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31. 发明授权

US5525335A Wound healing agent 失效
标题翻译：伤口愈合剂
公开(公告)号：US5525335A
公开(公告)日：1996-06-11
申请号：US167806
申请日：1993-12-21
申请人： Yoshiro Kitahara , Tsuyoshi Ohsumi , Yuzuru Eto , Satoshi Takano
发明人： Yoshiro Kitahara , Tsuyoshi Ohsumi , Yuzuru Eto , Satoshi Takano
IPC分类号： A61K38/45
CPC分类号： A61K38/45
摘要： Wound healing agents (especially a cicatricial contracture preventing agent, a wound protective or coating agent and a hemostatic agent) containing transglutaminaseas an active ingredient, which are novel and excellent wound healing agents with which cicatricial contracture prevention, wound protection or coating and blood stanching can be made simply and easily.
摘要翻译： PCT No.PCT / JP93 / 00501 Sec。 371日期：1993年12月21日 102（e）日期1993年12月21日PCT提交1993年4月19日PCT公布。公开号WO93 / 20837 日期：1993年10月28日。含有转谷氨酰胺酶作为活性成分的伤口愈合剂（特别是瘢痕挛缩预防剂，伤口保护剂或包衣剂和止血剂）是新颖且优秀的伤口愈合剂，其具有瘢痕挛缩预防，伤口可以简单，容易地进行保护，涂敷，血液保持。

32. 发明授权

US09844226B2 Use of peptides for imparting kokumi 有权
公开(公告)号：US09844226B2
公开(公告)日：2017-12-19
申请号：US13249523
申请日：2011-09-30
申请人： Fumie Futaki , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
发明人： Fumie Futaki , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
IPC分类号： A23L1/22 , A23L27/22 , A23L27/21
CPC分类号： A23L27/22 , A23L27/21
摘要： A substance is described which is capable of imparting a kokumi, which shows a more excellent kokumi-imparting effect, in particular, the initial taste-imparting type of kokumi-imparting effect, which is excellent in the stability and which can easily be produced at a low cost. Additionally, a kokumi-imparting composition which includes a substance as well as a kokumi-imparting agent including the substance and other substances possessing the CaSR agonist activities in combination. More particularly, the present invention herein provides a kokumi-imparting composition consisting of γ-Glu-Abu (L-γ-glutamyl-L-2-amino-butyric acid) and a complex kokumi-imparting agent which includes the foregoing substance and another substance having a CaSR agonist activity, in combination.

33. 发明授权

US09395376B2 Kokumi-imparting agent 有权
标题翻译： Kokumi传授代理
公开(公告)号：US09395376B2
公开(公告)日：2016-07-19
申请号：US12962051
申请日：2010-12-07
申请人： Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
发明人： Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino , Naohiro Miyamura , Tomohiko Yamanaka , Hiroaki Nagasaki
IPC分类号： G01N33/68 , A23L1/221 , A23L1/305 , C07K5/02
CPC分类号： G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要： The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译：本发明包括使用钙受体活性作为指标筛选赋粉性物质的方法，含有通过筛选方法得到的赋予口味的物质的组合物，赋予口味的食品或饮料的制造方法，以及送给kokumi的食物或饮料。

34. 发明授权

US08568814B2 Lanthionine derivatives 有权
标题翻译：黄嘌呤衍生物
公开(公告)号：US08568814B2
公开(公告)日：2013-10-29
申请号：US13533469
申请日：2012-06-26
申请人： Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
发明人： Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
IPC分类号： A23L1/226
CPC分类号： A23C9/156 , A23L27/204 , C07D281/06 , C07K5/0215
摘要： The present invention provides a variety of compounds having a CaSR agonist activity which possesses a superior kokumi-imparting function, and more particularly provides a kokumi-imparting composition, which contains the foregoing compound, and/or another substance having a CaSR agonist activity, in combination. The present invention also provides a kokumi-imparting composition which includes a lanthionine derivative and/or another substance having a CaSR agonist activity.
摘要翻译：本发明提供了各种具有CaSR激动剂活性的化合物，其具有优异的赋粉功能，更具体地，提供含有上述化合物和/或另一种具有CaSR激动剂活性的物质，赋予赋粉组合物，组合。本发明还提供了一种赋形剂组合物，其包含具有CaSR激动剂活性的叶酸衍生物和/或其它物质。

35. 发明授权

US08399417B2 Food 有权
标题翻译：餐饮
公开(公告)号：US08399417B2
公开(公告)日：2013-03-19
申请号：US12613590
申请日：2009-11-06
申请人： Hiroaki Nagasaki , Naohiro Miyamura , Yuzuru Eto
发明人： Hiroaki Nagasaki , Naohiro Miyamura , Yuzuru Eto
IPC分类号： A61K38/07 , A61K38/06
CPC分类号： A23D7/0053 , A23C9/1322 , A23C9/1526 , A23L27/31 , A23L27/32 , A23L27/60 , A23L33/175 , A23L33/18
摘要： A low-fat food containing an amino acid or a peptide which is able to activate a calcium receptor, examples of which include γ-Glu-X-Gly, γ-Glu-Val-Y, γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-Me), etc, wherein X and Y are an amino acid or an amino acid derivative.
摘要翻译：含有能够激活钙受体的氨基酸或肽的低脂肪食物，其实例包括γ-Glu-X-Gly，γ-Glu-Val-Y，γ-Glu-Ala，γ-Glu -Gly，γ-Glu-Cys，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly，Cys-Met，Glu-Cys，Gly -Cys，Leu-Asp，D-Cys，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，γ-Glu-Val- Ser，γ-Glu-Tau，γ-Glu-Cys（S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu， Me）等，其中X和Y是氨基酸或氨基酸衍生物。

36. 发明授权

US08106020B2 Calcium receptor activator 有权
标题翻译：钙受体活化剂
公开(公告)号：US08106020B2
公开(公告)日：2012-01-31
申请号：US12117041
申请日：2008-05-08
申请人： Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino
发明人： Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino
IPC分类号： C07K5/06
CPC分类号： A61K38/06 , A61K38/05
摘要： A calcium receptor activator and compositions containing at least one of the following: γ-Glu-Cys-Gly, γ-Glu-Cys(SNO)-Gly, γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, γ-Glu-Met(O), γ-Glu-Val-Val, γ-Glu-Val-Glu, γ-Glu-Val-Lys, γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-allyl)-Gly, γ-Glu-Gly-Gly, γ-Glu-Val-Phe, γ-Glu-Val-Ser, γ-Glu-Val-Pro, γ-Glu-Val-Arg, γ-Glu-Val-Asp, γ-Glu-Val-Met, γ-Glu-Val-Thr, γ-Glu-Val-His, γ-Glu-Val-Asn, γ-Glu-Val-Gln, γ-Glu-Val-Cys, γ-Glu-Val-Orn, γ-Glu-Ser-Gly, γ-Glu-Cys(S-Me), γ-Glu-Abu-Gly, γ-Glu-Cys(S-Me)-Gly, and γ-Glu-Val-Gly.
摘要翻译：钙受体激活剂和含有以下至少一种的组合物：γ-Glu-Cys-Gly，γ-Glu-Cys（SNO）-Gly，γ-Glu-Ala，γ-Glu-Gly，γ-Glu-Cys ，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly，Cys-Met，Glu-Cys，Gly-Cys，Leu-Asp，D -Cys，γ-Glu-Met（O），γ-Glu-Val-Val，γ-Glu-Val-Glu，γ-Glu-Val-Lys，γ-Glu-γ-Glu-Val， Val-NH 2，γ-Glu-Val-ol，γ-Glu-Ser，γ-Glu-Tau，γ-Glu-Cys（S-Me）（O） γ-Glu-t-Leu，γ-Glu-Cys（S-烯丙基）-Gly，γ-Glu-Gly-Gly，γ-Glu-Val-Phe，γ-Glu-Val-Ser， -Pro，γ-Glu-Val-Arg，γ-Glu-Val-Asp，γ-Glu-Val-Asp，γ-Glu-Val-Met，γ-Glu-Val-Thr，，γ-Glu-Val-Gln，γ-Glu-Val-Cys，γ-Glu-Val-Orn，γ-Glu-Ser-Gly，γ-Glu-Cys（S-Me） Gly，γ-Glu-Cys（S-Me）-Gly和γ-Glu-Val-Gly。

37. 发明申请

US20110070270A1 IMMUNOSTIMULATING AGENT 有权
标题翻译：免疫调节剂
公开(公告)号：US20110070270A1
公开(公告)日：2011-03-24
申请号：US12899045
申请日：2010-10-06
申请人： Tomohiro Kodera , Yuzuru Eto , Yoshinori Mine
发明人： Tomohiro Kodera , Yuzuru Eto , Yoshinori Mine
IPC分类号： A61K38/05 , A61K31/13 , A61P35/00 , A61P37/04 , A61P1/00 , A61P1/12 , A61P37/08
CPC分类号： A61K31/132 , A23L33/10 , A23L33/18 , A61K31/135 , A61K38/03 , A61K38/17 , Y02A50/473
摘要： An immunostimulating agent, which can stimulate immunity effectively, is described. The immunostimulating agent contains an active ingredient including a calcium receptor activator such as γ-Glu-X-Gly [wherein X represents an amino acid or a derivative thereof other than Cys], γ-Glu-Val-Y [wherein Y represents an amino acid or a derivative thereof], γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-Me), a cation having a valency of 2 or more, protamine, polylysine, spermine, spermidine, putrescine, cinacalcet, a cinacalcet analogue compound, and a salt of any one of the aforementioned components.
摘要翻译：描述了可以有效地刺激免疫的免疫刺激剂。免疫刺激剂含有包括钙受体活化剂如γ-Glu-X-Gly [其中X表示除Cys]以外的氨基酸或其衍生物的活性成分，γ-Glu-Val-Y [其中Y表示氨基酸或其衍生物]，γ-Glu-Ala，γ-Glu-Gly，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly ，Cys-Met，Glu-Cys，Gly-Cys，Leu-Asp，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，γ-Glu-Val- （S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu，γ- Glu-Cys（S-Me），2价以上的阳离子，鱼精蛋白，聚赖氨酸，精胺，亚精胺，腐胺，西那卡塞，西那卡塞类似物化合物和上述成分中的任一种的盐。

38. 发明申请

US20100183792A1 SWEETENER 有权
公开(公告)号：US20100183792A1
公开(公告)日：2010-07-22
申请号：US12613615
申请日：2009-11-06
申请人： Hiroaki Nagasaki , Naohiro Miyamura , Yuzuru Eto , Katsuya Seguro
发明人： Hiroaki Nagasaki , Naohiro Miyamura , Yuzuru Eto , Katsuya Seguro
IPC分类号： A23L1/236
CPC分类号： A23L27/31 , A23L27/00 , A23L27/32 , A23V2002/00 , A23V2200/16 , A23V2250/06 , A23V2250/2482 , A23V2250/264 , A23V2250/242
摘要： The body taste of a sweetener (for example, aspartame, sucralose, acesulfame, etc.) is improved by blending the sweetener with an amino acid or a peptide, which is able to activate a calcium receptor, such as γ-Glu-X-Gly (wherein X represents an amino acid or an amino acid derivative), γ-Glu-Val-Y (wherein Y represents an amino acid or an amino acid derivative), γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-Me), etc.
摘要翻译：甜味剂（例如，阿斯巴甜，三氯蔗糖，乙酰磺胺酸等）的身体味道通过将甜味剂与能够激活钙受体的氨基酸或肽混合来改进，所述钙受体例如γ-Glu-X- Gly（其中X表示氨基酸或氨基酸衍生物），γ-Glu-Val-Y（其中Y表示氨基酸或氨基酸衍生物），γ-Glu-Ala，γ-Glu-Gly， Glu-Cys，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly，Cys-Met，Glu-Cys，Gly-Cys， Asp，D-Cys，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，γ-Glu-Val-ol，γ-Glu-Ser， -Tau，γ-Glu-Cys（S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu，γ-Glu-Cys（S-Me）

39. 发明申请

US20090239808A1 CALCIUM RECEPTOR ACTIVATOR 有权
标题翻译：钙受体激活剂
公开(公告)号：US20090239808A1
公开(公告)日：2009-09-24
申请号：US12117041
申请日：2008-05-08
申请人： Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino
发明人： Takeaki Ohsu , Sen Takeshita , Yuzuru Eto , Yusuke Amino
IPC分类号： A61K38/06 , C07K5/093 , C07C55/02
CPC分类号： A61K38/06 , A61K38/05
摘要： A calcium receptor activator and compositions containing at least one of the following: γ-Glu-Cys-Gly, γ-Glu-Cys(SNO)-Gly, γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, γ-Glu-Met(O), γ-Glu-Val-Val, γ-Glu-Val-Glu, γ-Glu-Val-Lys, γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-allyl)-Gly, γ-Glu-Gly-Gly, γ-Glu-Val-Phe, γ-Glu-Val-Ser, γ-Glu-Val-Pro, γ-Glu-Val-Arg, γ-Glu-Val-Asp, γ-Glu-Val-Met, γ-Glu-Val-Thr, γ-Glu-Val-His, γ-Glu-Val-Asn, γ-Glu-Val-Gln, γ-Glu-Val-Cys, γ-Glu-Val-Orn, γ-Glu-Ser-Gly, γ-Glu-Cys(S-Me), γ-Glu-Abu-Gly, γ-Glu-Cys(S-Me)-Gly, and γ-Glu-Val-Gly.
摘要翻译：钙受体激活剂和含有以下至少一种的组合物：γ-Glu-Cys-Gly，γ-Glu-Cys（SNO）-Gly，γ-Glu-Ala，γ-Glu-Gly，γ-Glu-Cys ，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly，Cys-Met，Glu-Cys，Gly-Cys，Leu-Asp，D -Cys，γ-Glu-Met（O），γ-Glu-Val-Val，γ-Glu-Val-Glu，γ-Glu-Val-Lys，γ-Glu-γ-Glu-Val， Val-NH2，γ-Glu-Val-ol，γ-Glu-Ser，γ-Glu-Tau，γ-Glu-Cys（S-Me）（O），γ-Glu-Leu， γ-Glu-t-Leu，γ-Glu-Cys（S-烯丙基）-Gly，γ-Glu-Gly-Gly，γ-Glu-Val-Phe，γ-Glu-Val-Ser， -Pro，γ-Glu-Val-Arg，γ-Glu-Val-Asp，γ-Glu-Val-Met，γ-Glu-Val-Thr，γ-Glu-Val-His，，γ-Glu-Val-Gln，γ-Glu-Val-Cys，γ-Glu-Val-Orn，γ-Glu-Ser-Gly，γ-Glu-Cys（S-Me） Gly，γ-Glu-Cys（S-Me）-Gly和γ-Glu-Val-Gly。

40. 发明授权

US06872703B2 Insulin receptor-related receptor binding protein 失效
标题翻译：胰岛素受体相关受体结合蛋白
公开(公告)号：US06872703B2
公开(公告)日：2005-03-29
申请号：US09874056
申请日：2001-06-06
申请人： Akira Okano , Yuzuru Eto , Tetsuro Izumi
发明人： Akira Okano , Yuzuru Eto , Tetsuro Izumi
IPC分类号： A61K38/00 , C07K14/475 , C07K14/435 , A61K38/17
CPC分类号： C07K14/475 , A61K38/00
摘要： A protein or a variant thereof, which has a binding activity to IRR and the following characteristics and an insulin receptor-related receptor are allowed to bind in the presence of a test substance, and inhibition of the binding is measured to search for an agonist or antagonist of IRR ligand. (a) it has the amino acid sequence of SEQ ID NO: 1; (b) it has a molecular weight measured by mass spectrometry using the Fourier transformation ion cyclotron method of about 6135, 6206, 6250 or 6321.
摘要翻译：使具有与IRR的结合活性和以下特征的蛋白质或其变体与胰岛素受体相关受体在测试物质的存在下结合，并测定结合的抑制以寻找激动剂或（a）其具有SEQ ID NO：1的氨基酸序列;（b）通过使用约6135,6206,6250或6321的傅立叶变换离子回旋加速仪通过质谱法测量的分子量。

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