专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US4818680A Method and kit involving displacement and rehybridization of labeled polynucleotide 失效
标题翻译：标记多核苷酸置换和再杂交的方法和试剂盒
公开(公告)号：US4818680A
公开(公告)日：1989-04-04
申请号：US811034
申请日：1985-12-18
申请人： Mary Collins , Joseph P. Dougherty , Marian S. Ellwood , Edward F. Fritsch , Kenneth A. Jacobs
发明人： Mary Collins , Joseph P. Dougherty , Marian S. Ellwood , Edward F. Fritsch , Kenneth A. Jacobs
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6876 , C12Q1/6813 , C12Q1/6823 , Y10S435/81
摘要： A diagnostic reagent is disclosed which is capable of binding to a target nucleotide sequence which is bound to a labeled polynucleotide in a target binding region which is at least partially co-extensive with the target binding region in the probe polynucleotide which is capable of binding to the target nucleotide sequence. A method is disclosed in which the reagent is contacted with a sample and with a capturing polynucleotide under conditions such that target nucleotide which may be present in the sample binds to the probe polynucleotide and displaces labeled polynucleotide from the reagent complex, and the capturing polynucleotide binds selectively to the displaced labeled polynucleotide in the region of the labeled polynucleotide that had been bound to the probe polynucleotide. Determination of the displaced nucleotide gives a value which is a function of the presence and concentration of target nucleotide in the sample.
摘要翻译：公开了一种诊断试剂，其能够结合靶向结合区域中的标记的多核苷酸的靶核苷酸序列，所述靶结合区域与探针多核苷酸中的靶结合区域至少部分共同扩增，所述靶结合区域能够结合靶核苷酸序列。公开了一种方法，其中试剂与样品和捕获多核苷酸在条件下接触，使得可能存在于样品中的靶核苷酸与探针多核苷酸结合并从试剂复合物置换标记的多核苷酸，并且捕获多核苷酸结合选择性地与已经与探针多核苷酸结合的标记的多核苷酸的区域中的置换的标记的多核苷酸。取代的核苷酸的测定给出一个值，该值是样品中靶核苷酸的存在和浓度的函数。

32. 发明授权

US4752566A Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide 失效
标题翻译：位移多核苷酸方法和使用标记的探针多核苷酸的试剂复合物
公开(公告)号：US4752566A
公开(公告)日：1988-06-21
申请号：US809992
申请日：1985-12-17
申请人： Mary Collins , Joseph P. Dougherty
发明人： Mary Collins , Joseph P. Dougherty
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6823 , C12Q1/6816 , C12Q1/6834
摘要： A method for determining the presence and amount of a predetermined target nucleotide sequence in a biological sample is provided. The method employs a reagent complex which consists of a labeled probe polynucleotide having a target binding region and a second polynucleotide bound to the labeled probe in a second polynucleotide binding region thereof. The second binding region is at least partially coextensive with the target binding region. This reagent complex is contacted with a sample under conditions in which the target sequence binds to the labeled probe, displacing the second polynucleotide. Labeled probe/target hybrids are separated from intact reagent complexes and the presence and amount of these hybrids are determined.
摘要翻译：提供了用于确定生物样品中预定靶核苷酸序列的存在和量的方法。该方法使用由具有靶结合区域的标记的探针多核苷酸和在其第二多核苷酸结合区域中与标记探针结合的第二多核苷酸组成的试剂复合物。第二结合区域与靶结合区域至少部分共延伸。在靶序列与标记的探针结合的条件下使该试剂复合物与样品接触，置换第二多核苷酸。将标记的探针/靶杂交体与完整的试剂配合物分离，并确定这些杂交体的存在和量。

33. 发明申请

US20210298393A1 Multi-Layer Antibacterial Glove 有权
公开(公告)号：US20210298393A1
公开(公告)日：2021-09-30
申请号：US16828125
申请日：2020-03-24
申请人： Mary Collins
发明人： Mary Collins
IPC分类号： A41D19/015 , A41D31/30 , A41D19/00
摘要： A multi-layer antibacterial glove for providing effective and fashionable protection against germs includes a glove body comprising an inner layer, a second layer, a third layer, and an outer layer. The inner layer is breathable and is configured to form fit a user's hand. The second layer is continuously disposed around the inner layer. The second layer is moisture-resistant. The third layer continuously disposed around the second layer and is antibacterial. The outer layer is continuously disposed around the third layer. The outer layer is a fashionable or functional glove material.

34. 发明申请

US20080221016A1 CD25+ DIFFERENTIAL MARKERS AND USES THEREOF 审中-公开
标题翻译： CD25 +差异标记及其用途
公开(公告)号：US20080221016A1
公开(公告)日：2008-09-11
申请号：US12023470
申请日：2008-01-31
申请人： Michael Chapman Byrne , Ethan Menahem Shevach , Mary Collins , Rebecca Suzanne McHugh , Matthew James Whitters , Deborah Ann Young
发明人： Michael Chapman Byrne , Ethan Menahem Shevach , Mary Collins , Rebecca Suzanne McHugh , Matthew James Whitters , Deborah Ann Young
IPC分类号： A61K38/00 , C12N5/06 , A61P37/00
CPC分类号： A61K38/16 , A61K2039/505 , C07K16/28 , C07K16/2878 , C07K2319/00 , C07K2319/30 , G01N33/6863 , G01N2333/715
摘要： The present invention is directed to methods and compositions for the identification of novel targets for diagnosis, prognosis, therapeutic intervention and prevention of autoimmune disorders, transplant rejection and cancer. In particular, the present invention is directed to the identification of novel targets which are CD25+ differential markers. The present invention is further directed to methods of high-throughput screening for test compounds capable of modulating the activity of proteins encoded by the novel targets. Moreover, the present invention is also directed to methods that can be used to assess the efficacy of test compounds and therapies for the ability to inhibit an autoimmune disorder or transplant rejection. Methods for determining the long term prognosis in a subject are also provided.
摘要翻译：本发明涉及用于鉴定用于诊断，预后，治疗干预和预防自身免疫疾病，移植排斥和癌症的新靶标的方法和组合物。特别地，本发明涉及鉴定CD25 + + / / - 差异标记物的新靶标。本发明还涉及能够调节由新靶标编码的蛋白质的活性的测试化合物的高通量筛选方法。此外，本发明还涉及可用于评估测试化合物和治疗对抑制自身免疫病症或移植排斥的能力的功效的方法。还提供了确定受试者长期预后的方法。

35. 发明授权

US07351585B2 Retroviral vector 有权
标题翻译：逆转录病毒载体
公开(公告)号：US07351585B2
公开(公告)日：2008-04-01
申请号：US10654537
申请日：2003-09-02
申请人： Kyriacos Mitrophanous , Mary Collins , Yasuhiro Takeuchi , Yasuhiro Ikeda
发明人： Kyriacos Mitrophanous , Mary Collins , Yasuhiro Takeuchi , Yasuhiro Ikeda
IPC分类号： C12N5/10 , C12N15/48 , C12N15/49 , C12N15/63 , C12N15/64 , C12N15/867 , A61K48/00
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N2740/13022 , C12N2740/13043 , C12N2740/16043
摘要： Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.
摘要翻译：本文提供了包含并能够表达目标核苷酸（NOI）的逆转录病毒载体，其中NOI编码对细胞有害的RNA或蛋白质。

36. 发明申请

US20060258006A1 Retroviral vector 有权
公开(公告)号：US20060258006A1
公开(公告)日：2006-11-16
申请号：US10654537
申请日：2003-09-02
申请人： Kyriacos Mitrophanous , Mary Collins , Yasuhiro Takeuchi , Yasuhiro Ikeda
发明人： Kyriacos Mitrophanous , Mary Collins , Yasuhiro Takeuchi , Yasuhiro Ikeda
IPC分类号： C12N15/867
CPC分类号： C12N15/86 , A61K35/13 , A61K48/00 , C12N2740/13022 , C12N2740/13043 , C12N2740/16043
摘要： Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.

37. 发明申请

US20060257416A1 Materials and methods for improved vaccination 审中-公开
标题翻译：改善疫苗接种的材料和方法
公开(公告)号：US20060257416A1
公开(公告)日：2006-11-16
申请号：US10560389
申请日：2004-06-14
申请人： J Palmowski , Lucien Lopes , Yasuhiro Ikeda , Vincenzo Cerundolo , Mary Collins
发明人： J Palmowski , Lucien Lopes , Yasuhiro Ikeda , Vincenzo Cerundolo , Mary Collins
IPC分类号： A61K39/00 , A61K39/38
CPC分类号： C12N15/86 , A61K2039/51 , A61K2039/5154 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N2740/16043
摘要： The invention relates to materials and methods for improved vaccination strategies and in particular to the use of lentivirus comprising nucleic acid encoding an antigen, or antigen presenting cells transduced with such lentivirus, to stimulate immune responses against the encoded antigen, in heterologous prime-boost vaccination regimes.
摘要翻译：本发明涉及用于改进疫苗接种策略的材料和方法，特别是涉及使用包含编码抗原的核酸的慢病毒的方法，或使用这种慢病毒转导的抗原呈递细胞，以异源初次加强免疫接种刺激针对所编码的抗原的免疫应答政权。

38. 发明申请

US20060257403A1 Methods for treating and preventing fibrosis 失效
标题翻译：治疗和预防纤维化的方法
公开(公告)号：US20060257403A1
公开(公告)日：2006-11-16
申请号：US11402885
申请日：2006-04-13
申请人： Deborah Young , Thomas Wynn , Mary Collins , Michael Grusby
发明人： Deborah Young , Thomas Wynn , Mary Collins , Michael Grusby
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： G01N33/6869 , A61K33/24 , A61K38/13 , A61K38/1793 , A61K38/20 , A61K45/06 , A61K2039/505 , C07K14/7155 , C07K16/244 , C07K16/2866 , C07K2319/30 , G01N2800/00 , Y02A50/423 , A61K2300/00
摘要： The present invention provides methods of screening for compositions useful for treating, ameliorating, or preventing fibrosis and/or fibrosis-associated conditions by measuring changes in the level(s) of IL-21 and/or IL-21 receptor (IL-21R) (e.g., the level of expression of IL-21 and/or IL-21R protein and/or mRNA, the level of activity of IL-21 and/or IL-21R, the level of interaction of IL-21 with IL-21R). The invention further provides antagonists of IL-21 or IL-21R for the treatment of fibrosis and/or fibrosis-associated conditions. Further provided herein are methods of diagnosing, prognosing, and monitoring the progress (e.g., the course of treatment) of fibrosis and/or fibrosis-associated conditions by measuring the level of IL-21 and/or IL-21R (i.e., the level of activity of IL-21 and/or IL-21R, the level of expression of IL-21 and/or IL-21R (e.g., the level of IL-21 and/or IL-21R gene products), and/or the level of interaction of IL-21 with IL-21R).
摘要翻译：本发明提供了通过测量IL-21和/或IL-21受体（IL-21R）水平的变化来筛选用于治疗，改善或预防纤维化和/或纤维化相关病症的组合物的方法，（例如，IL-21和/或IL-21R蛋白和/或mRNA的表达水平，IL-21和/或IL-21R的活性水平，IL-21与IL-21R的相互作用水平）。本发明还提供了用于治疗纤维化和/或纤维化相关病症的IL-21或IL-21R拮抗剂。本文还提供了通过测量IL-21和/或IL-21R的水平来诊断，预测和监测纤维化和/或纤维化相关病症的进展（例如，治疗过程）的方法（即，水平的IL-21和/或IL-21R的活性，IL-21和/或IL-21R的表达水平（例如IL-21和/或IL-21R基因产物的水平）和/或 IL-21与IL-21R的相互作用水平）。

39. 发明授权

US07025899B2 Concentrated solutions of oxime metal extractants and method of formulating extractant compositions therefrom 有权
公开(公告)号：US07025899B2
公开(公告)日：2006-04-11
申请号：US10029612
申请日：2001-12-21
申请人： R. Brantley Sudderth , George A. Wolfe , Ralph L. Jensen , Gary A. Kordosky , Michael J. Virnig , Mary Collins , Stephen M. Olafson , Terry L. Crandell , Hans C. Hein
发明人： R. Brantley Sudderth , George A. Wolfe , Ralph L. Jensen , Gary A. Kordosky , Michael J. Virnig , Mary Collins , Stephen M. Olafson , Terry L. Crandell , Hans C. Hein
IPC分类号： C09K3/00 , C01B31/16 , B01D11/04 , C02F1/26
CPC分类号： C01G3/003 , C22B3/0017 , Y02P10/234
摘要： The preparation of concentrated solutions of oxime metal extractants, such as aldoximes and ketoximes, or mixtures of aldoxime and ketoxime, and the use thereof in formulating or preparing extraction reagent compositions for use in an extractant organic phase in a process of extracting metals from aqueous solutions containing metal values; and in particular, to concentrates which are solutions of individual ketoxime or aldoxime or mixtures of water-insoluble hydroxy aldoximes and ketoximes, in varying ratios by weight of 1:100 aldoxime to ketoxime, or conversely, 100:1 ketoxime to aldoxime, in water-immiscible hydrocarbon solvents or equilibrium modifiers. The invention also provides for maintaining stability of concentrates determined by accelerating rate calorimetry to define the ranges of oxime concentration and volume whereby the concentrate will be a stable, flowable, pourable and pumpable concentrate which can be safely stored long term. The extraction compositions may also optionally contain equilibrium modifiers or kinetic additives.

40. 发明授权

US06913747B1 Humanized immunoglobulin reactive with B7 therewith 失效
标题翻译：与B7反应的人源化免疫球蛋白
公开(公告)号：US06913747B1
公开(公告)日：2005-07-05
申请号：US09339596
申请日：1999-06-24
申请人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
发明人： Man Sung Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Cheryl Celniker , Mary Collins , Samuel Goldman , Gary S. Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida M. Veldman
IPC分类号： A61K39/395 , C07K16/28 , C12N15/13 , C12N15/63
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译：本发明涉及人源化抗B7-2和抗B7-1抗体，其中每个包含非人源可变区和至少一部分人源免疫球蛋白。本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式