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31. 发明授权

US07511017B2 Methods of treatment with TNFR5 失效
标题翻译： TNFR5治疗方法
公开(公告)号：US07511017B2
公开(公告)日：2009-03-31
申请号：US11182946
申请日：2005-07-18
申请人： Ying-Fei Wei , Jian Ni , Reiner L. Gentz , Steven M. Ruben
发明人： Ying-Fei Wei , Jian Ni , Reiner L. Gentz , Steven M. Ruben
IPC分类号： A61K38/16 , A61K38/00 , C07K14/435 , C07K14/00
CPC分类号： A61K31/522 , A61K31/66 , A61K39/395 , A61K45/06 , A61K48/00 , A61K2039/505 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C12N2799/026 , A61K2300/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

32. 发明授权

US06642006B2 Transforming growth factor alpha hii 有权
标题翻译：转化生长因子αhii
公开(公告)号：US06642006B2
公开(公告)日：2003-11-04
申请号：US09227853
申请日：1999-01-11
申请人： Ying-Fei Wei , Paul S. Meissner , Jian Ni
发明人： Ying-Fei Wei , Paul S. Meissner , Jian Ni
IPC分类号： C07K1700
CPC分类号： A61K38/1841 , A61K48/00 , C07K14/495 , Y10T436/143333
摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating would healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译：本发明公开了转化生长因子αHII多肽和编码这种多肽的多核苷酸。还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括刺激愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病，以及刺激胚胎发生和血管发生。还公开了抗这些多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

33. 发明授权

US06475753B1 94 Human Secreted Proteins 有权
标题翻译： 94人类分泌蛋白
公开(公告)号：US06475753B1
公开(公告)日：2002-11-05
申请号：US09461325
申请日：1999-12-14
申请人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. Lafleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
发明人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. Lafleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
IPC分类号： C12P2102
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

34. 发明授权

US06344547B1 Human MutT2 失效
标题翻译：人类MutT2
公开(公告)号：US06344547B1
公开(公告)日：2002-02-05
申请号：US09432253
申请日：1999-11-02
申请人： Ying-Fei Wei , Ewen F. Kirkness
发明人： Ying-Fei Wei , Ewen F. Kirkness
IPC分类号： C07H1900
CPC分类号： C12N9/16 , A61K38/00 , Y10S530/809
摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.
摘要翻译：公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。

35. 发明授权

US06255077B1 Human DNA topoisomerase I &agr; 有权
标题翻译：人类DNA拓扑异构酶Iα
公开(公告)号：US06255077B1
公开(公告)日：2001-07-03
申请号：US09325430
申请日：1999-06-04
申请人： Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann
发明人： Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann
IPC分类号： C12N1563
CPC分类号： C12N9/90 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Y599/01002
摘要： Disclosed is a human is a hTopI-&agr; polypeptide and DNA (RNA) encoding such hTopI-&agr; polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-&agr; for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的如抗肿瘤剂的作用以检测自身免疫性疾病或逆转录病毒感染并治疗结肠腺癌的方法。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

36. 发明申请

US20060234342A1 Human DNA topoisomerase I alpha 审中-公开
公开(公告)号：US20060234342A1
公开(公告)日：2006-10-19
申请号：US10602043
申请日：2003-06-24
申请人： Ying-Fei Wei , Mark Adams , Robert Fleischmann
发明人： Ying-Fei Wei , Mark Adams , Robert Fleischmann
IPC分类号： C07K16/18 , C07H21/04 , C12P21/06 , C12P21/04 , C12N5/06
CPC分类号： C12N9/90 , A61K38/00
摘要： Disclosed is a human is a hTopI-α polypeptide and DNA (RNA) encoding such hTopI-α polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-α for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

37. 发明申请

US20060099622A1 12 human secreted proteins 有权
公开(公告)号：US20060099622A1
公开(公告)日：2006-05-11
申请号：US11246999
申请日：2005-10-11
申请人： Jian Ni , Paul Young , Joseph Kenny , Henrik Olsen , Paul Moore , Ying-Fei Wei , John Greene , Steven Ruben , Ding Liu , Paul Crocker
发明人： Jian Ni , Paul Young , Joseph Kenny , Henrik Olsen , Paul Moore , Ying-Fei Wei , John Greene , Steven Ruben , Ding Liu , Paul Crocker
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/00 , C07K14/47
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

38. 发明授权

US06979443B2 Chemokine α-6 失效
标题翻译：趋化因子α-6
公开(公告)号：US06979443B2
公开(公告)日：2005-12-27
申请号：US10086882
申请日：2002-03-04
申请人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
发明人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/52 , C07K16/24 , C12N5/06 , C12N15/12 , C12N15/19 , G01N33/53 , G01N33/537 , G01N33/543 , A61K38/19 , C12N5/10 , C12N15/63
CPC分类号： C07K16/24 , A61K38/00 , C07K14/522
摘要： The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6 protein. CKα-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CKα-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
摘要翻译：本发明涉及作为α趋化因子家族成员的新型CKalpha-6蛋白。特别地，提供编码人CKalpha-6蛋白的分离的核酸分子。还提供了CKalpha-6多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法。还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和免疫系统相关疾病的治疗方法。

39. 发明授权

US06627741B2 Antibodies to secreted protein HCEJQ69 有权
标题翻译：分泌蛋白HCEJQ69的抗体
公开(公告)号：US06627741B2
公开(公告)日：2003-09-30
申请号：US10012542
申请日：2001-12-12
申请人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. LaFleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
发明人： Steven M. Ruben , Jian Ni , Craig A. Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel R. Soppet , Laurie A. Brewer , Gregory A. Endress , Kenneth C. Carter , Michael Mucenski , Reinhard Ebner , David W. LaFleur , Henrik Olsen , Yanggu Shi , Paul A. Moore , George Komatsoulis
IPC分类号： C07K1624
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/47 , G01N2500/20
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

40. 发明授权

US06610477B1 Human DNA mismatch repair proteins 失效
标题翻译：人类DNA错配修复蛋白
公开(公告)号：US06610477B1
公开(公告)日：2003-08-26
申请号：US08465679
申请日：1995-06-06
申请人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
发明人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen , Bert Vogelstein , Kenneth W. Kinzler , Nicholas C. Nicolaides , Nickolas Papadopoulos
IPC分类号： C12Q168
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译：本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA），以及通过重组技术生产此类蛋白质的方法。人类DNA修复蛋白hMLH1已被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗遗传易感性癌症。

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