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31. 发明申请

WO1992011253A1 PESTICIDAL COMPOUNDS 审中-公开
标题翻译：杀虫化合物
公开(公告)号：WO1992011253A1
公开(公告)日：1992-07-09
申请号：PCT/GB1991002239
申请日：1991-12-16
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： THE WELLCOME FOUNDATION LIMITED , LARKIN, John, Patrick , FRENKEL, Alexander, David
IPC分类号： C07D339/08
CPC分类号： C07D495/08 , A01N43/32 , A01N43/90 , C07D339/08
摘要： The present invention describes a compound of formula (I), wherein n and n' are the same or different and are each 0, 1 or 2; R is hydrogen or methyl, R' is methyl ethyl or cyclopropyl, R and R are the same or different and are each hydrogen or methyl; R is hydrogen or methyl, R is cyano or R and R are linked to form a group CH2S(O)m where m is 0, 1 or 2. A method for preparing the compounds of formula (I), pesticidal formulations containing the compounds and their use in controlling pests are also described.
摘要翻译：本发明描述了式（I）化合物，其中n和n'相同或不同，各自为0,1或2; R是氢或甲基，R'是甲基乙基或环丙基，R 2和R 3相同或不同，各自是氢或甲基; R a是氢或甲基，R b是氰基或R a和R b连接形成基团CH 2 S（O）m，其中m是0,1或2。还描述了式（I）化合物，含有化合物的杀虫剂及其在防治害虫中的用途。

32. 发明申请

WO1992006075A1 ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS 审中-公开
标题翻译：抗甲状腺素ARYL化合物
公开(公告)号：WO1992006075A1
公开(公告)日：1992-04-16
申请号：PCT/GB1991001646
申请日：1991-09-25
申请人： THE WELLCOME FOUNDATION LIMITED , FRANZMANN, Karl, Witold
发明人： THE WELLCOME FOUNDATION LIMITED
IPC分类号： C07C275/34
CPC分类号： C07D333/28 , C07C45/71 , C07C47/575 , C07C217/58 , C07C275/30 , C07C275/34 , C07D317/22 , Y10S514/824
摘要： The present invention is concerned with compounds of formula (I) wherein Ar is a mono- or bicyclic aromatic group optionally containing one or two heteroatoms independently selected from nitrogen, oxygen and sulphur, said group being optionally substituted by one or more atoms or groups independently selected from halogen, nitro, amino, -NRR where R and R are independently selected from hydrogen, C1-8 alkyl and C1-8 alkanoyl, cyano, carboxyalkoxy, alkoxycarbonylalkoxy, C1-8 alkyl (including cycloalkyl and cycloalkylalkyl), C1-8 alkoxy (including cycloalkoxy and cycloalkylalkoxy), C1-8 thioalkyl, said alkyl, alkoxy and/or thioalkyl group(s) being optionally substituted by one or more halogen atoms, aryl, aryloxy, aralkyl and aralkyloxy, said aryl, aryloxy, aralkyl and/or aralkyloxy group(s) being optionally substituted by one or more atoms or groups independently selected from halogen, alkyl, alkoxy, alkanoyl, hydroxyalkyl, perfluoroalkyl, perfluoroalkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, and C3-8 polyether groups containing from one to three oxygen atoms; D is -CH2-, -NH-, or -O-; E is ( alpha ) or ( beta ); F is -O- or ( psi ); G is C3-12 straight, branched, or cyclic alkyl, or aralkyl, said aralkyl group being optionally substituted by one or more atoms or groups independently selected from halogen, amino, N-(C1-6 alkyl)amino, N,N-di(C1-6 alkyl)amino, C1-6 alkyl and C1-6 alkoxy, or a C3-8 polyether group containing one to three oxygen atoms; J is a bond or C1-6 straight or branched alkylene; X is a C2-8 straight, branched, or cyclic alkylene group optionally substituted by one or more halogen atoms or C1-4 alkoxy groups, wherein one or two of the linear carbon atom(s) is/are replaced by oxygen; and Z is hydrogen, hydroxy, C1-4 alkyl, C2-5 alkanoyl, or carboxyl, said alkyl group being optionally substituted by one or more halogen atoms; and their physiologically functional derivatives, with processes for their preparation, with medicaments containing them and with their use as therapeutic agents, particularly in the prophylaxis and treatment of atherosclerosis.
摘要翻译：本发明涉及式（I）化合物，其中Ar是任选含有一个或两个独立地选自氮，氧和硫的杂原子的单环或双环芳基，所述基团任选被一个或多个独立地被一个或多个原子或基团取代选自卤素，硝基，氨基，-NRR 1，其中R和R 1独立地选自氢，C 1-8烷基和C 1-8烷酰基，氰基，羧基烷氧基，烷氧基羰基烷氧基，C 1-8烷基（包括环烷基和环烷基烷基），C 1-8烷氧基（包括环烷氧基和环烷基烷氧基），C1-8硫代烷基，所述烷基，烷氧基和/或硫代烷基任选被一个或多个卤素原子，芳基，芳氧基，芳烷基和芳烷氧基取代，所述芳基，芳氧基，芳烷基和/或芳烷氧基任选被一个或多个独立地选自卤素，烷基，烷氧基，烷酰基，羟烷基，全氟烷基，全氟烷氧基，羧烷氧基，烷氧基芳基烷氧基和含1-3个氧原子的C3-8聚醚基团; D是-CH 2 - ， - NH-或-O-; E为（α）或（β）; F为-O-或（psi）; G为C3-12直链，支链或环状烷基或芳烷基，所述芳烷基任选被一个或多个独立选自卤素，氨基，N-（C 1-6烷基）氨基，N，二（C 1-6烷基）氨基，C 1-6烷基和C 1-6烷氧基，或含有1-3个氧原子的C 3-8聚醚基团; J是键或C1-6直链或支链亚烷基; X是任选被一个或多个卤素原子或C 1-4烷氧基取代的C 2-8直链，支链或环状亚烷基，其中一个或两个直链碳原子被氧代替; Z为氢，羟基，C 1-4烷基，C 2-5烷酰基或羧基，所述烷基任选被一个或多个卤素原子取代; 及其生理功能衍生物，其制备方法，含有它们的药物和用作治疗剂，特别是用于预防和治疗动脉粥样硬化。

33. 发明申请

WO1992005798A1 ACELLULAR VACCINE 审中-公开
公开(公告)号：WO1992005798A1
公开(公告)日：1992-04-16
申请号：PCT/GB1991001669
申请日：1991-09-27
申请人： THE WELLCOME FOUNDATION LIMITED , CHARLES, Ian, George , FAIRWEATHER, Neil, Fraser
发明人： THE WELLCOME FOUNDATION LIMITED
IPC分类号： A61K39/10
CPC分类号： C07K14/235 , A61K39/00
摘要： A vaccine suitable for use in inducing immunity to whooping cough in humans comprises a synergistic combination of the 69kDa antigen of Bordetella pertussis and toxoided lymphocytosis promoting factor of Bordetella pertussis.
摘要翻译：适用于诱导人类百日咳免疫的疫苗包括百日咳博德特氏菌的69kDa抗原与百日咳杆菌属的类毒素淋巴细胞增生促进因子的协同组合。

34. 发明申请

WO1992001452A1 ENZYME INACTIVATORS 审中-公开
标题翻译： ENZYME灭活剂
公开(公告)号：WO1992001452A1
公开(公告)日：1992-02-06
申请号：PCT/GB1991001197
申请日：1991-07-18
申请人： THE WELLCOME FOUNDATION LIMITED , SPECTOR, Thomas , PORTER, David, John, Timothy , RAHIM, Saad, George
发明人： THE WELLCOME FOUNDATION LIMITED
IPC分类号： A61K31/505
CPC分类号： C07D239/54 , A61K31/505 , A61K31/513 , A61K31/70 , C07F7/0812 , A61K2300/00
摘要： Use of uracil reductase inactivators such as 5-substituted uracil derivatives for example 5-ethynyluracil to reduce the toxicity of the anti-HIV nucleoside analogue zidovudine.
摘要翻译：使用尿嘧啶还原酶灭活剂如5-取代的尿嘧啶衍生物例如5-乙炔基尿嘧啶以降低抗HIV核苷类似物齐多夫定的毒性。

35. 发明申请

WO1992000965A1 NEUROMUSCULAR BLOCKING AGENTS 审中-公开
标题翻译：神经阻滞剂
公开(公告)号：WO1992000965A1
公开(公告)日：1992-01-23
申请号：PCT/GB1991001150
申请日：1991-07-12
申请人： THE WELLCOME FOUNDATION LIMITED , HILL, Derek, Anthony , TURNER, Geoffrey, Lloyd
发明人： THE WELLCOME FOUNDATION LIMITED
IPC分类号： C07D217/20
CPC分类号： C07D217/20
摘要： 1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium) salt, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been found to have an advantageous combination of pharmacological properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockage, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockade), in comparison with the known mixture of geometrical and optical isomers.

36. 发明申请

WO1991005550A1 MEDICAMENT FOR THE TREATMENT OF CRYPTOSPORIDIOSIS 审中-公开
标题翻译：治疗结缔组织病的药物
公开(公告)号：WO1991005550A1
公开(公告)日：1991-05-02
申请号：PCT/GB1989001287
申请日：1989-10-26
申请人： THE WELLCOME FOUNDATION LIMITED , LATTER, Victoria, Susan
发明人： THE WELLCOME FOUNDATION LIMITED
IPC分类号： A61K31/12
CPC分类号： A61K31/12 , Y02A50/488
摘要： The present invention relates to the use of 2-[4-(4-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt or other physiologically functional derivative thereof for the manufacture of a medicament for the treatment and/or prophylaxis of cryptosporidiosis in animals, to pharmaceutical compositions for the treatment and/or prophylaxis of cryptosporidiosis, comprising said compound as active ingredient and to a method of treating or preventing cryptosporidiosis in an animal which comprises administering to said animal an effective amount of said compound.
摘要翻译：本发明涉及2- [4-（4-氯苯基）环己基] -3-羟基-1,4-萘醌或其生理上可接受的盐或其他生理功能衍生物在制备用于治疗的药物中的用途和/或预防动物中的隐孢子虫病，用于治疗和/或预防隐孢子虫病的药物组合物，其包含所述化合物作为活性成分，以及治疗或预防动物隐孢子虫病的方法，其包括向所述动物施用有效量的说化合物。

37. 发明申请

WO1988009332A1 THERAPEUTIC NUCLEOSIDES 审中-公开
标题翻译：治疗性核素
公开(公告)号：WO1988009332A1
公开(公告)日：1988-12-01
申请号：PCT/GB1988000424
申请日：1988-05-27
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： THE WELLCOME FOUNDATION LIMITED , KRENITSKY, Thomas, Anthony , KOSZALKA, George, Walter
IPC分类号： C07D405/04
CPC分类号： C07D473/00
摘要： This invention relates to certain derivatives of 2',3'-dideoxycytidine and their use in medical therapy particularly in the treatment and prophylaxis of HIV infections. Also provided are pharmaceutical formulations and processes for the manufacture of the compounds according to the invention.
摘要翻译：本发明涉及2'，3'-二脱氧胞苷的某些衍生物及其在药物治疗中的用途，特别是用于治疗和预防HIV感染。还提供了用于制备根据本发明的化合物的药物制剂和方法。

38. 发明授权

EP0549581B1 FRAMEWORK MUTATED ANTIBODIES AND THEIR PREPARATION 失效
标题翻译： Rahmenbau-突变体抗体及其制备方法
公开(公告)号：EP0549581B1
公开(公告)日：1997-01-22
申请号：EP91907669.5
申请日：1991-09-16
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： THE WELLCOME FOUNDATION LIMITED
IPC分类号： C12P21/08 , C12N15/13 , A61K39/395
CPC分类号： C07K16/2812 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species.

39. 发明申请

WO1996029556A1 FREEZE-DRYING PROCESS AND APPARATUS 审中-公开
标题翻译：冷冻干燥工艺和设备
公开(公告)号：WO1996029556A1
公开(公告)日：1996-09-26
申请号：PCT/GB1996000597
申请日：1996-03-14
申请人： THE WELLCOME FOUNDATION LIMITED , OUGHTON, Dominic, Michael, Anthony , SMITH, Philip, Russell, James , MACMICHAEL, Donald, Bruce, Atherton
发明人： THE WELLCOME FOUNDATION LIMITED
IPC分类号： F26B05/06
CPC分类号： F26B5/06
摘要： A freeze-drying process includes a freezing step of rotating the vial (1) about its longitudinal axis at a speed not less than that required to maintain by centrifugal force the aqueous material to be freeze-dried in the form of a shell (7) on the inner walls of the vial (1) and then subjecting the material to freezing conditions to freeze it in the form of said shell (7). In another aspect of the invention, the freeze-drying process also includes the step of drying the shell frozen material (7), by directing heat radially inwards from a heating block (14) to the shell frozen material (7) and increasing the temperature over a time period to dry the shell frozen material (7).
摘要翻译：冷冻干燥过程包括冷冻步骤，其以不小于通过离心力将待冷冻干燥的水性材料以壳体（7）的形式所需的速度旋转小瓶（1）的纵轴，在小瓶（1）的内壁上，然后对材料进行冷冻条件以使其以所述壳（7）的形式冷冻。在本发明的另一方面，冷冻干燥过程还包括通过将加热块（14）径向向内引导到壳体冷冻材料（7）并使温度升高的步骤来干燥壳体冷冻材料（7）在一段时间内干燥壳冷冻材料（7）。

40. 发明申请

WO1996028443A1 THERAPEUTIC BENZOXAZOLES 审中-公开
标题翻译：治疗苯并噻唑
公开(公告)号：WO1996028443A1
公开(公告)日：1996-09-19
申请号：PCT/GB1996000595
申请日：1996-03-14
申请人： THE WELLCOME FOUNDATION LIMITED , CLEARY, Darryl, Gene , CORY, Michael
发明人： THE WELLCOME FOUNDATION LIMITED
IPC分类号： C07D413/14
CPC分类号： C07D263/62 , C07D413/14
摘要： The present invention relates to certain bisbenzoxazole compounds and their use in medical therapy, particularly in the treatment of immunodeficiency virus infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.
摘要翻译：本发明涉及某些双苯并恶唑化合物及其在药物治疗中的用途，特别涉及治疗免疫缺陷病毒感染。还提供了用于制备根据本发明的化合物的药物制剂和方法。

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