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31. 发明申请

US20080167680A1 Fingertip Surgical Instrument 审中-公开
标题翻译：指尖手术器械
公开(公告)号：US20080167680A1
公开(公告)日：2008-07-10
申请号：US11621702
申请日：2007-01-10
申请人： James W. Voegele , Robert P. Gill , Wayne L. Poll
发明人： James W. Voegele , Robert P. Gill , Wayne L. Poll
IPC分类号： A61B17/29
CPC分类号： A61B17/00491 , A61B17/062 , A61B17/29 , A61B90/39 , A61B2017/00265 , A61B2017/00438 , A61B2017/00495 , A61B2017/2923 , A61B2090/395
摘要： Disclosed is a minimally invasive surgical instrument that may be used in hand-assisted laparoscopic surgeries. The device is a multifunctional surgical instrument that may be mounted directly on a surgeon's fingertip and inserted through an incision to allow the surgeon to manipulate tissue during a surgical procedure. Versions show a self-righting suture needle holder and a version with a dual pivoting jaw (e.g., grasper, cutter) that has an elongate neck to enhance the reach of the instrument. In addition, an elongate neck of an actuated fingertip instrument enhances the range reachable through a single incision.
摘要翻译：公开了可用于手辅助腹腔镜手术的微创手术器械。该装置是可以直接安装在外科医生的指尖上并通过切口插入以允许外科医生在手术过程中操纵组织的多功能手术器械。版本显示了一个自立的缝合针保持器和具有双枢转钳口（例如，抓紧器，切割器）的版本，其具有细长的颈部以增强器械的伸展。此外，致动的指尖仪器的细长颈部增强了通过单个切口可达到的范围。

32. 发明申请

US20080071208A1 Dispensing Fingertip Surgical Instrument 审中-公开
标题翻译：指尖指尖手术器械
公开(公告)号：US20080071208A1
公开(公告)日：2008-03-20
申请号：US11533506
申请日：2006-09-20
申请人： James W. Voegele , Robert P. Gill
发明人： James W. Voegele , Robert P. Gill
IPC分类号： A61M31/00
CPC分类号： A61B17/00234 , A61B17/062 , A61B17/29 , A61B90/39 , A61B2017/00265 , A61B2017/00438 , A61B2017/00495 , A61B2090/3933 , A61B2090/395
摘要： Disclosed is a minimally invasive surgical instrument that may be used in hand-assisted laparoscopic surgeries. The device is a multifunctional surgical instrument that may be mounted directly on a surgeon's fingertip and inserted through an incision to allow the surgeon to manipulate tissue during a surgical procedure. Versions include marking elements that are actuated to expose marking flowable fluid (e.g., ink pad, marker tip, roller ball). Versions include those that actuate to open an ampoule containing a flowable material (e.g., adhesive) with continued actuation causing dispensing. In addition, two compounds that are mixed at the time of application are provided with a bifurcated ampoule version and a dual cylinder/plunger version.
摘要翻译：公开了可用于手辅助腹腔镜手术的微创手术器械。该装置是可以直接安装在外科医生的指尖上并通过切口插入以允许外科医生在手术过程中操纵组织的多功能手术器械。版本包括被致动以标记可流动流体（例如，墨垫，标记末端，滚球）的标记元件。版本包括致动打开包含可流动材料（例如粘合剂）的安瓿的那些，其继续致动导致分配。此外，在使用时混合的两种化合物具有分叉安瓿版本和双柱/柱塞版本。

33. 发明授权

US08377044B2 Detachable end effectors 有权
标题翻译：可拆卸的末端执行器
公开(公告)号：US08377044B2
公开(公告)日：2013-02-19
申请号：US11693976
申请日：2007-03-30
申请人： Jonathan A. Coe , James W. Voegele , Gary L. Long , Andrew M. Zwolinski , Kyle P. Moore , Robert P. Gill
发明人： Jonathan A. Coe , James W. Voegele , Gary L. Long , Andrew M. Zwolinski , Kyle P. Moore , Robert P. Gill
IPC分类号： A61B17/00
CPC分类号： A61B17/29 , A61B17/00 , A61B17/00234 , A61B2017/00473 , A61B2017/00477 , A61B2017/2931
摘要： Methods and devices are provided for performing various procedures using interchangeable end effectors. In general, the methods and devices allow a surgeon to remotely and selectively attach various interchangeable surgical end effectors to a shaft located within a patient's body, thus allowing the surgeon to perform various procedures without the need to remove the shaft from the patient's body. In an exemplary embodiment, multiple end effectors can be introduced into a body cavity. The end effectors can be disassociated or separate from one another such that they float within the body cavity. A distal end of a shaft can be positioned within the body cavity and it can be used to selectively engage one of the end effectors. In particular, the device can be configured to allow each end effector to be remotely attached and detached from the distal end of the shaft. For example, a surgeon can actuate an actuation mechanism on the proximal end of the shaft to mate one of the end effectors to the distal end of the shaft without assistance from other tools and devices. After use of the end effector, the end effector can be released and another end effector can be remotely attached to the distal end of the shaft.
摘要翻译：提供了用于使用可互换的末端执行器执行各种过程的方法和装置。通常，所述方法和装置允许外科医生远程地和选择性地将各种可互换的手术端部执行器附接到位于患者体内的轴，从而允许外科医生执行各种程序，而不需要从患者身体移除轴。在示例性实施例中，可以将多个端部执行器引入体腔中。末端执行器可以彼此分离或分离，使得它们在体腔内浮动。轴的远端可以定位在体腔内，并且其可以用于选择性地接合末端执行器中的一个。特别地，该装置可以构造成允许每个端部执行器远离该轴远端附接和分离。例如，外科医生可以致动在轴的近端上的致动机构，以便在其他工具和装置的帮助下将端部执行器中的一个配合到轴的远端。在使用末端执行器之后，端部执行器可以被释放，而另一端部执行器可以远程连接到轴的远端。

34. 发明申请

US20080255425A1 NANOPARTICLE TREATED MEDICAL DEVICES 审中-公开
标题翻译：纳米治疗医疗器械
公开(公告)号：US20080255425A1
公开(公告)日：2008-10-16
申请号：US11771361
申请日：2007-06-29
申请人： James W. Voegele , Robert P. Gill , Michael A. Murray , Daniel F. Dlugos , Carl I. Shurtleff
发明人： James W. Voegele , Robert P. Gill , Michael A. Murray , Daniel F. Dlugos , Carl I. Shurtleff
IPC分类号： A61B1/00 , A61B17/00 , A61B17/04 , A61F2/00
CPC分类号： A61K41/0052 , A61B1/043 , A61B1/3132 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/415 , A61B5/418 , A61K49/0017 , A61K49/0093
摘要： Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.
摘要翻译：提供使用可用作标记物，指示剂和光源的荧光纳米颗粒的各种组合物，方法和装置。荧光纳米颗粒可以由包围生物相容的外壳如二氧化硅壳的荧光团芯形成。在一个实施方案中，荧光纳米颗粒可以被递送到组织以标记组织，使得能够识别和定位组织，和/或照亮组织周围的区域。在另一个实施方案中，荧光纳米颗粒可用于装置或植入物以将装置或植入物定位在体内，指示装置或植入物的取向，和/或照亮装置或植入物周围的区域。荧光纳米颗粒也可用于提供治疗效果。

35. 发明申请

US20080243106A1 DETACHABLE END EFFECTORS 有权
标题翻译：可分离的终端效应
公开(公告)号：US20080243106A1
公开(公告)日：2008-10-02
申请号：US11693976
申请日：2007-03-30
申请人： Jonathan A. Coe , James W. Voegele , Gary L. Long , Andrew M. Zwolinski , Kyle P. Moore , Robert P. Gill
发明人： Jonathan A. Coe , James W. Voegele , Gary L. Long , Andrew M. Zwolinski , Kyle P. Moore , Robert P. Gill
IPC分类号： A61B17/00
CPC分类号： A61B17/29 , A61B17/00 , A61B17/00234 , A61B2017/00473 , A61B2017/00477 , A61B2017/2931
摘要： Methods and devices are provided for performing various procedures using interchangeable end effectors. In general, the methods and devices allow a surgeon to remotely and selectively attach various interchangeable surgical end effectors to a shaft located within a patient's body, thus allowing the surgeon to perform various procedures without the need to remove the shaft from the patient's body. In an exemplary embodiment, multiple end effectors can be introduced into a body cavity. The end effectors can be disassociated or separate from one another such that they float within the body cavity. A distal end of a shaft can be positioned within the body cavity and it can be used to selectively engage one of the end effectors. In particular, the device can be configured to allow each end effector to be remotely attached and detached from the distal end of the shaft. For example, a surgeon can actuate an actuation mechanism on the proximal end of the shaft to mate one of the end effectors to the distal end of the shaft without assistance from other tools and devices. After use of the end effector, the end effector can be released and another end effector can be remotely attached to the distal end of the shaft.
摘要翻译：提供了用于使用可互换的末端执行器执行各种过程的方法和装置。通常，所述方法和装置允许外科医生远程地和选择性地将各种可互换的手术端部执行器附接到位于患者体内的轴，从而允许外科医生执行各种程序，而不需要从患者身体移除轴。在示例性实施例中，可以将多个端部执行器引入体腔中。末端执行器可以彼此分离或分离，使得它们在体腔内浮动。轴的远端可以定位在体腔内，并且其可以用于选择性地接合末端执行器中的一个。特别地，该装置可以构造成允许每个端部执行器远离该轴远端附接和分离。例如，外科医生可以致动在轴的近端上的致动机构，以便在其他工具和装置的帮助下将端部执行器中的一个配合到轴的远端。在使用末端执行器之后，端部执行器可以被释放，而另一端部执行器可以远程连接到轴的远端。

36. 发明授权

US08239007B2 Biocompatible nanoparticle compositions and methods 有权
标题翻译：生物相容性纳米颗粒组合物和方法
公开(公告)号：US08239007B2
公开(公告)日：2012-08-07
申请号：US11771384
申请日：2007-06-29
申请人： James W. Voegele , Robert P. Gill , Carl J. Shurtleff
发明人： James W. Voegele , Robert P. Gill , Carl J. Shurtleff
IPC分类号： A61B1/06
CPC分类号： A61K41/0052 , A61B1/043 , A61B1/3132 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/415 , A61B5/418 , A61K49/0017 , A61K49/0093
摘要： Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.
摘要翻译：提供使用可用作标记物，指示剂和光源的荧光纳米颗粒的各种组合物，方法和装置。荧光纳米颗粒可以由包围生物相容的外壳如二氧化硅壳的荧光团芯形成。在一个实施方案中，荧光纳米颗粒可以被递送到组织以标记组织，使得能够识别和定位组织，和/或照亮组织周围的区域。在另一个实施方案中，荧光纳米颗粒可用于装置或植入物以将装置或植入物定位在体内，指示装置或植入物的取向，和/或照亮装置或植入物周围的区域。荧光纳米颗粒也可用于提供治疗效果。

37. 发明申请

US20080319307A1 Method for medical imaging using fluorescent nanoparticles 审中-公开
标题翻译：使用荧光纳米粒子的医学成像方法
公开(公告)号：US20080319307A1
公开(公告)日：2008-12-25
申请号：US11820354
申请日：2007-06-19
申请人： James W. Voegele , Robert P. Gill
发明人： James W. Voegele , Robert P. Gill
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B6/032 , A61B6/037 , A61B6/481 , A61B6/485
摘要： A first method for medically imaging a patient includes obtaining a carrier medium containing fluorescent nanoparticles. The carrier medium containing the fluorescent nanoparticles is disposed inside the patient at a site where the carrier medium will migrate to specific tissue of known shape. The nanoparticles are activated to fluoresce. Image data of the patient is obtained including the specific tissue after the specific tissue has picked-up the fluorescing fluorescent nanoparticles. The known shape of the specific tissue is identified in the image data. An image representation of the image data is created using the identified known shape as a fiducial. An image of the image representation of the image data is displayed. In a second method, the carrier medium is injected inside tissue of the patient at a site where the carrier medium will be localized in the injected tissue, and the injecting deposits the medium in a predetermined shape in the tissue.
摘要翻译：用于医学成像患者的第一种方法包括获得含有荧光纳米颗粒的载体介质。含有荧光纳米颗粒的载体介质在载体介质将迁移到具有已知形状的特定组织的位置处置于患者体内。纳米颗粒被激活以发荧光。在特定组织拾取荧光荧光纳米颗粒后，获得包括特定组织的患者的图像数据。在图像数据中识别特定组织的已知形状。使用所识别的已知形状作为基准来创建图像数据的图像表示。显示图像数据的图像表示的图像。在第二种方法中，将载体介质注射到患者的组织内，在载体介质将被定位在注入的组织中的位置处，并且注射将培养基以预定形状沉积在组织中。

38. 发明申请

US20080255403A1 MAGNETIC NANOPARTICLE THERAPIES 审中-公开
标题翻译：磁性纳米治疗
公开(公告)号：US20080255403A1
公开(公告)日：2008-10-16
申请号：US11771399
申请日：2007-06-29
申请人： James W. Voegele , Robert P. Gill
发明人： James W. Voegele , Robert P. Gill
IPC分类号： A61N2/00
CPC分类号： A61K41/0052 , A61B1/043 , A61B1/3132 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/415 , A61B5/418 , A61K49/0017 , A61K49/0093
摘要： Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.
摘要翻译：提供使用可用作标记物，指示剂和光源的荧光纳米颗粒的各种组合物，方法和装置。荧光纳米颗粒可以由包围生物相容的外壳如二氧化硅壳的荧光团芯形成。在一个实施方案中，荧光纳米颗粒可以被递送到组织以标记组织，使得能够识别和定位组织，和/或照亮组织周围的区域。在另一个实施方案中，荧光纳米颗粒可用于装置或植入物以将装置或植入物定位在体内，指示装置或植入物的取向，和/或照亮装置或植入物周围的区域。荧光纳米颗粒也可用于提供治疗效果。

39. 发明申请

US20080114385A1 Method and Device for Effecting Anastomosis of Hollow Organ Structures Using Adhesive and Fasteners 有权
标题翻译：使用粘合剂和紧固件实现空心器官结构吻合的方法和装置
公开(公告)号：US20080114385A1
公开(公告)日：2008-05-15
申请号：US11558572
申请日：2006-11-10
申请人： Randal T. Byrum , Robert P. Gill , William D. Kelly , Ronald J. Kolata , Mark S. Ortiz , Frederick E. Shelton , Douglas J. Turner , James W. Voegele
发明人： Randal T. Byrum , Robert P. Gill , William D. Kelly , Ronald J. Kolata , Mark S. Ortiz , Frederick E. Shelton , Douglas J. Turner , James W. Voegele
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/1114 , A61B17/115 , A61B17/1155 , A61B17/1227 , A61B17/1285 , A61B2017/00004 , A61B2017/00893 , A61B2017/0641 , A61B2017/1107 , A61F2/0063 , A61F2/064
摘要： A method and devices for accomplishing the successful anastomosis of two hollow organ structures are disclosed. The method includes bringing the structures together, applying at least one fastener to hold the structures together and form a connection site, and applying, as alternatives or in conjunction, an adhesive, a wrap and/or a buttress about the connection site. Various examples of fasteners, fastener appliers, adhesives, adhesive initiators and buttress rings also are disclosed.
摘要翻译：公开了一种用于完成两个中空器官结构成功吻合的方法和装置。该方法包括将结构结合在一起，施加至少一个紧固件以将结构保持在一起并形成连接部位，并且作为替代或结合应用粘合剂，包裹和/或邻接连接部位的支撑。还公开了紧固件，紧固件施加器，粘合剂，粘合剂引发剂和支撑环的各种实例。

40. 发明申请

US20110040309A1 IMPLANTABLE RESTRICTION DEVICE WITH SPACER 审中-公开
标题翻译：带间隔的可植入限制装置
公开(公告)号：US20110040309A1
公开(公告)日：2011-02-17
申请号：US12541579
申请日：2009-08-14
申请人： Daniel F. Dlugos, JR. , Chad P. Boudreaux , Robert P. Gill , Steven G. Hall , Christopher J. Hess , Jerome R. Morgan , Frederick E. Shelton, IV , Jeffrey S. Swayze , Omar J. Vakharia , Lauren S. Weaner , William Bruce Weisenburgh, II , Andrew M. Zwolinski
发明人： Daniel F. Dlugos, JR. , Chad P. Boudreaux , Robert P. Gill , Steven G. Hall , Christopher J. Hess , Jerome R. Morgan , Frederick E. Shelton, IV , Jeffrey S. Swayze , Omar J. Vakharia , Lauren S. Weaner , William Bruce Weisenburgh, II , Andrew M. Zwolinski
IPC分类号： A61B17/00
CPC分类号： A61F5/005 , A61F5/0086
摘要： An implantable restriction device includes a belt and a balloon secured to the belt for engagement with tissue when the implantable restriction device is positioned about the stomach. A spacer is associated with the belt for maintaining the restriction device in a spaced relation with a staple line employed during gastric reduction surgery.
摘要翻译：植入式限制装置包括带和固定到带上的球囊，当可植入的限制装置围绕胃定位时，与球体接合。间隔件与带相关联，用于将限制装置与胃减压手术期间使用的缝合线保持间隔开。

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