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31. 发明授权

US09180993B2 Feeding device 有权
标题翻译：送料装置
公开(公告)号：US09180993B2
公开(公告)日：2015-11-10
申请号：US13482365
申请日：2012-05-29
申请人： Jian-Bin Zhou , Che-Yu Chou , Qun Huang , Tai-Shan Zhu , Tao Jiang , Wei-Wei Yu
发明人： Jian-Bin Zhou , Che-Yu Chou , Qun Huang , Tai-Shan Zhu , Tao Jiang , Wei-Wei Yu
IPC分类号： B65B39/00
CPC分类号： B65B39/002 , B65B39/003 , B65B39/005 , B65B2220/14
摘要： A feeding device includes a material pipe, a first container, a second container and a constant-length linkage mechanism. The material pipe is configured for feeding a first material. The first container is configured for receiving the first material and supplying a timed amount of the first material to a first material feed port. The second container is configured for storing a second material and supplying the second material to a second material feed port. The constant-length linkage mechanism is connected to the first container and the second container. When the first container is actually supplying the first material to the first material feed port, the constant-length linkage mechanism allows the second container to supply the second material to the second material feed port simultaneously.
摘要翻译：进料装置包括材料管，第一容器，第二容器和恒定长度连杆机构。材料管被配置为供给第一材料。第一容器构造成用于接收第一材料并将定时量的第一材料供应到第一材料供给口。第二容器构造成用于存储第二材料并将第二材料供应到第二材料进料口。恒定连杆机构连接到第一容器和第二容器。当第一容器实际上将第一材料供应到第一材料供给口时，恒定连杆机构允许第二容器同时将第二材料供应到第二材料进料口。

32. 发明申请

US20140253867A1 Pair of Projector Glasses 审中-公开
标题翻译：一对投影机眼镜
公开(公告)号：US20140253867A1
公开(公告)日：2014-09-11
申请号：US14198583
申请日：2014-03-05
申请人： Tao Jiang , Dazhang Zeng
发明人： Tao Jiang , Dazhang Zeng
IPC分类号： G02C11/00
CPC分类号： G02C11/10
摘要： A pair of projector glasses is an eyewear apparatus that provides a user with a convenient means of acquiring, viewing, and listening to digital content. The eyewear apparatus mainly includes a glasses frame, a pair of temples, a projector, a wireless module, a pair of headphone speakers, and a pair of portable power sources. The glasses frame and the pair of temples are used to support the eyewear apparatus on the user's head. The wireless module retrieves digital content from an external source such as a smart-phone, a computer, or the Internet. The wireless module then distributes the audio portion of the digital content to the pair of speakers and the visual portion of the digital content to the projector. The portable power sources are separately positioned on the eyewear apparatus so that each source can power the electrical components that are in close proximity to the source itself.
摘要翻译：一副投影机眼镜是一种眼镜装置，为用户提供了获取，观看和收听数字内容的便利手段。眼镜装置主要包括眼镜架，一对镜腿，投影仪，无线模块，一对耳机扬声器和一对便携式电源。眼镜架和一对镜腿用于支撑使用者头部的眼镜装置。无线模块从诸如智能电话，计算机或因特网的外部来源检索数字内容。无线模块然后将数字内容的音频部分分配给一对扬声器和数字内容的可视部分到投影仪。便携式电源分开地定位在眼镜装置上，使得每个源可以对靠近源本身的电气部件供电。

33. 发明授权

US08642561B2 Peptides whose uptake by cells is controllable 有权
标题翻译：细胞摄取的肽是可控的
公开(公告)号：US08642561B2
公开(公告)日：2014-02-04
申请号：US13314134
申请日：2011-12-07
申请人： Tao Jiang , Roger Y. Tsien
发明人： Tao Jiang , Roger Y. Tsien
IPC分类号： A61K38/06 , A61K38/16 , A61K38/10 , G01N33/533 , C07H19/04 , G03F7/00
CPC分类号： A61K49/0043 , A61K47/65 , A61K49/0056
摘要： A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability of the basic amino acids in B to drag cargo C into cells near the cleavage event. X is cleaved extracellularly, preferably under physiological conditions. D-amino acids are preferred for the A and B portions, to minimize immunogenicity and nonspecific cleavage by background peptidases or proteases.
摘要翻译：本发明的肽的一般结构包括A-X-B-C，其中C是货物部分，B部分包括碱性氨基酸，X是可切割的接头序列，A部分包括酸性氨基酸。完整结构不被细胞所占据; 然而，在X的细胞外裂解时，B-C部分被吸收，将货物运送到靶细胞。货物可以是例如用于诊断成像的对比剂，化学治疗药物或用于治疗的放射线敏化剂。 X的裂解允许A与B分离，揭示B中碱性氨基酸的正常能力，将货物C拖入裂解事件附近的细胞。 X在细胞外裂解，优选在生理条件下。对于A和B部分，D-氨基酸是优选的，以使由背景肽酶或蛋白酶的免疫原性和非特异性切割最小化。

34. 发明授权

US08629104B2 G-CSF and water-soluble polymer conjugate 有权
标题翻译： G-CSF和水溶性聚合物缀合物
公开(公告)号：US08629104B2
公开(公告)日：2014-01-14
申请号：US12918280
申请日：2008-02-18
申请人： Ruijun Wang , Changan Sun , Tao Jiang , Wang Yali
发明人： Ruijun Wang , Changan Sun , Tao Jiang , Wang Yali
IPC分类号： A61K38/00 , A61K38/19 , A61P7/06
CPC分类号： C07K14/535 , A61K38/00 , A61K47/60 , C07K17/08
摘要： Provided are a G-CSF and water-soluble polymer conjugate, or a pharmaceutically acceptable salt thereof, comprising a water-soluble polymer, a protein, and a linking group; a method for preparing thereof; and a pharmaceutical composition comprising the same.
摘要翻译：提供包含水溶性聚合物，蛋白质和连接基团的G-CSF和水溶性聚合物缀合物或其药学上可接受的盐; 其制备方法; 和含有该组合物的药物组合物。

35. 发明授权

US08367827B2 Process for preparing hydrocodone using a super acid 失效
标题翻译：使用超酸制备氢可酮的方法
公开(公告)号：US08367827B2
公开(公告)日：2013-02-05
申请号：US12627355
申请日：2009-11-30
申请人： Peter X. Wang , Tao Jiang , Subo Liao , Erin Moore
发明人： Peter X. Wang , Tao Jiang , Subo Liao , Erin Moore
IPC分类号： C07D489/02 , C07D221/22
CPC分类号： C07D489/02 , C07D221/28
摘要： The present disclosure generally relates to a process for converting a fused, tricyclic compound to a fused, tetracyclic compound that includes a furan ring therein. More particularly, the present disclosure related to a process for preparing a hydrocodone compound, or a compound structurally related thereto, and in particular (+)-hydrocodone, by subjecting a structurally corresponding sinomenine starting compound to a super acid-assisted furan ring closure reaction.
摘要翻译：本公开内容一般涉及将稠合的三环化合物转化为在其中包含呋喃环的稠合四环化合物的方法。更具体地，本公开涉及制备氢可酮化合物或其结构相关的化合物的方法，特别是（+） - 氢可酮，通过使结构相应的青藤碱起始化合物经受超酸辅助的呋喃环闭合反应。

36. 发明授权

US08168790B2 Process for the preparation of 6-beta hydroxy morphinan compounds 有权
标题翻译：制备6-β羟基吗啡喃化合物的方法
公开(公告)号：US08168790B2
公开(公告)日：2012-05-01
申请号：US12485200
申请日：2009-06-16
申请人： Jian Bao , Tao Jiang , Gary L. Cantrell
发明人： Jian Bao , Tao Jiang , Gary L. Cantrell
IPC分类号： C07D489/02 , C07D489/08
CPC分类号： C07D489/02
摘要： The invention provides processes for the conversion of a 6-keto morphinan to a 6-hydroxy morphinan. In particular, the invention provides a stereoselective process for the conversion of a 6-keto morphinan to a 6-beta-hydroxy morphinan.
摘要翻译：本发明提供了将6-酮基吗啡喃转化为6-羟基吗啡喃的方法。特别地，本发明提供了用于将6-酮基吗啡喃转化为6-β-羟基吗啡喃的立体选择性方法。

37. 发明授权

US08148528B2 Processes and compounds for the preparation of normorphinans 有权
标题翻译：用于制备正丝菌素的方法和化合物
公开(公告)号：US08148528B2
公开(公告)日：2012-04-03
申请号：US12469951
申请日：2009-05-21
申请人： Peter X. Wang , Frank W. Moser , Gary L. Cantrell , Tao Jiang , Robert E. Halvachs , Christopher W. Grote
发明人： Peter X. Wang , Frank W. Moser , Gary L. Cantrell , Tao Jiang , Robert E. Halvachs , Christopher W. Grote
IPC分类号： C07D489/08
CPC分类号： C07D489/02 , C07D221/28 , C07D489/08
摘要： The invention generally provides processes and intermediate compounds useful for the production of normorphinans and derivatives of normorphinans.
摘要翻译：本发明通常提供可用于生产正丝菌素和正大脑啡肽衍生物的方法和中间体化合物。

38. 发明申请

US20120035366A1 N-Demethylation of 6-Keto Morphinans 有权
标题翻译： 6-酮基吗啡的N-去甲基化
公开(公告)号：US20120035366A1
公开(公告)日：2012-02-09
申请号：US13196929
申请日：2011-08-03
申请人： Peter X. Wang , Tao Jiang , David W. Berberich , Subo Liao
发明人： Peter X. Wang , Tao Jiang , David W. Berberich , Subo Liao
IPC分类号： C07D489/02
CPC分类号： C07D489/08 , C07D489/02
摘要： The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan.
摘要翻译：本发明提供了包含酮官能团的N-甲基吗啡喃的去甲基化方法。特别地，本发明提供了保护酮官能团的方法，使得在N-甲基吗啡喃脱甲基期间不产生杂质。

39. 发明申请

US20110269963A1 Preparation of Saturated Ketone Morphinan Compounds Having Low Metal Content 有权
标题翻译：具有低金属含量的饱和酮吗啡吗啡烷化合物的制备
公开(公告)号：US20110269963A1
公开(公告)日：2011-11-03
申请号：US13093892
申请日：2011-04-26
申请人： Tao Jiang , Peter X. Wang , David W. Berberich
发明人： Tao Jiang , Peter X. Wang , David W. Berberich
IPC分类号： C07D489/02
CPC分类号： C07D489/02 , C07D489/04
摘要： The present invention provides processes for the preparation of saturated ketone morphinan compounds from a morphinan comprising an allyl alcohol ring moiety, wherein the final product has a low metal content. In particular, the invention provides processes that utilize isomerization reactions catalyzed by transition metal catalysts and the subsequent removal of the transition metal using metal scavengers.
摘要翻译：本发明提供从包含烯丙醇环部分的吗啡喃制备饱和酮吗啡喃化合物的方法，其中最终产物具有低的金属含量。特别地，本发明提供了利用由过渡金属催化剂催化的异构化反应和随后使用金属清除剂除去过渡金属的方法。

40. 发明申请

US20110190259A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20110190259A1
公开(公告)日：2011-08-04
申请号：US13048636
申请日：2011-03-15
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/506 , C07D401/14 , C12N9/99 , C07D239/24 , C07D413/14 , A61K31/5377 , C07D403/02 , A61P25/00 , A61P37/06
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译：本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。

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