专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

WO2006005725A2 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2006005725A2
公开(公告)日：2006-01-19
申请号：PCT/EP2005/053271
申请日：2005-07-08
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , STOJANOVIC, Aleksandar , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , STOJANOVIC, Aleksandar , QUIRMBACH, Michael
IPC分类号： C07D471/00
CPC分类号： C07D471/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I), in which L, R, R 1 , R 2 , W, X, Y, Z and n have the meanings explained in more detail in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aromatase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物，其中L，R，R

32. 发明申请

WO2005070871A2 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2005070871A2
公开(公告)日：2005-08-04
申请号：PCT/EP2005/050274
申请日：2005-01-21
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , MARTI, Christiane , QUIRMBACH, Michael
发明人： HEROLD, Peter , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , MARTI, Christiane , QUIRMBACH, Michael
IPC分类号： C07C213/00
CPC分类号： C07D471/10 , C07C235/60 , C07C237/06 , C07C237/10 , C07C237/22 , C07C237/24 , C07C243/28 , C07C275/14 , C07C311/05 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/18 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/06 , C07C2602/22 , C07C2603/74 , C07D211/76 , C07D295/13 , C07D311/00
摘要： The application relates to novel amino alcohols of general formula (I) where R, R 1 , R 2 , R 3 , R 4 , R 5 , X 1 and X 2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5，X 1和X 2各自具有在说明书中详细说明的定义，其制备方法和用途的这些化合物作为药物，特别是作为肾素抑制剂。

33. 发明申请

WO2005070877A1 DIAMINO ALCOHOLS AND THEIR USE AS RENIN INHIBITORS 审中-公开
标题翻译： DIAMINO酒精及其作为RININ抑制剂的用途
公开(公告)号：WO2005070877A1
公开(公告)日：2005-08-04
申请号：PCT/EP2005/050272
申请日：2005-01-21
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , MARTI, Christiane , QUIRMBACH, Michael
发明人： HEROLD, Peter , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , MARTI, Christiane , QUIRMBACH, Michael
IPC分类号： C07C233/36
CPC分类号： C07D207/27 , C07C233/36 , C07C233/78 , C07C311/05 , C07D205/04 , C07D207/12 , C07D207/273 , C07D209/18 , C07D211/34 , C07D211/76 , C07D213/56 , C07D223/10 , C07D239/10 , C07D277/42 , C07D295/13 , C07D295/15 , C07D303/48 , C07D309/04 , C07D333/34 , C07D413/06 , C07D471/10
摘要： The application relates to novel amino alcohols of the general formula (I) where R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法和用途的这些化合物作为药物，特别是作为肾素抑制剂。

34. 发明申请

WO2006128852A2 HETEROCYCLIC SPIRO-COMPOUNDS 审中-公开
标题翻译：杂环螺旋化合物
公开(公告)号：WO2006128852A2
公开(公告)日：2006-12-07
申请号：PCT/EP2006/062695
申请日：2006-05-30
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , MARTI, Christiane , JOTTERAND, Nathalie , SCHUMACHER, Christoph , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , MARTI, Christiane , JOTTERAND, Nathalie , SCHUMACHER, Christoph , QUIRMBACH, Michael
IPC分类号： C07D491/20 , C07D491/10 , C07D471/20 , C07D471/10 , A61P5/00
CPC分类号： C07D471/04 , C07D471/10 , C07D491/10
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R 1 , R 2 , U, V, W, X, Y, Z, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译：该专利申请涉及通式（I）的新的杂环化合物，其中A，R，R 1，R 2，U，V，W，X，Y Z，n和p具有在说明书中更详细阐述的定义，其制备方法和这些化合物作为药物，特别是醛固酮合酶抑制剂的用途。

35. 发明申请

WO2005118541A2 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2005118541A2
公开(公告)日：2005-12-15
申请号：PCT/EP2005/052418
申请日：2005-05-27
申请人： Speedel Experimenta AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , BEHNKE, Dirk , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , BEHNKE, Dirk , QUIRMBACH, Michael
IPC分类号： C07D213/00
CPC分类号： C07D471/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) in which R, R 1 , R 2 , X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物，其中R 1，R 2，R 2，X，Y，Z和n具有本说明书中定义的含义，其制备方法和使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。

36. 发明申请

WO2006128853A1 HETEROCYCLIC SPIRO-COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS 审中-公开
标题翻译：杂环化合物作为醛固酮合成酶抑制剂
公开(公告)号：WO2006128853A1
公开(公告)日：2006-12-07
申请号：PCT/EP2006/062696
申请日：2006-05-30
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , MARTI, Christiane , JOTTERAND, Nathalie , SCHUMACHER, Christoph , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , MARTI, Christiane , JOTTERAND, Nathalie , SCHUMACHER, Christoph , QUIRMBACH, Michael
IPC分类号： C07D471/20 , A61K31/35 , A61P9/00
CPC分类号： C07D471/20
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R 1 , R 2 , W, X, Y, Z and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译：该专利申请涉及通式（I）的新的杂环化合物，其中R 1，R 2，R 2，W，X，Y，Z和n具有在本说明书中更详细地描述了其定义，制备方法以及这些化合物作为药物，特别是醛固酮合酶抑制剂的用途。

37. 发明申请

WO2006128851A1 FUSED IMIDAZOLE DERIVATIVES AND USE THEREOF AS ALDOSTERONE SYNTHASE INHIBITORS 审中-公开
标题翻译：熔融咪唑衍生物及其作为阿糖胞苷合成酶抑制剂的用途
公开(公告)号：WO2006128851A1
公开(公告)日：2006-12-07
申请号：PCT/EP2006/062694
申请日：2006-05-30
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , MARTI, Christiane , JOTTERAND, Nathalie , SCHUMACHER, Christoph , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , MARTI, Christiane , JOTTERAND, Nathalie , SCHUMACHER, Christoph , QUIRMBACH, Michael
IPC分类号： A61K31/438 , C07D471/04 , C07D491/20 , C07D471/20 , A61P5/02
CPC分类号： C07D471/04
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R 1 , R 2 , X, Y, Z, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译：该专利申请涉及通式（I）的新的杂环化合物，其中A，R，R 1，R 2，X，Y，Z，n和p 在描述中更详细地定义了这些定义，其制备方法以及这些化合物作为药物，特别是作为醛固酮合酶抑制剂的用途。

38. 发明申请

WO2006061426A1 ω-PHENYLOCTANAMIDES 审中-公开
标题翻译：？-PHENYLOCTANAMIDES
公开(公告)号：WO2006061426A1
公开(公告)日：2006-06-15
申请号：PCT/EP2005/056622
申请日：2005-12-09
申请人： Speedel Experimenta AG , HEROLD, Peter , STUTZ, Stefan , MAH, Robert , TSCHINKE, Vincenzo , MARTI, Christiane
发明人： HEROLD, Peter , STUTZ, Stefan , MAH, Robert , TSCHINKE, Vincenzo , MARTI, Christiane
IPC分类号： C07C237/20 , A61K31/165
CPC分类号： C07C255/59 , C07C237/20 , C07D317/58 , C07D319/18
摘要： Compounds of the general formula (I) in which the substituents R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are each as defined in Claim 1 have renin-inhibiting properties and can be used as medicaments.
摘要翻译：通式（I）的化合物，其中取代基R 1，R 1，R 2，R 3，R 4， R 5，R 6和R 6各自如权利要求1中所定义，具有肾素抑制性质，可用作药物。

39. 发明申请

WO2009050253A1 TRISUBSTITUTED PIPERIDINES 审中-公开
标题翻译：三氯哌啶
公开(公告)号：WO2009050253A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/064010
申请日：2008-10-17
申请人： Speedel Experimenta AG , HEROLD, Peter , TSCHINKE, Vincenzo , BEHNKE, Dirk , JELAKOVIC, Stjepan , JOTTERAND, Nathalie , MAH, Robert
发明人： HEROLD, Peter , TSCHINKE, Vincenzo , BEHNKE, Dirk , JELAKOVIC, Stjepan , JOTTERAND, Nathalie , MAH, Robert
IPC分类号： C07D413/14 , C07D413/12 , A61K31/538 , A61P9/12
CPC分类号： C07D413/14 , C07D413/12
摘要： The application relates to trisubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R 1 , R 2 , R 3 and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译：本申请涉及通式（I）的三取代哌啶及其盐，优选其药学上可接受的盐，其中R 1，R 2，R 3和X具有说明书中所述的含义，其制备方法及其用途化合物作为药物，特别是作为肾素抑制剂。

40. 发明申请

WO2008077917A1 PROCESS FOR PREPARING (R OR S)-2-ALKYL-3-HETEROCYCLYL-1-PROPANOLS 审中-公开
标题翻译：制备（R或S）-2-烷基-3-环己基-1-丙醇的方法
公开(公告)号：WO2008077917A1
公开(公告)日：2008-07-03
申请号：PCT/EP2007/064405
申请日：2007-12-21
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , STUTZ, Stefan , MAH, Robert
发明人： HEROLD, Peter , STUTZ, Stefan , MAH, Robert
IPC分类号： C07D231/56 , C07D209/08 , C07D471/04
CPC分类号： C07D231/56 , C07D209/08 , C07D471/04
摘要： Compounds of the formula (I) in which R' 1 , R' 2 ,R' 3 and Het are each defined as specified in the description are obtainable in high yields by a stereoselective addition of R' 3 -substituted propionic esters onto R' 1 - and R' 2 -substituted unsaturated, bicyclic heterocyclylaldehydes of the formula R-CHO to give corresponding 3-(R)-3-hydroxy-2-R' 3 -propionic esters. Conversion of the OH group to a leaving group, a subsequent regioselective elimination to give 3-(R)-2-R' 3 -propenoic esters, followed by: 1) hydrolysis to the corresponding 3-(R)-2-R' 3 -propenoic acids, their enantioselective hydrogenation to corresponding chiral 3-(R)-2-R' 3 -propenoic acids and their reduction, or 2) hydrolysis to the corresponding 3-(R)-2-R' 3 -propenoic acids, their reduction to corresponding 3-(R)-2-R' 3 -allylalcohols and their enantioselective hydrogenation, or 3) reduction to corresponding 3-(R)-2-R' 3 -allylalcohols and their enantioselective hydrogenation, where R is formula (II) and the enantioselective hydrogenations are performed with metal complexes which have, as ligands, ferrocene-1,1'-diphosphines which have, in the 1-position, a ferrocene-substituted secondary phosphine group and, in the1'-position, a secondary phosphine group.
摘要翻译：其中R'1，R'2，R'3和Het的式（I）化合物各自如可通过立体选择性加成R 1'3 - 取代的丙酸酯在R'1 - 和R'2 - 取代的不饱和的双环杂环基醛，其具有式R-CHO，得到相应的3-（R）-3-羟基-2R'3'-丙酸酯。将OH基转化为离去基团，随后进行区域选择性消除，得到3-（R）-2-R'3 - 丙烯酸酯，然后：1）水解至相应的3-（ R）-2-R“3 - 丙烯酸，其相应的手性3-（R）-2-R” - 亚丙酸的对映选择性氢化及其还原，或2）水解成相应的3-（R）-2-R'3 - 丙烯酸，它们还原成相应的3-（R）-2-R'3 - 或其对映选择性氢化，或3）还原为相应的3-（R）-2-R“3 - 烯丙醇及其对映选择性氢化，其中R为式（II）和对映选择性氢化以具有二茂铁取代的次膦基1位的二茂铁-1,1'-二膦作为配位体，在1位具有仲膦基的金属络合物进行。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式