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31. 发明授权

US06402961B1 Process for preparing epoxysilanes 有权
标题翻译：制备环氧硅烷的方法
公开(公告)号：US06402961B1
公开(公告)日：2002-06-11
申请号：US09621076
申请日：2000-07-21
申请人： Stefan Bade , Uwe Schoen , Hartwig Rauleder
发明人： Stefan Bade , Uwe Schoen , Hartwig Rauleder
IPC分类号： B01D1508
CPC分类号： C07F7/1892
摘要： A process for preparing epoxysilanes by reacting a hydrogensilane with an allyl glycidyl ether in the presence of a catalyst and working up the crude product obtained, where the catalyst is removed from the crude product and the crude product is subsequently distilled.
摘要翻译：一种通过在催化剂存在下使氢硅烷与烯丙基缩水甘油醚反应来制备环氧硅烷的方法，并处理所得到的粗产物，其中从粗产物中除去催化剂和粗产物。

32. 发明授权

US06242630B1 Process for the continuous preparation of 3-halopropylorganosilanes 失效
标题翻译：连续制备3-卤代丙基有机硅烷的方法
公开(公告)号：US06242630B1
公开(公告)日：2001-06-05
申请号：US08908095
申请日：1997-08-11
申请人： Stefan Bade , Uwe Schoen , John Burkhard , Franz-Michael Bollenrath , Norbert Hofmann , Hermann-Josef Korte , Hartwig Rauleder , Uwe Tanger
发明人： Stefan Bade , Uwe Schoen , John Burkhard , Franz-Michael Bollenrath , Norbert Hofmann , Hermann-Josef Korte , Hartwig Rauleder , Uwe Tanger
IPC分类号： C07F708
CPC分类号： C07F7/14 , C07F7/0829 , C07F7/1876
摘要： A process for the continuous preparation of 3-halopropylorganosilanes of the general structure RbH3-a-bXaSiCH2CH2CH2Y (III), where: R is CH3, C2H5, C3H7, OCH3, OC2H5 or OC3H7, X is F, Cl, Br or I, Y is F, Cl, Br or I, and a and b are each one of the numbers 0, 1, 2 or 3 and the sum a+b is 1, 2 or 3, comprising reacting, as starting materials, an allyl halide with a silane carrying at least one H atom, wherein the starting materials are present in stoichiometric amounts or one of the starting materials is present in substoichiometric amounts, wherein the reaction carried out is a partial reaction of from 10% to 80%, on a molar basis, of the starting materials, based on either material, when both are present in stoichiometric amounts, or based on the substoichiometric material.
摘要翻译：连续制备通常结构的3-卤代丙基有机硅烷的方法，其中R为CH 3，C 2 H 5，C 3 H 7，OCH 3，OC 2 H 5或OC 3 H 7，X为F，Cl，Br或I，Y为F，Cl，Br或I，和b分别为数字0,1,2或3中的一个，并且和a + b为1,2或3，包括使烯丙基卤化物与携带至少一个H原子的硅烷作为原料，其中，原料以化学计量的量存在，或者一种起始原料以亚化学计量的量存在，其中进行的反应是基于摩尔的10％至80％的起始原料的部分反应，基于任一材料，当两者都以化学计量的量存在时，或基于亚化学计量的材料。

33. 发明授权

US5635511A Treatment of heart rhythm disorders by administration of 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds. 失效
标题翻译：通过给予3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗心律紊乱。
公开(公告)号：US5635511A
公开(公告)日：1997-06-03
申请号：US594946
申请日：1996-01-31
申请人： Uwe Schoen , Arman Farjam , Reinhard Brueckner , Dieter Ziegler
发明人： Uwe Schoen , Arman Farjam , Reinhard Brueckner , Dieter Ziegler
IPC分类号： A61K31/435 , A61K31/439 , A61K31/445 , A61P9/00 , A61P9/06 , C07D471/08 , C07D471/10 , A61K31/44
CPC分类号： C07D471/08 , C07D471/10
摘要： The use of 3,7,9,9-tetrasubstituted 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds for treating cardiac arrhytmias in larger mammals, including humans; novel antiarrhythmically active 3,7,9,9-tetrasubstituted compounds corresponding to the general formula Ia ##STR1## in which R.sup.1 is an alkyl group having 1-6 carbon atoms or a cycloalkylalkyl group having 4-7 carbon atoms,R.sup.2 is lower alkyl, andR.sup.3 is lower alkyl, orR.sup.2 and R.sup.3 together form an alkylene chain having 3-6 carbon atoms,R.sup.4' is cyano, an R.sup.6 --O--CO-- group in which R.sup.6 is lower alkyl, an R.sup.7 --SO.sub.2 --NH-- group in which R.sup.7 is lower alkyl, or an R.sup.8 --CO--NH-- group in which R.sup.8 is lower alkyl or a phenyl group which is optionally substituted by halogen, cyano, nitro, or an R.sup.9 --SO.sub.2 -- radical in which R.sup.9 is lower alkyl, or an imidazolyl radical located in position 4 of the phenyl ring, andR.sup.5 is hydrogen or halogen,and physiologically acceptable acid addition salts thereof, and processes and intermediates for preparing them.
摘要翻译：使用3,7,9,9-四取代的3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗大型哺乳动物，包括人类的心脏病变; 对应于其中R 1为具有1-6个碳原子的烷基或具有4-7个碳原子的环烷基烷基的通式Ia Ia的新型抗心律失活的3,7,9,9-四取代化合物，R2较低烷基，R3为低级烷基，或R2和R3一起形成3-6个碳原子的亚烷基链，R4'为氰基，R6为低级烷基的R6-O-CO-基团，R7-SO2-NH - 其中R 7为低级烷基的基团，或其中R 8为低级烷基的R 8 -CO-NH基或任选被卤素，氰基，硝基或R 9 -SO 2 - 基团取代的苯基，其中R 9为低级烷基或位于苯环4位的咪唑基，R5为氢或卤素，以及其生理上可接受的酸加成盐，以及制备它们的方法和中间体。

34. 发明授权

US5576327A Treatment of heart rhythym disorders by administration of 3-phenylsulfonyl-3, 7-diazabicyclo[3.3.1]nonane compounds 失效
标题翻译：通过给予3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗心律失调症
公开(公告)号：US5576327A
公开(公告)日：1996-11-19
申请号：US382262
申请日：1995-02-01
申请人： Uwe Schoen , Arman Farjam , Reinhard Brueckner , Dieter Ziegler
发明人： Uwe Schoen , Arman Farjam , Reinhard Brueckner , Dieter Ziegler
IPC分类号： A61K31/435 , A61K31/439 , A61K31/445 , A61P9/00 , A61P9/06 , C07D471/08 , C07D471/10
CPC分类号： C07D471/08 , C07D471/10
摘要： The use of 3,7,9,9-tetrasubstituted 3-phenylsulfonyl-3,7-diazabicyclo[3.3.1]nonane compounds for treating cardiac arrhythmias in larger mammals, including humans; novel antiarrhythmically active 3,7,9,9-tetrasubstituted compounds corresponding to the general formula Ia ##STR1## in which R.sup.1 is an alkyl group having 1-6 carbon atoms or a cycloalkylalkyl group having 4-7 carbon atoms,R.sup.2 is lower alkyl, andR.sup.3 is lower alkyl, orR.sup.2 and R.sup.3 together form an alkylene chain having 3-6 carbon atoms,R.sup.4 ' is cyano, an R.sup.6 --O--CO-- group in which R.sup.6 is lower alkyl, an R.sup.7 --SO.sub.2 --NH-- group in which R.sup.7 is lower alkyl, or an R.sup.8 --CO--NH-- group in which R.sup.8 is lower alkyl or a phenyl group which is optionally substituted by halogen, cyano, nitro or an R.sup.9 --SO.sub.2 -- radical in which R.sup.9 is lower alkyl, or an imidazolyl radical located in position 4 of the phenyl ring, andR.sup.5 is hydrogen or halogen,and physiologically acceptable acid addition salts thereof, and processes and intermediates for preparing them.
摘要翻译：使用3,7,9,9-四取代的3-苯基磺酰基-3,7-二氮杂双环[3.3.1]壬烷化合物治疗大型哺乳动物，包括人类的心律失常; 对应于其中R 1为具有1-6个碳原子的烷基或具有4-7个碳原子的环烷基烷基的通式Ia Ia的新型抗心律失活的3,7,9,9-四取代化合物，R2较低烷基，R3为低级烷基，或R2和R3一起形成3-6个碳原子的亚烷基链，R4'为氰基，R6为低级烷基的R6-O-CO-基团，R7-SO2-NH - 其中R 7为低级烷基的基团，或其中R 8为低级烷基的R 8 -CO-NH-基团或任选被卤素，氰基，硝基或R 9 -SO 2 - 基团取代的苯基，其中R 9为低级烷基或位于苯环4位的咪唑基，R5为氢或卤素，以及其生理上可接受的酸加成盐，以及其制备方法和中间体。

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