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31. 发明授权

US4924030A Process for preparing cyclic terpenoids 失效
标题翻译：制备环状萜类化合物的方法
公开(公告)号：US4924030A
公开(公告)日：1990-05-08
申请号：US164909
申请日：1988-03-07
申请人： Takashi Onishi , Shigeaki Suzuki , Toshiki Mori , Yoshiji Fujita
发明人： Takashi Onishi , Shigeaki Suzuki , Toshiki Mori , Yoshiji Fujita
IPC分类号： C07C315/04 , C07B37/08 , C07C20060101 , C07C67/00 , C07C313/00 , C07C315/06 , C07C317/14
CPC分类号： C07C317/00
摘要： A present invention provides a process for preparing a mixture of cyclic terpenoids of general formula (I), ##STR1## wherein R is a hydrogen atom or a lower alkyl group, and general formula (II), ##STR2## wherein R is defined as above, containing (I) predominant over (II) by the reaction of an acid with a cyclic terpenoid of general formula (II), or a mixture of cyclic terpenoids of general formulas (I) and (II), containing (II) predominant over (I).

32. 发明申请

US20090004171A1 COMPOUND PROFILING METHOD 审中-公开
标题翻译：化合物分析方法
公开(公告)号：US20090004171A1
公开(公告)日：2009-01-01
申请号：US12101719
申请日：2008-04-11
申请人： Masato Miyake , Yoshiji Fujita
发明人： Masato Miyake , Yoshiji Fujita
IPC分类号： A61K38/44 , C12Q1/68 , C40B30/06 , A61P35/00 , C12M1/34
CPC分类号： G01N33/5026 , C12Q1/6886 , C12Q2600/178 , G01N33/5011 , G16B5/00
摘要： The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.
摘要翻译：本发明提供了一种用于衍生生物体表型改变所必需的组分的上游或下游组分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径并且指定分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予活体有兴趣的兴奋剂，以确定表型改变所必需的组成部分的集合; 给生物体提供参考刺激物，以确定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注部件的收集中减去所述交叉点来计算差分收集。

33. 发明授权

US5143921A Terpene amino alcohols and medicinal uses thereof 失效
标题翻译：萜烯氨基醇及其药用
公开(公告)号：US5143921A
公开(公告)日：1992-09-01
申请号：US533395
申请日：1990-06-04
申请人： Koichi Kanehira , Katsushi Eziri , Manzo Shiono , Yoshiji Fujita , Johji Yamahara
发明人： Koichi Kanehira , Katsushi Eziri , Manzo Shiono , Yoshiji Fujita , Johji Yamahara
IPC分类号： C07D211/58 , C07D213/74 , C07D213/80 , C07D213/82 , C07D215/38 , C07D233/60 , C07D235/26 , C07D295/088 , C07D295/13 , C07D521/00
CPC分类号： C07D213/74 , C07D211/58 , C07D213/80 , C07D213/82 , C07D215/38 , C07D231/12 , C07D233/56 , C07D235/26 , C07D249/08 , C07D295/088 , C07D295/13
摘要： Novel terpene amino alcohols having an antiallergic activity or an activity of improving cerebral function are provided. Also provided are medicinal uses of the alcohols.
摘要翻译：提供具有抗过敏活性的新型萜烯氨基醇或改善脑功能的活性。还提供了醇的药用。

34. 发明授权

US4886916A Process for preparing sulfone compounds 失效
标题翻译：砜类化合物的制备方法
公开(公告)号：US4886916A
公开(公告)日：1989-12-12
申请号：US168408
申请日：1988-03-15
申请人： Takashi Onishi , Shigeaki Suzuki , Toshiki Mori , Hiroshi Fujii , Yoshiji Fujita
发明人： Takashi Onishi , Shigeaki Suzuki , Toshiki Mori , Hiroshi Fujii , Yoshiji Fujita
IPC分类号： C07C20060101 , C07C317/04 , C07C317/14
CPC分类号： C07C317/00
摘要： A process for preparing an allylic sulfone of the following general formula (I), ##STR1## wherein, R is a hydrogen atom or a lower alkyl group, and containing both cis and trans isomers, by a reaction of a compound selected from the group consisting of geranyl chloride, neryl chloride, and linalyl chloride with a phenyl sulfinate of the following general formula (III), ##STR2## wherein, R is a hydrogen atom, or a lower alkyl group, and M is a sodium atom or potassium atom, in the presence of (i) tetralkylammonium iodide in an anhydrous condition or (ii) a zinc halide and an iodide.

35. 发明授权

US4827056A Process for preparing chlorinated olefins 失效
标题翻译：氯化烯烃的制备方法
公开(公告)号：US4827056A
公开(公告)日：1989-05-02
申请号：US164917
申请日：1988-03-07
申请人： Shigeaki Suzuki , Toshiki Mori , Takashi Onishi , Yoshiji Fujita
发明人： Shigeaki Suzuki , Toshiki Mori , Takashi Onishi , Yoshiji Fujita
IPC分类号： C07C17/00 , C07C17/02 , C07C17/10 , C07C21/04 , C07C21/19 , C07C22/04 , C07C41/00 , C07C41/22 , C07C43/17 , C07C43/174 , C07C67/00 , C07C67/287 , C07C69/025
CPC分类号： C07C17/00 , C07C41/22 , C07C67/287 , C07C67/58
摘要： Chlorinated olefins of general formula (I), ##STR1## wherein R is an alkyl, aralkyl, or alkenyl group substituted or not substituted by a lower acyloxy, lower alkyloxy, alkenyloxy or benzyloxy group, are prepared by the reaction of hypochlorous acid, generated by the reaction of sodium hypochlorite with a strong mineral acid, and olefins of general formula (II), ##STR2## wherein R is the same as defined above, in a two-phase system of water phase and organic solvent phase, not being miscible with water.

36. 发明申请

US20100280096A1 TREATMENT OF INFLUENZA 失效
标题翻译：治疗流行性感冒
公开(公告)号：US20100280096A1
公开(公告)日：2010-11-04
申请号：US12666738
申请日：2008-07-02
申请人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
发明人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
IPC分类号： A61K31/7088 , C07H21/02 , C12N15/63 , C12Q1/70 , A61P31/16
CPC分类号： C12N15/1131 , C12N2310/14
摘要： The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.
摘要翻译：本发明提供了通过RNA干扰抑制乙型流感病毒复制的双链RNA，其中双链RNA包含与从流感基因组RNA转录的mRNA的一部分同源的具有19至25个核苷酸的RNA B病毒及其反义RNA。

37. 发明申请

US20080113923A1 Type II Cubic Liquid Crystal Composition 失效
标题翻译： II型立方液晶组合物
公开(公告)号：US20080113923A1
公开(公告)日：2008-05-15
申请号：US11665776
申请日：2005-10-19
申请人： Masakatsu Hatoh , Yoshiji Fujita , Toshitaka Ota , Masahisa Tanomura , Manzo Shiono
发明人： Masakatsu Hatoh , Yoshiji Fujita , Toshitaka Ota , Masahisa Tanomura , Manzo Shiono
IPC分类号： C09K19/06 , C07C9/22 , C07H15/04 , C07D307/62 , C07K17/04 , C07K17/10 , A61K31/70 , A61K31/341 , A61K31/185
CPC分类号： A61Q19/00 , A61K8/0295 , A61K8/345 , A61K8/375 , A61K8/66 , A61K31/575 , A61K38/00 , A61K47/69 , A61K2800/522 , A61Q19/02 , C07D307/62 , C09K19/02 , C09K19/04 , C09K19/54 , C12N9/0089 , C12N9/2462
摘要： A cubic liquid crystal composition comprising at least one amphiphilic compound having the following general formula (1) and having an IV/OV value of 0.65 to 0.95, and water or an aqueous medium: wherein R represents a hydrophilic group; X and Y each independently represent a hydrogen atom or together form an oxygen atom; n is an integer of 0 to 4; and m is an integer of 0 to 3.
摘要翻译：一种立方晶体组合物，其包含至少一种具有以下通式（1）的两亲化合物和IV / OV值为0.65至0.95的两亲化合物，以及水或水性介质：其中R表示亲水基团; X和Y各自独立地表示氢原子或一起形成氧原子; n为0〜4的整数。 m为0〜3的整数。

38. 发明申请

US20070082401A1 Method of preparing solution having composition of biological components 审中-公开
标题翻译：制备具有生物成分组成的溶液的方法
公开(公告)号：US20070082401A1
公开(公告)日：2007-04-12
申请号：US10570488
申请日：2004-09-06
申请人： Shigehisa Wada , Jun Utsumi , Yoshiji Fujita , Hiroyuki Sugaya , Satoko Yamada
发明人： Shigehisa Wada , Jun Utsumi , Yoshiji Fujita , Hiroyuki Sugaya , Satoko Yamada
IPC分类号： G01N31/00
CPC分类号： B01D63/02 , B01D69/02 , G01N1/4005 , G01N33/6842 , G01N2001/4016 , Y10T436/10 , Y10T436/25
摘要： The invention provides a method of preparing a biological components-containing solution suitable for clinical proteome analysis by mass spectrometry, electrophoresis, liquid chromatography or the like and an apparatus for the method. The method of the invention is a method for combining two steps among steps of (1) adsorbing proteins having a molecular weight equal to or higher than that of albumin; (2) fractionating proteins having a molecular weight equal to or higher than that of albumin; and (3) concentrating proteins: or a method for preparing the solution by separation using a membrane separation unit having a comparative permeation ratio of 50 or higher for proteins with a molecular weight less than 15,000 and proteins with a molecular weight of 60,000 or higher; or a method for preparing the solution by introducing a biological components-containing raw solution into a separation membrane module and successively passing a diluting solution for circulating the solution and passing a portion of the solution through a separation membrane.
摘要翻译：本发明提供了一种制备适用于通过质谱，电泳，液相色谱等进行临床蛋白质组分析的含生物成分的溶液的方法和该方法的装置。本发明的方法是（1）吸附分子量等于或高于白蛋白的蛋白质的步骤之中的两个步骤的组合方法。（2）分级分子量等于或高于白蛋白的蛋白质; 和（3）浓缩蛋白质的方法，或者是使用分子量小于15000的蛋白质和比例分子量为60,000以上的蛋白质，使用比较渗透率为50以上的膜分离单元进行分离来制备溶液的方法; 或通过将含有生物成分的原料溶液导入分离膜组件并依次通过用于循环溶液的稀释溶液并使一部分溶液通过分离膜来制备溶液的方法。

39. 发明授权

US5428056A Terpene amino alcohols and medicinal uses thereof 失效
公开(公告)号：US5428056A
公开(公告)日：1995-06-27
申请号：US151039
申请日：1993-11-12
申请人： Koichi Kanehira , Katsushi Eziri , Manzo Shiono , Yoshiji Fujita , Johji Yamahara
发明人： Koichi Kanehira , Katsushi Eziri , Manzo Shiono , Yoshiji Fujita , Johji Yamahara
IPC分类号： C07D211/58 , C07D213/74 , C07D213/80 , C07D213/82 , C07D215/38 , C07D233/60 , C07D235/26 , C07D295/088 , C07D295/13 , C07D521/00 , A61K31/40 , C07D207/06
CPC分类号： C07D213/74 , C07D211/58 , C07D213/80 , C07D213/82 , C07D215/38 , C07D231/12 , C07D233/56 , C07D235/26 , C07D249/08 , C07D295/088 , C07D295/13
摘要： Novel terpene amino alcohols having an antiallergic activity or an activity of improving cerebral function are provided. Also provided are medicinal uses of the alcohols.

40. 发明授权

US5284850A Terpene amino alcohols and medicinal uses thereof 失效
标题翻译：萜烯氨基醇及其药用
公开(公告)号：US5284850A
公开(公告)日：1994-02-08
申请号：US894567
申请日：1992-06-05
申请人： Koichi Kanehira , Katsushi Eziri , Manzo Shiono , Yoshiji Fujita , Johji Yamahara
发明人： Koichi Kanehira , Katsushi Eziri , Manzo Shiono , Yoshiji Fujita , Johji Yamahara
IPC分类号： C07D211/58 , C07D213/74 , C07D213/80 , C07D213/82 , C07D215/38 , C07D233/60 , C07D235/26 , C07D295/088 , C07D295/13 , C07D521/00 , A61K31/495 , C07D295/084
CPC分类号： C07D213/74 , C07D211/58 , C07D213/80 , C07D213/82 , C07D215/38 , C07D231/12 , C07D233/56 , C07D235/26 , C07D249/08 , C07D295/088 , C07D295/13
摘要： Novel terpene amino alcohols having an antiallergic activity or an activity of improving cerebral function are provided. Also provided are medicinal uses of the alcohols.
摘要翻译：提供具有抗过敏活性的新型萜烯氨基醇或改善脑功能的活性。还提供了醇的药用。

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