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31. 发明申请

US20060068377A1 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 失效
公开(公告)号：US20060068377A1
公开(公告)日：2006-03-30
申请号：US11273229
申请日：2005-11-14
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

32. 发明申请

US20060056016A1 System and method for increasing the contrast of an image produced by an epifluorescence microscope 失效
公开(公告)号：US20060056016A1
公开(公告)日：2006-03-16
申请号：US11225460
申请日：2005-09-13
申请人： Triantafyllos Tafas , Petros Tsipouras
发明人： Triantafyllos Tafas , Petros Tsipouras
IPC分类号： G02B21/00
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.

33. 发明申请

US20080106743A1 SYSTEM AND METHOD FOR INCREASING THE CONTRAST OF AN IMAGE PRODUCED BY AN EPIFLUORESCENCE MICROSCOPE 审中-公开
标题翻译：用于增加由差异显微镜产生的图像的对比度的系统和方法
公开(公告)号：US20080106743A1
公开(公告)日：2008-05-08
申请号：US11970198
申请日：2008-01-07
申请人： Triantafyllos Tafas , Petros Tsipouras
发明人： Triantafyllos Tafas , Petros Tsipouras
IPC分类号： G01N21/55 , G02B5/08 , G02B5/26
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a dichroic reflector behind the sample. The dichroic reflector reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.
摘要翻译：通过在荧光显微镜下产生的图像的对比可以通过在样品后面放置二向色反射镜来增加。二向色反射镜通过物镜反射由样品中的荧光标签发射的发射光，同时允许较短波长的激发光通过样品保持器。

34. 发明申请

US20080100911A1 SYSTEM AND METHOD FOR INCREASING THE CONTRAST OF AN IMAGE PRODUCED BY AN EPIFLUORESCENCE MICROSCOPE 审中-公开
公开(公告)号：US20080100911A1
公开(公告)日：2008-05-01
申请号：US11970189
申请日：2008-01-07
申请人： Triantafyllos Tafas , Petros Tsipouras
发明人： Triantafyllos Tafas , Petros Tsipouras
IPC分类号： G02B21/06
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a dichroic reflector behind the sample. The dichroic reflector reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.

35. 发明申请

US20060068375A1 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 审中-公开
公开(公告)号：US20060068375A1
公开(公告)日：2006-03-30
申请号：US11272612
申请日：2005-11-14
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

36. 发明授权

US06759663B2 Device and method for detecting and localizing cells by means of photosensitive waveguides 失效
标题翻译：用于通过光敏波导检测和定位电池的装置和方法
公开(公告)号：US06759663B2
公开(公告)日：2004-07-06
申请号：US10182210
申请日：2002-07-22
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G01N2164
CPC分类号： G01N21/7703 , G01N21/6428
摘要： The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.
摘要翻译：本发明提供用于在使用光敏波导的样品中检测诸如生物细胞的颗粒的装置和方法。响应于控制从颗粒发射的辐射，光敏波导以可检测的方式改变其透射率。在优选实施例中，波导是二维的，并且颗粒的位置以及它们的存在是通过在两个非平行方向扫描波导而获得的。所提供的装置优选用于定位标记的细胞。本发明还包括使用所提供的装置来检测和定位单元的控制系统和方法。

37. 发明授权

US07835869B2 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 有权
标题翻译：计算机控制稀有细胞的方法和装置，包括胎儿细胞，基于诊断
公开(公告)号：US07835869B2
公开(公告)日：2010-11-16
申请号：US11272613
申请日：2005-11-14
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G06F19/00 , G06K9/00 , G06K9/20 , G06K9/78
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.
摘要翻译：提供了一种用于检测和诊断组织样本中的稀有细胞类型的计算机控制方法，所述方法包括处理组织样本，使得其产生指示在罕见细胞的位置存在的第一信号，检测第一信号，处理检测到第一信号的位置以产生指示诊断有用的细胞特征的第二信号并检测第二信号。在染色之前或之后，第一信号可以是形态学或寻找细胞中存在的颜色。第二信号可以通过原位PCR或PCR原位杂交产生。在一个优选实施方案中，稀有细胞类型是母体血液组织样品中的胎儿细胞，所述样品由未培养的母体血液的涂片组成。在另一个实施方案中，该方法用于诊断或基因型血液或组织活检样本中的癌细胞。

38. 发明申请

US20060078877A1 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 审中-公开
公开(公告)号：US20060078877A1
公开(公告)日：2006-04-13
申请号：US11273126
申请日：2005-11-14
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

39. 发明授权

US07522757B2 Method and apparatus for computer controlled cell based diagnosis 有权
标题翻译：用于基于计算机控制的基于细胞的诊断的方法和装置
公开(公告)号：US07522757B2
公开(公告)日：2009-04-21
申请号：US11264273
申请日：2005-11-01
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G06K9/00
CPC分类号： G01N1/312 , G01N15/1475 , G01N2001/282 , G01N2001/317 , G01N2015/1006 , G01N2015/1472 , G01N2015/1477 , G01N2015/1488 , G01N2800/36 , G06K9/00127
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.
摘要翻译：提供了一种用于检测和诊断组织样本中的稀有细胞类型的计算机控制方法，所述方法包括处理组织样本，使得其产生指示在罕见细胞的位置存在的第一信号，检测第一信号，处理检测到第一信号的位置以产生指示诊断有用的细胞特征的第二信号并检测第二信号。在染色之前或之后，第一信号可以是形态学或寻找细胞中存在的颜色。第二信号可以通过原位PCR或PCR原位杂交产生。在一个优选实施方案中，稀有细胞类型是母体血液组织样品中的胎儿细胞，所述样品由未培养的母体血液的涂片组成。在另一个实施方案中，该方法用于诊断或基因型血液或组织活检样本中的癌细胞。

40. 发明申请

US20080241848A1 METHODS FOR PRENATAL DIAGNOSIS OF ANEUPLOIDY 审中-公开
标题翻译：用于临床诊断肾功能的方法
公开(公告)号：US20080241848A1
公开(公告)日：2008-10-02
申请号：US12117281
申请日：2008-05-08
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： C12Q1/68
CPC分类号： G01N33/5005 , C12Q1/6841 , G01N21/6458 , G01N33/5073 , G01N33/5094 , G06K9/0014 , G06T7/0012 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024 , C12Q2565/601
摘要： Methods are disclosed for the automated prenatal genetic diagnosis of aneuploidy using an automated fluorescence microscope, conducted on samples of maternal blood that have been hybridized with FISH probes.
摘要翻译：公开了使用自动荧光显微镜对已经与FISH探针杂交的母体血液样品进行的非整倍体的自动产前遗传诊断的方法。

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