专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US5985872A 2-amino-benzoxazinones for the treatment of viral infections 失效
标题翻译： 2-氨基 - 苯并恶嗪酮用于治疗病毒感染
公开(公告)号：US5985872A
公开(公告)日：1999-11-16
申请号：US448795
申请日：1995-05-24
申请人： Norman Anthony Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A Schretzman , Clara I Villamil
发明人： Norman Anthony Abood , Daniel L. Flynn , Daniel P. Becker , Brian M. Bax , Hui Li , Roger A. Nosal , Lori A Schretzman , Clara I Villamil
IPC分类号： C07D265/22 , A61K31/535 , A61P31/12 , A61P43/00 , C07D265/12 , C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
CPC分类号： C07D265/24 , C07D413/04 , C07D413/12 , C07D417/12
摘要： A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.28 is selected from (a) amino substituted with one or two radicals selected from alkyl, aralkyl, heterocycoalkyl, heterocyclo, and aryl, and (b) amino acid residues and derivatives thereof; wherein R.sup.29 is selected from hydrido, alkyl, halo, ##STR2## wherein R.sup.30 is selected from alkyl, alkoxy, alkylamino, carboxyalkyl, alkoxyalkyl, alkylaminoalkyl, cycloalkyl, heterocyclo, heterocycloalkyl, heterocycloalkoxy, alkylaminoalkoxy, alkylaminoalkylamino, heterocycloalkylamino, and N-aralkylamino; wherein R.sup.31 is alkyl; wherein R.sup.32 is alkyl and aryl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类用于治疗病毒感染的化合物。特别感兴趣的化合物由式II定义，其中R28选自（a）被一个或两个选自烷基，芳烷基，杂核烷基，杂环和芳基的基取代的氨基，和（b）氨基酸残基及其衍生物; 其中R 29选自氢，烷基，卤素，其中R 30选自烷基，烷氧基，烷基氨基，羧基烷基，烷氧基烷基，烷基氨基烷基，环烷基，杂环基，杂环烷基，杂环烷氧基，烷基氨基烷氧基，烷基氨基烷基氨基，杂环烷基氨基和N-芳烷基氨基。其中R31是烷基; 其中R32是烷基和芳基; 或其药学上可接受的盐。

32. 发明授权

US5945425A Method of using (H.sup.+ /K.sup.+)ATPase inhibitors as antiviral agents 失效
标题翻译：使用（H + / K +）ATP酶抑制剂作为抗病毒剂的方法
公开(公告)号：US5945425A
公开(公告)日：1999-08-31
申请号：US737251
申请日：1996-10-24
申请人： Alan E. Moormann , Daniel P. Becker , Daniel L. Flynn , Hui Li , Clara I. Villamil
发明人： Alan E. Moormann , Daniel P. Becker , Daniel L. Flynn , Hui Li , Clara I. Villamil
IPC分类号： A61K31/00 , A61K31/4164 , A61K31/4184 , A61K31/437 , A61K31/4402 , A61K31/4439 , C07D235/28 , C07D401/12 , C07D403/12 , A61K31/42 , A61K31/415 , A61K31/425
CPC分类号： C07D401/12 , A61K31/00 , A61K31/4164 , A61K31/4184 , A61K31/437 , A61K31/4402 , A61K31/4439 , C07D235/28 , C07D403/12
摘要： A class of compounds which are (H.sup.+ /K.sup.+)ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula III: ##STR1## wherein D is N or CH; wherein R.sup.7 is one or more radicals selected from hydrido, alkoxy, amino, cyano, nitro, hydroxyl, alkyl, halo, haloalkyl, carboxyl, alkanoyl, nitro, amino, alkylamino, aminocarbonyl, aminosulfonyl, alkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylthio, alkylsulfinyl and alkylsulfonyl; wherein R.sup.8 is selected from hydrido, alkyl and cycloalkyl; wherein R.sup.9 is one or more radicals selected from hydrido, alkoxy, amino, alkyl, halo, cyano, nitro, hydroxyl, haloalkyl, nitro, carboxyl, alkanoyl, amino, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, aminosulfonyl, alkylaminosulfonyl, alkylsulfonylamino, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; and wherein R.sup.10 and R.sup.11 are independently selected from hydrido, alkyl, aryl, alkylcarbonyl and arylcarbonyl wherein the aryl ring may be further substituted with one or more radicals selected from alkyl, halo, hydrazidylcarbonyl, aminocarbonyl and alkoxy; or wherein R.sup.10 and R.sup.11 together with the nitrogen atom form a heterocyclic ring.
摘要翻译： PCT No.PCT / US95 / 05021 Sec。 371日期1996年10月24日第 102（e）日期1996年10月24日PCT提交1995年5月1日PCT公布。出版物WO95 / 29897 1995年11月9日，一类（H + / K +）ATP酶抑制剂的化合物可用于治疗病毒感染。特别感兴趣的化合物由式III定义：其中D是N或CH; 其中R7是一个或多个选自氢，烷氧基，氨基，氰基，硝基，羟基，烷基，卤素，卤代烷基，羧基，烷酰基，硝基，氨基，烷基氨基，氨基羰基，氨基磺酰基，烷基氨基羰基，烷基羰基氨基，烷氧基羰基，烷基氨基磺酰基，，烷硫基，烷基亚磺酰基和烷基磺酰基; 其中R8选自氢，烷基和环烷基; 其中R9是一个或多个选自氢，烷氧基，氨基，烷基，卤素，氰基，硝基，羟基，卤代烷基，硝基，羧基，烷酰基，氨基，烷基氨基，二烷基氨基，氨基羰基，烷基氨基羰基，烷基羰基氨基，氨基磺酰基，烷基氨基磺酰基，，烷氧基羰基，烷硫基，烷基亚磺酰基和烷基磺酰基; 并且其中R 10和R 11独立地选自氢，烷基，芳基，烷基羰基和芳基羰基，其中所述芳基环可以进一步被一个或多个选自烷基，卤素，肼基羰基，氨基羰基和烷氧基的基团取代; 或其中R 10和R 11与氮原子一起形成杂环。

33. 发明授权

US5612366A Meso-azacyclic aromatic acid amides and esters as novel serotonergic agents 失效
标题翻译：中等氮杂环芳香酰胺和酯作为新的5-羟色胺能药剂
公开(公告)号：US5612366A
公开(公告)日：1997-03-18
申请号：US234336
申请日：1994-04-28
申请人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moorman , Roger Nosal , Clara I. Villamil
发明人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moorman , Roger Nosal , Clara I. Villamil
IPC分类号： A61K31/435 , A61P25/24 , A61P25/26 , C07D471/08 , C07D487/04 , C07D487/08 , A01K31/40
CPC分类号： C07D471/08 , C07D487/04 , C07D487/08
摘要： The meso-azacyclic aromatic acid amides and esters of the present invention are useful in the treatment of the central nervous system and gastrointestinal motility disorders such as gastroesophageal reflux, non-ulcer dyspepsia, delayed gastric emptying, ileus, irritable bowel syndrome, and the like. Additionally, the compounds of the present invention find utility as antagonists of serotonin 5-HT.sub.3 receptors. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, irritable bowel syndrome, emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
摘要翻译：本发明的内消旋 - 氮杂环芳香酰胺和酯可用于治疗中枢神经系统和胃肠动力障碍，例如胃食管反流，非溃疡性消化不良，胃排空迟缓，肠梗阻，肠易激综合征等。此外，本发明的化合物可用作5-羟色胺5-HT 3受体的拮抗剂。因此，它们可用于治疗其中5-HT 3受体拮抗作用有益的人和动物。治疗指示但不限于治疗焦虑，精神病，抑郁症（特别是伴有焦虑的抑郁症），认知障碍，药物滥用依赖和/或戒断，肠易激综合征，由化学治疗剂引起的呕吐和内脏痛。此外，本发明的化合物可以用作生物活性化合物的鼻吸收增强剂。

34. 发明授权

US5604239A Imidazopyridines as serotonergic 5-HT.sub.3 antagonists 失效
标题翻译：咪唑并吡啶作为5-羟色胺能5-HT3拮抗剂
公开(公告)号：US5604239A
公开(公告)日：1997-02-18
申请号：US424732
申请日：1995-04-18
申请人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Roger Nosal , Clara I. Villamil
发明人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Roger Nosal , Clara I. Villamil
IPC分类号： A61K31/40 , A61K31/435 , A61K31/445 , A61K31/4468 , A61K31/46 , A61P43/00 , C07C219/12 , C07C233/62 , C07D211/46 , C07D211/58 , C07D451/04 , C07D451/06 , C07D451/14 , C07D453/02 , C07D471/04 , C07D471/06 , C07D471/22 , C07D487/04 , C07D487/08 , C07D519/00 , A61K31/44
CPC分类号： C07D471/04
摘要： The imidazopyridines compounds of the present invention are serotonergic 5-HT.sub.3 antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, gastric stasis, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
摘要翻译：本发明的咪唑并吡啶化合物是5-羟色胺能5-HT 3拮抗剂。因此，它们可用于治疗其中5-HT 3受体拮抗作用有益的人和动物。治疗指示但不限于治疗焦虑，精神病，抑郁症（特别是伴有焦虑症的抑郁症），认知障碍，药物滥用依赖和戒断，胃肠蠕动窒息（包括食管反流，消化不良，胃潴留，肠易激惹）综合征），化疗引起的呕吐和内脏痛。此外，本发明的化合物可以用作生物活性化合物的鼻吸收增强剂。

35. 发明授权

US5541344A Intermediates useful in a process for the preparation of azanoradamantane benzamides 失效
标题翻译：可用于制备氮杂烷基金刚烷苯甲酰胺的方法中的中间体
公开(公告)号：US5541344A
公开(公告)日：1996-07-30
申请号：US444489
申请日：1995-05-19
申请人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Clara I. Villamil
发明人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Clara I. Villamil
IPC分类号： C07D307/00 , C07D307/93 , C07D471/18
CPC分类号： C07D307/00 , C07D307/93
摘要： The present invention is directed to intermediates of the formula ##STR1## which are useful in a process for the preparation of aminoazanoradamanatanes.
摘要翻译：本发明涉及可用于制备氨基氮杂卓丹那坦的方法的式“IMAGE”的中间体。

36. 发明授权

US5530018A Meso-azanoradamantanes 失效
标题翻译：中 - 阿氮杂多金刚烷
公开(公告)号：US5530018A
公开(公告)日：1996-06-25
申请号：US192213
申请日：1994-02-04
申请人： Daniel P. Becker , Daniel L. Flynn , Clara I. Villamil
发明人： Daniel P. Becker , Daniel L. Flynn , Clara I. Villamil
IPC分类号： C07D471/18 , A61K31/40 , C07D487/04
CPC分类号： C07D471/18
摘要： This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein Z is selected from the group consisting of ##STR2## R.sub.1 is alkoxy of one to six carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group consisting of hydrogen, halogen, CF.sub.3, hydroxy, alkoxy of one to six carbon atoms, acyl of two to seven carbon atoms, amino, amino substituted by one or two alkyl groups of one to six carbon atoms, C.sub.2 -C.sub.7 acylamino, aminocarbonyl, aminosulfonyl optionally substituted by one or two alkyl groups of one to six carbon atoms, C.sub.1 -C.sub.6 alkylsulfonyl and nitro;n is 0, 1 or 2;m is 0 or 1;X is 0 or NR.sub.7 ; andR.sub.7 is hydrogen or alkyl of 1 to 6 carbon atoms.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐，其中Z选自由下列组成的组：R1是1-6个碳原子的烷氧基; R 2，R 3，R 4和R 5相同或不同，并且选自氢，卤素，CF 3，羟基，1至6个碳原子的烷氧基，2至7个碳原子的酰基，氨基，被1个或两个1-6个碳原子的烷基，C 2 -C 7酰基氨基，氨基羰基，任选被1至6个碳原子的一个或两个烷基取代的氨基磺酰基，C 1 -C 6烷基磺酰基和硝基; n为0,1或2; m为0或1; X为0或NR7; 且R 7为氢或1至6个碳原子的烷基。

37. 发明授权

US5430040A New meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof 失效
标题翻译：咪唑并吡啶羧酸的新型内消旋 - 氮杂环酰胺及其类似物
公开(公告)号：US5430040A
公开(公告)日：1995-07-04
申请号：US140374
申请日：1993-10-21
申请人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Clara I. Villamil
发明人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Clara I. Villamil
IPC分类号： C07D519/00 , C07D471/02 , A61K31/44 , C07D471/04
CPC分类号： C07D519/00
摘要： The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
摘要翻译：含有本文所述的内消旋 - 侧链侧链的咪唑并吡啶可用作5-羟色胺5-HT 3受体的拮抗剂。因此，它们可用于治疗其中5-HT 3受体拮抗作用有益的人和动物。治疗指示但不限于治疗焦虑症，精神病，抑郁症（特别是伴有焦虑症的抑郁症），认知障碍，药物滥用依赖和/或戒断，胃肠蠕动性窒息（包括食管反流，消化不良，肠易激综合征），由化疗药引起的呕吐和内脏痛。此外，本发明的化合物可以用作生物活性化合物的鼻吸收增强剂。

38. 发明授权

US5314886A N-substituted lactams useful as cholecystokinin antagonists 失效
标题翻译：可用作缩胆囊素拮抗剂的N-取代的内酰胺
公开(公告)号：US5314886A
公开(公告)日：1994-05-24
申请号：US968617
申请日：1992-10-29
申请人： Daniel P. Becker , Daniel L. Flynn , Clara I. Villamil
发明人： Daniel P. Becker , Daniel L. Flynn , Clara I. Villamil
IPC分类号： A61K31/40 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/47 , A61K31/495 , A61P43/00 , C07D205/085 , C07D207/273 , C07D207/277 , C07D207/28 , C07D401/12 , C07D403/12
CPC分类号： C07D401/12 , C07D207/28 , C07D403/12
摘要： This invention relates to novel N-substituted lactams having the following formula ##STR1## useful in the treatment and prevention of Cholecystokinin (CCK) related disorders of the gastrointestinal, central nervous and appetite regulatory systems of mammals.
摘要翻译：本发明涉及具有下式的新型N-取代内酰胺，其可用于治疗和预防哺乳动物胃肠道，中枢神经和食欲调节系统中胆囊收缩素（CCK）相关疾病。

39. 发明授权

US5280029A Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof 失效
标题翻译：咪唑并吡啶羧酸的间 - 环氮杂酰胺及其类似物
公开(公告)号：US5280029A
公开(公告)日：1994-01-18
申请号：US896273
申请日：1992-06-10
申请人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Clara I. Villamil
发明人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Clara I. Villamil
IPC分类号： C07D519/00 , A61K31/44 , C07D471/04
CPC分类号： C07D519/00
摘要： The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
摘要翻译：含有本文所述的内消旋 - 侧链侧链的咪唑并吡啶可用作5-羟色胺5-HT 3受体的拮抗剂。因此，它们可用于治疗其中5-HT 3受体拮抗作用有益的人和动物。治疗指示但不限于治疗焦虑症，精神病，抑郁症（特别是伴有焦虑症的抑郁症），认知障碍，药物滥用依赖和/或戒断，胃肠蠕动性窒息（包括食管反流，消化不良，肠易激综合征），由化疗药引起的呕吐和内脏痛。此外，本发明的化合物可以用作生物活性化合物的鼻吸收增强剂。

40. 发明授权

US06822120B2 Sulfone liver X-receptor modulators 失效
标题翻译：磺胺肝X受体调节剂
公开(公告)号：US06822120B2
公开(公告)日：2004-11-23
申请号：US10445370
申请日：2003-05-23
申请人： Daniel P. Becker , Gary A. DeCrescenzo , James W. Malecha , Julie M. Miyashiro , Jennifer Ann Van Camp , Joe T. Collins
发明人： Daniel P. Becker , Gary A. DeCrescenzo , James W. Malecha , Julie M. Miyashiro , Jennifer Ann Van Camp , Joe T. Collins
IPC分类号： C07C31704
CPC分类号： C07C317/22 , C07C317/24
摘要： The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula I.
摘要翻译：本发明涉及选择性LXR调节剂，对应于式I的小分子化合物，并且还涉及使用治疗有效剂量的式I化合物治疗由LXR调节的哺乳动物状况的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式