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31. 发明授权

US07626030B2 Compounds and methods of use 有权
标题翻译：化合物和使用方法
公开(公告)号：US07626030B2
公开(公告)日：2009-12-01
申请号：US11042398
申请日：2005-01-24
申请人： Tae-Seong Kim , Jean-Christophe Harmange , David Bauer , Shon Booker , Yuan Cheng , Shimin Xu , Ning Xi , Joseph L. Kim , Andrew Tasker
发明人： Tae-Seong Kim , Jean-Christophe Harmange , David Bauer , Shon Booker , Yuan Cheng , Shimin Xu , Ning Xi , Joseph L. Kim , Andrew Tasker
IPC分类号： C07D215/38
CPC分类号： C07D495/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

32. 发明申请

US20090176774A1 Compounds and methods of use 有权
公开(公告)号：US20090176774A1
公开(公告)日：2009-07-09
申请号：US12157303
申请日：2008-06-09
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号： A61K31/536 , A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

33. 发明申请

US20080114875A1 METHODS AND APPARATUS FOR REAL USER MONITORING 有权
标题翻译：用于真实用户监控的方法和设备
公开(公告)号：US20080114875A1
公开(公告)日：2008-05-15
申请号：US11877804
申请日：2007-10-24
申请人： Paul Anastas , William Ryan Breen , Yuan Cheng , Allen Lieberman , Imad Mouline
发明人： Paul Anastas , William Ryan Breen , Yuan Cheng , Allen Lieberman , Imad Mouline
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： G06F17/30896 , G06Q30/02
摘要： A system monitors browser operation on a web page to identify objects referenced by the web page. For objects referenced by the web page, the system tracks a performance metric associated with each object. The system performs post-processing on the performance metrics of objects referenced by the web page to create a performance record for that web page, and transfers the performance record to a remote server for analysis of performance of web page operation in the browser.
摘要翻译：系统监视网页上的浏览器操作，以识别网页引用的对象。对于网页引用的对象，系统会跟踪与每个对象相关联的性能指标。系统对网页引用的对象的性能指标执行后处理，以创建该网页的性能记录，并将性能记录传输到远程服务器，以分析浏览器中网页操作的性能。

34. 发明申请

US20070295768A1 MULTIFUNCTION POURING SPOUT WITH PIVOTING HANDLE 有权
标题翻译：多功能甩卖手柄
公开(公告)号：US20070295768A1
公开(公告)日：2007-12-27
申请号：US11778168
申请日：2007-07-16
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： A47G19/14 , B65D5/72 , B65D25/40 , B65D25/00
CPC分类号： B44D3/127 , B44D3/128 , B44D3/14 , B65D25/2829 , B65D25/48
摘要： An inventive pouring spout that is selectively attachable to a container and fitted to the opening of the container with which it is used. In a preferred embodiment, the pouring spout is fitted to the dimensions of a one-quart container and includes a wall, a sealing member, a mouth and a handle. The handle is connected to the wall with a hinge that enables the handle to pivot away from the container to allow the sealing member to be appropriately positioned while the container rests flat on a surface. After the sealing member is in place, the handle is then pivoted back in position to securely hold the container. The handle includes a plurality of upwardly extending projections adapted to securely engage the bottom rim of the container. Furthermore, thermoplastic material is applied at the handle area forming a handle cover that is comfortable and easy to grip. Thermoplastic material is also preferably utilized in the construction of the sealing member for forming a seal between the spout and opening of the container.
摘要翻译：一种创造性的倾倒口，其可选择性地附接到容器并且装配到与其一起使用的容器的开口上。在一个优选实施例中，倾倒嘴适应于一夸脱容器的尺寸，并且包括壁，密封构件，口和手柄。手柄通过铰链连接到壁上，该铰链能够使手柄远离容器枢转，以允许密封构件在容器平放在表面上时被适当地定位。在密封构件就位之后，把手然后枢转回到适当位置以牢固地固定容器。手柄包括多个向上延伸的凸起，其适于牢固地接合容器的底部边缘。此外，热塑性材料被施加在手柄区域，形成舒适且易于抓握的手柄盖。热塑性材料也优选用于密封构件的构造，用于在容器的喷口和开口之间形成密封。

35. 发明申请

US20070009081A1 Computed tomography system for imaging of human and small animal 审中-公开
标题翻译：用于人和小动物成像的计算机断层扫描系统
公开(公告)号：US20070009081A1
公开(公告)日：2007-01-11
申请号：US11441281
申请日：2006-05-25
申请人： Otto Zhou , Jianping Lu , Yueh Lee , Weili Lin , Yuan Cheng , Jian Zhang
发明人： Otto Zhou , Jianping Lu , Yueh Lee , Weili Lin , Yuan Cheng , Jian Zhang
IPC分类号： A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
CPC分类号： B82Y10/00 , A61B6/032 , A61B6/4028 , A61B6/508 , A61B6/541 , G01N23/046 , G01N2223/316 , G01N2223/419 , G01N2223/612 , H01J35/065 , H01J2201/30469 , H01J2235/068
摘要： Computed tomography device comprising an x-ray source and an x-ray detecting unit. The x-ray source comprises a cathode with a plurality of individually programmable electron emitting units that each emit an electron upon an application of an electric field, an anode target that emits an x-ray upon impact by the emitted electron, and a collimator. Each electron emitting unit includes an electron field emitting material. The electron field emitting material includes a nanostructured material or a plurality of nanotubes or a plurality of nanowires. Computed tomography methods are also provided.
摘要翻译：计算机断层摄影装置，包括x射线源和x射线检测单元。 x射线源包括具有多个单独可编程的电子发射单元的阴极，每个单独可编程的电子发射单元在施加电场时发射电子，在被所发射的电子撞击时发射x射线的阳极靶和准直器。每个电子发射单元包括电子场发射材料。电子场发射材料包括纳米结构材料或多个纳米管或多个纳米线。还提供了计算机断层扫描方法。

36. 发明申请

US20060274889A1 Method and apparatus for controlling electron beam current 审中-公开
标题翻译：用于控制电子束电流的方法和装置
公开(公告)号：US20060274889A1
公开(公告)日：2006-12-07
申请号：US11415953
申请日：2006-05-02
申请人： Jianping Lu , Otto Zhou , Yuan Cheng
发明人： Jianping Lu , Otto Zhou , Yuan Cheng
IPC分类号： H01J35/00
CPC分类号： H01J35/06 , A61B6/032 , A61B6/4021 , A61B6/4028 , A61B6/405 , A61B6/4488 , A61B6/482 , B82Y10/00 , H01J3/021 , H01J35/065 , H01J35/08 , H01J35/105 , H01J35/14 , H01J35/22 , H01J35/28 , H01J35/30 , H01J2201/30469 , H01J2235/06 , H01J2235/062 , H01J2235/064 , H01J2235/068 , H05G1/34
摘要： An x-ray generating device includes a field emission cathode formed at least partially from a nanostructure-containing material having an emitted electron current density of at least 4 A/cm2. High energy conversion efficiency and compact design are achieved due to easy focusing of cold cathode emitted electrons and dramatic reduction of heating at the anode. In addition, by pulsing the field between the cathode and the gate or anode and focusing the electron beams at different anode materials, pulsed x-ray radiation with varying energy can be generated from a single device. Methods and apparatus for independent control of electron emission current and x-ray energy in x-ray tubes are also provided. The independent control can be accomplished by adjusting the distance between the cathode and anode. The independent control can also be accomplished by adjusting the temperature of the cathode. The independent control can also be accomplished by optical excitation of the cathode. The cathode can include field emissive materials such as carbon nanotubes.
摘要翻译： X射线产生装置包括至少部分地由具有至少4A / cm 2的发射电子电流密度的含纳米结构的材料形成的场致发射阴极。由于容易聚焦冷阴极发射电子并显着降低阳极的加热，因此实现了高能量转换效率和紧凑设计。此外，通过在阴极和栅极或阳极之间脉冲电场并将电子束聚焦在不同的阳极材料处，可以从单个器件产生具有变化能量的脉冲X射线辐射。还提供了用于独立控制X射线管中的电子发射电流和X射线能量的方法和装置。独立控制可以通过调节阴极和阳极之间的距离来实现。独立控制也可以通过调节阴极的温度来实现。独立控制也可以通过阴极的光学激发来实现。阴极可以包括诸如碳纳米管的场发射材料。

37. 发明申请

US20050245547A1 Compounds and methods of use 有权
标题翻译：化合物和使用方法
公开(公告)号：US20050245547A1
公开(公告)日：2005-11-03
申请号：US11042398
申请日：2005-01-24
申请人： Tae-Seong Kim , Jean-Christophe Harmange , David Bauer , Shon Booker , Yuan Cheng , Shimin Xu , Ning Xi , Joseph Kim , Andrew Tasker
发明人： Tae-Seong Kim , Jean-Christophe Harmange , David Bauer , Shon Booker , Yuan Cheng , Shimin Xu , Ning Xi , Joseph Kim , Andrew Tasker
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/517 , A61K31/519 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/02 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/02 , C07D495/04
CPC分类号： C07D495/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

38. 发明申请

US20050226361A1 Computed tomography scanning system and method using a field emission x-ray source 有权
标题翻译：计算机断层扫描系统和使用场发射X射线源的方法
公开(公告)号：US20050226361A1
公开(公告)日：2005-10-13
申请号：US11051332
申请日：2005-02-07
申请人： Otto Zhou , Yuan Cheng , Jian Zhang , Yueh Lee , Jianping Lu , Weili Lin
发明人： Otto Zhou , Yuan Cheng , Jian Zhang , Yueh Lee , Jianping Lu , Weili Lin
IPC分类号： A61B6/00 , A61B6/03 , A61B6/14 , G01N23/00 , G01N23/04 , G21K1/12 , H01J35/06 , H01J35/14 , H05G1/60
CPC分类号： A61B6/032 , A61B6/4028 , A61B6/4488 , A61B6/508 , A61B6/541 , B82Y10/00 , G01N23/046 , G01N2223/419 , G01N2223/612 , H01J35/065 , H01J35/14
摘要： Computed tomography scanning systems and methods using a field emission x-ray source are disclosed. An exemplary micro-computed tomography scanner comprises a micro-focus field emission x-ray source, an x-ray detector, an object stage placed between the x-ray source and the detector, an electronic control system and a computer that control the x-ray radiation and detector data collection, and computer software that reconstructs the three dimension image of the object using a series of projection images collected from different projection angles. Exemplary methods obtain a computed tomography image of an object in oscillatory motion using the micro computed tomography scanner.
摘要翻译：公开了使用场致发射X射线源的计算机断层摄影扫描系统和方法。示例性的微型计算机断层扫描仪包括微焦点场发射x射线源，x射线检测器，放置在x射线源和检测器之间的物体台，控制x射线源的电子控制系统和计算机射线辐射和检测器数据采集，以及使用从不同投影角度收集的一系列投影图像重建对象的三维图像的计算机软件。示例性方法使用微型计算机断层摄影扫描仪获得振荡运动中物体的计算机断层摄影图像。

39. 发明授权

US09296698B2 Amino heteroaryl compounds as beta-secretase modulators and methods of use 有权
标题翻译：氨基杂芳基化合物作为β-分泌酶调节剂和使用方法
公开(公告)号：US09296698B2
公开(公告)日：2016-03-29
申请号：US13511359
申请日：2010-11-19
申请人： Yuan Cheng , Timothy Powers , Kate Ashton , James Brown , Scott Harried , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Thomas Nixey , Nick A. Paras , Steve F. Poon , David J. St. Jean, Jr. , Qiufen Xue , Wenge Zhong
发明人： Yuan Cheng , Timothy Powers , Kate Ashton , James Brown , Scott Harried , Stephen A. Hitchcock , Ted Judd , Patricia Lopez , Thomas Nixey , Nick A. Paras , Steve F. Poon , David J. St. Jean, Jr. , Qiufen Xue , Wenge Zhong
IPC分类号： C07D215/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/12 , C07D417/04
CPC分类号： C07D215/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/12 , C07D417/04
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B1, B2, B3, L, R1, R4, R5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I，其中式I的环A，B 1，B 2，B 3，L，R 1，R 4，R 5和m如本文所定义。本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

40. 发明授权

US08921363B2 Derivatives of 1 H-isoindol-3-amine, 1 H-iso-aza-indol-3amine, 3,4-dihydroisoquinolin-1-amine, and 1,4-dihydroisoquinolin-3-amine as beta-secretase inhibitors 有权
标题翻译： 1H-异吲哚-3-胺，1H-异氮杂 - 吲哚-3-胺，3,4-二氢异喹啉-1-胺和1,4-二氢异喹啉-3-胺的衍生物作为β-分泌酶抑制剂
公开(公告)号：US08921363B2
公开(公告)日：2014-12-30
申请号：US13814232
申请日：2011-08-04
申请人： Ana Elena Minatti , Yuan Cheng , Wenge Zhong
发明人： Ana Elena Minatti , Yuan Cheng , Wenge Zhong
IPC分类号： C07D491/20 , A61K31/436 , A61K31/437 , A61K31/537 , C07D491/22 , C07D498/20 , C07D498/22
CPC分类号： C07D491/20 , A61K31/436 , A61K31/437 , A61K31/537 , C07D491/22 , C07D498/20 , C07D498/22
摘要： The present invention relates to a compound represented by general formula I: or a stereoisomer, tautomer, hydrate, solvate or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, A6, R2, R7, W, X, Y and Z are defined within. These compounds are useful for the modulation of β-secretase enzyme activity and for the treatment of β-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions.
摘要翻译：本发明涉及由通式I表示的化合物或其立体异构体，互变异构体，水合物，溶剂化物或药学上可接受的盐，其中A1，A2，A3，A4，A5，A6，R2，R7，W，X，Y 和Z在其中定义。这些化合物可用于调节分泌酶活性和用于治疗分泌型介导的疾病，包括阿尔茨海默病（AD）和相关病症。

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