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31. 发明授权

US4260751A Pyrazolo [1,2-a][1,2,4] benzotriazines 失效
标题翻译：吡唑并[1,2-a] [1,2,4]苯并三嗪
公开(公告)号：US4260751A
公开(公告)日：1981-04-07
申请号：US144482
申请日：1980-04-28
申请人： Uwe D. Treuner
发明人： Uwe D. Treuner
IPC分类号： A61K31/53 , A61P29/00 , C07D487/04
CPC分类号： C07D487/04
摘要： Pyrazolo[1,2-a][1,2,4] benzotriazines having the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, nitro, amino, lower alkylamino, di(lower alkyl)amino, --SR.sub.4, --OR.sub.4 or halogen;R.sub.2 is hydrogen, lower alkyl or aralkyl;R.sub.3 is hydrogen, lower alkyl or a salt forming ion;R.sub.4 is hydrogen or lower alkyl; and Y is oxygen or sulfur.The compounds are useful as intermediates and as antiinflammatory agents.
摘要翻译：其中R 1为氢，低级烷基，硝基，氨基，低级烷基氨基，二（低级烷基）氨基，-SR 4，-OR 4或 - 或具有下式的吡唑并〔1,2-a〕〔1,2,4〕苯并三嗪卤素; R2是氢，低级烷基或芳烷基; R3是氢，低级烷基或形成盐的离子; R4是氢或低级烷基; Y是氧或硫。该化合物可用作中间体和抗炎剂。

32. 发明授权

US4169947A 7.beta.-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins 失效
标题翻译： 7B - （（（（2-氨基亚氨基）-1,2-二氧代乙基）氨基）乙酰氯化物
公开(公告)号：US4169947A
公开(公告)日：1979-10-02
申请号：US910548
申请日：1978-05-30
申请人： Uwe D. Treuner , Hermann Breuer
发明人： Uwe D. Treuner , Hermann Breuer
IPC分类号： C07D307/68 , C07D501/20 , C07D501/36 , C07D501/22 , C07D501/34 , C07D501/46
CPC分类号： C07D307/68
摘要： 7.beta.-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.4 is lower alkyl, cycloalkyl, phenyl, substituted phenyl or certain heterocyclic groups; and X is hydrogen, lower alkanoyloxy, carbamoyloxy, lower alkoxy, lower alkylthio, ##STR2## or certain heterothio groups, are useful as antibacterial agents.

33. 发明授权

US4168266A 6-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]-amino]acyl penicillins 失效
标题翻译： 6- {8 {8（8-氰基甲基）氨基{9-1,2-二氧代乙基{9-氨基{9酰基青霉素
公开(公告)号：US4168266A
公开(公告)日：1979-09-18
申请号：US910546
申请日：1978-05-30
申请人： Uwe D. Treuner , Hermann Breuer
发明人： Uwe D. Treuner , Hermann Breuer
IPC分类号： C07D333/24 , C07D499/00 , C07D499/64 , C07D499/66 , C07D499/68 , C07D499/70
CPC分类号： C07C255/00 , C07D333/24 , C07D499/00
摘要： 6-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]acyl pencillins which have the formula ##STR1## wherein R is hydrogen, lower alkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl or cycloalkyl; and R.sub.4 and R.sub.5 each is hydrogen or lower alkyl, are useful as antibacterial agents.
摘要翻译：具有式“IMAGE”的6 - [[（2-氰基甲基）氨基] -1,2-二氧代乙基]氨基]酰基青霉素，其中R是氢，低级烷基，三（低级烷基）甲硅烷基，三（低级烷基）甲锡烷基，三卤代乙基或成盐离子; R 1是氢，低级烷基，饱和或不饱和环烷基，苯基，苯基 - 低级烷基，取代的苯基或某些杂环基; R2是氢或甲氧基; R3是氢，低级烷基，苯基 - 低级烷基或环烷基; 并且R 4和R 5各自为氢或低级烷基，可用作抗菌剂。

34. 发明授权

US4124764A Meso-ionic didehydro derivatives of 1,7-dehydro-1-substituted-3H-pyrazolo[4,]-1,2,4-triazolo[4,3-c]pyrimidin e-3-thiones and 3-ones 失效
标题翻译： 1,7-脱氢-1-取代-3H-吡唑并[8,4-e {9 -1,2,4-三唑并[8,3,3-c {9嘧啶-3-硫杂的间 - 离子二脱水衍生物和3 -
公开(公告)号：US4124764A
公开(公告)日：1978-11-07
申请号：US833103
申请日：1977-09-13
申请人： Uwe D. Treuner , Hermann Breuer
发明人： Uwe D. Treuner , Hermann Breuer
IPC分类号： A61K31/505 , A61K31/535 , A61P29/00 , C07D231/38 , C07D487/04 , C07D487/14
CPC分类号： C07D231/38 , C07D487/04 , C07D487/14 , Y10S514/87
摘要： New 1,7-dihydro-1-substituted-3H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidine-3-thione and 3-one mesoionic didehydro derivatives which have the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, phenyl-lower alkyl, cycloalkyl or hydroxy-lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is lower alkyl, cycloalkyl or hydroxy-lower alkyl; andX is sulfur or oxygen,Are useful as anti-inflammatory agents.
摘要翻译：新的1,7-二氢-1-取代-3H-吡唑并[4,3-e] -1,2,4-三唑并[4,3-c]吡啶-3-硫酮和3-酮中间偶氮二氢衍生物，其中具有下式的化合物，其中R 1是氢，低级烷基，苯基 - 低级烷基，环烷基或羟基 - 低级烷基; R2是氢或低级烷基; R3是低级烷基，环烷基或羟基 - 低级烷基; X是硫或氧，有用作抗炎剂。

35. 发明授权

US4097670A Carboxyalkylureido cephalosporins 失效
标题翻译：羧甲基脲基头孢菌素
公开(公告)号：US4097670A
公开(公告)日：1978-06-27
申请号：US673222
申请日：1976-04-05
申请人： Hermann Breuer , Uwe D. Treuner
发明人： Hermann Breuer , Uwe D. Treuner
IPC分类号： C07D333/24 , C07D501/36
CPC分类号： C07C265/00 , C07D333/24
摘要： Carboxyalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R.sub.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, diphenyl-lower alkyl, alkali metal ion or alkaline earth metal ion; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are disclosed. These compounds are useful as antibacterial agents.
摘要翻译：其中R为氢，低级烷基，苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤代乙基，成盐离子或基团R 1的羧基烷基脲基头孢菌素为其中R为氢，甲氧基 A是1至6个碳的直链或支链亚烷基; R2是氢，低级烷基，苯基，苯基 - 低级烷基，二苯基 - 低级烷基，碱金属离子或碱土金属离子; R3是氢或低级烷基; R4是氢，低级烷基，环烷基，环烯基，环链二烯基，苯基，苯基 - 低级烷基，取代的苯基，取代的苯基 - 低级烷基或某些杂环基; R5是氢或低级烷基; R6是低级烷基; X是氢，低级烷酰氧基，或者某些杂硫基; 被披露。这些化合物可用作抗菌剂。

36. 发明授权

US4091212A Hydrazinocarbonylamino cephalosporins 3-heterocyclicthio 7-hydrazinocarbonylamino acetylamino cephalosporins 失效
标题翻译：肼基羰基氨基头孢菌素3-杂环硫代7-肼基羰基氨基乙酰氨基头孢菌素
公开(公告)号：US4091212A
公开(公告)日：1978-05-23
申请号：US745156
申请日：1976-11-26
申请人： Hermann Breuer , Uwe D. Treuner
发明人： Hermann Breuer , Uwe D. Treuner
IPC分类号： C07D333/24 , C07D501/20 , C07D501/36
CPC分类号： C07D333/24
摘要： New .alpha.-hydrazinocarbonylamino cephalosporins which have the formula ##STR1## are useful as antimicrobial agents.
摘要翻译：具有式“IMAGE”的新的α-肼基羰基氨基头孢菌素可用作抗微生物剂。

37. 发明授权

US4038271A [[[(2,4-Dioxo-1-imidazolidinyl)amino]-carbonyl]amino]acetylpenicillin derivatives 失效
标题翻译：（+8（（2,4-二氧代-1-咪唑啉基）氨基） - 氨基）氨基）乙酰苯胺衍生物
公开(公告)号：US4038271A
公开(公告)日：1977-07-26
申请号：US740163
申请日：1976-11-08
申请人： Hermann Breuer , Uwe D. Treuner
发明人： Hermann Breuer , Uwe D. Treuner
IPC分类号： C07D233/88 , C07D499/00 , C07D499/64 , C07D499/66 , C07D499/68 , C07D499/70
CPC分类号： C07D233/88 , C07D499/00
摘要： [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylpenicillin derivatives of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; R.sub.2, R.sub.3 and R.sub.5 each are independently selected from hydrogen and lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.6 is lower alkyl; are disclosed. These compounds are useful as antibacterial agents.

38. 发明授权

US4024135A (Carbamoyl)pyridino derivatives of ureidocephalosporins 失效
标题翻译：（氨基甲酰基）吡啶衍生物脲基头孢菌素
公开(公告)号：US4024135A
公开(公告)日：1977-05-17
申请号：US664335
申请日：1976-03-05
申请人： Hermann Breuer , Uwe D. Treuner
发明人： Hermann Breuer , Uwe D. Treuner
IPC分类号： C07D333/24 , C07D501/38 , C07D501/44
CPC分类号： C07D333/24
摘要： Ureido cephalosporin derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen or methoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl; or certain heterocyclic groups; are disclosed. These compounds are useful as antibacterial agents.
摘要翻译：其中R1是氢或甲氧基的式（Ⅰ）所示的脲基头孢菌素衍生物; R2是氢或低级烷基; R3是氢，低级烷基，环烷基，环烯基，环链二烯基，苯基，苯基 - 低级烷基，取代的苯基，取代的苯基 - 低级烷基; 或某些杂环基团; 被披露。这些化合物可用作抗菌剂。

39. 发明授权

US3996219A 3-Heterothio derivatives of (.alpha.-thiocarbonylamino) cephalosporins 失效
标题翻译：（{ - 硫代羰基氨基）头孢菌素的3-异硫脲衍生物
公开(公告)号：US3996219A
公开(公告)日：1976-12-07
申请号：US581446
申请日：1975-05-28
申请人： Hermann Breuer , Uwe D. Treuner
发明人： Hermann Breuer , Uwe D. Treuner
IPC分类号： C07D333/24 , C07D501/36 , C07D501/22 , C07D501/24
CPC分类号： C07D333/24
摘要： 3-Heterothio(.alpha.-thiocarbonylamino)cephalosporin derivatives of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R.sub.2 and R.sub.5 each is hydrogen or lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.
摘要翻译：其中R为氢，低级烷基，苯基 - 低级烷基，三（低级烷基）甲硅烷基，三卤代乙基，形成成盐离子或基团的3-异硫代（α-硫代羰基氨基）头孢菌素衍生物是氢，低级烷基，环低级烷基，不饱和环 - 低级烷基，苯基，取代的苯基或噻吩基; R2和R5各自为氢或低级烷基; R3是五或六元氮，硫和/或含氧环系; 和R4是低级烷基，苯基或苯基 - 低级烷基; 作为抗菌剂是有用的。

40. 发明授权

US3994893A 4-Amino derivatives of pyrozolo[1,5-a]quinoxaline-3-carboxylic acid and esters 失效
标题翻译：吡咯并[8，1,5-a {9喹喔啉-3-羧酸和酯的4-氨基衍生物
公开(公告)号：US3994893A
公开(公告)日：1976-11-30
申请号：US628277
申请日：1975-11-03
申请人： Uwe D. Treuner
发明人： Uwe D. Treuner
IPC分类号： A61K31/495 , A61K31/535 , A61P29/00 , C07D231/14 , C07D487/04
CPC分类号： C07D487/04 , C07D231/14
摘要： New 4-amino derivatives of pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, esters and their salts have the formula ##SPC1##R.sub.1 is hydrogen, lower alkyl or a salt forming ion;R.sub.2 and R.sub.3 each is hydrogen, lower alkyl, cyclolower alkyl, phenyl, substituted phenyl, phenyl-lower alkylene, di-lower alkylamino-lower alkylene or R.sub.2 and R.sub.3 together with the nitrogen form an unsubstituted or substituted 5- or 6-membered nitrogen heterocyclic in which an additional nitrogen or oxygen may be present.R.sub.4 is hydrogen, lower alkyl or halogen.The new compounds are useful as anti-inflammatory agents.
摘要翻译：吡唑并[1,5-a]喹喔啉-3-羧酸的新4-氨基衍生物，酯及其盐具有式+ q，10 R1是氢，低级烷基或形成盐的离子; R 2和R 3各自为氢，低级烷基，环己烷基，苯基，取代的苯基，苯基 - 低级亚烷基，二低级烷基氨基 - 低级亚烷基或R 2和R 3与氮一起形成未取代或取代的5-或6-元氮可以存在另外的氮或氧的杂环。

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