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    • 33. 发明专利
    • Surgical system, and method of operating surgical console thereof
    • 手术系统及手术操作方法
    • JP2003319965A
    • 2003-11-11
    • JP2003108731
    • 2003-04-14
    • Alcon Incアルコン,インコーポレイティド
    • BRODY GEORGESORENSEN GARY P
    • A61F9/007A61M1/00
    • A61F9/00745A61M1/0058A61M2205/123A61M2210/0612
    • PROBLEM TO BE SOLVED: To provide a surgical system in which a pressure within a irrigation fluid container is controlled without need for direct ventilation to a gas contained in the fluid container. SOLUTION: The surgical system having a cassette equipped with an aspirant collection chamber and an aspiration exhaust line that drains into the aspirant collection chamber is provided. A fluid from the irrigation fluid container is vented into the aspirant collection chamber by a fluid line containing a valve. A source of pressurized air is connected to the fluid container, and is used to pressurize the fluid container. When the pressure within the fluid container needs to be increased, pressurized air from the pressurized air source is allowed to enter the fluid container. When the pressure within the fluid container needs to be decreased, the irrigation fluid is allowed to be bled out of the fluid container and enter the collection chamber. In this manner, a direct fluidic connection with the gas contained in the fluid container does not need to be maintained. COPYRIGHT: (C)2004,JPO
    • 要解决的问题:提供一种外科系统,其中控制冲洗流体容器内的压力而不需要直接通向容纳在流体容器中的气体。 解决方案:提供具有装备有吸气收集室和排入吸入器收集室的抽吸排气管的盒的外科系统。 来自冲洗流体容器的流体通过包含阀的流体管线排放到吸入器收集室中。 加压空气源连接到流体容器,并用于对流体容器加压。 当需要增加流体容器内的压力时,允许来自加压空气源的加压空气进入流体容器。 当需要减少流体容器内的压力时,可将冲洗液从流体容器中排出并进入收集室。 以这种方式,不需要维持与容纳在流体容器中的气体的直接流体连接。 版权所有(C)2004,JPO
    • 34. 发明专利
    • Surgical cassette
    • 外科手术
    • JP2003319963A
    • 2003-11-11
    • JP2003105399
    • 2003-04-09
    • Alcon Incアルコン,インコーポレイティド
    • SORENSEN GARY PBRODY GEORGE
    • A61F9/007A61M1/00
    • A61M1/0058A61F9/00736A61M2205/123A61M2205/128
    • PROBLEM TO BE SOLVED: To provide a cassette to be used for a surgical system for cataract. SOLUTION: The cassette has an aspirant collection chamber and an aspiration exhaust line that drains into the aspirant collection chamber. A fluid line containing a valve allows a fluid from an irrigation fluid container to be vented into the aspirant collection chamber. A source of pressurized air is connected to the irrigation fluid chamber and is used to pressurize the irrigation fluid chamber. When the pressure within the fluid container needs to be increased, pressurized air from the pressurized air source is allowed to enter the fluid container. When the pressure within the fluid container needs to be decreased, an irrigation fluid is allowed to be bled out of the irrigation fluid container and enter the aspirant collection chamber. Thus, a direct fluidic connection with the gas contained within the fluid container does not need to be maintained. COPYRIGHT: (C)2004,JPO
    • 要解决的问题:提供用于白内障手术系统的盒子。

      解决方案:盒式磁带具有吸入式收集室和排入吸入室的抽吸排气管线。 包含阀门的流体管线允许来自冲洗流体容器的流体排放到吸入剂收集室中。 加压空气源连接到冲洗流体室,并用于对冲洗流体室加压。 当需要增加流体容器内的压力时,允许来自加压空气源的加压空气进入流体容器。 当需要降低流体容器内的压力时,可以将冲洗液从冲洗流体容器中排出并进入吸气室。 因此,不需要维持与容纳在流体容器内的气体的直接流体连接。 版权所有(C)2004,JPO

    • 40. 发明专利
    • RNAi INHIBITION OF CTGF FOR TREATMENT OF OCULAR DISORDER
    • 用于治疗眼部疾病的CTGF的RNAi抑制
    • JP2012097119A
    • 2012-05-24
    • JP2012029499
    • 2012-02-14
    • Alcon Incアルコン,インコーポレイテッド
    • SHEPARD ALLAN RPANG IOK-HOU
    • A61K31/7105A61K48/00A61P27/02A61P27/06C12N15/113
    • C12N15/1136A61K31/713C12N15/111C12N2310/14C12N2320/32
    • PROBLEM TO BE SOLVED: To provide RNA interference for inhibition of connective tissue growth factor mRNA expression in ocular disorders involving CTGF expression.SOLUTION: Ocular disorders involving aberrant CTGF expression include glaucoma, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and wound healing. Such disorders are treated by administering interfering RNAs. There is provided a method of attenuating expression of connective tissue growth factor mRNA in an eye of a subject. The method comprises administering to the eye of the subject a composition comprising an effective amount of interfering RNA such as adouble-stranded (ds) siRNA or single-stranded (ss) siRNA having a lentgh of 19 to 49 nucleotides and a pharmaceutically acceptable carrier.
    • 要解决的问题:提供RNA干扰,用于抑制涉及CTGF表达的眼部疾病中的结缔组织生长因子mRNA表达。 涉及异常CTGF表达的眼部疾病包括青光眼,黄斑变性,糖尿病性视网膜病变,脉络膜新生血管形成,增生性玻璃体视网膜病变和伤口愈合。 通过施用干扰RNA来治疗这些病症。 提供了减弱受试者眼睛中结缔组织生长因子mRNA表达的方法。 该方法包括向受试者的眼睛施用包含有效量的干扰RNA的组合物,所述干扰RNA例如具有19至49个核苷酸的寡核苷酸的双链(ds)siRNA或单链(ss)siRNA和药学上可接受的载体。 版权所有(C)2012,JPO&INPIT