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31. 发明申请

US20120205535A1 METHOD FOR DETECTING MOLECULES THROUGH MASS SPECTROMETRY 有权
标题翻译：通过质谱分析检测分子的方法
公开(公告)号：US20120205535A1
公开(公告)日：2012-08-16
申请号：US13496949
申请日：2010-09-15
申请人： Jéröme Lemoine , Arnaud Salvador , Jean-Philippe Charrier , Tanguy Fortin , Philippe Dugourd
发明人： Jéröme Lemoine , Arnaud Salvador , Jean-Philippe Charrier , Tanguy Fortin , Philippe Dugourd
IPC分类号： H01J49/26
CPC分类号： G01N33/6848 , H01J49/0031 , H01J49/42 , H01J49/427
摘要： A method for detecting at least one target molecule in a sample by mass spectrometry, comprising ionizing the molecules of the sample and then conducting the following steps (i) and (ii) n times, n being equal to 0, 1, 2, 3 or 4: (i) at least one ion obtained in the preceding step is selected, according to the target molecule, in a mass analyser, and (ii) the ion thus selected is fragmented in a fragmentation cell; trapping at least two different sampled ions, when n is zero, or when n is other than zero, in a mass analyser, the at least two ions thus trapped having a mass-to-charge ratio m/z characteristic of the target molecule; ejecting the trapped ions from the mass analyser; and detecting the ejected ions ejected by means of a detection device. The method is characterized in that the characteristic ions are ejected simultaneously and detected simultaneously.
摘要翻译：一种用于通过质谱法检测样品中的至少一种靶分子的方法，包括使样品的分子电离，然后进行以下步骤（i）和（ii）n次，n等于0,1,2,3 或4：（i）根据靶分子在质量分析器中选择前述步骤中获得的至少一种离子，和（ii）所选择的离子在碎裂单元中碎裂; 捕获至少两种不同的采样离子，当n为零时，或当n不为零时，在质量分析器中，至少两个离子因此被捕获，其具有靶分子的质荷比m / z特性; 从质量分析器中排出被捕获的离子; 并且检测通过检测装置喷射的喷射离子。该方法的特征在于同时喷射特征离子并同时检测。

32. 发明授权

US07517653B2 Immunological test and diagnostic kit for prostate adenocarcinoma 有权
标题翻译：前列腺腺癌免疫测试和诊断试剂盒
公开(公告)号：US07517653B2
公开(公告)日：2009-04-14
申请号：US10311014
申请日：2001-06-12
申请人： Jean-Philippe Charrier
发明人： Jean-Philippe Charrier
IPC分类号： G01N33/53
CPC分类号： G01N33/57434
摘要： This invention concerns a test method for the purposes of diagnosis, prognosis or therapeutic monitoring in male patients with adenocarcinoma of the prostate or benign prostatic hyperplasia, which does not require a biopsy of prostate tissue, and which exploits the combination of at least one tissue-specific marker and at least one marker for inflammation in order to arrive at a diagnosis.The invention also concerns a process using such a method, an immunological test to implement such a process, and a diagnostic kit.The invention is applied to the diagnosis of adenocarcinoma of the prostate and benign prostatic hyperplasia.
摘要翻译：本发明涉及一种用于诊断，预后或治疗性监测的男性患者的前列腺或良性前列腺增生的测试方法，其不需要前列腺组织的活组织检查，并且利用至少一种组织 - 特异性标记物和至少一种用于炎症的标志物以便达到诊断。本发明还涉及使用这种方法的方法，实施这种方法的免疫学测试和诊断试剂盒。本发明适用于前列腺腺癌和良性前列腺增生的诊断。

33. 发明申请

US20070020710A1 Antibodies that spefically recognize inactive PSA, and uses thereof 审中-公开
标题翻译：识别无活性PSA的抗体及其用途
公开(公告)号：US20070020710A1
公开(公告)日：2007-01-25
申请号：US11525990
申请日：2006-09-25
申请人： Jean-Philippe Charrier , Colette Jolivet-Reynaud , Sandrine Michel
发明人： Jean-Philippe Charrier , Colette Jolivet-Reynaud , Sandrine Michel
IPC分类号： G01N33/574
CPC分类号： C07K16/3069 , G01N33/57434
摘要： An immunoassay for the quantitative determination of inactive, non-zymogen, free PSA in a biological sample taken from an individual, including contacting the biological sample with a reagent, where the reagent comprises an antibody or antibody fragments that bind specifically to inactive, non-zymogen, free PSA, the antibody being a purified polyclonal antibody or a monoclonal antibody, and evaluating the amount of inactive, non-zymogen, free PSA bound to the antibodies or antibody fragments.
摘要翻译：用于定量测定取自个体的生物样品中的无活性非酶原游离PSA的免疫测定法，包括使生物样品与试剂接触，其中试剂包含特异性结合于非活性的非 - 酶原，游离PSA，抗体是纯化的多克隆抗体或单克隆抗体，并评估与抗体或抗体片段结合的无活性，非酶原游离PSA的量。

34. 发明授权

US06929918B1 Method for diagnosing an adenocarcinoma or a benign prostate pathology 失效
标题翻译：诊断腺癌或良性前列腺病理学的方法
公开(公告)号：US06929918B1
公开(公告)日：2005-08-16
申请号：US09720717
申请日：1999-07-05
申请人： Jean-Philippe Charrier , Carole Tournel , Michel Jolivet
发明人： Jean-Philippe Charrier , Carole Tournel , Michel Jolivet
IPC分类号： G01N33/53 , G01N33/574
CPC分类号： G01N33/57488 , G01N33/57434
摘要： The invention concerns a method for diagnosing a prostate adenocarcinoma in a male human patient without performing a prostatic biopsy, using the PSA protein (prostate specific antigen) present in the patient's blood, serum, urine or seminal fluid that involves measuring the free PSA total level, i.e., cleaved and non-cleaved; measuring the level of all or part of the cleaved free PSA; calculating the proportion of cleaved free PSA relative to the total free PSA, non-cleaved free PSA to free PSA, and/or cleaved free PSA to any of non-cleaved free, total, or complexed PSA; and diagnosing that the patient suffers from a prostate adenocarcinoma when the ratio used is not more than a reference value or a benign pathology when the ratio used is higher than the reference value.
摘要翻译：本发明涉及使用存在于患者的血液，血清，尿液或精液中的PSA蛋白（前列腺特异性抗原）进行前列腺活检的男性人类患者中的前列腺腺癌的诊断方法，其涉及测量游离PSA总水平，即切割和未切割; 测量全部或部分切割的游离PSA的水平; 计算切割的游离PSA相对于游离PSA的总游离PSA，游离PSA的游离PSA，和/或将游离PSA切割成任何未裂解的游离的，总的或络合的PSA的比例。并且当所使用的比例不超过参考值或良性病理学，当所使用的比例高于参考值时，诊断患者患有前列腺腺癌。

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