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31. 发明授权

US08312836B2 Method and apparatus for application of a fresh coating on a medical device 有权
标题翻译：用于在医疗装置上施加新鲜涂层的方法和装置
公开(公告)号：US08312836B2
公开(公告)日：2012-11-20
申请号：US12182261
申请日：2008-07-30
申请人： Scott E. Corbeil , Roger Labrecque , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Edward Bromander , Georgette Henrich
发明人： Scott E. Corbeil , Roger Labrecque , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Edward Bromander , Georgette Henrich
IPC分类号： B05C3/00 , A61F2/06 , A61F2/00
CPC分类号： A61M25/0009 , A61F2/86 , A61F2240/001 , A61F2250/0067 , A61M25/0045
摘要： A method, a kit, and an apparatus provide a coating on an implantable medical device. The apparatus includes housing, a sealed reservoir chamber disposed in the housing, a reducing template, and a reservoir access port. The sealed reservoir contains the coating material. The reducing template is sized to receive a medical device therethrough for application of the coating material. A seal breaching mechanism can be provided and adapted to breach the sealed reservoir upon activation of the apparatus. The reservoir access port, which is disposed in the housing, is adapted to fluidly couple the reducing template with the reservoir chamber upon activation of the apparatus for coating the medical device.
摘要翻译：方法，试剂盒和装置在可植入医疗装置上提供涂层。该装置包括壳体，设置在壳体中的密封储存室，还原模板和储存器进入端口。密封的容器包含涂料。还原模板的尺寸适于接收穿过其中的医疗装置以施加涂层材料。可以提供密封破裂机构并适于在启动装置时破坏密封储存器。设置在壳体中的储存器进入端口适于在激活用于涂覆医疗装置的装置时将还原模板与储存室流体联接。

32. 发明申请

US20120213839A1 HYDROPHOBIC CROSS-LINKED GELS FOR BIOABSORBABLE DRUG CARRIER COATINGS 有权
标题翻译：用于生物可溶性药物载体涂层的疏水性交联凝胶
公开(公告)号：US20120213839A1
公开(公告)日：2012-08-23
申请号：US13404487
申请日：2012-02-24
申请人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
发明人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
IPC分类号： A61K9/00 , A61K47/14 , A61P9/00 , A61P7/02 , A61P35/00 , A61K47/12 , A61P29/00
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
摘要翻译：描述了用于医疗装置的涂层，制备涂层的方法及其使用方法。

33. 发明授权

US07740793B2 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US07740793B2
公开(公告)日：2010-06-22
申请号：US11068680
申请日：2005-02-28
申请人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译：一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸，径向膨胀力。该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。

34. 发明授权

US06923927B2 Method for forming expandable polymers having drugs or agents included therewith 失效
标题翻译：形成含有药物或试剂的可发性聚合物的方法
公开(公告)号：US06923927B2
公开(公告)日：2005-08-02
申请号：US10807709
申请日：2004-03-23
申请人： Paul Martakos , Roger Labrecque , Geoffrey Moodie , Steve A. Herweck , Theodore Karwoski
发明人： Paul Martakos , Roger Labrecque , Geoffrey Moodie , Steve A. Herweck , Theodore Karwoski
IPC分类号： A61F2/06 , B29B11/10 , B29B11/14 , B29B13/00 , B29B13/02 , B29B15/00
CPC分类号： A61F2/06
摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The wettable liquid can be formed of a drug and/or an agent, such that the resulting polymer contains and emits the drug upon positioning at a target location of a patient body. The expandable polymer can also have the drug or agent added to its structure at a polymer resin preparation stage, through use of an aqueous solution mixed with one or more fluoropolymers, or in a mixing stage. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.
摘要翻译：本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比。可湿性液体可以由药物和/或药剂形成，使得所得聚合物在定位在患者身体的目标位置时含有和释放药物。可膨胀聚合物还可以通过使用与一种或多种含氟聚合物混合的水溶液，或在混合阶段中，在聚合物树脂制备阶段将药物或试剂加入到其结构中。本发明还可以实现具有独特性质和处理特性的材料。这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。

35. 发明授权

US5980799A Methods of making controlled porosity expanded polytetrafluoroethylene products and fabrication 失效
标题翻译：制造控制孔隙率膨胀聚四氟乙烯产品和制造方法
公开(公告)号：US5980799A
公开(公告)日：1999-11-09
申请号：US98195
申请日：1998-06-16
申请人： Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/06 , A61L27/16 , A61L27/56 , B29C47/00 , B29C55/00 , B29C69/00 , B29D23/00 , B29K27/12 , B29K105/04 , D02J1/06 , B29C55/22
CPC分类号： B29D23/001 , A61F2/06 , A61L27/16 , A61L27/56 , B01D67/0027 , B01D69/02 , B01D69/12 , B01D71/36 , B29C47/0004 , B29C47/0021 , B29C55/005 , B01D2325/02 , B29C47/0023 , B29C47/0026 , B29C47/0042 , B29C47/0057 , B29C47/062 , B29C47/065 , B29K2027/18 , B29K2105/04 , B29L2023/005 , B29L2023/007 , Y10T428/139 , Y10T428/1397 , Y10T428/24273 , Y10T428/249986 , Y10T428/24999 , Y10T428/249992 , Y10T428/31544
摘要： A method of forming porous articles with a varying pore distribution by extrusion from a billet with a varying lubricant distribution. A single-polymer polytetrafluoroethylene is extruded and then stretched and sintered to provide a differential porous PTFE structure composed of fibers and nodes connected to one another by these fibers. The microfibrous structure has a portion within the cross-section that possesses a different pore size, accompanied by a different node and fiber geometry, than adjacent areas within that cross section. In a vascular graft, the pores taper inwardly, providing a fluid-tight lumen wall structure that prevents leakage, yet promotes cellular ingrowth and natural tissue regeneration. A node structure of radially-oriented plates provides flexibility, suture strength, and enhanced protection against collapse.
摘要翻译：通过从具有变化的润滑剂分布的坯料挤出形成具有不同孔分布的多孔制品的方法。挤出单聚合物聚四氟乙烯，然后进行拉伸和烧结，以提供由纤维和由这些纤维相互连接的节点组成的差异多孔PTFE结构。微纤维结构在横截面内具有与该截面内的相邻区域不同的孔径的部分，伴随不同的节点和纤维几何形状。在血管移植物中，孔向内逐渐变细，提供流体密封的腔壁结构，其防止泄漏，但促进细胞向内生长和天然组织再生。径向定向板的节点结构提供柔性，缝合强度和增强的防止塌陷的保护。

36. 发明授权

US5824050A Prosthesis with in-wall modulation 失效
公开(公告)号：US5824050A
公开(公告)日：1998-10-20
申请号：US760115
申请日：1996-12-03
申请人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
发明人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/04
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： The wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure transmission, or locally alters fluid-born-distribution of biological material through the wall and allows more natural gradients for tissue regeneration and growth in the outer region of the wall.

37. 发明授权

US09801913B2 Barrier layer 有权
公开(公告)号：US09801913B2
公开(公告)日：2017-10-31
申请号：US11237420
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K38/13 , A61L27/36 , A61L27/52 , A61K9/00 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L31/10 , A61L27/54 , A61F13/02 , A61L2/07 , A61L2/08 , A61L2/20 , A61L31/00 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.

38. 发明授权

US08722132B2 Application of a coating on a medical device 有权
标题翻译：涂在医疗器械上的应用
公开(公告)号：US08722132B2
公开(公告)日：2014-05-13
申请号：US13185135
申请日：2011-07-18
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05D3/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译：用于在可植入医疗装置上提供涂层的方法和装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。

39. 发明授权

US08124127B2 Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings 有权
标题翻译：用于生物可吸收药物载体涂层的疏水交联凝胶
公开(公告)号：US08124127B2
公开(公告)日：2012-02-28
申请号：US11582135
申请日：2006-10-16
申请人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
发明人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
IPC分类号： A61K9/00 , A61F2/00
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
摘要翻译：描述了用于医疗装置的涂层，制备涂层的方法及其使用方法。

40. 发明申请

US20110274823A1 APPLICATION OF A COATING ON A MEDICAL DEVICE 有权
标题翻译：涂料在医疗器械上的应用
公开(公告)号：US20110274823A1
公开(公告)日：2011-11-10
申请号：US13185135
申请日：2011-07-18
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05D7/00 , B05D1/00 , B05D1/18 , B05D1/28 , B05D3/00 , B05D1/02
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译：用于在可植入医疗装置上提供涂层的方法和装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。

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