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31. 发明专利

AU2020201457A1 Compositions and methods for managing or improving bone disorders, cartilage disorders, or both 未知
公开(公告)号：AU2020201457A1
公开(公告)日：2020-03-19
申请号：AU2020201457
申请日：2020-02-28
申请人： UNIGEN INC , UNIGEN INC
发明人： BROWNELL LIDIA ALFARO , CHU MIN , HONG MEI-FENG , HYUN EU-JIN , JIA QI , JIAO PING , KIM HYUN-JIN , KIM TAE-WOO , LEE YOUNG-CHUL , NAM JEONG-BUM , YIMAN MESFIN , KIM MI-RAN
IPC分类号： A61K36/605 , A61K31/352 , A61K31/7034 , A61K36/48 , A61P19/00
摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.

32. 发明专利

AU2014281781B2 Compositions and methods for joint health 未知
公开(公告)号：AU2014281781B2
公开(公告)日：2018-11-29
申请号：AU2014281781
申请日：2014-06-16
申请人： UNIGEN INC , UNIGEN INC
发明人： BROWNELL LIDIA ALFARO , CHU MIN , HONG MEI-FENG , HYUN EU-JIN , JIA QI , JIAO PING , KIM HYUN-JIN , KIM MI-RAN , KIM TAE-WOO , LEE BO-SU , LEE YOUNG-CHUL , MOORE BREANNA , NAM JEONG-BUM , OH MI-SUN , PARK MI-HYE , YIMAM MESFIN , ZHANG QIAN
IPC分类号： C07K14/415 , A61K36/48 , A61K36/605 , A61P19/02 , C07H15/20
摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

33. 发明专利

HK1245654A1 用於控制體重的組合物和方法未知
公开(公告)号：HK1245654A1
公开(公告)日：2018-08-31
申请号：HK18105239
申请日：2018-04-23
申请人： UNIGEN INC , UNIGEN INC
发明人： BROWNELL LIDIA ALFARO , CHOI BYONG-IL , CORNELIUSEN BRANDON , HONG MEI-FENG , HYUN EU-JIN , JIA QI , JIAO PING , KIM HYUN-JIN , KIM MI-RAN , KIM TAE-WOO , LEE BO-SU , LEE YOUNG-CHUL , NAM JEONG-BUM , YIMAM MESFIN , HWANG JI-HYE , OH MI-SUN
IPC分类号： A61K20060101 , A61P20060101

34. 发明专利

CA3025292A1 COMPOSITIONS AND METHODS FOR MANAGING OR IMPROVING BONE DISORDERS, CARTILAGE DISORDERS, OR BOTH 未知
公开(公告)号：CA3025292A1
公开(公告)日：2015-12-23
申请号：CA3025292
申请日：2015-06-16
申请人： UNIGEN INC , UNIGEN INC
发明人： BROWNELL LIDIA ALFARO , CHU MIN , HONG MEI-FENG , HYUN EU-JIN , JIA QI , JIAO PING , KIM HYUN-JIN , YIMAM MESFIN , NAM JEONG-BUM , LEE YOUNG-CHUL , KIM TAE-WOO , KIM MI-RAN
IPC分类号： A61K36/74 , A61K36/605 , A61P19/00 , A61P19/08
摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.

35. 发明公开

EP3010928A4 COMPOSITIONS AND METHODS FOR JOINT HEALTH 审中-公开
标题翻译：新泽西州维吾尔文森林保护区
公开(公告)号：EP3010928A4
公开(公告)日：2017-01-04
申请号：EP14813460
申请日：2014-06-16
申请人： UNIGEN INC , UNIGEN INC
发明人： BROWNELL LIDIA ALFARO , CHU MIN , HONG MEI-FENG , HYUN EU-JIN , JIA QI , JIAO PING , KIM HYUN-JIN , KIM MI-RAN , KIM TAE-WOO , LEE BO-SU , LEE YOUNG-CHUL , MOORE BREANNA , NAM JEONG-BUM , OH MI-SUN , PARK MI-HYE , YIMAM MESFIN , ZHANG QIAN
IPC分类号： C07H15/20 , A61K31/05 , A61K31/352 , A61K31/353 , A61K31/7008 , A61K31/7028 , A61K31/7034 , A61K36/48 , A61K36/534 , A61K36/605 , A61P19/00 , A61P19/02 , C07K14/415
CPC分类号： A61K36/605 , A61K31/05 , A61K31/352 , A61K31/353 , A61K31/7008 , A61K31/7028 , A61K31/7034 , A61K36/48 , A61K36/534 , A61K2300/00
摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.
摘要翻译：本公开提供了异戊烯酮化黄酮，二苯乙烯或二者与黄烷或姜黄素或两者能够调节关节炎症，关节疼痛，关节僵硬，软骨降解或改善移动性，运动范围，柔韧性，关节物理功能或任何其组合。异构乙烯基化黄酮，二苯乙烯或二者与黄烷或姜黄素或二者的这种混合物可以任选地与其它联合管理剂，例如非甾体抗炎剂/止痛剂，COX / LOX抑制剂，葡糖胺化合物，神经性疼痛缓解剂等。

36. 发明申请

WO2017083363A9 NATURAL PRESERVATIVES AND ANTIMICROBIAL AGENTS, INCLUDING COMPOSITIONS THEREOF 审中-公开
标题翻译：天然防腐剂和抗微生物剂，包括其组合物
公开(公告)号：WO2017083363A9
公开(公告)日：2017-07-13
申请号：PCT/US2016061102
申请日：2016-11-09
申请人： UNIGEN INC
发明人： JIAO PING , JIA QI , HONG MEI FENG , KIM MISUN
IPC分类号： A61K36/575 , A23L3/3472 , A61K8/97 , A61K36/48 , A61Q17/00
CPC分类号： A61K47/46 , A23L3/3472 , A23L33/105 , A23V2002/00 , A61K8/922 , A61K8/97 , A61K36/48 , A61K36/575 , A61Q17/005 , A61Q19/00 , A61K2300/00
摘要： Compositions are disclosed herein that comprise a mixture of at least one Albizia extract and a Magnolia extract. In some embodiments, the composition comprises a mixture of at least one Albizia extract enriched for one or more macrocyclic alkaloids and at least one Magnolia extract enrich for one or more lignans.
摘要翻译：本文公开了包含至少一种合欢花提取物和木兰提取物的混合物的组合物。在一些实施方案中，组合物包含至少一种富含一种或多种大环生物碱的合欢extract提取物和至少一种厚朴提取物的混合物，其富含一种或多种木脂素。

37. 发明申请

WO2012106551A1 BAKUCHIOL COMPOSITIONS FOR TREATMENT OF POST INFLAMMATORY HYPERPIGMENTATION 审中-公开
标题翻译：用于治疗后炎症反应的苦瓜组合物
公开(公告)号：WO2012106551A1
公开(公告)日：2012-08-09
申请号：PCT/US2012023686
申请日：2012-02-02
申请人： UNIGEN INC , HONG MEI FENG , JIA QI , BROWNELL LIDIA ALFARO
发明人： HONG MEI FENG , JIA QI , BROWNELL LIDIA ALFARO
IPC分类号： A61K31/05 , A61K31/60 , A61P17/00 , A61P29/00
CPC分类号： A61K31/05 , A61K8/347 , A61K31/60 , A61K2800/30 , A61Q19/02
摘要： Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.
摘要翻译：公开了治疗过度色素沉着的方法，包括治疗炎症后色素沉着过度（PIH）。所公开的方法包括向哺乳动物施用包含基本上不含呋喃香豆素的苯醚酚的组合物。还公开了包含bakuchiol的组合物及其制备方法。

38. 发明专利

ES2405773T3 Cromonas como agentes terapéuticos 未知
公开(公告)号：ES2405773T3
公开(公告)日：2013-06-03
申请号：ES08713667
申请日：2008-01-09
申请人： UNIGEN INC
发明人： ZHAO JI-FU , TSENG-CRANK JULIE , YIMAM MESFIN , JIA QI
IPC分类号： A61K31/35
摘要： Una cromona o una mezcla de cromonas para uso en el tratamiento de una enfermedad seleccionada de resistencia a la insulina, intolerancia a la glucosa, hiperglucemia, síndromes metabólicos, dislipidemia e hipertrigliceridemia, en donde dicha cromona o una mezcla de cromonas se selecciona del grupo de compuestos que tienen la estructura: en donde R1, R2, R3, R4, R5 y R6 se seleccionan independientemente del grupo constituido por -H, -OH, -CH3, -SH, alquilo, alquenilo, oxoalquilo, oxoalquenilo, hidroxialquilo, hidroxilalquenilo, -OCH3, -SCH3, -OR, -SR, -NH2, -NRH, -NR2, -NR3+X-, un éster seleccionado del grupo constituido por galato, acetato, ésteres de cinnamoílo y de hidroxil-cinnamoílo, ésteres de trihidroxibenzoílo y ésteres de cafeoílo; y una hexosa o pentosa, en donde dicha hexosa o pentosa está unida a la cromona mediante un carbono, nitrógeno, azufre u oxígeno y en donde dicha hexosa o pentosa se selecciona del grupo constituido por aldopentosas, metil-aldopentosa, aldohexosas, cetohexosa y los derivados químicos de los mismos, incluidos un dímero, un trímero y otras cromonas polimerizadas; en donde dicho grupo alquilo y/o alquenilo es una cadena lineal y/o ramificada que tiene entre 1-20 átomos de carbono con y/o sin dobles enlaces y un grupo o grupos de sustitución seleccionados del grupo constituido por -OH, >=O y -OR en diferentes posiciones; X se selecciona del grupo de contraaniones farmacéuticamente aceptables que incluye hidroxilo, cloruro, yoduro, sulfato, fosfato, acetato, fluoruro, carbonato; y R es un grupo alquilo que tiene entre 1-20 átomos de carbono.

39. 发明专利

CA2826262A1 BAKUCHIOL COMPOSITIONS FOR TREATMENT OF POST INFLAMMATORY HYPERPIGMENTATION 未知
公开(公告)号：CA2826262A1
公开(公告)日：2012-08-09
申请号：CA2826262
申请日：2012-02-02
申请人： UNIGEN INC
发明人： HONG MEI FENG , JIA QI , BROWNELL LIDIA ALFARO
IPC分类号： A61K31/05 , A61K31/60 , A61P17/00 , A61P29/00
摘要： Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

40. 发明专利

HK1095536A1 1-(3-METHYL-2,4-DIMETHOXYPHENYL)-3-(2',4'-DIHYDROXYPHENYL)-PROPANE AS A POTENT TYROSINASE INHIBITOR 未知
公开(公告)号：HK1095536A1
公开(公告)日：2007-06-29
申请号：HK07102730
申请日：2007-03-13
申请人： UNIGEN INC , JIA QI , ZHAO JI FU
发明人： JIA QI , ZHAO JI-FU
IPC分类号： A61K20060101 , A61K31/015 , A61K31/05 , A61K31/704 , A61P20060101 , C07C39/15 , C07C39/367 , C07C43/23 , C07C45/67 , C07C49/835 , C07C215/74 , C07D20060101 , C07D321/12
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

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