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31. 发明授权

EP2766045B1 TREATMENT OF BREAST CANCER WITH COMPANION DIAGNOSTIC 有权转让
标题翻译：。UNG。。。。。。。。。。。。。
公开(公告)号：EP2766045B1
公开(公告)日：2016-12-07
申请号：EP12840745.9
申请日：2012-10-15
申请人： The Regents of the University of California
发明人： WADEHRA, Madhuri , BRAUN, Jonathan
IPC分类号： C07K16/30 , A61K39/395 , A61K38/10 , A61K38/16 , A61K48/00 , A61P35/00 , A61K39/00 , A61K45/06 , A61K47/48
CPC分类号： A61K39/39558 , A61K38/10 , A61K45/06 , A61K2039/505 , C07K16/3015 , C07K16/3069 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/626 , C07K2317/73

32. 发明公开

EP2958575A1 COMPOSITIONS AND METHODS FOR PROMOTING GROWTH OF BENEFICIAL MICROBES TO TREAT OR PREVENT DISEASE OR PROLONG LIFE 有权
标题翻译：组合物和向有益芽的对于疾病的治疗或预防或FOR延寿促进生长的方法
公开(公告)号：EP2958575A1
公开(公告)日：2015-12-30
申请号：EP14753847.4
申请日：2014-02-19
申请人： The Regents of the University of California
发明人： YAMAMOTO, Mitsuko, L. , SCHIESTL, Robert, H. , RELIENE, Ramune , BORNEMAN, James , PRESLEY, Laura, L. , BRAUN, Jonathan
IPC分类号： A61K35/74 , A61K35/66 , A61P35/00
CPC分类号： A61K35/747 , A61K35/741 , A61K35/76 , A61K45/06 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone diseases, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespan in a simple, non-invasive manner.

33. 发明公开

EP2831110A1 ANTI-EMP2 THERAPY REDUCES CANCER STEM CELLS 有权转让
标题翻译： ANTI-EMP2治疗减少癌症干细胞
公开(公告)号：EP2831110A1
公开(公告)日：2015-02-04
申请号：EP13770310.4
申请日：2013-03-14
申请人： The Regents of the University of California , Paganini Biopharma, Inc.
发明人： WADEHRA, Madhuri , BRAUN, Jonathan , GORDON, Lynn, K. , LAZAR, Gary, S.
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K47/6823 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , A61K2039/55 , C07K16/22 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34 , C07K2317/626 , C07K2317/73 , C07K2317/92 , G01N33/57492 , G01N2333/4703 , G01N2333/70585 , G01N2333/70596 , G01N2333/90203 , A61K2300/00
摘要： Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1α, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.

34. 发明授权

EP2831110B1 ANTI-EMP2 THERAPY REDUCES CANCER STEM CELLS 有权转让
标题翻译：抗-EMP2治疗减少癌症干细胞
公开(公告)号：EP2831110B1
公开(公告)日：2018-05-09
申请号：EP13770310.4
申请日：2013-03-14
申请人： The Regents of the University of California , Paganini Biopharma, Inc.
发明人： WADEHRA, Madhuri , BRAUN, Jonathan , GORDON, Lynn, K. , LAZAR, Gary, S.
IPC分类号： C07K16/00 , A61K39/395 , C07K16/30 , A61K39/00 , A61K45/06 , C07K16/18 , C07K16/22 , C07K16/28 , G01N33/574
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K47/6823 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , A61K2039/55 , C07K16/22 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34 , C07K2317/626 , C07K2317/73 , C07K2317/92 , G01N33/57492 , G01N2333/4703 , G01N2333/70585 , G01N2333/70596 , G01N2333/90203 , A61K2300/00
摘要： Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1α, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.

35. 发明公开

EP2812354A1 EMP2 REGULATES ANGIOGENESIS IN CANCER CELLS THROUGH INDUCTION OF VEGF 无效
标题翻译： EMP2作为癌症细胞血管生成调节通过感应血管内皮生长因子
公开(公告)号：EP2812354A1
公开(公告)日：2014-12-17
申请号：EP13747090.2
申请日：2013-02-06
申请人： The Regents of the University of California
发明人： WADEHRA, Madhuri , BRAUN, Jonathan , GORDON, Lynn, K.
IPC分类号： C07K16/00 , C07K16/18 , A61K39/395 , A61P35/04
CPC分类号： C07K16/30 , A61K31/69 , A61K38/14 , A61K39/39558 , A61K47/6415 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2857 , C07K2317/24 , C07K2317/34 , C07K2317/622
摘要： Disclosed herein are methods and compositions for modulating neovascularization. The disclosed compositions find particular use in the treatment of uterine cancers, specifically endometrial cancers.

36. 发明公开

EP2766045A2 TREATMENT OF BREAST CANCER WITH COMPANION DIAGNOSTIC 有权转让
标题翻译：乳腺癌的伴随诊断治疗
公开(公告)号：EP2766045A2
公开(公告)日：2014-08-20
申请号：EP12840745.9
申请日：2012-10-15
申请人： The Regents of the University of California
发明人： WADEHRA, Madhuri , BRAUN, Jonathan
IPC分类号： A61K39/395 , A61K38/10 , A61K38/16 , A61K48/00 , A61P35/00
CPC分类号： A61K39/39558 , A61K38/10 , A61K45/06 , A61K2039/505 , C07K16/3015 , C07K16/3069 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/626 , C07K2317/73
摘要： (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/056248 A2 18 April 2013 (18.04.2013) WI PO I P CT (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, A61K 39/395 (2006.01) A61K 48/00 (2006.01) DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, A61K 38/10 (2006.01) A61P 35/00 (2006.01) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, A 61K 38/16 (2006.01) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (21) International Application Number: NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, PCT/US2012/060288 RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (22) International Filing Date: TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, 15 October 2012 (15.10.2012) ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (30) Priority Data: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 61/546,982 13 October 2011 (13.10.2011) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicant: THE REGENTS OF THE UNIVERSITY MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, OF CALIFORNIA [US/US]; 1111 Franklin Street, Oak- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, land, CA 94607-5200 (US). ML, MR, NE, SN, TD, TG). (72) Inventors: WADEHRA, Madhuri; 1604 N. Poinsettia Declarations under Rule 4.17: Avenue, Manhattan Beach, CA 90266 (US). BRAUN, - as to applicant's entitlement to applyfor and be granted a Jonathan; 3924 Hilton Head Way, Tarzana, CA 91356 patent (Rule 4.17(ii) (US). - as to the applicant's entitlement to claim the priority of the (74) Agent: PARENT, Annette; Morgan, Lewis & Bockius earlier application (Rule 4.17(iii)) LLP, One Market, Spear Street Tower, San Francisco, CA 94105 (US). Published: (81) Designated States (unless otherwise indicated, for every with declaration under Article 17(2)(a); without abstract; kind of national protection available): AE, AG, AL, AM, title not checked by the International Searching Authority AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, O (54) Title: TREATMENT OF BREAST CANCER WITH COMPANION DIAGNOSTIC (57) Abstract:

37. 发明公开

EP2536433A2 EPITHELIAL MEMBRANE PROTEIN 2 (EMP2) BINDING REAGENTS AND THEIR THERAPEUTIC USES IN OCULAR DISEASES 失效
标题翻译：装订EPITHELIALMEMBRANENPROTEIN-2（EMP2）及其治疗的试剂用途眼疾
公开(公告)号：EP2536433A2
公开(公告)日：2012-12-26
申请号：EP11745457.9
申请日：2011-02-22
申请人： The Regents of the University of California , United States Government Department Of Veterans Affairs
发明人： GORDON, Lynn K. , BRAUN, Jonathan , MORALES, Shawn , TELANDER, David, G. , WADEHRA, Madhuri
IPC分类号： A61K39/395 , A61P27/02 , A61K31/7105 , A61P27/00 , A61K38/16
CPC分类号： C07K16/18 , A61K38/00 , C07K16/28 , C07K2317/21 , C07K2317/35 , C07K2317/76 , C12N15/1138 , C12N2310/14

38. 发明授权

EP0959900B1 DIAGNOSIS OF ULCERATIVE COLITIS, AND CLINICAL SUBTYPES THEREOF, USING HISTONE H1 失效
标题翻译：结肠炎结肠炎诊断和临床亚型蛋白H1
公开(公告)号：EP0959900B1
公开(公告)日：2008-06-11
申请号：EP97924522.2
申请日：1997-04-11
申请人： The Regents of the University of California , Cedars-Sinai Medical Center
发明人： BRAUN, Jonathan , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： A61K39/00 , G01N33/564
CPC分类号： G01N33/564 , A61K39/0008
摘要： The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of human histone H1, or pANCA-reactive fragment thereof, and antibody to human histone H1; and detecting the presence or absence of the complex, where the presence of the complex indicates that the individual has UC. The invention also provides related methods of diagnosing a perinuclear anti-neutrophil cytoplasmic antibody positive (pANCA-positive) clinical subtype of UC in a patient with UC. In addition, the invention further provides methods of determining susceptibility to UC in an individual. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC by administering an effective dose of histone H1, or tolerogenic fragment thereof, to the pANCA-positive patient with UC. Compositions of histone H1, or fragment thereof, combined with a tolerogizing molecule also are provided.

39. 发明公开

EP1285271A2 DIAGNOSIS, PREVENTION AND TREATMENT OF CROHN'S DISEASE USING THE OMPC ANTIGEN 有权
标题翻译：诊断，预防和克罗恩病处理中的抗原OMPC
公开(公告)号：EP1285271A2
公开(公告)日：2003-02-26
申请号：EP01935666.6
申请日：2001-05-17
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： TARGAN, Stephan, R. , BRAUN, Jonathan , SUTTON, Christopher, L.
IPC分类号： G01N33/53 , G01N33/543 , G01N33/564 , C12Q1/68 , C07H21/02
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.

40. 发明公开

EP0959900A1 DIAGNOSIS, PREVENTION AND TREATMENT OF ULCERATIVE COLITIS, AND CLINICAL SUBTYPES THEREOF, USING HISTONE H1 失效
标题翻译：结肠炎结肠炎诊断和临床亚型蛋白H1
公开(公告)号：EP0959900A1
公开(公告)日：1999-12-01
申请号：EP97924522.0
申请日：1997-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CEDARS-SINAI MEDICAL CENTER
发明人： BRAUN, Jonathan , TARGAN, Stephan, R. , EGGENA, Mark
IPC分类号： A61K39 , G01N33
CPC分类号： G01N33/564 , A61K39/0008
摘要： The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of human histone H1, or pANCA-reactive fragment thereof, and antibody to human histone H1; and detecting the presence or absence of the complex, where the presence of the complex indicates that the individual has UC. The invention also provides related methods of diagnosing a perinuclear anti-neutrophil cytoplasmic antibody positive (pANCA-positive) clinical subtype of UC in a patient with UC. In addition, the invention further provides methods of determining susceptibility to UC in an individual. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC by administering an effective dose of histone H1, or tolerogenic fragment thereof, to the pANCA-positive patient with UC. Compositions of histone H1, or fragment thereof, combined with a tolerogizing molecule also are provided.

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