专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

WO1986005183A1 ANTIBACTERIAL COMPOUNDS, THEIR PRODUCTION AND USE 审中-公开
标题翻译：抗菌化合物，其生产和使用
公开(公告)号：WO1986005183A1
公开(公告)日：1986-09-12
申请号：PCT/JP1986000099
申请日：1986-02-28
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MIYAKE, Akio , KONDO, Masahiro , FUJINO, Masahiko
IPC分类号： C07D501/46
CPC分类号： C07D277/587 , C07D285/08 , C07D463/22 , C07D471/04 , C07D487/04 , C07D505/00
摘要： A compound of formula (I), wherein R is an amino group which may be protected R is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S O, O or CH2, R is a hydrogen atom, methoxy group or formamido group, R is a hydrogen atom, methyl group, hydroxyl group or halogen atom and A is an optionally substituted imidazolium-l-yl group forming a condensed ring at the 2,3- or 3,4-position or a pharmaceutically acceptable salt or ester thereof is novel and has excellent antibacterial activity.
摘要翻译：式（I）化合物，其中R 1为可被保护的氨基，R 3为氢原子或任选取代的烃残基; Z是S，S，O，O或CH 2，R 4是氢原子，甲氧基或甲酰氨基，R 13是氢原子，甲基，羟基或卤素原子，A + >是在2,3-或3,4-位上形成稠环的任选取代的咪唑鎓-1-基，或其药学上可接受的盐或酯是新颖的，具有优异的抗菌活性。

32. 发明申请

WO1986005094A1 ANTIOBESITY AGENT AND COMPOSITION 审中-公开
标题翻译：抗菌剂和组合物
公开(公告)号：WO1986005094A1
公开(公告)日：1986-09-12
申请号：PCT/JP1985000118
申请日：1985-03-08
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MATSUO, Takao , HORII, Satoshi , KITAMORI, Nobuyuki
IPC分类号： A61K31/13
CPC分类号： A61K35/744 , A61K31/13 , A61K31/70 , A61K2300/00
摘要： An antiobesity agent comprising a combination of an alpha-glucosidase inhibitor and non-pathogenic, lactic acid-yielding bacteria, and an anti-obesity composition containing them. Obesity can be prevented or treated without temperance in eating, by oral administration of the agent or the composition. They are not substantially accompanied by diarrhea, meteorism, etc. which are induced by administration of an alpha-glucosidase inhibitor alone.
摘要翻译：包含α-葡糖苷酶抑制剂和非致病性乳酸产生细菌的组合的抗肥胖剂和含有它们的抗肥胖组合物。通过口服给药或组合物，可以预防或治疗无节制的肥胖。它们基本上不伴有通过单独施用α-葡糖苷酶抑制剂诱导的腹泻，气象等。

33. 发明申请

WO1986003753A1 PIPERIDINE DERIVATIVES 审中-公开
标题翻译：哌啶衍生物
公开(公告)号：WO1986003753A1
公开(公告)日：1986-07-03
申请号：PCT/JP1984000608
申请日：1984-12-21
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , SUGIHARA, Hirosada , NISHIKAWA, Kohei , ITO, Katsumi
IPC分类号： C07K05/06
CPC分类号： C07K5/0222 , A61K38/00
摘要： Novel compounds represented by general formula (I), wherein A represents an alpha -amino acid residue, B represents formula (II) (wherein R represents hydrogen, lower alkyl, aralkyl or amino-lower alkyl), the bond between A and B represents a peptide bond, with R in B being optionally bound to A, R represents hydrogen, lower alkyl or aralkyl, R represents hydrogen, lower alkyl, aralkyl or acyl, and X represents alkylene, and salts thereof are effective in inhibiting angiotensin-converting enzyme, and are useful as agents for diagnosis, prophylaxis, and treatment of hypertension, heart diseases, apoplexy, etc.
摘要翻译：由通式（I）表示的新型化合物，其中A表示α-氨基酸残基，B表示式（II）（其中R 4表示氢，低级烷基，芳烷基或氨基 - 低级烷基），A B表示肽键，B中的R 4任选地与A结合，R 1表示氢，低级烷基或芳烷基，R 2表示氢，低级烷基，芳烷基或酰基，X表示亚烷基及其盐对抑制血管紧张素转换酶有效，可用作高血压，心脏病，中风等的诊断，预防和治疗药物。

34. 发明申请

WO1986002068A1 MUTUAL SEPARATION OF PROTEINS 审中-公开
标题翻译：蛋白质的相互分离
公开(公告)号：WO1986002068A1
公开(公告)日：1986-04-10
申请号：PCT/JP1984000460
申请日：1984-09-26
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , KATO, Koichi , YAMADA, Takao , KAWAHARA, Kenji
IPC分类号： C07C103/52
CPC分类号： C07K14/56 , C07K1/28 , C07K14/55 , Y10S530/806 , Y10S530/808 , Y10S530/82 , Y10S530/827
摘要： Method for mutually separating a mixture of an interleukin-2 and another interleukin-2 having a methionine residue at its amino terminal by utilizing the difference in isoelectric point between the two interleukins.
摘要翻译：通过利用两个白介素之间的等电点的差异，在其氨基末端相互分离白细胞介素-2和具有甲硫氨酸残基的另一种白细胞介素-2的混合物的方法。

35. 发明申请

WO1986000618A1 CONDENSED 7-MEMBERED RING COMPOUNDS AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：浓缩的7-会员环化合物及其制备方法
公开(公告)号：WO1986000618A1
公开(公告)日：1986-01-30
申请号：PCT/JP1984000363
申请日：1984-07-13
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , SUGIHARA, Hirosada , NISHIKAWA, Kohei , ITO, Katsumi
IPC分类号： C07D281/10
CPC分类号： C07D209/48 , A61K38/00 , C07D281/10 , C07D417/04 , C07K5/0222
摘要： Novel condensed 7-membered ring compounds represented by formula (I), (wherein R and R each represents hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy or, when taken together, they represent tri- or tetramethylene, R and R each represents hydrogen, lower alkyl or arakyl, R represents hydrogen or lower alkyl, R represents a condensed or non-condensed hetero-alicyclic group containing at least one N, O or S as a ring atom, A represents an alkylene chain, and n represents 1 or 2) and salts thereof. These compounds and their salts are effective in inhibiting angiotensin-converting enzyme, and are useful for diagnosis, prophylaxis, and treatment of circulatory system diseases, e.g., hypertension, heart disease or apoplexy.
摘要翻译：由式（I）表示的新型稠合的7-元环化合物（其中R 1和R 2各自代表氢，卤素，三氟甲基，低级烷基或低级烷氧基，或者当它们一起表示三 - 或四亚甲基 R 3和R 5各自表示氢，低级烷基或芳烷基，R 4表示氢或低级烷基，R 6表示含有至少一个N， O或S为环原子，A表示亚烷基链，n表示1或2）及其盐。这些化合物及其盐对抑制血管紧张素转化酶有效，可用于诊断，预防和治疗循环系统疾病，例如高血压，心脏病或中风。

36. 发明申请

WO1986000070A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO1986000070A1
公开(公告)日：1986-01-03
申请号：PCT/JP1984000295
申请日：1984-06-07
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MIYAKE, Akio , KONDO, Masahiro , FUJINO, Masahiko
IPC分类号： C07D501/46
CPC分类号： C07D519/00 , C07D505/00
摘要： Novel cephem compounds represented by general formula (I), wherein R1 represents an optionally protected amino group, R2 represents hydrogen or halogen, R3 represents hydrogen or an optionally substituted hydrocarbon residue, R4 represents hydrogen or methoxy, A represents an optionally substituted pyrazol-2-yl group forming a fused ring at positions 1 and 5, and n represents 0 or 1. They possess an excellent antibacterial activity.
摘要翻译：由通式（I）表示的新型头孢烯化合物，其中R 1表示任选保护的氨基，R 2表示氢或卤素，R 3表示氢或任选取代的烃基，R 4表示氢或甲氧基，A表示任选取代的吡唑-2-基在1位和5位上形成稠合环，n表示0或1.它们具有优异的抗菌活性。

37. 发明申请

WO1985004879A1 CEPHEM COMPOUNDS 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO1985004879A1
公开(公告)日：1985-11-07
申请号：PCT/JP1984000212
申请日：1984-04-23
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MIYAKE, Akio , KONDO, Masahiro , FUJINO, Masahiko
IPC分类号： C07D501/46
CPC分类号： C07D277/587 , C07D471/04 , C07D505/00
摘要： Novel cephem compounds of general formula (I), wherein R1 represents and optionally amino group, R2 represents H or halogen, R3 represents H or an optionally substituted hydrocarbon residue, R4 represents H or methoxy, A represents an optionally substituted imidazol-l-yl group forming a fuzed ring at positions 2 and 3 or 3 and 4, and n represents 0 or 1. They have an excellent antibacterial activity.
摘要翻译：通式（I）的新型头孢烯化合物，其中R 1表示和任选的氨基，R 2表示H或卤素，R 3表示H或任选取代的烃基，R 4表示H或甲氧基，A表示任选取代的咪唑-1-基在2位和3位或3位和4位形成一个杂环，n代表0或1.它们具有优异的抗菌活性。

38. 发明申请

WO1985004658A1 1,5-BENZOXATHIEPINE DERIVATIVES AND THEIR PREPARATION 审中-公开
标题翻译： 1,5-苯并吡喃衍生物及其制备
公开(公告)号：WO1985004658A1
公开(公告)日：1985-10-24
申请号：PCT/JP1984000168
申请日：1984-04-04
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , SUGIHARA, Hirosada , HIRATA, Minoru
IPC分类号： C07D327/02
CPC分类号： C07D411/06 , C07D327/02 , C07D411/12
摘要： Novel 1,5-benzoxathiepine derivatives represented by formula (I), wherein R1 and R2 each represents hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy, R3 and R4 each represents hydrogen, lower alkyl or optionally substituted cycloalkyl or aralkyl or, when taken together, R3 and R4 form a ring together with the adjacent nitrogen atom, X represents hydrogen, optionally substituted lower alkyl, optionally substituted aryl, or optionally esterified or amidated carboxyl, Y represents > C=O or > CH-OR5 (wherein R5 represents hydrogen, acyl, or optionally substituted amido), m represents an integer of 0 to 2, and n represents and integer of 1 to 6, and salts thereof show the effect of blocking serotonin S receptor, calcium-competitive effect, diuretic effect, and anti-thrombotic effect, and are useful for prophylaxis and treatment of ischemic heart disease, thrombosis, and hypertension.
摘要翻译：由式（I）表示的新的1,5-苯并氧硫杂环庚酮衍生物，其中R 1和R 2各自表示氢，卤素，羟基，低级烷基或低级烷氧基，R 3和R 4各自表示氢，低级烷基或任选取代的环烷基或芳烷基， R 3和R 4与相邻的氮原子一起形成环，X表示氢，任选取代的低级烷基，任选取代的芳基或任选酯化或酰胺化的羧基，Y表示> C = O或> CH-OR 5（其中R 5 表示氢，酰基或任选取代的酰氨基），m表示0〜2的整数，n表示1〜6的整数，其盐表示阻断5-羟色胺S受体，钙竞争效应，利尿作用，和抗血栓形成作用，可用于预防和治疗缺血性心脏病，血栓形成和高血压。

39. 发明申请

WO1985004170A1 THIAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING SAME 审中-公开
标题翻译：噻唑烷二酮衍生物，其制备方法和含有其的药物组合物
公开(公告)号：WO1985004170A1
公开(公告)日：1985-09-26
申请号：PCT/JP1984000117
申请日：1984-03-21
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , MEGURO, Kanji , FUJITA, Takeshi
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07D417/12
CPC分类号： C07D213/30 , C07D213/89 , C07D417/12
摘要： Thiazolidinedione derivatives represented by general formula (I), wherein R and R may be the same or different and each represents hydrogen or lower alkyl, R represents hydrogen or acyl, and n represents 0 or 1, and their salts are novel compounds showing an effect of lowering blood sugar level and blood lipid level, and are useful as agents for treating diabetes and hyperlipemia.
摘要翻译：由通式（I）表示的噻唑烷二酮衍生物，其中R 1和R 2可以相同或不同，各自表示氢或低级烷基，R 3表示氢或酰基，n表示0或1，并且它们的盐是显示降低血糖水平和血脂水平的作用的新化合物，并且可用作治疗糖尿病和高脂血症的药剂。

40. 发明申请

WO1985001502A1 7-OXO-1-AZABICYCLO AD3.2.0BD HEPT-2-ENE-2-CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE 审中-公开
标题翻译： 7-氧代-1-氮杂双环[3.2.0] HEPT-2-环己基-2-羧酸衍生物，其制备方法及其用途
公开(公告)号：WO1985001502A1
公开(公告)日：1985-04-11
申请号：PCT/JP1983000319
申请日：1983-09-28
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD. , YOSHIOKA, Koichi , TAMURA, Norikazu , NATSUGARI, Hideaki
IPC分类号： C07D487/04
CPC分类号： C07D409/04 , C07D205/08 , C07D477/20 , C07F7/10
摘要： Compounds represented by formula (I), (wherein X represents a lower alkenylene or lower alkylene group optionally containing a hydroxy group, Y represents (1) a lower alkyl group, (2) a C3-8 cycloalkyl group, (3) a lower alkenyl group, (4) an aryl group, (5) an aralkyl group, or (6) a 3- to 8-membered hetero cyclic group, or X and Y of the Y-SO2-X group are bound to each other and represent (II), (wherein represents an integer of 0 to 3, and m and n each represent an integer of 0 to 6, with the sum of m and n being 2 to 6), and R represents an optionally substituted hydrocarbyl group or a 3- to 8-membered heterocyclic group) or the salts thereof, process represented by the scheme (III), (wherein Z represents an eliminatable group, COOR represents an optionally protected carboxyl group, and other symbols are as defined above) and antibacterial composition containing compound (I) or its salt.
摘要翻译：由式（I）表示的化合物（其中X表示低级亚烯基或任选含有羟基的低级亚烷基，Y表示（1）低级烷基，（2）C3-8环烷基，（3）较低级烯基，（4）芳基，（5）芳烷基或（6）3-至8-元杂环基，或Y-SO2-X基的X和Y彼此结合，表示（II），（其中表示0〜3的整数，m和n各自表示0〜6的整数，m和n的和为2〜6），R表示任意取代的烃基或3-至8-元杂环基）或其盐，由方案（III）表示的方法（其中Z表示可消除基团，COOR 1表示任选保护的羧基，其它符号是如上所述）和含有化合物（I）或其盐的抗菌组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式