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31. 发明专利

AU2018217094A1 In vivo drug delivery devices and methods for drug delivery 未知
公开(公告)号：AU2018217094A1
公开(公告)日：2019-08-22
申请号：AU2018217094
申请日：2018-02-01
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , ABBATE EMILY , HOCKING SARAH , GIESING DENNIS
IPC分类号： A61M31/00 , A61K9/00
摘要： Drug delivery devices and methods of administering drugs to patients are provided. A device (50) includes a reservoir (60) containing a drug (58). The reservoir (60) is defined by a wall (64) having a water-permeable portion, such that the water-permeable portion permits water to enter the device (50) and contact the drug (58). A restraining plug (56) closes off an opening of the device (50) such that transient microchannels (62) form between an elastic portion (54) of the device (50) and the restraining plug (56), upon the generation of a sufficient pressure within the reservoir (60), to release the drug (58) from the device (50). Methods of treating patients for neurogenic detrusor overactivity resulting from a spinal cord injury and/or for idiopathic overactive bladder and urinary incontinence are also described.

32. 发明专利

CA3081839A1 METHODS OF TREATMENT AND MAINTENANCE THERAPY FOR BLADDER CANCER USING GEMCITABINE 未知
公开(公告)号：CA3081839A1
公开(公告)日：2019-05-16
申请号：CA3081839
申请日：2018-11-07
申请人： TARIS BIOMEDICAL LLC
发明人： CUTIE CHRISTOPHER , GIESING DENNIS
IPC分类号： A61K31/7068 , A61K9/00 , A61M31/00 , A61P13/10 , A61P35/00
摘要： Provided are methods of treating urothelial carcinomas of the lower tract comprising administering comprising administering gemcitabine continuously and locally to the bladder of an individual in an induction therapy and/or maintenance therapy.

33. 发明专利

AU2013308465B2 Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine 未知
公开(公告)号：AU2013308465B2
公开(公告)日：2018-05-17
申请号：AU2013308465
申请日：2013-09-03
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS
IPC分类号： A61K31/7068 , A61K9/00 , A61L29/14 , A61L29/16 , A61L31/16 , A61M31/00 , A61P13/08 , A61P13/10 , A61P35/00
摘要： Methods, devices, and medicaments that include gemicitabine are provided for use in the treatment of the prostate disease by locally administering gemicitabine into the bladder of a patient to achieve a sustained concentration of the drug in urine in the bladder sufficient to produce a therapeutic concentration of the drug in the prostate. Gemicitabine may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the drug into the urine in the bladder over an extended period of hours or days.

34. 发明专利

SG11201502104YA DRUG DELIVERY SYSTEMS AND METHODS FOR TREATMENT OF BLADDER VOIDING DYSFUNCTION AND OTHER LOWER URINARY TRACT DISORDERS BY USING TROSPIUM 未知
公开(公告)号：SG11201502104YA
公开(公告)日：2015-05-28
申请号：SG11201502104Y
申请日：2013-09-18
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS
IPC分类号： A61K31/439 , A61K9/00 , A61L29/14 , A61L29/16 , A61L31/16 , A61M31/00 , A61P13/00 , A61P13/10

35. 发明专利

AU2013318146A1 Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium 未知
公开(公告)号：AU2013318146A1
公开(公告)日：2015-03-19
申请号：AU2013318146
申请日：2013-09-18
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS
IPC分类号： A61K31/439 , A61K9/00 , A61L29/14 , A61L29/16 , A61L31/16 , A61M31/00 , A61P13/00 , A61P13/10
摘要： Methods, devices, and medicaments that include trospium are provided for use in the treatment of bladder dysfunction by locally administering the trospium into the bladder to achieve a sustained concentration of trospium in urine in the bladder sufficient to produce a therapeutic concentration of trospium in bladder tissue. The drug may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the drug into the urine in the bladder over an extended period of hours or days.

36. 发明专利

ES2930435T3 Sistemas y métodos de administración de fármacos para el tratamiento del cáncer de vejiga con gemcitabina 未知
公开(公告)号：ES2930435T3
公开(公告)日：2022-12-13
申请号：ES15711373
申请日：2015-03-06
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS , LEE HEEJIN , DANIEL KAREN
IPC分类号： A61K9/00 , A61K31/7068 , A61P13/10 , A61P35/00

37. 发明专利

DK2890384T3 LÆGEMIDDELLEVERINGSYSTEMER OG FREMGANGSMÅDER TIL BEHANDLING AF BLÆREKRÆFT OMFATTENDE OXALIPLATIN 未知
公开(公告)号：DK2890384T3
公开(公告)日：2022-01-10
申请号：DK13765839
申请日：2013-09-03
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS
IPC分类号： A61K31/555 , A61K9/00 , A61M31/00 , A61P13/10 , A61P35/00

38. 发明专利

ES2873084T3 Dispositivos para la administración de fármacos in vivo 未知
公开(公告)号：ES2873084T3
公开(公告)日：2021-11-03
申请号：ES18705786
申请日：2018-02-01
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , ABBATE EMILY , HOCKING SARAH , GIESING DENNIS
IPC分类号： A61M31/00 , A61K9/00
摘要： Un dispositivo de administración de fármacos (50, 700) que comprende: un cuerpo (52) que comprende una pared (64, 82) que delimita un depósito (60) definido dentro del cuerpo, la pared teniendo por lo menos un orificio pasante preformado (66) dispuesto en la misma y que comprende una parte permeable al agua, el cuerpo comprendiendo una parte elástica (54); y una formulación de fármaco (58) que comprende un fármaco, la formulación de fármaco estando dispuesta dentro del depósito; en donde el dispositivo de administración de fármacos comprende por lo menos un tapón de contención (56) que cierra una abertura del cuerpo y hace contacto con la parte elástica del cuerpo, la abertura estando en comunicación fluida con el depósito, en donde la parte permeable al agua de la pared está configurada para permitir que el agua entre en el dispositivo de administración de fármacos y entre en contacto con la formulación de fármaco localizada en el depósito, caracterizado porque la liberación del fármaco desde el dispositivo se controla mediante (i) la liberación del fármaco a través del por lo menos un orificio pasante preformado en la pared, y (ii) la liberación del fármaco a través de la formación transitoria de uno o más microcanales (62) entre los la parte elástica del cuerpo y el por lo menos un tapón de contención, que se extiende hasta la abertura, tras la generación dentro del depósito de una presión hidrostática efectiva para formar el uno o más microcanales.

39. 发明专利

HRP20210571T1 UREĐAJI ZA PRIMJENU LIJEKA IN VIVO 未知
公开(公告)号：HRP20210571T1
公开(公告)日：2021-09-03
申请号：HRP20210571
申请日：2021-04-09
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , ABBATE EMILY , HOCKING SARAH , GIESING DENNIS
IPC分类号： A61M31/00 , A61K9/00

40. 发明专利

SG10202101978SA DRUG DELIVERY SYSTEMS AND METHODS FOR TREATMENT OF BLADDER CANCER WITH GEMCITABINE 未知
公开(公告)号：SG10202101978SA
公开(公告)日：2021-04-29
申请号：SG10202101978S
申请日：2015-03-06
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS , LEE HEEJIN , DANIEL KAREN
摘要： Drug delivery devices and methods are provided for administering gemcitabine to a patient in need of treatment of bladder cancer by intravesically administering gemcitabine into the bladder of the patient to achieve a sustained concentration of the gemcitabine in urine in the bladder sufficient to produce a therapeutically effective concentration of the gemcitabine in the tissues of the bladder. In embodiments, the local administration into the patient's bladder is at a mean average amount of from 1 mg/day to about 300 mg/day of the gemcitabine (FBE).

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