VELARDE STEPHEN , NING SHOUCHENG , BEDNARSKI MARK D
IPC分类号： A61K31/21
摘要： Un compuesto de Fórmula estructural (I):**Fórmula** o sales, solvatos o hidratos de éste en el que: R1, R2, R3 y R4 son cada uno independientemente, hidrógeno, alquilo, alquilo sustituido, arilo, arilo sustituido, arilalquilo, arilalquilo sustituido, heteroarilo, heteroarilo sustituido, heteroalquilo, heteroalquilo sustituido, heteroarilalquilo, heteroarilalquilo sustituido, halo, hidroxi o nitro; R5 y R6 son cada uno independientemente, hidrógeno, alquilo, alquilo sustituido, arilo, arilo sustituido, arilalquilo, arilalquilo sustituido, heteroarilo, heteroarilo sustituido, heteroalquilo, heteroalquilo sustituido, heteroarilalquilo, heteroarilalquilo sustituido, halo, hidroxi o nitro; o es 0, 1, 2, 3 ó 4; R7 es acilo sustituido con uno o más de halógeno, -CF3 o -OS(O)2R8; R8 es alquilo, alquilo sustituido, arilo o arilo sustituido; siempre que al menos uno de R1, R2, R3, R4, R5 y R6 sean nitro; en el que, excepto como ya se ha proporcionado para la variable R7, sustituido se refiere a los sustituyentes M, -R60, -O, -OR60, -SR60, -S, -NR60R61, -NR60, -CF3, -CN, -OCN, -SCN, -NO, -NO2, -ONO2, -N2, -N3, -S(O)2OH, -S(O)2R60, -OS(O)2R60, -OP(O)(OR60)(OR61), -C(O)R60, -C(S)R60, -C(O)OR60, -C(O)NR60R61, -C(S)OR60, -NR62C(O)NR60R61, -NR62C(S)NR60R61, -NR62C(NR63)NR60R61 y -C(NR62)NR60R61 en los que M es independientemente un halógeno; R60, R61, R62 y R63 son independientemente hidrógeno, alquilo, alquilo sustituido, alcoxi, alcoxi sustituido, cicloalquilo, cicloalquilo sustituido, cicloheteroalquilo, cicloheteroalquilo sustituido, arilo, arilo sustituido, heteroarilo o heteroarilo sustituido, u opcionalmente R60 y R61 junto con el átomo de nitrógeno al que están unidos forman un anillo cicloheteroalquilo o cicloheteroalquilo sustituido.

36. 发明授权

EP3737372B1 METHODS AND COMPOSITIONS UTILIZING RRX-001 FOR RADIOPROTECTION 有权转让
公开(公告)号：EP3737372B1
公开(公告)日：2024-05-01
申请号：EP19729867.2
申请日：2019-01-08
IPC分类号： A61K31/397 , A61K45/06 , A61P35/00 , A61P39/00
CPC分类号： A61K31/397 , A61K45/06 , A61P39/00 , A61P35/00

37. 发明公开

EP3688037A1 IMMUNOMODULATORY FUSION PROTEINS 审中-公开
公开(公告)号：EP3688037A1
公开(公告)日：2020-08-05
申请号：EP18862997.6
申请日：2018-09-27
申请人： EpicentRx, Inc.
发明人： LARSON, Christopher , REID, Tony, R. , ORONSKY, Bryan, T.
IPC分类号： C07K19/00 , C07K14/715 , A61K38/16 , A61P35/00

38. 发明专利

IL265970A Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine 未知
公开(公告)号：IL265970A
公开(公告)日：2022-03-01
申请号：IL26597019
申请日：2019-04-11
申请人： EPICENTRX INC
IPC分类号： A61K31/397 , A61K38/05 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/00 , A61P33/00 , A61P35/00
摘要： The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoimmune disease, infection, or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(3,3-dinitroaze-tidin-1-yl)-2-oxoethyl)sulfinyl)-D-alanine and variants thereof.

39. 发明专利

PL3402480T4 KOMPOZYCJE I SPOSOBY DOŻYLNEGO PODAWANIA 2-BROMO-1-(3,3-DINITROAZETYDYN-1-YLO)ETANONU 未知
公开(公告)号：PL3402480T4
公开(公告)日：2021-11-22
申请号：PL17738834
申请日：2017-01-11
申请人： EPICENTRX INC
发明人： ORONSKY BRYAN T , SCICINSKI JAN , CAROEN SCOTT
IPC分类号： A61K31/397 , A61K9/08 , A61K35/14 , A61P35/00

40. 发明专利

MX2019008921A ADENOVIRUS RECOMBINANTE DE TRANSGENES MÚLTIPLES. 未知
公开(公告)号：MX2019008921A
公开(公告)日：2019-11-08
申请号：MX2019008921
申请日：2018-01-30
申请人： EPICENTRX INC
发明人： BRYAN T ORONSKY , CHRISTOPHER LARSON , TONY R REID
IPC分类号： C12N7/01 , A61K35/761 , A61P35/00 , C12N15/861
摘要： La invención proporciona un adenovirus recombinante que comprende dos (o más) transgenes terapéuticos, por ejemplo, CD80 y CD137L. Dichos transgenes terapéuticos se insertan preferiblemente en un sitio de inserción Elb-19K y/o en un sitio de inserción E3.

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