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31. 发明申请

US20200277654A1 Method for Detecting multiple DNA Mutations and Copy Number Variations 审中-公开
公开(公告)号：US20200277654A1
公开(公告)日：2020-09-03
申请号：US16875381
申请日：2020-05-15
申请人： Yan Wang
发明人： Yan Wang
IPC分类号： C12Q1/686 , C12Q1/6827 , C12Q1/6876 , C12Q1/6848
摘要： Disclosed are methods for detecting DNA mutations of target genes in a DNA sample by combining single-molecule clonal amplification and mutant primer specific extension detection. In the method, thousands and millions of DNA molecules are locally amplified to form immobilized DNA clusters of identical sequences. Mutation specific primers are used to anneal to the mutant sequences in the DNA clusters and are extended by DNA polymerase to make labeled DNA strands. The labeled DNA clusters are detected to identify the DNA clusters of mutant sequences. This method enables detection of single mutation molecule and direct enumeration of mutation molecules in the sample. Once generated from a DNA sample, the immobilized DNA clusters can be reused many times for detection of different mutations or sequences of interest. Methods for determining differential gene expression and chromosome copy number variation are also disclosed.

32. 外观设计

USD884545S1 Pendant 有权
公开(公告)号：USD884545S1
公开(公告)日：2020-05-19
申请号：US29711601
申请日：2019-11-01
申请人： Yan Wang
设计人： Yan Wang
摘要： FIG. 1 is a perspective view of a pendant showing my new design;
FIG. 2 is a front view thereof of open state;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines are for the purposes of illustrating portions of the pendant and form no part of the claimed design.

33. 发明授权

US10513563B2 Method for uses of proinsulin transferrin fusion proteins as prodrugs 有权
公开(公告)号：US10513563B2
公开(公告)日：2019-12-24
申请号：US13476812
申请日：2012-05-21
申请人： Wei-Chiang Shen , Yan Wang , Jennica Krankel
发明人： Wei-Chiang Shen , Yan Wang , Jennica Krankel
IPC分类号： C07K19/00 , A61K38/28 , C07K14/62 , C07K14/79 , A61K47/64
摘要： The present invention provides compositions useful as prodrugs and methods for making the same. The compositions include a fusion protein having a first delivery domain and a second protein precursor domain linked together via a linker sequence. The delivery domain is a protein capable of facilitating entry to a target cells via the endocytotic pathway, such as transferrin. The protein precursor is a prohormone or a profactor, such as proinsulin. Methods of this invention include the steps of selecting a protein suitable as the delivery domain, constructing a vector to encode the fusion protein, and expressing the fusion protein in a suitable expression host. Also disclosed is a method for targeted-delivery of prodrugs to livers and a method of reducing hepatic glucose production.

34. 外观设计

USD849167S1 Cactus float 有权
公开(公告)号：USD849167S1
公开(公告)日：2019-05-21
申请号：US29593710
申请日：2017-02-10
申请人： Yan Wang
设计人： Yan Wang
摘要： FIG. 1 is a perspective view showing my new design;
FIG. 2 is a top elevation view thereof;
FIG. 3 is a bottom elevation view thereof;
FIG. 4 is a left side elevation view thereof;
FIG. 5 is a right side elevation view thereof;
FIG. 6 is a front elevation view thereof; and,
FIG. 7 is a rear elevation view thereof.
The broken line in the drawings depicts unclaimed portion of the float only and forms no part of the claimed design.

35. 发明授权

US10058691B2 Disposable array-type micro injection needle head and prefilled syringe 有权
公开(公告)号：US10058691B2
公开(公告)日：2018-08-28
申请号：US14352987
申请日：2012-08-07
申请人： Ruifeng Yue , Yan Wang
发明人： Ruifeng Yue , Yan Wang
IPC分类号： A61M5/00 , A61M37/00 , A61M5/28 , A61M5/32
CPC分类号： A61M37/0015 , A61M5/283 , A61M5/3298 , A61M2037/0023 , A61M2037/003 , A61M2037/0061 , F04C2270/0421
摘要： The invention discloses a disposable array-type micro injection needle head which comprises a lower needle seat which is configured as a cylindrical column opening at one end and having a top cap at the other end and which is configured to be connected with an injection reservoir; an upper needle seat which is located above the top cap of the lower needle seat with a cavity formed between the upper needle seat and the top cap; a through-hole formed in the top cap which is configured for communicating the cylindrical column with the cavity, wherein a pipetting needle is mounted in the through-hole which has one end communicated with the cavity and the other end located in the cylindrical column and which is configured for extracting injection from the injection reservoir into the cavity; and at least two needle tubes mounted in the upper needle seat, each of which has one end comprising a needle tip for puncturing and for injecting the injection and the other end for mounting on the upper needle seat and for communicating with the cavity. The needle head can be used directly on existing insulin pen, or the cylindrical column can be provided inside it with an injection reservoir to form a disposable prefilled syringe. By using a plurality of thin, short needle tubes for injecting simultaneously, vertical hypodermic injection of medicines such as insulin can be preformed rapidly, leakproof, painlessly, safely and conveniently at various sites of a human body, without needing to pinch skin, while a potential trouble that the medicines be injected into muscles can be avoided. Patient adherence to the treatment regimen and the treatment effect are improved.

36. 发明授权

US09867902B2 Dense fibrillar collagen matrices for tissue repair and the preparation method thereof 有权
公开(公告)号：US09867902B2
公开(公告)日：2018-01-16
申请号：US13701071
申请日：2011-05-30
申请人： Marie-Madeleine Giraud-Guille , Nadine Nassif , Yan Wang , Christophe Helary , Anne Pelle
发明人： Marie-Madeleine Giraud-Guille , Nadine Nassif , Yan Wang , Christophe Helary , Anne Pelle
IPC分类号： A61L27/24 , A61L27/18
CPC分类号： A61L27/24 , A61L27/18 , A61L2430/40 , C08L71/02
摘要： Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.

37. 发明申请

US20160184344A1 STIMULI RESPONSIVE COMPOSITIONS FOR IRON CHELATION 有权
标题翻译：用于钢铁焊接的刺激性反应组合物
公开(公告)号：US20160184344A1
公开(公告)日：2016-06-30
申请号：US14876740
申请日：2015-10-06
申请人： May Pang Xiong , Zhi Liu , Yan Wang
发明人： May Pang Xiong , Zhi Liu , Yan Wang
IPC分类号： A61K31/785 , C08F220/28 , C08F230/04
CPC分类号： A61K31/785 , A61K47/58 , A61K47/61 , A61K47/6903 , C08B37/0012 , C08B37/0015 , C08F2220/282 , C08L5/16
摘要： The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.
摘要翻译：本技术提供了包含至少一种交联共聚物的新组合物。在一些实施方案中，聚丙烯酰胺共聚物包含水溶性亚基，交联亚基和铁螯合亚基。在其它实施方案中，共聚物包含可与铁螯合剂缀合的水溶性单元，交联亚单元和取代亚单元。当这些新的颗粒暴露于某些环境，如强酸或氧化剂的存在时，这些颗粒能够分解，使得铁螯合剂可以从其环境中螯合铁或其它金属。还提供了制备这些新组合物的方法。包含本技术的纳米凝胶的这些组合物或组合物可用于治疗由慢性输血引起的金属过载状况，例如铁超载。

38. 发明授权

US09243242B2 Methods of making di-tagged DNA libraries from DNA or RNA using double-tagged oligonucleotides 有权
标题翻译：使用双标记寡核苷酸从DNA或RNA制备二标记DNA文库的方法
公开(公告)号：US09243242B2
公开(公告)日：2016-01-26
申请号：US14226321
申请日：2014-03-26
申请人： Yan Wang
发明人： Yan Wang
IPC分类号： C12N15/10 , C12N15/65 , C12N15/66 , C12Q1/68
CPC分类号： C12N15/1065 , C12N15/65 , C12N15/66 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869 , C12Q2525/119 , C12Q2525/131 , C12Q2525/155 , C12Q2525/186 , C12Q2525/191 , C12Q2535/122
摘要： Disclosed are methods, compositions and kits related to making double-tagged DNA libraries from RNA/DNA samples. A double-tagged oligonucleotide (DTO) is employed to efficiently add two different tags to ends of DNAs to make a double-tagged DNA libraries. Also disclosed are methods to make mate pair libraries using the double-tagged oligonucleotide, and methods to make double-tagged single stranded DNA. The double-tagged DNA libraries of the invention are ready to be used on next generation sequencing machines.
摘要翻译：公开了与从RNA / DNA样品制备双标记DNA文库相关的方法，组合物和试剂盒。使用双重标记的寡核苷酸（DTO）来有效地将两个不同的标签添加到DNA的末端以制备双标记的DNA文库。还公开了使用双标记寡核苷酸制备配对文库的方法，以及制备双标记单链DNA的方法。本发明的双标记DNA文库可以在下一代测序机上使用。

39. 发明申请

US20150354006A1 MARKERS FOR ACUTE LYMPHOBLASTIC LEUKEMIA 审中-公开
标题翻译：急性淋巴细胞白血病标志物
公开(公告)号：US20150354006A1
公开(公告)日：2015-12-10
申请号：US14434063
申请日：2013-10-15
申请人： Ho Man CHAN , Nathan P. ENGLUND , Levi GARRAWAY , Min HU , Jacob JAFFE , Gregory KRYUKOV , Jun LIU , Xianghui LIU , Rob MCDONALD , Frank Peter STEGMEIER , Zhaofu WANG , Yan WANG , Haiping WU , Feng YAN
发明人： Ho Man Chan , Nathan P. Englund , Levi Garraway , Min Hu , Jacob Jaffe , Gregory Kryukov , Jun Liu , Xianghui Liu , Rob McDonald , Frank Peter Stegmeier , Zhaofu Wang , Yan Wang , Haiping Wu , Feng Yan
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , G01N33/5011 , G01N33/57426 , G01N2333/91017 , G01N2440/12 , G01N2500/04 , G01N2500/10
摘要： The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.
摘要翻译：本发明提供检测癌细胞NSD2突变的方法，方法癌症诊断和筛选NSD2抑制剂的方法。

40. 发明申请

US20150168424A1 IGFBP2 Biomarker 审中-公开
标题翻译： IGFBP2生物标志物
公开(公告)号：US20150168424A1
公开(公告)日：2015-06-18
申请号：US14556402
申请日：2014-12-01
申请人： Yan Wang
发明人： Yan Wang
IPC分类号： G01N33/68 , A61K39/395 , A61K45/06 , C07K16/28
CPC分类号： G01N33/6872 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N2333/65
摘要： The present invention provides method for quickly and conveniently determining if a given treatment regimen of IGF1R inhibitor is sufficient, e.g., to saturate IGF1R receptors in the body of a subject. Several clinically relevant determinations may be made based on this point, including, for example, whether the dosage of the regimen is sufficient or should be increased.
摘要翻译：本发明提供了用于快速和方便地确定给定的IGF1R抑制剂治疗方案是否足够的方法，例如饱和受试者体内的IGF1R受体。可以基于这一点进行若干临床相关的测定，包括例如方案的剂量是否足够或应当增加。

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