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31. 发明授权

US4565861A Serirubicum 失效
标题翻译：丝。属
公开(公告)号：US4565861A
公开(公告)日：1986-01-21
申请号：US567792
申请日：1984-01-03
申请人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Hiroshi Naganawa , Tsutomu Sawa , Takeshi Uchida , Masaya Imoto
发明人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Hiroshi Naganawa , Tsutomu Sawa , Takeshi Uchida , Masaya Imoto
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465 , C07H15/24
CPC分类号： C07H15/252 , C12P19/56 , C12R1/465
摘要： An anthracycline, serirubicin, of the formula: ##STR1## wherein R represents the substituent: ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, serirubicin, and then recovering the anthracycline compound, serirubicin, from the cultured medium. This serirubicin, or an acid addition salt of the serirubicin, can be contained as the active ingredient in anti-tumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.
摘要翻译：蒽环霉素，维拉霉素，其结构式如下：其中R表示取代基：IMAMA是通过包括在需氧条件下在合适的培养基中培养链霉菌属菌株的方法产生的，所述菌株具有产生蒽环霉素化合物，苏维菌素，然后从培养基中回收蒽环霉素化合物，丝衣霉素。作为抗肿瘤剂和用于治疗由革兰氏阳性微生物诱导的感染的药物组合物，可以含有这种苏维菌素或者苏维菌素的酸加成盐作为活性成分，从而获得了良好的效果。

32. 发明授权

US4242453A Cultivating streptomyces to produce an esterase inhibitor 失效
标题翻译：培养链霉菌产生酯酶抑制剂
公开(公告)号：US4242453A
公开(公告)日：1980-12-30
申请号：US39094
申请日：1979-05-14
申请人： Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人： Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
IPC分类号： A61K31/335 , A61K31/337 , A61K38/55 , A61P37/06 , C07D305/12 , C07G99/00 , C12N9/99 , C12P1/06 , C12P13/00 , C12P17/02 , C12R1/465
CPC分类号： C07D305/12 , C12P17/02 , Y10S435/899
摘要： A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a micro-organism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture. Esterastin is the compound having the formula ##STR1##
摘要翻译：现在提供一种名为酯酶的新的生理活性物质，其抑制酯酶的活性，并且可用作免疫抑制药物。通过培养鉴定为FERM-P 3723或ATCC的微生物链霉菌属MD4-C1产生甾类化合物。 31336在有氧条件下在培养基中，并从所得培养物中回收。甾类化合物是具有式CH 3（CH 2）4 CHCHCH 2 CH + TR 的化合物

33. 发明授权

US4198480A Process for producing antibiotic baumycin complex and components 失效
标题翻译：生产抗生素鲍曼霉素复合物及成分的方法
公开(公告)号：US4198480A
公开(公告)日：1980-04-15
申请号：US886987
申请日：1978-03-15
申请人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
发明人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Hiroshi Naganawa , Toshikazu Oki , Taiji Inui
IPC分类号： C12P1/06 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465
CPC分类号： C12R1/465 , C07H15/252 , C12P19/56 , Y10S435/886
摘要： A novel anthracycline antibiotic complex designated herein as baumycin complex is produced by fermentation of a baumycin-producing strain of Streptomyces, e.g. Streptomyces coeruleorubidus ME 130-A4 (FERM-P3540, ATCC 31276). The complex and four bioactive components thereof designated baumycin A.sub.1, A.sub.2, B.sub.1 and B.sub.2 are useful as antibacterial and antitumor agents.
摘要翻译：本文称为鲍曼霉素复合物的新型蒽环类抗生素复合物是通过发酵生产巴霉素的链霉菌菌株，例如， Streptomyces coeruleorubidus ME 130-A4（FERM-P3540，ATCC 31276）。其中称为baumycin A1，A2，B1和B2的复合物和四种生物活性成分可用作抗细菌剂和抗肿瘤剂。

34. 发明授权

US4189438A Physiologically active substance esterastin 失效
标题翻译：生理活性物质酯酶
公开(公告)号：US4189438A
公开(公告)日：1980-02-19
申请号：US873350
申请日：1978-01-30
申请人： Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
发明人： Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka
IPC分类号： A61K31/335 , A61K31/337 , A61K38/55 , A61P37/06 , C07D305/12 , C07G99/00 , C12N9/99 , C12P1/06 , C12P13/00 , C12P17/02 , C12R1/465
CPC分类号： C07D305/12 , C12P17/02 , Y10S435/899
摘要： A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a microorganism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture. Esterastin is the compound having the formula ##STR1##
摘要翻译：现在提供一种名为酯酶的新的生理活性物质，其抑制酯酶的活性，并且可用作免疫抑制药物。通过培养鉴定为FERM-P 3723或ATCC的微生物Streptomyces MD4-C1产生酯甾烷酮。 31336在有氧条件下在培养基中，并从所得培养物中回收。酯甾体是具有式（IMAGE）的化合物

35. 发明授权

US4179573A (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid 失效
标题翻译：（2S，3R）-3-氨基-2-羟基-4-苯基丁酸
公开(公告)号：US4179573A
公开(公告)日：1979-12-18
申请号：US825997
申请日：1977-08-19
申请人： Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Yoshiro Okami
发明人： Hamao Umezawa , Takaaki Aoyagi , Tomio Takeuchi , Masa Hamada , Yoshiro Okami
IPC分类号： C12P13/04 , C12P21/02 , C07C101/72
CPC分类号： C12P21/02 , C12P13/04
摘要： This invention provides the amino acid (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid which is prepared by hydrolysis of bestatin. Bestatin is a chemical which inhibits aminopeptidase B, leucine aminopeptidase and bleomycin hydrolase, enhances the antitumor effect of bleomycin, has the chemical name [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, has the following structure ##STR1## and is prepared by cultivating a strain of streptomyces which produces bestatin in a nutrient medium under aerobic conditions until substantial activity inhibitory to aminopeptidase B is imparted to said cultured medium and then recovering said bestatin from said cultured medium. A preferred strain is Streptomyces olivoreticuli FERM-P No. 2590 (A.T.C.C. 31159).
摘要翻译：本发明提供通过水解苦参碱制备的氨基酸（2S，3R）-3-氨基-2-羟基-4-苯基丁酸。美白汀是抑制氨肽酶B，亮氨酸氨基肽酶和博来霉素水解酶的化学物质，增强了博莱霉素的抗肿瘤作用，具有化学名称[（2S，3R）-3-氨基-2-羟基-4-苯基丁酰] -L-亮氨酸，具有以下结构，并且通过培养在需氧条件下在营养培养基中产生普拉汀的链霉菌菌株制备，直到对所述培养的培养基赋予对氨基肽酶B的抑制作用，然后从所述培养基中回收所述的bestatin。优选的菌株是橄榄链霉菌FERM-P No.2590（A.T.C.C. 31159）。

36. 发明授权

US3992524A Antitumor antibiotic macracidmycin 失效
标题翻译：抗肿瘤抗生素macracidmycin
公开(公告)号：US3992524A
公开(公告)日：1976-11-16
申请号：US555011
申请日：1975-03-03
申请人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Akira Takamatsu , Toshikazu Oki , Hiroshi Tone
发明人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Masaaki Ishizuka , Akira Takamatsu , Toshikazu Oki , Hiroshi Tone
IPC分类号： C12P21/00 , A61K35/74 , C07G11/00 , C12P1/06
CPC分类号： A61K36/06 , C07G11/00 , Y10S435/886
摘要： A new antitumor agent named macracidmycin, which is a macromolecular peptide and inhibits the growth of various tumor cells and experimental animal tumors such as Ehrlich ascites carcinoma and Sarcoma 180 is produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces atrofaciens (M590-G2 and A.T.C.C. 31104); it is recovered from the broth by conventional methods for recovering antibiotics.
摘要翻译：通过发酵属于链霉菌属（Streptomyces）属的链霉菌属（Streptomyces）属的链霉菌属（Streptomyces）的发酵产生了称为macracidmycin的新型抗肿瘤剂，其是大分子肽，抑制各种肿瘤细胞的生长和实验动物肿瘤如Ehrlich腹水癌和肉瘤180 致病杆菌（M590-G2和ATCC 31104）; 通过用于回收抗生素的常规方法从肉汤中回收。

37. 发明授权

US07271147B2 Antibiotics, tripropeptins and process for producing the same 有权
标题翻译：抗生素，三杀菌素及其制备方法
公开(公告)号：US07271147B2
公开(公告)日：2007-09-18
申请号：US10239324
申请日：2001-03-28
申请人： Tomio Takeuchi , Hideki Hashizume , Masayuki Igarashi , Hiroshi Naganawa , Masa Hamada
发明人： Tomio Takeuchi , Hideki Hashizume , Masayuki Igarashi , Hiroshi Naganawa , Masa Hamada
IPC分类号： A01K31/16 , C12P21/06 , C12N1/20
CPC分类号： C07K7/06 , A61K38/00 , C07K11/02
摘要： By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general formula (I): wherein R is 7-methyl-octyl group, 8-methyl-nonyl group, 9-methyl-dodecyl group, 10-methyl-undecyl group or 11-methyl-dodecyl group, is obtained as antibiotics having excellent antibacterial activities against bacteria and having a novel molecular structure. These tripropeptins each have an excellent antibacterial activity against various bacteria and drug-resistant strains thereof, such as methicillin-resistant strains and vancomycin-resistant strains.
摘要翻译：通过培养溶菌杆菌 BMK333-48F3（FERM BP-7477的保藏号），抗生素，三聚胰蛋白酶Z，三聚肽A，三聚蛋白B，三抗抑素C或由通式（I）表示的三聚蛋白D：其中R为7-甲基 - 辛基，8 甲基 - 壬基，9-甲基 - 十二烷基，10-甲基 - 十一烷基或11-甲基 - 十二烷基作为对细菌具有优异抗菌活性并具有新的分子结构的抗生素。这些三柔比星各自对各种细菌和耐药菌株具有优异的抗菌活性，如耐甲氧西林株和万古霉素抗性菌株。

38. 发明授权

US06780616B1 Antibiotic caprazamycins and process for producing the same 有权
标题翻译：抗生素caprazamycins及其生产方法
公开(公告)号：US06780616B1
公开(公告)日：2004-08-24
申请号：US10049970
申请日：2002-05-09
申请人： Tomio Takeuchi , Masayuki Igarashi , Hiroshi Naganawa , Masa Hamada
发明人： Tomio Takeuchi , Masayuki Igarashi , Hiroshi Naganawa , Masa Hamada
IPC分类号： A61K3170
CPC分类号： C07H19/06 , C12P17/16 , Y10S435/886
摘要： There have been obtained, by cultivation of Streptomyces sp. MK730-62F2 (deposit number of FERM BP-7218), antibiotic caprazamycins A to F having by the following general formula (I) wherein R is tridecyl group, 11-methyl-dodecyl group, and others. These caprazamycins have excellent antibacterial activities against various acid-fast bacteria and various bacteria as well as their drug-resistant strains.
摘要翻译：已经通过培养链霉菌获得了。 MK730-62F2（FERM BP-7218的保藏号），具有以下通式（I）的抗生素caprazamycins A至F，其中R为十三烷基，11-甲基 - 十二烷基等。这些caprazamycins对各种耐酸菌和各种细菌以及耐药菌株具有优异的抗菌活性。

39. 发明授权

US5527820A Antibiotics having immunosuppressive activity, delaminomycins and processes for the production of the same 失效
标题翻译：具有免疫抑制活性的抗生素，去霉菌素及其生产方法
公开(公告)号：US5527820A
公开(公告)日：1996-06-18
申请号：US356267
申请日：1995-01-20
申请人： Masaaki Ishizuka , Mitsuhiro Ueno , Hironobu Iinuma , Hiroshi Naganawa , Masa Hamada , Kenji Maeda , Tomio Takeuchi
发明人： Masaaki Ishizuka , Mitsuhiro Ueno , Hironobu Iinuma , Hiroshi Naganawa , Masa Hamada , Kenji Maeda , Tomio Takeuchi
IPC分类号： C07D207/36 , C07D207/38 , C07D209/96 , C12P17/10 , A61K31/40
CPC分类号： C07D207/38 , C07D207/36 , C07D209/96 , C12P17/10
摘要： As new antibiotics are obtained delaminomycins A, B and C having a formula (I) or (I') shown below, or salts thereof. Delaminomycins preferentially inhibit T cells and are useful as immunosuppressants, antineoplastic agents and antibacterial agents. ##STR1## wherein X is a hydroxyl group for delaminomycin A, a methoxy group for delaminomycin B and a hydrogen atom for delaminomycin C.
摘要翻译： PCT No.PCT / JP93 / 00845 Sec。 371 1995年1月20日第 102（e）日期1995年1月20日PCT提交1993年6月22日PCT公布。公开号WO94 / 00430 日期为1994年6月1日。作为新抗生素，得到具有下式（I）或（I'）的脱氨霉素A，B和C或其盐。脱氨霉素优先抑制T细胞，可用作免疫抑制剂，抗肿瘤剂和抗菌剂。（I）其中X是脱氨基霉素A的羟基，德拉霉素B的甲氧基和脱氨基霉素C的氢原子。

40. 发明授权

US5359138A Poststatin and related compounds or salts thereof 失效
标题翻译：后抑素及其相关化合物或其盐
公开(公告)号：US5359138A
公开(公告)日：1994-10-25
申请号：US905792
申请日：1992-06-29
申请人： Tomio Takeuchi , Takaaki Aoyagi , Masa Hamada , Hiroshi Naganawa , Keiji Ogawa , Machiko Nagai , Yasuhiko Muraoka , Makoto Tsuda
发明人： Tomio Takeuchi , Takaaki Aoyagi , Masa Hamada , Hiroshi Naganawa , Keiji Ogawa , Machiko Nagai , Yasuhiko Muraoka , Makoto Tsuda
IPC分类号： A61K38/00 , C07K5/02 , C07K7/02 , C07C229/00 , A61K37/00 , A61K37/02 , C07K5/00
CPC分类号： C07K5/0202 , C07K7/02 , A61K38/00
摘要： A novel, biologically active substance, poststatin, has been isolated from a culture medium of microorganism belonging to Streptomyces. The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. Thus substance has a high endopeptidase inhibition activity. It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. These compounds also have an endopeptidase inhibition activity.
摘要翻译：已经从属于链霉菌的微生物的培养基中分离出一种新的生物活性物质，后抑制素。该新物质是具有新结构的肽化合物，其中肽链具有酮基。因此，物质具有高内肽酶抑制活性。可以在肽链中化学合成具有酮基的后抑制素相关化合物。这些化合物还具有内肽酶抑制活性。

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