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31. 发明授权

US08889126B2 Methods and compositions for treating neuropathies 有权
标题翻译：治疗神经病的方法和组合物
公开(公告)号：US08889126B2
公开(公告)日：2014-11-18
申请号：US12790722
申请日：2010-05-28
申请人： Jeffrey Milbrandt , Toshiyuki Araki , Yo Sasaki
发明人： Jeffrey Milbrandt , Toshiyuki Araki , Yo Sasaki
IPC分类号： A61K38/51 , C12N9/12 , C12N15/00 , A61K38/50 , A61K31/7084 , A61K38/45 , A61K48/00
CPC分类号： A61K31/7084 , A61K31/405 , A61K31/455 , A61K31/706 , A61K38/45 , A61K38/50 , A61K48/00 , C07H19/20 , C12N9/1241
摘要： Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.
摘要翻译：公开了治疗或预防哺乳动物神经病变轴突降解的方法。所述方法可以包括向哺乳动物施用有效量的通过增加患病和/或损伤的神经元中的沉默调节蛋白的活性而起作用的药剂。所述方法还可以包括向哺乳动物施用有效量的通过在患病和/或损伤的神经元中增加NAD活性而起作用的药剂。还公开了用于治疗神经病的筛选剂和用于治疗或预防神经病的重组载体的方法。

32. 发明申请

US20100227778A1 Diagnosis and Treatment of Noonan Syndrome and Neoplastic Disorders 审中-公开
标题翻译： Noonan综合征和肿瘤疾病的诊断和治疗
公开(公告)号：US20100227778A1
公开(公告)日：2010-09-09
申请号：US12377909
申请日：2007-08-17
申请人： Benjamin G. Neel , Amy E. Roberts , Raju Kucherlapati , Kenneth D. Swanson , Toshiyuki Araki
发明人： Benjamin G. Neel , Amy E. Roberts , Raju Kucherlapati , Kenneth D. Swanson , Toshiyuki Araki
IPC分类号： C40B50/00 , G01N33/53 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： Methods and compositions for diagnosing and treating Noonan syndrome and neoplastic disorders are provided herein.
摘要翻译：本文提供了诊断和治疗Noonan综合征和肿瘤性疾病的方法和组合物。

33. 发明授权

US07776326B2 Methods and compositions for treating neuropathies 有权
标题翻译：治疗神经病的方法和组合物
公开(公告)号：US07776326B2
公开(公告)日：2010-08-17
申请号：US11144358
申请日：2005-06-03
申请人： Jeffrey Milbrandt , Toshiyuki Araki , Yo Sasaki
发明人： Jeffrey Milbrandt , Toshiyuki Araki , Yo Sasaki
IPC分类号： A61K38/00
CPC分类号： A61K31/7084 , A61K31/405 , A61K31/455 , A61K31/706 , A61K38/45 , A61K38/50 , A61K48/00 , C07H19/20 , C12N9/1241
摘要： Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.
摘要翻译：公开了治疗或预防哺乳动物神经病变轴突降解的方法。所述方法可以包括向哺乳动物施用有效量的通过增加患病和/或损伤的神经元中的沉默调节蛋白的活性而起作用的药剂。所述方法还可以包括向哺乳动物施用有效量的通过在患病和/或损伤的神经元中增加NAD活性而起作用的药剂。还公开了用于治疗神经病的筛选剂和用于治疗或预防神经病的重组载体的方法。

34. 发明申请

US20080279405A1 In-The-Ear Hearing Aid 审中-公开
标题翻译：耳内助听器
公开(公告)号：US20080279405A1
公开(公告)日：2008-11-13
申请号：US12158769
申请日：2005-12-28
申请人： Takatoshi Isogi , Toshiyuki Araki
发明人： Takatoshi Isogi , Toshiyuki Araki
IPC分类号： H04R25/02
CPC分类号： H04R25/60 , H04R25/602 , H04R2225/025 , H04R2460/09 , H04R2460/17
摘要： In an in-the-ear hearing aid provided with a pull-out type linear member, a housing section is provided to house a pull-out type linear member 25. The housing section is a guide tunnel 24 penetrating a case body 23. The pull-out type linear member 25 is provided, at both ends, with small bulges 25a and 25b. The pull-out type linear member 25 is provided in such a manner that the front small bulge 25b is located outside the guide tunnel 24 and the rear small bulge 25a is located inside the guide tunnel 24. A small diameter port 24a is provided at an opening section of the guide tunnel 24 to serve as a stopper for the rear small bulge 25a.
摘要翻译：在设置有拉出型线性构件的耳内助听器中，设置有用于容纳拉出型线状构件25的容纳部。壳体部分是贯穿壳体23的引导通道24。拉出型线性构件25在两端设置有小凸起25a和25b。拉出型直线部件25的设置方式为，前小凸块25b位于引导通道24的外侧，后小凸起部25a位于引导通道24的内部。小直径端口24a设置在引导通道24的开口部分处，用作后部小凸起部25a的止动件。

35. 发明申请

US20050135750A1 Mach-zehnder interferometer, optical coupler, and manufacturing method of optical coupler 审中-公开
标题翻译：马赫 - 泽德干涉仪，光耦合器和光耦合器的制造方法
公开(公告)号：US20050135750A1
公开(公告)日：2005-06-23
申请号：US11015064
申请日：2004-12-17
申请人： Takao Sakurai , Toshiyuki Araki , Nobuhito Kishi
发明人： Takao Sakurai , Toshiyuki Araki , Nobuhito Kishi
IPC分类号： G02B6/122 , G02B6/12 , G02B6/125 , G02B6/13 , G02B6/134 , G02B6/26
CPC分类号： G02B6/1345 , G02B6/125 , G02B6/1342 , G02B2006/12147
摘要： An optical coupler having a Y-branch operable to mix and output a first light and a second light from outside. The optical coupler includes: a first input optical wave guide operable to propagate the first light from outside; a second input optical wave guide operable to propagate the second light from outside; an optical coupler operable to output a mixed light, which is a mixture of the first light and the second light; and an output optical wave guide operable to propagate the mixed light and to output it from an end, wherein percentage per unit length of emitting light being propagated in the output optical wave guide to a periphery of the output optical wave guide is higher than that of the first input optical wave guide or the second input optical wave guide.
摘要翻译：一种具有Y分支的光耦合器，其可操作以从外部混合并输出第一光和第二光。光耦合器包括：可操作以从外部传播第一光的第一输入光波导; 可操作以从外部传播第二光的第二输入光波导; 光耦合器，其可操作以输出作为所述第一光和所述第二光的混合的混合光; 以及输出光波导，其可操作以传播所述混合光并从一端输出，其中在所述输出光波导中传播到所述输出光波导周边的每单位长度的发射光的百分比高于第一输入光波导或第二输入光波导。

36. 发明授权

US06243735B1 Microcontroller, data processing system and task switching control method 有权
标题翻译：微控制器，数据处理系统和任务切换控制方法
公开(公告)号：US06243735B1
公开(公告)日：2001-06-05
申请号：US09144474
申请日：1998-08-31
申请人： Hiroshi Imanishi , Toshiyuki Araki
发明人： Hiroshi Imanishi , Toshiyuki Araki
IPC分类号： G06F900
CPC分类号： G06F9/4881 , G06F9/3009 , G06F9/3851 , G06F9/463
摘要： A processor, a task management table, and a scheduler are built in a microcontroller. The processor sequentially runs a plurality of tasks for controlling hardware engines (cores) respectively allocated thereto. The task management table stores task management information which includes state information (ST INFO) representative of the execution state of each task, priority information (PRI INFO) representative of the execution priority of each task, and core identification information (CID INFO) representative of the allocation of the tasks to the cores. The scheduler allows the processor to switch between tasks on the basis of the task management information when a given instruction is decoded or when the execution of any one of the cores is terminated.
摘要翻译：处理器，任务管理表和调度器内置在微控制器中。处理器顺序地运行用于控制分配给其的硬件引擎（内核）的多个任务。任务管理表存储表示各任务的执行状态的状态信息（ST INFO）的任务管理信息，表示各任务的执行优先级的优先级信息（PRI INFO）以及代表每个任务的执行优先级的核心识别信息（CID INFO）将任务分配给内核。调度器允许处理器在给定指令被解码时或当任一核心的执行终止时基于任务管理信息在任务之间切换。

37. 发明授权

US5977358A Asymmetric dioxazine compounds, intermediate compounds therefor and application of the asymmetric dioxazine compounds 失效
标题翻译：不对称二恶嗪化合物，其中间体化合物和不对称二嗪化合物的应用
公开(公告)号：US5977358A
公开(公告)日：1999-11-02
申请号：US115593
申请日：1998-07-15
申请人： Masato Inoue , Junya Hada , Toshiyuki Araki
发明人： Masato Inoue , Junya Hada , Toshiyuki Araki
IPC分类号： C07D498/04 , C09B19/02 , C09B62/04 , C09B62/503 , D06P1/382 , D06P1/384 , C07D498/22
CPC分类号： C09B19/02
摘要： An asymmetric dioxazine compound represented, when shown in free acid form, by the general formula (I): ##STR1## wherein T.sub.1 and T.sub.2 represent a hydrogen atom, a chlorine atom, a bromine atom, a lower alkyl group, a phenoxy group or others, A.sub.1 represents an alkyl group, a chlorine atom, a carboxyl group or others, A.sub.2 represents a hydrogen atom, an alkyl group, a chlorine atom, a carboxyl group or others, R represents a hydrogen atom or a lower alkyl group, X and Y represent a halogen atom, a fiber-reactive group or others, respectively, with the proviso that at least one of X and Y is a fiber-reactive group is provided.The compound is suitable for dyeing or printing of a fiber material or the like which has a hydroxy group and/or an amide group, and provides a blue-dyed product with various fastness, including particularly chlorine fastness.
摘要翻译：以游离酸形式表示的由通式（I）表示的不对称二嗪类化合物：其中，T1和T2表示氢原子，氯原子，溴原子，低级烷基，苯氧基等，A1 表示烷基，氯原子，羧基等，A2表示氢原子，烷基，氯原子，羧基等，R表示氢原子或低级烷基，X和Y表示卤素原子，纤维反应性基团等，条件是提供X和Y中的至少一个是纤维反应性基团。该化合物适用于具有羟基和/或酰胺基的纤维材料等的染色或印刷，并提供具有各种牢度的蓝色染色产品，特别是耐氯牢度。

38. 发明授权

US5834148A Electrically-conductive substrate for electrophotographic photoreceptor, electrophotographic photoreceptor comprising same and process for the preparation thereof 失效
标题翻译：用于电子照相感光体的导电性基材，包含该电子照相感光体的电子照相感光体及其制备方法
公开(公告)号：US5834148A
公开(公告)日：1998-11-10
申请号：US833775
申请日：1997-04-09
申请人： Masakatsu Murayama , Susumu Taguchi , Toshiyuki Araki
发明人： Masakatsu Murayama , Susumu Taguchi , Toshiyuki Araki
IPC分类号： G03G5/10
CPC分类号： G03G5/102
摘要： The present invention prevents the deterioration of electrophotographic photoreceptor properties due to non-uniform dissolution of the surface of an aluminum substrate or production of hydrates during rinsing or drying from hot pure water in an aqueous cleaning process, assuring the uniformity and stability on the surface of an electrically-conductive substrate for electrophotographic photoreceptor. The resulting electrically-conductive substrate for electrophotographic photoreceptor exhibits an excellent corrosion resistance that can be expected to provide a high environmental stability. Further, the resulting electrophotographic photoreceptor can exhibit improved electrical properties. The present invention provides a novel electrically-conductive substrate for electrophotographic photoreceptor comprising aluminum or aluminum alloy, wherein the element ratio of aluminum in metallic form to aluminum in oxide form on the surface of said substrate as determined by X-ray photoelectron spectroscopy is 1:1 to 1:2.5 and the element ratio of aluminum to phosphorus on the surface of said substrate as determined by X-ray photoelectron spectroscopy is 1:0.02 to 1:0.1.
摘要翻译：本发明防止了在水性清洗过程中由于热纯水的漂洗或干燥过程中由于铝基板表面的不均匀溶解或水合物的形成而导致的电子照相感光体特性劣化，从而确保表面上的均匀性和稳定性用于电子照相感光体的导电基底。所得到的用于电子照相感光体的导电性基材表现出优异的耐腐蚀性，可以预期提供高的环境稳定性。此外，所得的电子照相感光体可以表现出改善的电性能。本发明提供了一种新颖的电子照相感光体基片，其包含铝或铝合金，其中通过X射线光电子能谱测定，所述衬底表面上的金属形式的铝与氧化物形式的铝的元素比为1： 1〜1:2.5，通过X射线光电子能谱测定，所述基板表面的铝与磷的元素比例为1:0.02〜1:0.1。

39. 发明授权

US5717077A Fiber reactive phthalocyanine monoazo compounds having improved dyeing properties 失效
标题翻译：具有改善染色性能的纤维反应性酞菁单偶氮化合物
公开(公告)号：US5717077A
公开(公告)日：1998-02-10
申请号：US570415
申请日：1995-12-11
申请人： Toshiyuki Araki , Takemi Tokieda , Shin-ichi Yabushita , Yasuyoshi Ueda , Bunzi Tsukise
发明人： Toshiyuki Araki , Takemi Tokieda , Shin-ichi Yabushita , Yasuyoshi Ueda , Bunzi Tsukise
IPC分类号： C09B62/44 , C09B62/503 , C09B47/24 , C09B62/085
CPC分类号： C09B62/503 , C09B62/4403
摘要： A phthalocyanine monoazo compound which is represented by the following formula (I): ##STR1## wherein Pc represents a phthalocyanine group; M represents nickel, cobalt or copper; R.sub.1 represents a hydrogen atom or a lower alkyl group; R.sub.2 and R.sub.3 represent a hydrogen atom, a lower alkyl group, a lower alkoxy group or a sulfo group; R.sub.4 represents a hydrogen or a lower alkyl group; A represents a group containing a triazine group or a pyrazole group and/or --SO.sub.2 X wherein X represents --CH.dbd.CH.sub.2 or --CH.sub.2 CH.sub.2 Y and Y represents a group splittable by the action of an alkali; p is a number of 0-2; q is a number of 1-3; r is a number of 1-2; p+q+r is 4 or less or which is a salt of the compound of formula (I).
摘要翻译：由下式（I）表示的酞菁单偶氮化合物：其中Pc表示酞菁基团; M表示镍，钴或铜; R1表示氢原子或低级烷基; R2和R3表示氢原子，低级烷基，低级烷氧基或磺基; R4表示氢或低级烷基; A表示含有三嗪基或吡唑基和/或-SO 2 X的基团，其中X表示-CH = CH 2或-CH 2 CH 2 Y，Y表示可通过碱的作用而分裂的基团; p是0-2的数; q是1-3的数量; r是1-2的数量; p + q + r为4以下，或者为式（I）的化合物的盐。

40. 外观设计

USD354568S Hearing aid 失效
公开(公告)号：USD354568S
公开(公告)日：1995-01-17
申请号：US018537
申请日：1994-02-09
申请人： Toshiyuki Araki , Yoshiyuki Narisawa , Noboru Inoue
设计人： Toshiyuki Araki , Yoshiyuki Narisawa , Noboru Inoue

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