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31. 发明申请

US20090205959A1 AUTOMATIC SAMPLE PROCESSING METHOD AND AUTOMATIC SAMPLE PROCESSING APPARATUS FOR LID-SEALED MICROCHIPS FOR BIOANALYSIS 审中-公开
标题翻译：自动样品加工方法和自动样品加工设备用于生物分析的密封微生物
公开(公告)号：US20090205959A1
公开(公告)日：2009-08-20
申请号：US11815837
申请日：2006-02-08
申请人： Machiko Fujita , Hisao Kawaura
发明人： Machiko Fujita , Hisao Kawaura
IPC分类号： G01N27/447 , B01D57/02
CPC分类号： G01N27/44791 , G01N27/44717
摘要： The present invention provides a technique for automating the operation to peel off and remove a lid seal part adhered and fixed to the top face of a substrate part constituting a lid-sealed “microchip” after subjecting a sample solution to be analyzed to electrophoretic separation. After subjecting sample solution to be analyzed to desired electrophoretic separation the by utilizing a channel formed in the lid-sealed microchip, the electrophoretically separated liquid sample held in the channel undergoes freezing of the aqueous solvent contained and then, while the whole electrophoretically separated liquid sample remains sustained in the frozen state, an end of the lid seal part used for sealing the top face of channel formed in the substrate part is lifted up at a predetermined speed so as to peel and remove it from the substrate part under a condition of maintaining a bend of a predetermined radius of curvature.
摘要翻译：本发明提供一种在将样品溶液进行电泳分离后，使构成盖密封的“微芯片”的基板部件的顶面上粘贴固定的盖密封部件剥离除去操作的技术。在将样品溶液进行分析以进行所需的电泳分离后，通过利用形成在盖密封微芯片中的通道，保持在通道中的电泳分离的液体样品经受所含水性溶剂的冷冻，然后在整个电泳分离的液体样品保持在冻结状态，用于密封形成在基板部分中的通道的顶面的盖密封部分的端部以预定的速度被提升，以便在维护的条件下从基板部件剥离并将其从基板部件移除预定曲率半径的弯曲。

32. 发明申请

US20080070283A1 DNA FRAGMENT AMPLIFICATION METHOD, REACTION APPARATUS FOR AMPLIFYING DNA FRAGMENT AND PROCESS FOR PRODUCING SAME 审中-公开
标题翻译： DNA片段扩增方法，用于扩增DNA片段的反应装置及其生产方法
公开(公告)号：US20080070283A1
公开(公告)日：2008-03-20
申请号：US11854315
申请日：2007-09-12
申请人： Toru Sano , Masakazu Baba , Kazuhiro Ilda , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
发明人： Toru Sano , Masakazu Baba , Kazuhiro Ilda , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
IPC分类号： C12P19/34 , C12M1/00
CPC分类号： G01N33/54366 , C12Q1/686 , C12Q2565/518 , C12Q2523/307
摘要： A reaction apparatus (10) includes a substrate (12) and a plurality of columnar members (14) formed on the substrate (12). Oligonucleotides for immobilization (16) having sequences complementary to sequences of both ends of a starting template DNA (18) is adhered on the surfaces of the substrate (12) and the columnar members (14). The starting template DNA (18) can be immobilized over the adjacent columnar members (14) by introducing the starting template DNA (18) under the elongated condition. PCR is conducted in such condition.
摘要翻译：反应装置（10）包括基板（12）和形成在基板（12）上的多个柱状部件（14）。具有与起始模板DNA（18）两端的序列互补的序列的固定化寡核苷酸（16）粘附在基材（12）和柱状构件（14）的表面上。通过在细长条件下引入起始模板DNA（18），起始模板DNA（18）可以固定在相邻的柱状构件（14）上。 PCR在这种条件下进行。

33. 发明申请

US20060035386A1 Fine particle handling unit, chip and sensor mounted with same, and methods for separating, capturing and sensing protein 有权
标题翻译：精细粒子处理单元，安装有芯片和传感器的传感器，以及分离，捕获和感测蛋白质的方法
公开(公告)号：US20060035386A1
公开(公告)日：2006-02-16
申请号：US10537292
申请日：2003-11-25
申请人： Wataru Hattori , Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Hiroko Someya
发明人： Wataru Hattori , Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Hiroko Someya
IPC分类号： G01N33/558
CPC分类号： B01D61/18 , B01D29/00 , B01D67/0062 , B01D69/00 , B01D71/02 , B01D71/027 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0816 , B01L2400/086 , G01N33/5302
摘要： A channel (1) formed in a substrate (41) branches into channels (2, 3) at a branch point (43). On this branch point, obstacles (8) having a columnar structure are aligned at certain intervals.
摘要翻译：形成在基板（41）中的通道（1）在分支点（43）处分支成通道（2,3）。在该分支点上，具有柱状结构的障碍物（8）以一定间隔对准。

34. 发明授权

US08421049B2 Metal atom migration switching device, drive and manufacturing methods for the same, integrated circuit device and memory device using same 有权
标题翻译：金属原子迁移开关器件，驱动和制造方法相同，集成电路器件和使用其的存储器件
公开(公告)号：US08421049B2
公开(公告)日：2013-04-16
申请号：US13173792
申请日：2011-06-30
申请人： Hisao Kawaura , Hiroshi Sunamura
发明人： Hisao Kawaura , Hiroshi Sunamura
IPC分类号： H01L29/02 , H01L29/06
CPC分类号： H01L27/10 , H01L45/085 , H01L45/1206 , H01L45/1226 , H01L45/1266
摘要： Provided is a switching device including ion conducting part 4 having an ion conductor, first electrode 1 formed at a first gap away from ion conducting part 4, second electrode 2 formed to be in contact with ion conducting part 4 and third electrode 3 formed at a second gap away from ion conducting part 4. Second electrode 2 supplies metal ions to the ion conductor, or receives the metal ions from the ion conductor to precipitate metal corresponding to the metal ions.
摘要翻译：本发明提供一种切换装置，其具有离子导体部4，具有离子导体的第一电极1，与离子导电部4隔开的第一间隙形成的第一电极1，与离子导电部4接触形成的第二电极2，第二间隙远离离子传导部分4.第二电极2向离子导体提供金属离子，或者从离子导体接收金属离子以沉淀对应于金属离子的金属。

35. 发明授权

US08003969B2 Switching device, drive and manufacturing method for the same, integrated circuit device and memory device 有权
标题翻译：开关器件，驱动和制造方法相同，集成电路器件和存储器件
公开(公告)号：US08003969B2
公开(公告)日：2011-08-23
申请号：US11722825
申请日：2005-12-22
申请人： Hisao Kawaura , Hiroshi Sunamura
发明人： Hisao Kawaura , Hiroshi Sunamura
IPC分类号： H01L29/02 , H01L29/06
CPC分类号： H01L27/10 , H01L45/085 , H01L45/1206 , H01L45/1226 , H01L45/1266
摘要： Provided is a switching device including ion conducting part 4 having an ion conductor, first electrode 1 formed at a first gap away from ion conducting part 4, second electrode 2 formed to be in contact with ion conducting part 4 and third electrode 3 formed at a second gap away from ion conducting part 4. Second electrode 2 supplies metal ions to the ion conductor, or receives the metal ions from the ion conductor to precipitate metal corresponding to the metal ions.
摘要翻译：本发明提供一种切换装置，其具有离子导体部4，具有离子导体的第一电极1，与离子导电部4隔开的第一间隙形成的第一电极1，与离子导电部4接触形成的第二电极2，第二间隙远离离子传导部分4.第二电极2向离子导体提供金属离子，或者从离子导体接收金属离子以沉淀对应于金属离子的金属。

36. 发明申请

US20090045058A1 MICROCHIP AND ANALYSIS METHOD USING THE MICROCHIP 审中-公开
标题翻译： MICROCHIP和分析方法使用MICROCHIP
公开(公告)号：US20090045058A1
公开(公告)日：2009-02-19
申请号：US12097479
申请日：2006-12-12
申请人： Machiko Fujita , Hisao Kawaura , Wataru Hattori
发明人： Machiko Fujita , Hisao Kawaura , Wataru Hattori
IPC分类号： G01N27/26 , B01J19/00
CPC分类号： G01N27/44791 , B01L3/502707 , B01L3/502746 , B01L7/50 , B01L2200/027 , B01L2200/0678 , B01L2300/046 , B01L2300/047 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/161 , B01L2400/0406 , B01L2400/0421 , B01L2400/086
摘要： With the object of realizing a microchip that allows drying and fixing of a substance that is the object of analysis in a shorter time while maintaining the separation capabilities of a separation operation, a microchip used to implement a separation operation of an analysis sample without contamination or spillage is composed of a substrate and a cover, the substrate being provided with a trench-shaped channel in its upper surface and substrate reservoirs that are linked with this channel, and the cover hermetically sealing the upper surface of the channel, attachable to or detachable from the substrate, and provided with through-holes formed at positions corresponding to the substrate reservoirs, cover reservoirs that are formed on the inner sides of the through-holes for holding liquid that is introduced when the cover is in the state of hermetically sealing the upper surface of the channel, and partitions that are formed on the bottom surfaces of the cover reservoirs. The areas of the openings of the partitions are smaller than the areas of the openings of the cover reservoirs that are over the partitions.
摘要翻译：本发明的目的是在保持分离操作的分离能力的同时，在较短的时间内实现对作为分析对象的物质进行干燥和定影的微芯片，用于实现分析样品的分离操作的微芯片而没有污染，溢出物由衬底和覆盖物组成，衬底在其上表面设有沟槽形通道，与该通道连接的衬底储存器，盖子气密地密封通道的上表面，可附接到或可拆卸并且设置有形成在与基板储存器相对应的位置处的通孔，形成在用于保持液体的通孔的内侧的盖储存器，所述通孔用于当盖处于气密密封状态时被引入通道的上表面，以及形成在盖储存器的底表面上的隔板。隔板的开口面积小于在隔板上方的盖子储存器的开口的面积。

37. 发明申请

US20070284610A1 Switching Device, Drive And Manufacturing Method For The Same, Integrated Circuit Device And Memory Device 有权
标题翻译：开关器件，驱动器及其制造方法，集成电路器件和存储器件
公开(公告)号：US20070284610A1
公开(公告)日：2007-12-13
申请号：US11722825
申请日：2005-12-22
申请人： Hisao Kawaura , Hiroshi Sunamura
发明人： Hisao Kawaura , Hiroshi Sunamura
IPC分类号： H01L29/74 , G06G7/12 , H01L21/332
CPC分类号： H01L27/10 , H01L45/085 , H01L45/1206 , H01L45/1226 , H01L45/1266
摘要： Provided is a switching device including ion conducting part 4 having an ion conductor, first electrode 1 formed at a first gap away from ion conducting part 4, second electrode 2 formed to be in contact with ion conducting part 4 and third electrode 3 formed at a second gap away from ion conducting part 4. Second electrode 2 supplies metal ions to the ion conductor, or receives the metal ions from the ion conductor to precipitate metal corresponding to the metal ions.
摘要翻译：本发明提供一种切换装置，其具有离子导体部4，具有离子导体的第一电极1，与离子导电部4隔开的第一间隙形成的第一电极1，与离子导电部4接触形成的第二电极2，第二间隙远离离子传导部分4.第二电极2向离子导体提供金属离子，或者从离子导体接收金属离子以沉淀对应于金属离子的金属。

38. 发明申请

US20060177350A1 Microchip, sampling method, sample separating method, sample analyzing method, and sample recovering method 审中-公开
标题翻译： Microchip，采样方法，样品分离方法，样品分析方法和样品回收方法
公开(公告)号：US20060177350A1
公开(公告)日：2006-08-10
申请号：US10549284
申请日：2004-03-19
申请人： Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
发明人： Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
IPC分类号： G01N1/10
CPC分类号： B01D57/02 , B01L3/502707 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/0415 , B01L2400/0454 , G01N1/40 , G01N27/44743 , G01N35/08
摘要： A sample-carrier complex (119) is introduced into a sample introducing portion (107), and the sample-carrier complex (119) is moved and deposited on a damming portion (111). The damming portion (111) is heated at a stage in which the predetermined amount of sample-carrier complex (119) is deposited on the damming portion (111). A temperature is increased to a predetermined temperature to break down the sample-carrier complex (119) into a sample (121) and a carrier (123). A voltage is applied between the sample introducing portion (107) and a sample recovery portion (109) to cause the sample (121) to pass through a gap between columnar bodies (115) and move into a second channel (106) to perform predetermined separation and analysis or recovery operation.
摘要翻译：将样本 - 载体复合体（119）引入到样本引入部分（107）中，并且样本 - 载体复合体（119）移动并沉积在阻挡部分（111）上。阻挡部分（111）在预定量的样品载体复合物（119）沉积在阻挡部分（111）上的阶段被加热。将温度升高到预定温度以将样品 - 载体复合物（119）分解成样品（121）和载体（123）。在样品导入部（107）和样品回收部（109）之间施加电压使样品（121）通过柱状体（115）之间的间隙并移动到第二通道（106）中，以进行预定的分离和分析或恢复操作。

39. 发明授权

US07842514B2 Particle manipulation unit, chip and detection device having the same, mounted thereon, and methods of separating, capturing and detecting proteins 有权
标题翻译：其上安装有颗粒操作单元，芯片和检测装置，以及分离，捕获和检测蛋白质的方法
公开(公告)号：US07842514B2
公开(公告)日：2010-11-30
申请号：US10537292
申请日：2003-11-25
申请人： Wataru Hattori , Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Hiroko Someya
发明人： Wataru Hattori , Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Hiroko Someya
IPC分类号： G01N33/558
CPC分类号： B01D61/18 , B01D29/00 , B01D67/0062 , B01D69/00 , B01D71/02 , B01D71/027 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0816 , B01L2400/086 , G01N33/5302
摘要： A channel (1) formed in a substrate (41) branches into channels (2, 3) at a branch point (43). On this branch point, obstacles (8) having a columnar structure are aligned at certain intervals.
摘要翻译：形成在基板（41）中的通道（1）在分支点（43）处分支成通道（2,3）。在该分支点上，具有柱状结构的障碍物（8）以一定间隔对准。

40. 发明申请

US20100035291A1 METHOD FOR DEGRADING PEPTIDES, METHOD FOR ANALYZING PEPTIDES, DEVICE FOR DEGRADING PEPTIDES AND DEVICE FOR ANALYZING PEPTIDES 审中-公开
标题翻译：降解肽的方法，分析肽的方法，降解肽的装置和分析肽的装置
公开(公告)号：US20100035291A1
公开(公告)日：2010-02-11
申请号：US12507440
申请日：2009-07-22
申请人： Kenji MIYAZAKI , Yo Tabuse , Hiroko Someya , Wataru Hattori , Hisao Kawaura
发明人： Kenji MIYAZAKI , Yo Tabuse , Hiroko Someya , Wataru Hattori , Hisao Kawaura
IPC分类号： C12Q1/37 , C12N9/50 , C12M1/00 , G01N27/00
CPC分类号： C07K5/0812 , C07K1/12 , C07K5/0821
摘要： A fragmenting reaction of peptide is achieved while maintaining the isolated state of peptide. Isolated peptide fractions isolated by electrophoresis are prepared in flow paths. Subsequently, prepared peptide fractions are dried by each of the flow paths. Then, dried peptide fractions are in contact with protease. Then, independent liquid membranes of a solvent are formed over the surfaces of peptide fractions, which have been in contact with protease, disposed on the flow paths, respectively.
摘要翻译：在保持肽的分离状态的同时实现肽的片段化反应。在流路中制备通过电泳分离的分离的肽级分。随后，通过每个流动路径干燥制备的肽级分。然后，干燥的肽级分与蛋白酶接触。然后，在分别设置在流路上的与肽蛋白酶接触的肽部分的表面上分别形成溶剂的独立液膜。

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