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31. 发明授权

US08552146B2 Peptide vaccines for cancers expressing MPHOSPH1 or DEPDC1 polypeptides 有权
公开(公告)号：US08552146B2
公开(公告)日：2013-10-08
申请号：US13562250
申请日：2012-07-30
申请人： Tomoaki Fujioka , Yusuke Nakamura , Takuya Tsunoda , Ryuji Osawa , Midori Shida
发明人： Tomoaki Fujioka , Yusuke Nakamura , Takuya Tsunoda , Ryuji Osawa , Midori Shida
IPC分类号： C07K5/00 , C12P21/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/54 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , C07K7/06 , C07K14/4703
摘要： The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 7, 8, 9, 10, 11, 12, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 249, 253, 254 or 255, as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, wherein the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with the over-expression of MPHOSPH1 and/or DEPDC1, e.g. cancers, containing these peptides as an active ingredient. The peptides of the present invention can also be used as vaccines.

32. 发明申请

US20130203625A1 SUV420H1 AND SUV420H2 AS TARGET GENES FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
标题翻译： SUV420H1和SUV420H2作为癌症治疗和诊断的靶基因
公开(公告)号：US20130203625A1
公开(公告)日：2013-08-08
申请号：US13817812
申请日：2011-08-18
申请人： Ryuji Hamamoto , Yusuke Nakamura , Takuya Tsunoda
发明人： Ryuji Hamamoto , Yusuke Nakamura , Takuya Tsunoda
IPC分类号： G01N33/50 , C12Q1/68 , C12Q1/48 , G01N33/68
CPC分类号： G01N33/5011 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12Q1/48 , C12Q1/6897 , C12Y201/01043 , G01N33/57407 , G01N33/6872 , G01N2500/04
摘要： The present invention relates to the roles played by the SUV420H1 and SUV420H2 genes in carcinogenesis and features a method for treating or preventing cancer by administering a double-stranded molecule against the SUV420H1 or SUV420H2 gene or a composition or vector containing such a double-stranded molecule. The present invention also features methods and kits for detecting or diagnosing cancer in a subject, including detecting an expression level of the SUV420H1 or SUV420H2 gene. The present invention further features methods and kits for assessing or determining the prognosis of a subject with cancer, including detecting the expression level of an SUV420H2 gene. Also, disclosed are methods of screening for candidate substances for treating or preventing cancer or inhibiting cancer cell growth, using as an index their effect on the expression or activity of SUV420H1 or SUV420H2.
摘要翻译：本发明涉及SUV420H1和SUV420H2基因在癌发生中的作用，其特征在于通过对SUV420H1或SUV420H2基因施用双链分子或含有这种双链分子的组合物或载体来治疗或预防癌症的方法。本发明还特征在于检测或诊断受试者的癌症的方法和试剂盒，包括检测SUV420H1或SUV420H2基因的表达水平。本发明还涉及用于评估或确定患有癌症的受试者的预后的方法和试剂盒，包括检测SUV420H2基因的表达水平。此外，公开了使用作为SUV420H1或SUV420H2的表达或活性的指标作为指标来筛选用于治疗或预防癌症或抑制癌细胞生长的候选物质的方法。

33. 发明申请

US20130034574A1 MODIFIED MELK PEPTIDES AND VACCINES CONTAINING THE SAME 有权
标题翻译：改良的梅毒肽和含有其的疫苗
公开(公告)号：US20130034574A1
公开(公告)日：2013-02-07
申请号：US13574774
申请日：2011-01-24
申请人： Yusuke Nakamura , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe
发明人： Yusuke Nakamura , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe
IPC分类号： A61K39/00 , C12N15/12 , C12N5/10 , C12N15/85 , C12N5/0784 , C12N5/0783 , C07K7/06 , A61P35/00
CPC分类号： C12Y207/11025 , A61K39/0011 , A61K39/39 , C12N9/1205
摘要： Isolated peptides composed of the amino acid sequence of the modified MELK epitope peptide or immunologically active fragments thereof that bind to HLA antigens and have higher cytotoxic T lymphocyte (CTL) inducibility than that of the wild type MELK epitope peptide and thus are suitable for use in the context of cancer immunotherapy or endometriosis immunotherapy, more particularly cancer or endometriosis vaccines are described herein. The present invention further provides peptides that include one, two, or several amino acid insertions, substitutions or additions to the aforementioned peptides or fragments, but yet retain the requisite cytotoxic T cell inducibility. Further provided are nucleic acids encoding any of these aforementioned peptides as well as pharmaceutical substances and compositions including any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical substances and compositions of this invention find particular utility in the treatment of cancers, tumors, and endometriosis.
摘要翻译：由修饰的MELK表位肽或其免疫活性片段的氨基酸序列组成的分离肽，其结合HLA抗原并且具有比野生型MELK表位肽更高的细胞毒性T淋巴细胞（CTL）诱导性，因此适用于本文描述了癌症免疫治疗或子宫内膜异位症免疫治疗的背景，更特别的是癌症或子宫内膜异位症疫苗。本发明进一步提供了肽，其包括前述肽或片段的一个，两个或几个氨基酸插入，取代或添加，但仍保留所需的细胞毒性T细胞诱导性。进一步提供了编码这些上述肽中的任何一种的核酸以及包含上述肽或核酸中任何一种的药物物质和组合物。本发明的肽，核酸，药物和组合物在癌症，肿瘤和子宫内膜异位症的治疗中具有特别的用途。

34. 发明申请

US20120320212A1 SURROUNDING AREA MONITORING APPARATUS FOR VEHICLE 有权
标题翻译：环境监测装置
公开(公告)号：US20120320212A1
公开(公告)日：2012-12-20
申请号：US13580864
申请日：2011-02-14
申请人： Makoto Aimura , Yusuke Nakamura
发明人： Makoto Aimura , Yusuke Nakamura
IPC分类号： H04N7/18
CPC分类号： B60R1/00 , B60R2300/106 , B60R2300/207 , B60R2300/307 , B60R2300/8093 , G01C21/3602 , G06K9/00805 , G08G1/166
摘要： A surrounding area of a vehicle is imaged, and target objects in the area are detected based on captured images. A driver is warned of the presence of the detected target objects by displaying a warning indication on the displayed image. If a total number of simultaneously detected target objects is equal to or less than a specified number, the warning indication of a first display mode is applied in which each target object is emphasized individually. If the total number is more than the specified number, the warning indication of a second warning display mode is applied in which one emphasized indication predefined is displayed for the whole displayed image without displaying the warning indication of the first display mode. The warning image becomes easier to understand for a driver, compared to an image where all detected objects are always emphasized individually regardless of the total number of them.
摘要翻译：成像车辆的周围区域，并且基于捕获的图像来检测该区域中的目标物体。通过在显示的图像上显示警告指示来警告驾驶员检测到的目标对象的存在。如果同时检测到的目标对象的总数等于或小于指定数量，则应用每个目标对象被单独强调的第一显示模式的警告指示。如果总数超过指定数量，则应用第二警告显示模式的警告指示，其中针对整个显示图像显示预定义的强调指示，而不显示第一显示模式的警告指示。与所有检测到的对象总是单独强调的图像相比，驾驶员的警告图像变得更容易理解，不管它们的总数。

35. 发明授权

US08208358B2 Optical information recording method, optical information reproduction method and optical disk device 有权
标题翻译：光信息记录方法，光信息再现方法和光盘装置
公开(公告)号：US08208358B2
公开(公告)日：2012-06-26
申请号：US12485131
申请日：2009-06-16
申请人： Koichiro Nishimura , Yusuke Nakamura
发明人： Koichiro Nishimura , Yusuke Nakamura
IPC分类号： G11B5/09
CPC分类号： G11B20/10009 , G11B7/00456 , G11B7/1267 , G11B20/10046 , G11B20/10055 , G11B20/10194 , G11B20/10212 , G11B20/10222 , G11B20/10481
摘要： When a phase shift is to be evaluated, based on a difference between an output from a waveform equalization circuit to equalize an input reproduced signal to a predetermined target equalization characteristic and the target equalization characteristic, the phase shift of the reproduced signal relative to a channel clock, a group delay characteristic with respect to the frequency of the waveform equalization circuit is fixed. Hence, an equalized waveform as an output from the waveform equalization circuit can preserve phase shift information of the inputted reproduced signal to correctly detect the phase shift of the reproduced waveform using the equalized waveform. It is hence possible to realize, with high precision, optimal value learning of various parameters for the recording, reproduction, and servo by use of the phase shift as an index.
摘要翻译：当要评估相移时，基于来自波形均衡电路的输出之间的差以将输入再现信号均衡到预定的目标均衡特性和目标均衡特性，再现信号相对于通道的相移时钟，相对于波形均衡电路的频率的组延迟特性是固定的。因此，作为来自波形均衡电路的输出的均衡波形可以保存输入的再现信号的相移信息，以使用均衡波形来正确地检测再现波形的相移。因此，通过使用相移作为指标，可以高精度地实现用于记录，再现和伺服的各种参数的最佳值学习。

36. 发明申请

US20120135020A1 TTK PEPTIDES AND VACCINES INCLUDING THE SAME 失效
标题翻译： TTK肽和疫苗，包括它们
公开(公告)号：US20120135020A1
公开(公告)日：2012-05-31
申请号：US13320022
申请日：2010-05-10
申请人： Yusuke Nakamura , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Wantanabe
发明人： Yusuke Nakamura , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Wantanabe
IPC分类号： A61K39/00 , C12N15/12 , C12N5/078 , C12N15/85 , A61K48/00 , A61P35/00 , C07K16/18 , C12N15/63 , C12N1/21 , C12N5/10 , A61P37/04 , C07K7/06 , C12N5/0783
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/572 , C07K14/4748
摘要： Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the TTK gene that elicit CTLs are provided. Antigen-presenting cells and isolated CTLs that target such peptides, as well as methods for inducing the antigen-presenting cell, or CTL are also provided. The present invention further provides pharmaceutical compositions containing as active ingredients peptides derived from TTK or polynucleotides encoding the peptides. Furthermore, the present invention provides methods for the treatment and/or prophylaxis (i.e., prevention) of cancers (tumors), and/or the prevention of postoperative recurrence thereof, as well as methods for inducing CTLs, methods for inducing anti-tumor immunity, using the peptides derived from TTK, polynucleotides encoding the peptides, or antigen-presenting cells presenting the peptides, or the pharmaceutical compositions of the present invention.
摘要翻译：本文描述了针对癌症的肽疫苗。特别地，提供了衍生自引起CTL的TTK基因的表位肽。还提供抗原呈递细胞和靶向这些肽的分离的CTL以及诱导抗原呈递细胞或CTL的方法。本发明还提供含有作为活性成分的衍生自TTK的肽或编码肽的多核苷酸的药物组合物。此外，本发明提供了治疗和/或预防（即预防）癌症（肿瘤）和/或预防其术后复发的方法，以及诱导CTL的方法，诱导抗肿瘤免疫的方法，使用衍生自TTK的肽，编码肽的多核苷酸或呈递肽的抗原呈递细胞，或本发明的药物组合物。

37. 发明申请

US20120128705A1 C6ORF167 PEPTIDES AND VACCINES CONTAINING THE SAME 审中-公开
标题翻译： C6ORF167肽及其含有的疫苗
公开(公告)号：US20120128705A1
公开(公告)日：2012-05-24
申请号：US13260900
申请日：2010-03-31
申请人： Yusuke Nakamura , Yataro Daigo , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe
发明人： Yusuke Nakamura , Yataro Daigo , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe
IPC分类号： A61K38/08 , C07H21/04 , A61K31/711 , A61K39/00 , C12N15/63 , A61P35/00 , C12N5/02 , C12N5/00 , C12Q1/68 , G01N33/53 , C07K7/06 , C07K16/00
CPC分类号： G01N33/57407 , A61K39/0011 , C12Q1/6886 , C12Q2600/112
摘要： Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the C6orf167 gene that elicit CTLs are provided. Antigen-presenting cells and isolated CTLs that target such peptides, as well as methods for inducing the antigen-presenting cell, or CTL are also provided. The present invention further provides pharmaceutical compositions containing peptides derived from C6orf167 or polynucleotides encoding the polypeptides as active ingredients. Furthermore, the present invention provides methods for the treatment and/or prophylaxis of (i.e., preventing) cancers (tumors), and/or the prevention of postoperative recurrence thereof, as well as methods for inducing CTLs, methods for inducing anti-tumor immunity, using the peptides derived from C6orf167, polynucleotides encoding the peptides, or antigen-presenting cells presenting the peptides, or the pharmaceutical compositions of the present invention.
摘要翻译：本文描述了针对癌症的肽疫苗。特别地，提供了衍生自引起CTL的C6orf167基因的表位肽。还提供抗原呈递细胞和靶向这些肽的分离的CTL以及诱导抗原呈递细胞或CTL的方法。本发明还提供含有衍生自C6orf167的肽或编码多肽作为活性成分的多核苷酸的药物组合物。此外，本发明提供了治疗和/或预防（即预防）癌症（肿瘤）和/或预防其术后复发的方法，以及诱导CTL的方法，诱导抗肿瘤免疫的方法，使用衍生自C6orf167的肽，编码肽的多核苷酸或呈递肽的抗原呈递细胞，或本发明的药物组合物。

38. 发明授权

US08182997B2 Prostate cancer related gene STYK1 失效
标题翻译：前列腺癌相关基因STYK1
公开(公告)号：US08182997B2
公开(公告)日：2012-05-22
申请号：US12376714
申请日：2007-08-08
申请人： Yusuke Nakamura , Hidewaki Nakagawa , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Hidewaki Nakagawa , Shuichi Nakatsuru
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K39/0011 , C12N9/1205 , C12N15/1137 , C12N2310/14 , C12N2310/53 , C12Q2600/136 , C12Y207/10002
摘要： The present invention provides methods for detecting and diagnosing cancer, which method involves the determination of the expression level of the STYK1 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer, and methods for vaccinating a subject against cancer. Moreover, the present invention provides siRNAs targeting the STYK1 gene, which are suggested to be useful in the treatment of cancer.
摘要翻译：本发明提供了检测和诊断癌症的方法，该方法涉及确定STYK1基因的表达水平。发现该基因能够将癌细胞与正常细胞区分开来。此外，本发明提供了筛选用于治疗癌症的治疗剂的方法，用于治疗癌症的方法以及用于接种受试者接种癌症的方法。此外，本发明提供靶向STYK1基因的siRNA，其被认为可用于治疗癌症。

39. 发明申请

US20120093845A1 NEIL3 PEPTIDES AND VACCINES INCLUDING THE SAME 有权
标题翻译： NEIL3肽和疫苗，包括它们
公开(公告)号：US20120093845A1
公开(公告)日：2012-04-19
申请号：US13256580
申请日：2010-03-15
申请人： Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa watanabe , Yusuke Nakamura , Yoichi Furukawa
发明人： Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa watanabe , Yusuke Nakamura , Yoichi Furukawa
IPC分类号： A61K39/00 , C07H21/00 , C12N5/078 , C12N15/85 , C07K14/74 , C07K16/18 , C12N15/63 , C12N5/0783 , C12N1/21 , C12N5/10 , C12Q1/68 , G01N33/574 , A61P35/00 , A61P37/04 , C07K7/06
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , A61K39/39 , A61K2039/53 , A61K2039/572 , C12N9/88 , C12Y402/99018 , Y02A50/396
摘要： The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include the above mentioned amino acid sequence with substitution deletion, or addition of one, two, or several amino acids sequences. The invention also provides pharmaceutical compositions including these peptides. The peptides of this invention can be used for diagnosing or treating cancer.
摘要翻译：本发明提供分离的肽或衍生自SEQ ID NO：45的片段，其结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL）。肽可以包括具有取代缺失的上述氨基酸序列，或加入一个，两个或几个氨基酸序列。本发明还提供了包括这些肽的药物组合物。本发明的肽可用于诊断或治疗癌症。

40. 发明授权

US08159923B2 Optical information recording apparatus, optical information recording method, optical information reproducing apparatus and optical information reproducing method 有权
标题翻译：光信息记录装置，光信息记录方法，光信息重放装置和光信息重放方法
公开(公告)号：US08159923B2
公开(公告)日：2012-04-17
申请号：US12457376
申请日：2009-06-09
申请人： Yusuke Nakamura
发明人： Yusuke Nakamura
IPC分类号： G11B7/00
CPC分类号： G11B7/1374 , G11B7/0065 , G11B7/128
摘要： An optical information recording/reproducing apparatus and an optical information recording/reproducing method that record information using holography, wherein the optical information recording/reproducing apparatus includes a signal generation unit that generates two-dimensional data by a two-dimensional encoding method in which a lower-limit value of a number of continuous ON/OFF pixels in an array in one direction of pixels in a two-dimensional spatial light modulator is K(K≧2, K: natural number); and a pickup that records the two-dimensional data, generated by the signal generation unit, on a hologram disc.
摘要翻译：一种使用全息记录信息的光学信息记录/再现装置和光学信息记录/再现方法，其中光学信息记录/再现装置包括：信号生成单元，其通过二维编码方法生成二维数据，其中二维空间光调制器中的一个像素方向的阵列中连续的ON / OFF像素的数量的下限值为K（K≥2，K：自然数）; 以及将由信号生成单元生成的二维数据记录在全息图盘上的拾取器。

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