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31. 发明申请

US20050167370A1 Resin microchannel substrate and method of manufacturing the same 审中-公开
标题翻译：树脂微通道基板及其制造方法
公开(公告)号：US20050167370A1
公开(公告)日：2005-08-04
申请号：US10814177
申请日：2004-04-01
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Taiji Nishi , Takenori Kitani , Yukihiro Yanagawa , Motohiro Fukuda
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Taiji Nishi , Takenori Kitani , Yukihiro Yanagawa , Motohiro Fukuda
IPC分类号： B81B1/00 , B01D29/00 , B01D29/46 , B01F3/08 , B01F5/04 , B01F13/00 , B01J13/00 , B01J19/00 , B01D37/00 , H01L21/302 , H01L21/461
CPC分类号： B01F13/0059 , B01D29/00 , B01F3/0807 , B01F5/0475 , B01F5/0483 , B01F2215/0431
摘要： The resin microchannel substrate has a surface where a recess leading to a fluid supply port and a bank adjacent to the recess and having many micro grooves on a surface are formed. The grooves form microchannels connecting the inside of the recess and the outside of the recess when the surface of the substrate is firmly attached to a flat plate serving as a cover. The width and height of the microchannel are within a range of 1 to 300 μm, and the width/height ratio of the channel is within a range of 1:20 to 20:1.
摘要翻译：树脂微通道基板具有表面，其中形成有通向流体供给口的凹部和与凹部相邻的堤，并且在表面上具有许多微槽。当基板的表面牢固地附接到用作盖的平板时，凹槽形成连接凹部的内部和凹部的外部的微通道。微通道的宽度和高度在1至300μm的范围内，并且通道的宽/高比在1:20至20:1的范围内。

32. 发明授权

US06227973B1 Video game system using terrain profile information 失效
标题翻译：视频游戏系统使用地形资料信息
公开(公告)号：US06227973B1
公开(公告)日：2001-05-08
申请号：US08841505
申请日：1997-04-23
申请人： Yuji Kikuchi
发明人： Yuji Kikuchi
IPC分类号： A63F1300
CPC分类号： A63F13/5378 , A63F13/10 , A63F13/52 , A63F13/5375 , A63F13/812 , A63F2300/303 , A63F2300/64 , A63F2300/66 , A63F2300/8011 , G06T17/05
摘要： A video game system for simulating a golf game displays three-dimensional image information indicative of the terrain profile of a golf course and image information of a golf ball on the display screen of a television monitor. The golf ball is moved on the display screen based on the image information indicative of the terrain profile and a command from a controller operated by the game player. A guide comprising a matrix of lines is displayed on the display screen, and the luminance and length of each of said lines are established based on the image information indicative of the terrain profile. The guide is three-dimensionally displayed over the three-dimensional image information indicative of the terrain profile on said display screen. The three-dimensionally displayed guide allows the game player to visually recognize heights and distances of various areas of the golf course in an intuitive fashion, and hence allows the game player to operate the controller in a manner to match terrain features of the golf course in the game space.
摘要翻译：用于模拟高尔夫游戏的视频游戏系统在电视监视器的显示屏上显示指示高尔夫球场的地形轮廓的三维图像信息和高尔夫球的图像信息。基于指示地形轮廓的图像信息和来自游戏者操作的控制器的命令，高尔夫球在显示屏幕上移动。在显示屏幕上显示包括行矩阵的指南，并且基于指示地形轮廓的图像信息来建立每条线的亮度和长度。在所述显示屏幕上指示地形轮廓的三维图像信息上三维地显示引导件。三维显示的指南允许游戏者以直观的方式直观地识别高尔夫球场的各个区域的高度和距离，并且因此允许游戏者以匹配高尔夫球场的地形特征的方式操作控制器游戏空间。

33. 发明授权

US5336271A Method for increasing the proportion of a crystalline organic compound which remains uncrystallized in a composite particulate product and suppressing recrystallization 失效
标题翻译：增加在复合颗粒产品中保持未结晶的结晶有机化合物的比例并抑制再结晶的方法
公开(公告)号：US5336271A
公开(公告)日：1994-08-09
申请号：US854840
申请日：1992-03-20
申请人： Takafumi Ishizaka , Yuji Kikuchi , Masumi Koishi
发明人： Takafumi Ishizaka , Yuji Kikuchi , Masumi Koishi
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50 , B01J2/00 , B01J2/10 , B01J8/00
CPC分类号： B01J2/003 , A61K9/1676 , A61K9/146
摘要： A method for increasing the proportion of a crystalline organic compound which remains amorphous and suppressing recrystallization in which a crystalline organic compound and a hydrophilic polymer substance are fixed onto a surface of core particles by means of impacts applied in a high velocity gas stream. The solubility and stability of the resulting composite product, such as a drug for internal use, can be improved.
摘要翻译：通过施加在高速气流中的冲击，增加结晶有机化合物和亲水性聚合物物质固定在芯颗粒表面上的结晶有机化合物的比例保持无定形并抑制再结晶的方法。可以提高所得复合制品如内用药物的溶解度和稳定性。

34. 发明授权

US4946826A Thermal transfer sheet comprising an improved ink layer 失效
标题翻译：包含改进的油墨层的热转印片
公开(公告)号：US4946826A
公开(公告)日：1990-08-07
申请号：US381348
申请日：1989-07-18
申请人： Naoyuki Kubo , Kiyoshi Senzaki , Yuji Kikuchi , Tsutomu Yashiro
发明人： Naoyuki Kubo , Kiyoshi Senzaki , Yuji Kikuchi , Tsutomu Yashiro
IPC分类号： B41M5/035 , B41M5/26 , B41M5/395
CPC分类号： B41M5/395 , Y10S428/913 , Y10S428/914 , Y10T428/31507 , Y10T428/31855
摘要： A thermal transfer sheet is provided which comprises a support and an ink layer formed on one side of the support. The ink layer is made of a composition of a sublimable dye and a resin binder comprised of not less than 15 parts by weight of an epoxy resin and not less than 30 parts by weight of a butyral resin. The resin binder is effective in suppressing soiling on a sheet to be transferred as will be caused by the dye additionally deposited on the background of the thermal transfer sheet during the thermal printing procedure.
摘要翻译：提供了一种热转印片，其包括支撑体和形成在支撑体的一侧上的墨层。油墨层由可升华的染料和树脂粘合剂的组合物制成，该粘合剂由不小于15重量份的环氧树脂和不小于30重量份的丁缩醛树脂组成。树脂粘合剂有效地抑制在热敏打印过程中由在热转印片背景上附加沉积的染料引起的被转印片材上的污染。

35. 发明授权

US07432110B2 Microchannel array 有权
标题翻译：微通道阵列
公开(公告)号：US07432110B2
公开(公告)日：2008-10-07
申请号：US11659952
申请日：2005-08-04
申请人： Yuji Kikuchi , Mitsutoshi Nakajima , Taiji Nishi , Motohiro Fukuda
发明人： Yuji Kikuchi , Mitsutoshi Nakajima , Taiji Nishi , Motohiro Fukuda
IPC分类号： G01N1/18
CPC分类号： B01L3/502761 , B01F3/0807 , B01F5/0453 , B01F5/0456 , B01F13/0059 , B01L3/502707 , B01L2200/0668 , B01L2300/0816 , C12M23/16 , Y10T436/25375
摘要： A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.
摘要翻译：根据本发明的微通道阵列包括第一基板1和结合到第一基板1的第二基板11。两组，即一组第一通孔9，第一凹槽7和第一凹槽8以及一组第二通孔4，第二凹槽2和第二凹槽3形成在第一基板1。不同的集合由分区5分隔。通过使用这种微通道阵列可以增加微注射后的细胞分化/增殖速度。

36. 发明授权

US07259008B2 Microsample treatment apparatus 失效
标题翻译：微型样品处理装置
公开(公告)号：US07259008B2
公开(公告)日：2007-08-21
申请号：US10181707
申请日：2001-12-06
申请人： Shiro Kanegasaki , Yuji Kikuchi
发明人： Shiro Kanegasaki , Yuji Kikuchi
IPC分类号： C12M1/34
CPC分类号： B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2400/086 , G01N15/1456 , G01N2015/1486
摘要： A microsample treatment apparatus and an apparatus for detecting chemotaxis of cells and separating chemotactic cells includes a number of wells that are connected to each other via a part having resistance to fluids. The wells are each provided with tubes for injecting/sucking a sample and, if necessary, tubes for relieving pressure changes at the injection/suction. The tubes have a space in common at the top ends thereof in which a liquid can be held.
摘要翻译：用于检测细胞的趋化性和分离趋化细胞的微量样品处理装置和装置包括通过具有耐流体性的部分彼此连接的多个孔。每个井都设有用于注入/吸取样品的管子，如果需要的话，管子用于在注入/抽吸时减轻压力变化。管在其顶端具有共同的空间，其中可以保持液体。

37. 发明授权

US06761389B2 Automobile heel stopper shock-absorbing structure 失效
标题翻译：汽车脚跟挡板减震结构
公开(公告)号：US06761389B2
公开(公告)日：2004-07-13
申请号：US10411683
申请日：2003-04-11
申请人： Kosuke Akasaka , Shinji Kumagai , Keiichi Honda , Yuji Kikuchi
发明人： Kosuke Akasaka , Shinji Kumagai , Keiichi Honda , Yuji Kikuchi
IPC分类号： B60N306
CPC分类号： B60N3/066
摘要： An automobile heel stopper shock-absorbing structure is formed from a receiving plate that on the outside has a heel receiving surface and on the inside faces a dash panel with a space therebetween, a front support plate connected integrally to a front end part of the receiving plate and having its extremity joined to the dash panel, and a rear support plate connected integrally to a rear end part of the receiving plate and having its extremity joined to at least one of the dash panel and a floor panel. The rear support plate is made weaker than the receiving plate and the front support plate so that the rear support plate will buckle when a pushing-in load acting on the receiving plate is equal to or greater than a predetermined value. The values of flexural rigidity of the front support plate and the receiving plate are set so that the front support plate falls forward so as to make the receiving plate sink forward when the pushing-in load acting on the receiving plate is equal to or greater than a predetermined value.
摘要翻译：汽车后跟挡板缓冲结构由接收板形成，所述接收板在外侧具有跟部接收表面，并且在内侧面上具有间隙的仪表板，前支撑板一体地连接到接收器的前端部分并且其末端连接到仪表板，以及后支撑板，其一体地连接到接收板的后端部并且其末端连接到仪表板和地板面板中的至少一个。后支撑板比接收板和前支撑板更弱，使得当作用在接收板上的推入载荷等于或大于预定值时，后支撑板将弯曲。设置前支撑板和接收板的弯曲刚度值，使得前支撑板向前倾斜，以便当作用在接收板上的推入载荷等于或大于预定值。

38. 发明授权

US06451608B1 Method for measuring amount of active oxygen produced by leukocytes and oxidative stress 失效
标题翻译：用于测量由白细胞产生的活性氧的量和氧化应激的方法
公开(公告)号：US06451608B1
公开(公告)日：2002-09-17
申请号：US09490450
申请日：2000-01-24
申请人： Yuji Kikuchi
发明人： Yuji Kikuchi
IPC分类号： G01N3348
CPC分类号： G01N33/84 , G01N33/5047
摘要： A method for measuring luminol enhancing light emission without separating leukocytes and erythrocytes, that is, using whole blood and a method for measuring the number of leukocytes trapped by the capillary bed or the time required for leukocytes to pass through the capillary bed to thereby provide an effective index for ability of leukocytes to protect infection and for oxidative stress caused by leukocytes are provided. Specifically, a method is provided for measuring an amount of active oxygen produced by leukocytes and oxidative stress, where the method includes allowing an anticoagulated whole blood sample collected from a human or an animal to pass through a microchannel array including a substrate with a fine channel array arranged on its surface and a transparent substrate which is adhered onto the substrate by contact bonding, and measuring a light emission level from whole leukocytes passing through the microchannel array through the transparent substrate to use the measured light emission level as an index of an amount of active oxygen produced by leukocytes and oxidative stress.
摘要翻译：一种在不分离白细胞和红细胞的情况下，即使用全血测定鲁米诺增强发光的方法，以及测定毛细血管床捕获的白细胞数或白细胞通过毛细血管床所需时间的方法，提供白细胞保护感染和由白细胞引起的氧化应激的能力的有效指标。具体地说，提供了一种测定由白细胞产生的活性氧的量和氧化应激的方法，其中该方法包括允许从人或动物收集的抗凝血全血样品通过包含具有精细通道的底物的微通道阵列排列在其表面上的阵列和通过接触粘合粘附到基底上的透明基底，并且通过透明基底测量通过微通道阵列的全部白细胞的发光水平，以使用测量的发光水平作为量的指标的白细胞产生的活性氧和氧化应激。

39. 发明授权

US06258858B1 Cross-flow microchannel apparatus and method of producing or separating emulsions making use thereof 失效
标题翻译：交叉流动微通道装置及其制造或分离乳液的方法
公开(公告)号：US06258858B1
公开(公告)日：2001-07-10
申请号：US09260416
申请日：1999-03-01
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Takahiro Kawakatsu , Hideaki Komori , Toshikuni Yonemoto
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Takahiro Kawakatsu , Hideaki Komori , Toshikuni Yonemoto
IPC分类号： B01D1704
CPC分类号： B01F5/0401 , B01D17/041 , B01D17/044 , B01D17/10 , B01D61/18 , B01F3/0807 , B01F3/0865 , B01F5/0206 , B01F5/0475 , B01F13/0059 , B01F2003/0834 , B01F2005/0011 , Y10S366/03 , Y10S516/924 , Y10T137/0329 , Y10T137/87652
摘要： Cross-flow microchannel apparatus for producing emulsions includes a pump 9 and a pump 11 which are driven to respectively supply a continuous phase to a concave portion 4 via a supply pipe 10, a supply hole 6 and a supply port 18 and a dispersed phase to a space between the outside of a base 3 and the inside of a concave portion 2 formed in a case 1 via a supply pipe 12 and a supply hole 7. Then, by applying a predetermined pressure to the dispersed phase, the dispersed phase is formed into fine particles via a microchannels 21 and mixed with the continuous phase, thereby forming emulsions. The emulsions are withdrawn to a tank and so on via a withdrawal port 19, a withdrawal hole 8, and a withdrawal pipe 13 for emulsions. The apparatus can alternatively be used to separate an emulsion by pumping the emulsion within the concave portion 4 via pipe 10, hole 6 and port 18, such that the emulsion is separated via the microchannels 21 into a continuous phase that is withdrawn from the hole 7, and a dispersed phase that is withdrawn from the hole 8.
摘要翻译：用于制造乳液的横流微通道装置包括泵9和泵11，其被驱动以经由供给管10，供应孔6和供给口18以及分散相分别向凹部4提供连续相，经由供给管12和供给孔7形成在基体3的外部和形成在壳体1中的凹部2的内部之间的空间。然后，通过对分散相施加规定的压力，形成分散相通过微通道21成为细颗粒并与连续相混合，从而形成乳液。乳液经由抽出口19，抽出孔8和用于乳液的抽出管13而被抽出到罐等中。该装置可以替代地用于通过管道10，孔6和端口18在凹部4内泵送乳液来分离乳液，使得乳液通过微通道21分离成从孔7中取出的连续相，以及从孔8中取出的分散相。

40. 发明授权

US6155710A Method and device for producing emulsions 失效
标题翻译：生产乳液的方法和装置
公开(公告)号：US6155710A
公开(公告)日：2000-12-05
申请号：US125403
申请日：1998-08-18
申请人： Mitsutoshi Nakajima , Yuji Kikuchi , Takahiro Kawakatsu
发明人： Mitsutoshi Nakajima , Yuji Kikuchi , Takahiro Kawakatsu
IPC分类号： B01F3/08 , B01F5/00 , B01F5/02 , B01F5/04 , B01F5/06 , B01F13/00 , B01J13/00 , B01F15/02
CPC分类号： B01J13/00 , B01F13/0059 , B01F3/08 , B01F3/0807 , B01F3/0865 , B01F5/0206 , B01F5/0401 , B01F5/0475 , B01F2003/0834 , B01F2005/0011
摘要： A dispersed phase (O) supplied inside a bulkhead member (17) through a supply port (14) enters a gap (20) between a plate (16) and a base (18) through a supply port (19) of the base (18) and the dispersed phase (O) having entered the gap (20) then enters a continuous phase (W) through a boundary section (21) by virtue of pressure applied by a pressurizing means such as a pump. Then, the dispersed phase is made into a particle having a predetermined diameter by a microchannel (24) in passing through this boundary section (21), thereby forming an emulsion (E) in which the dispersed phase (O) of the predetermined diameter is dispersed in the continuous phase (W).
摘要翻译： PCT No.PCT / JP96 / 03492 Sec。 371日期1998年8月18日 102（e）1998年8月18日PCT PCT 1996年11月28日PCT公布。公开号WO97 / 30783 日期1997年8月28日通过供给口（14）在隔板部件（17）内供给的分散相（O）通过供给口（19）进入板（16）和基部（18）之间的间隙（20））和已经进入间隙（20）的分散相（O）之后，通过借助诸如泵等加压装置施加的压力，通过边界部分（21）进入连续相（W）。然后，分散相通过微通道（24）通过该边界部分（21）制成具有预定直径的颗粒，从而形成乳液（E），其中预定直径的分散相（O）为分散在连续相（W）中。

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