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31. 发明授权

US5635177A Protein tyrosine kinase agonist antibodies 失效
标题翻译：蛋白酪氨酸激酶激动剂抗体
公开(公告)号：US5635177A
公开(公告)日：1997-06-03
申请号：US222616
申请日：1994-04-04
申请人： Brian D. Bennett , David Goeddel , William Matthews
发明人： Brian D. Bennett , David Goeddel , William Matthews
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P43/00 , C07H21/04 , C07K7/08 , C07K14/71 , C07K14/82 , C07K16/18 , C07K16/28 , C07K16/40 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/02 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/566 , G01N33/573 , C07K16/00 , C12N5/12
CPC分类号： C07K19/00 , C07K14/71 , C07K14/82 , C07K16/2863 , C12N9/1205 , C12Q1/6876 , A61K2039/505 , A61K38/00 , C07K2317/75 , C12Q2600/158
摘要： Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.
摘要翻译：公开了激动剂抗体，其结合受体蛋白酪氨酸激酶pTK的细胞外结构域，从而引起细胞内酪氨酸激酶结构域的二聚化和活化。抗体可用于激活其各自的受体，从而能够研究酪氨酸激酶受体在细胞生长和/或分化中的作用。还公开了包含受体pTK的细胞外结构域和免疫球蛋白恒定域序列的嵌合蛋白。

32. 发明申请

US20110091303A1 SHEET MATERIAL LIFTS 失效
标题翻译：物资资料
公开(公告)号：US20110091303A1
公开(公告)日：2011-04-21
申请号：US12826573
申请日：2010-06-29
申请人： William Matthews
发明人： William Matthews
IPC分类号： E04G21/18 , B66F3/00 , B66F11/00 , E04G21/14
CPC分类号： E04F21/1894 , E04G21/167
摘要： sheet material lifts including an elongate body extending along a longitudinal axis between a first end and a second end, a foot extending transverse the longitudinal axis from the second end of the elongate body, a support element disposed on the foot distal the elongate body, a base defining a fulcrum coupled to the foot, and an arm extending transverse the longitudinal axis from the elongate body at a position intermediate the first end and the second end. In some examples, the arm includes a sleeve, and a shaft slidingly mounted within the sleeve, the shaft being configured to slide along a path between a retracted position proximate the elongate body and an extended position distal the elongate body.
摘要翻译：板材升降机包括沿第一端和第二端之间的纵向轴线延伸的细长体，从所述细长体的第二端横向于纵向轴线延伸的脚，在所述细长体的远侧设置的支撑元件，基部，其限定了联接到所述脚的支点，以及在所述第一端和所述第二端的中间位置处从所述细长主体横向延伸的臂。在一些示例中，臂包括套筒和滑动地安装在套筒内的轴，该轴构造成沿着靠近细长主体的缩回位置和远离细长主体的延伸位置之间的路径滑动。

33. 发明申请

US20070181552A1 METHOD OF PULSE WELDING AND CONTACT TIP THEREFOR 有权
标题翻译：脉冲焊接方法及其接点
公开(公告)号：US20070181552A1
公开(公告)日：2007-08-09
申请号：US11735165
申请日：2007-04-13
申请人： William Matthews , Bryan Nelson
发明人： William Matthews , Bryan Nelson
IPC分类号： B23K9/28
CPC分类号： B23K9/287
摘要： A contact tip for a welding gun having a central passage for a welding wire moving in a given direction toward a workpiece and receiving a welding signal by contact of the wire with the tip. The passage has an innermost end, an outermost exit end and a length of at least 1.5 inches and an opening in the contact tip intersects the passage so a pressure block slidably mounted in the opening is biased toward the wire by a spring around the contact tip urging the block against the wire. This tip is dimensioned and constructed to perform pulse welding by a relatively ductile aluminum wire.
摘要翻译：一种用于焊枪的接触头，其具有用于焊丝的中心通道，用于沿给定方向朝向工件移动，并且通过接触导线与尖端接收焊接信号。通道具有最内端，最外侧的出口端和至少1.5英寸的长度，并且接触尖端中的开口与通道相交，使得可滑动地安装在开口中的压力块通过围绕接触尖端的弹簧被偏压到线推动块抵抗线。该尖端尺寸和构造为通过相对延性的铝线进行脉冲焊接。

34. 发明申请

US20070181551A1 METHOD OF PULSE WELDING AND CONTACT TIP THEREFOR 有权
公开(公告)号：US20070181551A1
公开(公告)日：2007-08-09
申请号：US11735121
申请日：2007-04-13
申请人： William Matthews , Bryan Nelson
发明人： William Matthews , Bryan Nelson
IPC分类号： B23K9/28
CPC分类号： B23K9/287
摘要： A contact tip for a welding gun having a central passage for a welding wire moving in a given direction toward a workpiece and receiving a welding signal by contact of the wire with the tip. The passage has an innermost end, an outermost exit end and a length of at least 1.5 inches and an opening in the contact tip intersects the passage so a pressure block slidably mounted in the opening is biased toward the wire by a spring around the contact tip urging the block against the wire. This tip is dimensioned and constructed to perform pulse welding by a relatively ductile aluminum wire.

35. 发明申请

US20060172413A1 Transgenic mice containing melanocyte stimulating hormone receptor gene disruptions 审中-公开
公开(公告)号：US20060172413A1
公开(公告)日：2006-08-03
申请号：US11376438
申请日：2006-03-14
申请人： Keith Allen , William Matthews , Mark Moore , Russell Phillips
发明人： Keith Allen , William Matthews , Mark Moore , Russell Phillips
IPC分类号： C12N15/63
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/705 , C07K14/70567 , C07K14/7158 , C07K14/72 , C07K14/723 , C12N9/13 , C12N9/16 , C12N2800/30
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in melanocyte stimulating hormone receptor genes. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

36. 发明申请

US20060143724A1 Transgenic mice containing anaphylatoxin C3a gene disruptions 审中-公开
公开(公告)号：US20060143724A1
公开(公告)日：2006-06-29
申请号：US11363579
申请日：2006-02-27
申请人： Thomas Brennan , William Matthews , Mark Moore
发明人： Thomas Brennan , William Matthews , Mark Moore
IPC分类号： A01K67/027 , C12N15/87
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/705 , C12N2800/30 , G01N33/564 , G01N2333/4716 , G01N2500/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an anaphylatoxin C3a receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

37. 发明申请

US20050272656A1 Method for enhancing proliferation or differentiation of a cell using OB protein 审中-公开
标题翻译：使用OB蛋白增强细胞增殖或分化的方法
公开(公告)号：US20050272656A1
公开(公告)日：2005-12-08
申请号：US11192219
申请日：2005-07-27
申请人： William Matthews
发明人： William Matthews
IPC分类号： A61K38/17 , A61K38/22
CPC分类号： A61K38/2264
摘要： Uses for WSX ligands in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for stimulating hematopoiesis (e.g., myelopoiesis, erythropoiesis and especially, lymphopoiesis) using a WSX ligand (e.g., anti-WSX receptor agonist antibodies or OB protein), and optionally another cytokine, are described.
摘要翻译：公开了用于造血中WSX配体的用途。特别地，描述了使用WSX配体（例如抗WSX受体激动剂抗体或OB蛋白）和任选的另外的细胞因子刺激造血（例如，骨髓细胞增生，红细胞生成，特别是淋巴细胞生成）的体外和体内方法。

38. 发明申请

US20050019325A1 WSX receptor agonist antibodies 审中-公开
标题翻译： WSX受体激动剂抗体
公开(公告)号：US20050019325A1
公开(公告)日：2005-01-27
申请号：US10921710
申请日：2004-08-18
申请人： Paul Carter , Nancy Chiang , Kyung Kim , William Matthews , Maria Rodrigues
发明人： Paul Carter , Nancy Chiang , Kyung Kim , William Matthews , Maria Rodrigues
IPC分类号： A61K38/00 , C07K14/715 , C07K14/72 , A61K39/395 , C07K16/28 , G01N33/53 , G01N33/567
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/715 , C07K14/72 , C07K14/721 , C07K2317/24 , C07K2319/00 , C07K2319/02 , G01N33/6869 , G01N33/6893 , G01N2500/00 , G01N2800/042
摘要： The WSX receptor and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed, including various uses therefor. Uses for WSX ligands (e.g., anti-WSX receptor agonist antibodies or OB protein) in hematopoiesis are also disclosed.
摘要翻译：公开了与其结合的WSX受体和抗体（包括激动剂和中和抗体），包括其各种用途。还公开了在造血作用中用于WSX配体（例如抗WSX受体激动剂抗体或OB蛋白）。

39. 发明授权

US06541604B1 Leptin receptor having a WSX motif 失效
标题翻译：具有WSX基序的瘦蛋白受体
公开(公告)号：US06541604B1
公开(公告)日：2003-04-01
申请号：US08780562
申请日：1997-01-08
申请人： Brian Bennett , William Matthews
发明人： Brian Bennett , William Matthews
IPC分类号： C07K14705
CPC分类号： C07K14/72 , A61K38/00 , C07K14/721 , C07K2319/00
摘要： The WSX receptor, WSX receptor extracellular domain (ECD), WSX receptor variants, chimeric WSX receptor (e.g., WSX receptor immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described.
摘要翻译：公开了WSX受体，WSX受体细胞外结构域（ECD），WSX受体变体，嵌合WSX受体（例如WSX受体免疫粘附素）和与其结合的抗体（包括激动剂和中和抗体）。描述了这些分子的各种用途。

40. 发明授权

US6159462A Uses of Wnt polypeptides 失效
标题翻译：使用Wnt多肽
公开(公告)号：US6159462A
公开(公告)日：2000-12-12
申请号：US911860
申请日：1997-08-15
申请人： William Matthews , Timothy W. Austin
发明人： William Matthews , Timothy W. Austin
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C12N5/02 , C12N5/0787 , C12N5/0789 , A61K45/05 , A01N37/18 , C07K1/00
CPC分类号： C12N5/0647 , A61K38/18 , A61K38/19 , C12N5/0642 , C12N2501/125 , C12N2501/415 , C12N2502/99 , Y10S514/814 , Y10S530/868
摘要： Uses for Wnt polypeptides in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for enhancing proliferation, differentiation or maintenance of a hematopoietic stem/progenitor cell using a Wnt polypeptide, and optionally another cytokine, are described.
摘要翻译：公开了用于造血中Wnt多肽的用途。特别地，描述了使用Wnt多肽和任选的另外的细胞因子增强，分化或维持造血干细胞/祖细胞的体外和体内方法。

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