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31. 发明授权

US4370323A 2-Cyanoaziridinyl-(1)-2-substituted-aziridinyl-(1)-methanes 失效
标题翻译： 2-氰基氮丙啶基 - （1）-2-取代的吖丙啶基 - （1） - 甲烷
公开(公告)号：US4370323A
公开(公告)日：1983-01-25
申请号：US776068
申请日：1977-03-09
申请人： Wolfgang Kampe , Max Thiel , Erich Fauland , Uwe Bicker , Gottfried Hebold
发明人： Wolfgang Kampe , Max Thiel , Erich Fauland , Uwe Bicker , Gottfried Hebold
IPC分类号： C07D203/06 , A61K31/395 , A61K31/396 , A61K31/435 , A61P35/00 , A61P37/04 , C07D203/08 , C07D203/12 , C07D203/14 , C07D333/00 , C07D335/00 , C07D403/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D403/06 , C07D401/14
CPC分类号： C07D203/08 , C07D451/14 , Y10S514/885
摘要： A 2-cyanoaziridinyl-(1)-2-substituted-aziridinyl-(1)-methane ##STR1## wherein R is a nitrile or carbamoyl group, andR.sub.1 and R.sub.2 each independently is a hydrogen atom, an aliphatic hydrocarbon radical containing up to 10 carbon atoms optionally substituted by hydroxyl, alkoxy, amino, alkylamino, dialkylamino, alkoxycarbonyl, cyano, 1, 2 or 3 halogens, cycloalkyl, phenyl or phenoxy; nitrile, carboxyl, alkoxycarbonyl or optionally hydrogenated monocyclic heteroaryl or phenyl optionally substituted by alkyl, alkoxy, hydroxy, alkoxcarbonyl, dialkylamino, alkylthio, trifluoromethyl, nitro, carbamoyl, nitrile, sulphonamido, hydroxyalkyl, methylenedioxy, or halogen; or R.sub.1 and R.sub.2, together with the carbon atom to which they are attached, form a ring containing up to 8 ring members of which at least one may be oxygen, sulphur, SO, SO.sub.2 NH, N-alkyl, N-acyl or N-alkoxycarbonylalkyl, and which can be substituted by alkyl, alkoxy, hydroxyl, alkylenedioxy, alkoxycarbonyl, hydroxyalkyl, alkoxycarbonylalkyl, dialkylamino, oxo or 2-cyanoaziridino groups, or can be fused to 1 or 2 benzene rings or can be bridged by alkylene radicals containing up to 3 carbon atoms.The compounds are characterized by cytostatic and immune response-stimulating activity.
摘要翻译： 2-氰基氮丙啶基 - （1）-2-取代的吖丙啶基 - （1） - 甲烷，其中R是腈或氨基甲酰基，R 1和R 2各自独立地为氢原子，含有至多任选被羟基，烷氧基，氨基，烷基氨基，二烷基氨基，烷氧基羰基，氰基，1,2或3卤素，环烷基，苯基或苯氧基取代的10个碳原子; 腈，羧基，烷氧基羰基或任选氢化的单环杂芳基或任选被烷基，烷氧基，羟基，烷氧基羰基，二烷基氨基，烷硫基，三氟甲基，硝基，氨基甲酰基，腈，磺酰胺基，羟烷基，亚甲二氧基或卤素取代的苯基。或R 1和R 2与它们所连接的碳原子一起形成含有至多8个环成员的环，其中至少一个可以是氧，硫，SO，SO 2 + L，NH，N-烷基，酰基或N-烷氧基羰基烷基，其可以被烷基，烷氧基，羟基，亚烷基二氧基，烷氧基羰基，羟基烷基，烷氧基羰基烷基，二烷基氨基，氧代或2-氰基氮丙啶基取代，或者可以与1或2个苯环稠合，或可以被含有至多3个碳原子的亚烷基。该化合物的特征在于细胞抑制和免疫应答刺激活性。

32. 发明授权

US4284633A Derivatives of xanthine 失效
标题翻译：黄嘌呤衍生物
公开(公告)号：US4284633A
公开(公告)日：1981-08-18
申请号：US148870
申请日：1980-05-12
申请人： Walter-Gunar Friebe , Max Thiel , Wolfgang Kampe , Otto-Henning Wilhelms , Androniki Roesch
发明人： Walter-Gunar Friebe , Max Thiel , Wolfgang Kampe , Otto-Henning Wilhelms , Androniki Roesch
IPC分类号： A61K31/52 , A61K31/522 , A61P11/08 , A61P37/08 , C07D473/08 , C07D473/10 , C07D473/06
CPC分类号： C07D473/08 , C07D473/10 , Y10S514/826
摘要： The present invention provides xanthine derivatives of the general formula: ##STR1## wherein one of the symbols R.sub.1 and R.sub.2 stands for a methyl radical and the other for a radical of the general formula: ##STR2## wherein R.sub.3 is a hydrogen atom or an acyl radical; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them and is also concerned with the use thereof for the preparation of pharmaceutical compositions for the treatment of allergies.
摘要翻译：本发明提供了以下通式的黄嘌呤衍生物：其中符号R1和R2之一代表甲基，另一个代表下列通式的基团：其中R3是氢原子或酰基激进; 及其药理学上可接受的盐。本发明还提供了制备这些化合物和含有它们的药物组合物的方法，并且还涉及其用于制备用于治疗过敏症的药物组合物的用途。

33. 发明授权

US4330549A Coumarins connected via an oxyalkyl group with a piperidine ring having anti-allergic action 失效
标题翻译：通过氧烷基连接的香豆素与具有抗过敏作用的哌啶环
公开(公告)号：US4330549A
公开(公告)日：1982-05-18
申请号：US104205
申请日：1979-12-17
申请人： Walter-Gunar Friebe , Werner Winter , Max Thiel , Androniki Roesch , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Werner Winter , Max Thiel , Androniki Roesch , Otto-Henning Wilhelms
IPC分类号： C07D409/14 , A61K31/085 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4468 , A61K31/4709 , A61P9/12 , A61P37/00 , A61P37/08 , C07D215/02 , C07D233/60 , C07D311/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/14 , A61K31/445 , C07D311/16
CPC分类号： C07D401/12 , Y10S514/826
摘要： The present invention provides aryl ether derivatives of the general formula: ##STR1## wherein A is an oxygen atom or the group >N--R.sub.1, R.sub.1 being a hydrogen atom or a lower alkyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R.sub.4 is a hydrogen atom or a hydroxyl group, R.sub.5 is a hydrogen atom or an acyl radical, R.sub.7 is a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical and R.sub.8 is a hydrogen atom, a lower alkyl radical, a lower alkoxy radical or a hydroxyl group; and the pharmacologically acceptable salts thereof.The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. It is also concerned with the use of these compounds for combating allergic diseases.
摘要翻译：本发明提供以下通式的芳醚衍生物：其中A为氧原子或基团> N-R 1，R 1为氢原子或低级烷基，R 2和R 3可以相同或为不同的是氢原子或低级烷基，R4是氢原子或羟基，R5是氢原子或酰基，R7是氢原子，低级烷基或低级烷酰基，R8是氢原子，低级烷基，低级烷氧基或羟基; 及其药理学上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。还关注这些化合物用于防治过敏性疾病。

34. 发明授权

US4053624A Indole-2-carbaldehyde compounds and blood sugar reducing compositions 失效
标题翻译：吲哚二羧酸化合物和血糖减少组合物
公开(公告)号：US4053624A
公开(公告)日：1977-10-11
申请号：US573214
申请日：1975-04-30
申请人： Manfred Hubner , Ruth Heerdt , Felix Schmidt , Max Thiel
发明人： Manfred Hubner , Ruth Heerdt , Felix Schmidt , Max Thiel
IPC分类号： C07D209/12 , A61K31/40
CPC分类号： C07D209/12 , Y10S514/866
摘要： New indole-2-carbaldehyde compounds of the formula ##STR1## wherein R.sub.1 is lower alkylR.sub.2 is hydrogen, halogen, or lower alkyl or alkoxy,With the proviso that when R.sub.2 is halogen or ethyl,R.sub.1 can also be hydrogenAnd the physiologically compatible derivatives thereof, are outstandingly effective in lowering excessive blood sugar in mammals.

35. 发明授权

US4427680A 1,2-Dihydroquinolines connected via an oxyalkyl group with a piperidine ring and having anti-allergic action 失效
标题翻译：通过氧烷基与哌啶环连接并具有抗过敏作用的1,2-二氢喹啉
公开(公告)号：US4427680A
公开(公告)日：1984-01-24
申请号：US346790
申请日：1982-02-08
申请人： Walter-Gunar Friebe , Werner Winter , Max Thiel , Androniki Roesch , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Werner Winter , Max Thiel , Androniki Roesch , Otto-Henning Wilhelms
IPC分类号： C07D409/14 , A61K31/085 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4468 , A61K31/4709 , A61P9/12 , A61P37/00 , A61P37/08 , C07D215/02 , C07D233/60 , C07D311/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/14 , A61K31/47 , C07D215/22
CPC分类号： C07D401/12 , Y10S514/826
摘要： The present invention provides aryl ether derivatives of the general formula: ##STR1## wherein A is an oxygen atom or the group >N--R.sub.1, R.sub.1 being a hydrogen atom or a lower alkyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R.sub.4 is a hydrogen atom or a hydroxyl group, R.sub.5 is a hydrogen atom or an acyl radical, R.sub.7 is a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical and R.sub.8 is a hydrogen atom, a lower alkyl radical, a lower alkoxy radical or a hydroxyl group; and the pharmacologically acceptable salts thereof.The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. It is also concerned with the use of these compounds for combating allergic diseases.
摘要翻译：本发明提供以下通式的芳醚衍生物：其中A是氧原子或基团> N-R 1，R 1是氢原子或低级烷基，R 2和R 3，其中可以相同或不同，为氢原子或低级烷基，R4为氢原子或羟基，R5为氢原子或酰基，R7为氢原子，低级烷基或低级烷酰基 R8为氢原子，低级烷基，低级烷氧基或羟基; 及其药理学上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。还关注这些化合物用于防治过敏性疾病。

36. 发明授权

US3962242A 3-(5-Nitro-2-furyl)-6-cyano-s-triazolo(4,3-b)pyridazine 失效
标题翻译： 3-（5-硝基-2-呋喃基）-6-氰基-S-三唑（4,3-B）吡啶
公开(公告)号：US3962242A
公开(公告)日：1976-06-08
申请号：US545661
申请日：1975-01-30
申请人： Herbert Berger , Rudi Gall , Max Thiel , Wolfgang Vomel , Winfriede Sauer
发明人： Herbert Berger , Rudi Gall , Max Thiel , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D487/04 , C07D237/26
CPC分类号： C07D487/04
摘要： Nitrofuryl-triazolo[4,3-b]pyridazine compounds of the formula ##SPC1##WhereinR.sub.1 is lower alkoxy radical or a saturated 5- or 6-membered heterocyclic ring attached via a cyclic nitrogen atom, which heterocyclic ring can also contain, in addition to said cyclic nitrogen atom, a cyclic oxygen atom or an optionally lower alkylated cyclic nitrogen atom and R.sub.2 is a hydrogen atom or R.sub.1 and R.sub.2 together represent an additional valency bond,Are outstandingly effective as bacteriostats and are particularly useful in the treatment of bacterial infections in the urinary tract.

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