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31. 发明申请

US20060018971A1 Nucleic acid microspheres, production and delivery thereof 有权
标题翻译：核酸微球，其生产和递送
公开(公告)号：US20060018971A1
公开(公告)日：2006-01-26
申请号：US11127362
申请日：2005-05-12
申请人： Terrence Scott , Debra Lafreniere , Vered Bisker-Leib , Larry Brown
发明人： Terrence Scott , Debra Lafreniere , Vered Bisker-Leib , Larry Brown
IPC分类号： A61K48/00 , A61K9/14
CPC分类号： A61K9/1629 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2320/32 , Y10T428/2982
摘要： Nucleic acids are prepared by dissolving compounds containg them in a suitable solvent or solvent system and forming microshperes from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nuceic acids is useful, such as in treatment of autoimmune disease.
摘要翻译：通过将含有它们的化合物溶解在合适的溶剂或溶剂体系中并从所得溶液中形成微胶粒来制备核酸。将微球体施用于个体，作为防止尿酸递送有用的条件，例如治疗自身免疫性疾病。

32. 发明授权

US06986368B2 Hydraulic control system for tree cutting saw 失效
标题翻译：树锯锯液压控制系统
公开(公告)号：US06986368B2
公开(公告)日：2006-01-17
申请号：US10208806
申请日：2002-08-01
申请人： Larry Brown
发明人： Larry Brown
IPC分类号： A01G23/091
CPC分类号： F15B11/20 , A01G23/091
摘要： A hydraulic circuit for a tree-cutting machine having a feed mechanism powered by hydraulic fluid at the output of a hydraulic motor. The hydraulic motor may comprise a variable-displacement motor. The hydraulic circuit may comprise elements which provide an anti-stall mode, wherein the feed mechanism is operated to withdraw the cutting element upon pressure at an input port of the hydraulic motor exceeding a threshold.
摘要翻译：一种用于树切割机的液压回路，具有由液压马达的输出端上的液压流体驱动的进给机构。液压马达可以包括可变排量马达。液压回路可以包括提供防失速模式的元件，其中进给机构被操作以在液压马达的输入端口处的压力超过阈值时将切割元件撤回。

33. 发明申请

US20050136778A1 Ultrasonically laminated multi-ply fabrics 有权
标题翻译：超薄层压多层织物
公开(公告)号：US20050136778A1
公开(公告)日：2005-06-23
申请号：US10745339
申请日：2003-12-23
申请人： Craig Thomaschefsky , Larry Brown
发明人： Craig Thomaschefsky , Larry Brown
IPC分类号： B32B5/26 , B32B7/04 , B32B37/20 , B32B38/06 , D04H11/08 , D04H13/00 , B32B27/14
CPC分类号： B32B5/26 , B32B7/04 , B32B37/00 , B32B37/206 , B32B38/06 , B32B2307/728 , B32B2310/028 , B32B2432/00 , B32B2459/00 , D04H1/555 , D04H1/559 , Y10T428/24826 , Y10T442/659 , Y10T442/689
摘要： A multi-ply fabric is provided that includes an inner ply positioned between two outer plies that contain both thermoplastic fibers and absorbent staple fibers. The plies are ultrasonically bonded together. The material used to form the inner ply may be selectively controlled to optimize certain properties of the fabric for a particular application, such as strength, bulk, absorption capacity, absorption rate, handfeel, etc.
摘要翻译：提供了一种多层织物，其包括位于两个外层之间的内层，其中包含热塑性纤维和吸收性短纤维。层叠超声波粘合在一起。可以选择性地控制用于形成内层的材料，以针对特定应用（例如强度，体积，吸收能力，吸收率，手感等）优化织物的某些性能。

34. 发明申请

US20050097194A1 Downloadable code in a distributed process control system 有权
标题翻译：分布式过程控制系统中可下载的代码
公开(公告)号：US20050097194A1
公开(公告)日：2005-05-05
申请号：US10886272
申请日：2004-07-06
申请人： Clyde Eisenbeis , Brent Larson , Steve Packwood , Larry Brown
发明人： Clyde Eisenbeis , Brent Larson , Steve Packwood , Larry Brown
IPC分类号： G06F11/00 , G05B15/02 , G05B19/042 , G05B19/418 , G06F9/445 , G06F15/177 , G11C11/34
CPC分类号： G05B19/4185 , G05B19/0426 , G05B2219/23298 , G05B2219/25014 , G05B2219/25428 , G05B2219/31121 , G05B2219/31135 , G05B2219/31138 , Y02P90/18
摘要： The present invention is directed to a method of reprogramming a field device in a process control network using the standard communications protocol for the network, and a reprogrammable field device in the process control network adapted for being reprogrammed using the standard communications protocol for the network. The method and device of the present invention use the standard communications protocol to transmit the downloaded code to the field device and store the downloaded code in the field device while the device is enabled to perform process control. Once the new code is downloaded and stored in the field device, the field device is set to a steady state condition and/or disabled from performing process control, reprogrammed to execute the downloaded code, and reenabled to perform process control.
摘要翻译：本发明涉及一种使用网络的标准通信协议对过程控制网络中的现场设备进行重新编程的方法，以及适于使用网络的标准通信协议重新编程的过程控制网络中的可重新编程的现场设备。本发明的方法和装置使用标准通信协议将下载的代码发送到现场设备，并且在设备能够执行过程控制的同时将下载的代码存储在现场设备中。一旦将新代码下载并存储在现场设备中，现场设备被设置为稳定状态条件和/或禁止执行过程控制，重新编程以执行下载的代码，并重新启用以执行过程控制。

35. 发明授权

US09914506B1 Pontoon boat driven by PWC 有权
公开(公告)号：US09914506B1
公开(公告)日：2018-03-13
申请号：US15099584
申请日：2016-04-14
申请人： Larry Brown , Danielle Brown
发明人： Larry Brown , Danielle Brown
IPC分类号： B63B35/70 , B63B21/62 , B63B21/56 , B63B1/12 , B63B35/66 , B63B59/02
CPC分类号： B63B21/62 , B63B1/121 , B63B21/56 , B63B35/66 , B63B35/70 , B63B59/02 , B63B2021/563
摘要： The present invention relates to a pontoon boats that may couple and be driven by a PWC. The invention further relates to pontoon boats having a portion that moves into an open water recess at the rear of the pontoon boat. The invention further relates to an engagement assembly for securing a PWC to such a pontoon boat.

36. 发明授权

US08924408B2 Automatic generation of database invocation mechanism for external web services 有权
标题翻译：自动生成外部Web服务的数据库调用机制
公开(公告)号：US08924408B2
公开(公告)日：2014-12-30
申请号：US09967553
申请日：2001-09-28
申请人： Larry Brown , James C. Kleewein , Rong Qu , Berthold Reinwald , Peter M. Schwarz , Charles Daniel Wolfson
发明人： Larry Brown , James C. Kleewein , Rong Qu , Berthold Reinwald , Peter M. Schwarz , Charles Daniel Wolfson
IPC分类号： G06F17/30
CPC分类号： G06F17/3089
摘要： An external service at a service provider server is invoked from a database by accessing from over a network a description of the external service published by the service provider external to the database. A database invocation mechanism is generated from the accessed description of the external service, wherein the database invocation mechanism comprises code within the database. A database program invokes the database invocation mechanism code within the database to invoke and interact with the external service. The database receives data from the external service in response to invoking and interacting with the external service.
摘要翻译：通过从网络访问由数据库外部的服务提供商公布的外部服务的描述，从数据库调用服务提供者服务器上的外部服务。从访问的外部服务的描述生成数据库调用机制，其中数据库调用机制包括数据库内的代码。数据库程序调用数据库中的数据库调用机制代码来调用和与外部服务交互。响应于外部服务的调用和交互，数据库从外部服务器接收数据。

37. 发明授权

US08333995B2 Protein microspheres having injectable properties at high concentrations 失效
标题翻译：具有高浓度注射性能的蛋白微球
公开(公告)号：US08333995B2
公开(公告)日：2012-12-18
申请号：US11127704
申请日：2005-05-12
申请人： Larry Brown , Vered Bisker-Leib , Debra LaFreniere , John McGeehan , Julia Rashba-Step , Terrence Scott
发明人： Larry Brown , Vered Bisker-Leib , Debra LaFreniere , John McGeehan , Julia Rashba-Step , Terrence Scott
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , A61K9/0019 , A61K9/10 , A61K9/1688 , C07K16/2866 , C07K16/36 , C07K2317/24
摘要： The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins.
摘要翻译：本发明涉及制备方法的组合物和组合物活性剂颗粒的小组合物。根据生产方法，将活性剂溶解在含有溶解的相分离增强剂（PSEA）的水溶性或水溶性溶剂中以形成单一液相中的溶液。使溶液进行液固相分离，使活性剂形成基本上无定形或非结晶的小球形，并且可以通过高浓度的细针针进行注射。本发明对高分子量蛋白质具有特殊应用。

38. 发明授权

US07926765B1 Pipe locator and support 有权
标题翻译：管道定位器和支撑
公开(公告)号：US07926765B1
公开(公告)日：2011-04-19
申请号：US12008854
申请日：2008-01-15
申请人： Larry Brown , Virgil E. O'Neil , John R. Thomas , Jeffrey A. Jaramillo
发明人： Larry Brown , Virgil E. O'Neil , John R. Thomas , Jeffrey A. Jaramillo
IPC分类号： F16L5/00
CPC分类号： F16L3/223 , E03C1/021 , E03C2001/028 , F16L5/00
摘要： An plumbing pipe locator and support is provided for fixing plumbing pipes in position relative to studs in a building. The pipe locator and support comprises an elongated supporting strap having upper and lower sides extending along opposing sides of a longitudinal axis. A first plurality of longitudinally aligned, larger pipe openings are interspersed with a second plurality of smaller, aligned fastener openings that extend into ends of the strap. The upper and lower sides undulate to provide a substantially uniform width between first holes and the adjacent sides and the second holes and the adjacent sides. This undulating surface can provide a strap using less material, with reduced manufacturing time, and a strap that can bend without forming creases or stress fractures.
摘要翻译：提供了一种管道定位器和支撑件，用于将管道管道相对于建筑物中的螺栓固定在适当位置。管定位器和支撑件包括细长的支撑带，其具有沿着纵向轴线的相对侧延伸的上侧和下侧。第一组多个纵向排列较大的管道开口与第二多个较小的对准的紧固件开口相交，该紧固件开口延伸到带的端部。上侧和下侧波动以在第一孔和相邻侧面以及第二孔和相邻侧面之间提供基本均匀的宽度。这种起伏的表面可以使用较少的材料提供带，减少制造时间，以及可以弯曲而不形成折痕或应力断裂的带。

39. 发明申请

US20080026068A1 PULMONARY DELIVERY OF SPHERICAL INSULIN MICROPARTICLES 审中-公开
标题翻译：脉冲胰岛素微生物的脉冲递送
公开(公告)号：US20080026068A1
公开(公告)日：2008-01-31
申请号：US11736372
申请日：2007-04-17
申请人： Larry Brown , John McGeehan , Qin Yuanxi , Julia Rashba-Step , Terrence Scott
发明人： Larry Brown , John McGeehan , Qin Yuanxi , Julia Rashba-Step , Terrence Scott
IPC分类号： A61K9/14 , A61K38/28 , A61P11/00
CPC分类号： A61K9/0075 , A61K38/28
摘要： Compositions of spherical insulin particles having improved pulmonary application potentials and methods of forming and using these compositions are disclosed in the present application. In one clinical trial with 30 healthy male human subjects, no coughing was observed upon a single pulmonary administration of the spherical insulin particles at an insulin dose of 6.5 mg, nor during the 10-hour post dosing period.
摘要翻译：在本申请中公开了具有改善的肺部施用电位的球形胰岛素颗粒的组合物以及形成和使用这些组合物的方法。在30名健康雄性人类受试者的一项临床试验中，在胰岛素剂量为6.5mg的单次肺部施用球素胰岛素颗粒时，也不在给药后10小时期间观察不到咳嗽。

40. 发明申请

US20070207210A1 Protein Microspheres Retaining Pharmacokinetic and Pharmacodynamic Properties 有权
标题翻译：蛋白质微球保留药代动力学和药效学性质
公开(公告)号：US20070207210A1
公开(公告)日：2007-09-06
申请号：US11557486
申请日：2006-11-07
申请人： Larry Brown , Mark Yang , Ed O'Connell
发明人： Larry Brown , Mark Yang , Ed O'Connell
IPC分类号： A61K39/395 , A61K38/28 , A61K9/14
CPC分类号： A61K9/0019 , A61K9/10 , A61K9/1688 , A61K38/28 , C07K16/2866 , C07K16/2896 , C07K16/36 , C07K2317/24
摘要： The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical particles that are substantially amorphous or non-crystalline and are injectable through fine bore needles at high concentrations. The particles exhibit the pharmacokinetic and pharmacodynamnic properties of the active agent. The disclosure has special application for higher molecular weight proteins such as antibodies.
摘要翻译：本公开涉及制备方法的组合物和组合物活性剂颗粒的小组合物。根据生产方法，将活性剂溶解在含有溶解的相分离增强剂（PSEA）的水溶性或水溶性溶剂中以形成单一液相中的溶液。使溶液进行液 - 固相分离，使活性剂形成基本上无定形或非结晶的小球形颗粒，并且可以通过高浓度的细孔针进行注射。颗粒表现出活性剂的药代动力学和药效学性质。本公开内容对于分子量较高的蛋白质如抗体具有特殊应用。

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