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31. 发明授权

US08080695B2 Method of synthesizing higher-molecular alcohol 有权
标题翻译：合成高分子醇的方法
公开(公告)号：US08080695B2
公开(公告)日：2011-12-20
申请号：US11757588
申请日：2007-06-04
申请人： Takashi Tsuchida , Shuji Sakuma
发明人： Takashi Tsuchida , Shuji Sakuma
IPC分类号： C07C31/02
CPC分类号： C07C29/34 , C07C31/12
摘要： The present invention provides a production method with which high molecular alcohols having an even number of carbon atoms such as 1-butanol, hexanol, octanol and decanol, and a mixture of these are efficiently collected through clean processes with the use of ethanol as a raw material. High molecular alcohols are produced from ethanol by using calcium phosphate-based compounds such as hydroxyapatite Ca10(PO4)6(OH)2, tricalcium phosphate Ca3(PO4)2, calcium monohydrogen phosphate CaHPO4.(0˜2)H2O, calcium diphosphate Ca2P2O7, octacalcium phosphate Ca8H2(PO4)6.5H2O, tetracalcium phosphate Ca4(PO4)2O or amorphous calcium phosphate Ca3(PO4)2. nH2O as a catalyst, using ethanol as a starting material, and setting a contact time at 0.4 second or longer.
摘要翻译：本发明提供一种制备方法，通过使用乙醇作为原料，通过清洁方法有效地收集具有偶数个碳原子的高分子醇如1-丁醇，己醇，辛醇和癸醇，以及它们的混合物材料。高分子醇通过使用磷酸钙基化合物如羟基磷灰石Ca10（PO4）6（OH）2，磷酸三钙Ca3（PO4）2，磷酸一氢钙CaHPO 4（0-2）H 2 O，二磷酸钙Ca 2 P 2 O 7 ，磷酸三钙Ca8H2（PO4）6.5H2O，磷酸四钙Ca4（PO4）2O或无定形磷酸钙Ca3（PO4）2。 nH 2 O作为催化剂，使用乙醇作为原料，并将接触时间设定为0.4秒以上。

32. 发明申请

US20090056204A1 METHOD OF SYNTHESIZING CHEMICAL INDUSTRY RAW MATERIALS AND FUEL COMPOSITIONS 审中-公开
标题翻译：合成化学工业原料和燃料组合物的方法
公开(公告)号：US20090056204A1
公开(公告)日：2009-03-05
申请号：US12198059
申请日：2008-08-25
申请人： Takashi Tsuchida , Shuji Sakuma , Tetsuya Yoshioka , Jun Kubo
发明人： Takashi Tsuchida , Shuji Sakuma , Tetsuya Yoshioka , Jun Kubo
IPC分类号： C10L1/18
CPC分类号： C07C29/34 , C07C31/12 , C07C31/10 , C07C31/125
摘要： The present invention is to provide a novel method for manufacturing various organic compounds from 2 or more kinds of alcohol, or 1 kind of alcohol having 3 or more carbon atoms. It is a method for synthesizing 1 kind of, or 2 or more kinds of organic compounds comprising allowing 2 or more kinds of alcohol or 1 kind of alcohol having 3 or more carbon atoms to contact hydroxyapatite (except those supporting metal catalysts or metal ion catalysts acting on alcohol).
摘要翻译：本发明提供一种由2种以上的醇或1种具有3个以上碳原子的醇制造各种有机化合物的新方法。合成1种或2种以上有机化合物的方法，包括使2种以上的醇或1种具有3个以上碳原子的醇与羟基磷灰石接触（除载体金属催化剂或金属离子催化剂作用于酒精）。

33. 发明申请

US20080069896A1 Antitumor Composition 审中-公开
标题翻译：抗肿瘤成分
公开(公告)号：US20080069896A1
公开(公告)日：2008-03-20
申请号：US11575883
申请日：2005-09-26
申请人： Shuji Sakuma , Kiminori Atsumi , Keiichiro Kikukawa
发明人： Shuji Sakuma , Kiminori Atsumi , Keiichiro Kikukawa
IPC分类号： A61K33/24 , A61P35/00
CPC分类号： A61K9/1611 , A61K9/143 , A61K33/24 , A61K33/42 , A61K47/02 , A61K2300/00
摘要： Antitumor agents with high antitumor effect have much side-effect, and its activity decreases when the toxicity decreases. Thus, satisfactory antitumor effects are not always obtained. Therefore, development of an antitumor agent having a high antitumor effect, with less side-effect and low toxicity is awaited. The present invention is to provide an antitumor agent of fine particles, wherein platinum chloride, chloroplatinic acids and hydroxyapatite are blend. Platinum chloride and chloroplatinic acids are platinum tetrachloride, tetrachloroplatinate, hexachloroplatinate, disodium platinum tetrachloride, disodium platinum hexachloride, dipotassium platinum tetrachloride, or dipotassium platinum hexachloride. The maximum particle diameter of hydroxyapatite is 1 μm or less.
摘要翻译：具有高抗肿瘤作用的抗肿瘤剂具有很大的副作用，当毒性降低时，其活性降低。因此，不能始终获得令人满意的抗肿瘤效果。因此，期待开发具有高抗肿瘤效果，副作用小，毒性低的抗肿瘤剂。本发明提供一种微粒的抗肿瘤剂，其中氯化铂，氯铂酸和羟基磷灰石是共混的。氯化铂和氯铂酸是四氯化铂，四氯铂酸盐，六氯铂酸盐，四氯化二钠，六氯化钠，四氯化铂钾或六氯化钾。羟基磷灰石的最大粒径为1μm以下。

34. 发明申请

US20070166362A1 Transdermal and transmucosal preparations 审中-公开
标题翻译：透皮和透粘膜制剂
公开(公告)号：US20070166362A1
公开(公告)日：2007-07-19
申请号：US10552541
申请日：2005-02-22
申请人： Shuji Sakuma , Kiminori Atsumi , Keiichiro Kikukawa
发明人： Shuji Sakuma , Kiminori Atsumi , Keiichiro Kikukawa
IPC分类号： A61K9/70 , A61K33/42
CPC分类号： A61K36/38 , A61K9/0014 , A61K9/7053 , A61K31/00 , A61K38/27 , A61K38/28 , A61K47/02
摘要： Transdermal and transmucosal preparations are often insufficiently absorbed. Thus, there is a need for additives that can enhance the transdermal and/or transmucosal absorption of various drugs. The present invention provides compositions for enhancing transdermal and/or transmucosal absorption, comprising a hydroxyapatite and essential ingredients. The hydroxyapatite has a maximum particle size of 1 μm or less, preferably 0.1 μm or less, and the content of the hydroxyapatite relative to a drug to be formulated ranges from 0.1 to 1000 weight percent.
摘要翻译：透皮和透粘膜制剂常常不充分吸收。因此，需要可以增强各种药物的经皮和/或经粘膜吸收的添加剂。本发明提供了用于增强透皮和/或经粘膜吸收的组合物，其包含羟基磷灰石和必需成分。羟基磷灰石的最大粒径为1μm以下，优选为0.1μm以下，羟基磷灰石相对于药物的含量为0.1〜1000重量％。

35. 发明授权

US5670827A Protein-based semiconductor integrated circuit 失效
标题翻译：基于蛋白质的半导体集成电路
公开(公告)号：US5670827A
公开(公告)日：1997-09-23
申请号：US543919
申请日：1995-10-17
申请人： Shuji Sakuma , Kiminori Atsumi , Tsutomu Ishizaki
发明人： Shuji Sakuma , Kiminori Atsumi , Tsutomu Ishizaki
IPC分类号： H01L29/43 , C23C14/06 , H01L21/28 , H01L21/314 , H01L51/30 , H01L23/48 , H01L23/52 , H01L29/40
CPC分类号： H01L51/0093 , B82Y10/00
摘要： A semiconductor integrated circuit comprises a conductive protein electrode, such as cytochrome c, deposited on the surface of an apatite insulating layer such as hydroxyapatite, fluorinated apatite or chlorinated apatite. The apatite insulating layer is thin film coated onto a substrate such that it is substantially C-axis (002) oriented, which allows the integrated circuit to be of small size while minimizing undesired electron transfer between electrodes because the conductive protein electrode adopts the orientation of the apatite insulating film.
摘要翻译：半导体集成电路包括沉积在磷灰石绝缘层如羟基磷灰石，氟化磷灰石或氯化磷灰石表面上的导电蛋白电极，如细胞色素c。磷灰石绝缘层是涂覆在基板上的薄膜，使得其基本上是C轴（002）取向的，这允许集成电路具有小尺寸，同时最小化电极之间的不期望的电子转移，因为导电蛋白电极采用磷灰石绝缘膜。

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