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31. 发明授权

US07323328B2 Obligately symbiotic thermophile Symbiobacterium toebii SC-1 producing thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase 有权
标题翻译：共生共生嗜热菌共培养杆菌SC-1产生热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶
公开(公告)号：US07323328B2
公开(公告)日：2008-01-29
申请号：US11186559
申请日：2005-07-21
申请人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Ok Jeon , Joong-Jae Kim , Kwang Kim , Jae Jun Song
发明人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Ok Jeon , Joong-Jae Kim , Kwang Kim , Jae Jun Song
IPC分类号： C12N1/20 , C12N9/88 , C12P39/00
CPC分类号： C12R1/01 , C12N9/88 , C12P13/227
摘要： The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1 (Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The present invention also relates to a pure culture method of Symbiobacterium toebii SC-1, a method of growth measurement for Symbiobacterium toebii SC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains of Symbiobacterium toebii SC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.
摘要翻译：本发明涉及一种新型的共生共生嗜热ile ile i i i i i i i i））i i i i i i i i i i i i i i i i i。。。。。。。。。。。。。。。。。。。。本发明还涉及使用硝酸盐呼吸的共生杆菌SC-1的纯培养方法，使用硝酸盐呼吸显示低生长产量的共生杆菌SC-1及其相对共生菌的生长方法，以及相对共生菌株的筛选方法的来自环境的共表达杆菌SC-1使用特异性抗体。因此，在本发明中由共生杆菌（Toibii）SC-1产生的热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶可以在酶生物转化过程中提供更稳定的催化剂，其中酶促产生有价值的羟基 - 氨基酸3,4-脱羟基 - L-苯丙氨酸（L-DOPA）和L-色氨酸。

32. 发明授权

US07255855B2 Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase 失效
标题翻译：使用编码聚-γ-谷氨酸合成酶的基因的肽P5和Anal3的表面表达方法
公开(公告)号：US07255855B2
公开(公告)日：2007-08-14
申请号：US10789164
申请日：2004-02-27
申请人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Kyung Park , Chul-Joong Kim , Ha-Ryoung Poo
发明人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Kyung Park , Chul-Joong Kim , Ha-Ryoung Poo
IPC分类号： A01N63/00 , C12N15/00 , C12N1/20
CPC分类号： C07K14/32
摘要： The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Ana13 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived from Bacillus sp. strains and involved in the synthesis of poly-gamma-glutamate. Moreover, the present invention relates to lactic acid-forming bacteria having each of the peptide antibiotics P5 15 and Ana13 43 expressed on their surface, and the use thereof.According to the present invention, the peptide antibiotics can be expressed on the surface of various microorganisms transformed with the surface expression vectors. The inventive method for the surface expression of the peptide antibiotics allows the peptide antibiotics to be mass-produced without a purification process. Thus, the inventive method has very high industrial applicability. Further, the present invention can be applied to other peptide antibiotics besides P5 3 and Ana13 35.
摘要翻译：本发明涉及一种用于表达具有两亲性的肽抗生素P5 3和Ana1335的方法，并且在微生物表面上显示出抗菌，抗真菌和抗癌活性61,63,65,67,69,71，使用含有外源的载体来自芽孢杆菌属的膜蛋白基因（pgsBCA）菌株并参与了聚-γ-谷氨酸的合成。此外，本发明涉及在其表面表达的各种肽抗生素P515和Ana1343的乳酸形成细菌及其用途。根据本发明，肽抗生素可以在用表面表达载体转化的各种微生物的表面上表达。肽抗生素表面表达的本发明方法允许肽抗生素在没有纯化过程的情况下批量生产。因此，本发明的方法具有非常高的工业实用性。此外，本发明可以应用于除P5 3和Ana1335之外的其它肽抗生素。

33. 发明授权

US07183077B2 Promoters and gene expression method by using the promoters 有权
标题翻译：启动子和使用启动子的基因表达方法
公开(公告)号：US07183077B2
公开(公告)日：2007-02-27
申请号：US10258482
申请日：2001-04-26
申请人： Moon-Hee Sung , Seung-Goo Lee , Seung-Pyo Hong , Hwa-Jung Seo
发明人： Moon-Hee Sung , Seung-Goo Lee , Seung-Pyo Hong , Hwa-Jung Seo
IPC分类号： C12P21/00 , C12N1/21 , C12N15/70 , C12N15/74 , C07H21/04
CPC分类号： C07K14/32 , C12N15/70 , C12N15/75
摘要： To provide a promoter, a recombinant DNA, a gene expression vector, an expression vector, and a transformant, which are capable of expressing a gene without inducing gene expression with an inducer; and a method for producing a protein and a kit therefor, which can be operated easily and performed inexpensively by convenient and inexpensive steps. An isolated DNA having the nucleotide sequence of SEQ ID NO: 1 or 2 of Sequence Listing or a fragment thereof, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; an isolated DNA having a nucleotide sequence of a nucleic acid capable of hybridizing to the above DNA, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; a recombinant DNA comprising the above DNA and a foreign gene, wherein the foreign gene is operably located; a gene expression vector, at least comprising the above DNA; an expression vector comprising the recombinant DNA; a transformant having the above recombinant DNA, or the above expression vector; a method for producing a protein, characterized by culturing the above transformant, and collecting a protein from the resulting culture; and a kit for producing a protein, at least comprising the above DNA, or the above gene expression vector.
摘要翻译：提供能够表达基因而不诱导基因表达的启动子，重组DNA，基因表达载体，表达载体和转化体; 以及用于制备蛋白质及其试剂盒的方法，其可以容易地操作并且通过方便和便宜的步骤廉价地进行。具有序列表的SEQ ID NO：1或2的核苷酸序列或其片段的分离的DNA，其中所述分离的DNA在大肠杆菌或属于芽孢杆菌属的细菌中显示组成型启动子活性; 具有能够与上述DNA杂交的核酸的核苷酸序列的分离的DNA，其中所述分离的DNA在大肠杆菌或属于芽孢杆菌属的细菌中显示出组成型启动子活性; 包含上述DNA和外来基因的重组DNA，其中所述外源基因可操作地定位; 至少包含上述DNA的基因表达载体; 包含重组DNA的表达载体; 具有上述重组DNA的转化体或上述表达载体; 一种生产蛋白质的方法，其特征在于培养上述转化体，并从得到的培养物中收集蛋白质; 以及用于生产至少包含上述DNA或上述基因表达载体的蛋白质的试剂盒。

34. 发明申请

US20050255090A1 Obligately symbiotic thermophile Symbiobacterium toebii SC-1 producing thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase 有权
标题翻译：共生共生嗜热菌共培养杆菌SC-1产生热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶
公开(公告)号：US20050255090A1
公开(公告)日：2005-11-17
申请号：US11186559
申请日：2005-07-21
申请人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Jeon , Joong-Jae Kim , Kwang Kim , Jae Song
发明人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Jeon , Joong-Jae Kim , Kwang Kim , Jae Song
IPC分类号： G01N33/569 , C12N1/20 , C12N9/88 , C12P13/22 , C12Q1/06 , C12R1/01 , G01N21/77 , A61K45/00
CPC分类号： C12R1/01 , C12N9/88 , C12P13/227
摘要： The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1 (Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The present invention also relates to a pure culture method of Symbiobacterium toebii SC-1, a method of growth measurement for Symbiobacterium toebii SC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains of Symbiobacterium toebii SC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.
摘要翻译：本发明涉及一种新型的共生共生嗜热ile ile i i i i i i i i））i i i i i i i i i i i i i i i i i。。。。。。。。。。。。。。。。。。。。本发明还涉及使用硝酸盐呼吸的共生杆菌SC-1的纯培养方法，使用硝酸盐呼吸显示低生长产量的共生杆菌SC-1及其相对共生菌的生长方法，以及相对共生菌株的筛选方法的来自环境的共表达杆菌SC-1使用特异性抗体。因此，在本发明中由共生杆菌（Toibii）SC-1产生的热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶可以在酶生物转化过程中提供更稳定的催化剂，其中酶促产生有价值的羟基 - 氨基酸3,4-脱羟基 - L-苯丙氨酸（L-DOPA）和L-色氨酸。

35. 发明申请

US20050191720A1 Surface expression method of peptides P5 and ANAL3 using the gene encoding poly-gamma-glutamate synthetase 失效
标题翻译：使用编码聚-γ-谷氨酸合成酶的基因的肽P5和ANAL3的表达表达方法
公开(公告)号：US20050191720A1
公开(公告)日：2005-09-01
申请号：US10789164
申请日：2004-02-27
申请人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Park , Chul-Joong Kim , Ha-Ryoung Poo
发明人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Park , Chul-Joong Kim , Ha-Ryoung Poo
IPC分类号： C07H21/04 , C07K14/32 , C07K16/30 , C12N1/21 , C12N15/74 , C12P21/06
CPC分类号： C07K14/32
摘要： The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived from Bacillus sp. strains and involved in the synthesis of poly-gamma-glutamate. Moreover, the present invention relates to lactic acid-forming bacteria having each of the peptide antibiotics P5 15 and Anal3 43 expressed on their surface, and the use thereof. According to the present invention, the peptide antibiotics can be expressed on the surface of various microorganisms transformed with the surface expression vectors. The inventive method for the surface expression of the peptide antibiotics allows the peptide antibiotics to be mass-produced without a purification process. Thus, the inventive method has very high industrial applicability. Further, the present invention can be applied to other peptide antibiotics besides P5 3 and Anal3 35.
摘要翻译：本发明涉及在微生物表面上表达具有两亲性的肽抗生素P5 3和Anal335各自表现出抗菌，抗真菌，抗癌活性的方法，来自芽孢杆菌属的膜蛋白基因（pgsBCA）菌株并参与了聚-γ-谷氨酸的合成。此外，本发明涉及在其表面表达的各肽抗生素P515和Anal343各自的乳酸形成细菌及其用途。根据本发明，肽抗生素可以在用表面表达载体转化的各种微生物的表面上表达。肽抗生素表面表达的本发明方法允许肽抗生素在没有纯化过程的情况下批量生产。因此，本发明的方法具有非常高的工业实用性。此外，本发明可以应用于除P5 3和Anal335之外的其它肽抗生素。

36. 发明授权

US09231593B2 Apparatus for compensating for process variation of resistor in electronic circuit 有权
标题翻译：用于补偿电子电路中电阻器工艺变化的装置
公开(公告)号：US09231593B2
公开(公告)日：2016-01-05
申请号：US13270384
申请日：2011-10-11
申请人： Jeong-Ho Lee , Seung-Pyo Hong , Ju-Ho Son , Seung-Ho Jang , Hyun-Tae Gill , Joon-Hee Lee , Yi-Ju Roh
发明人： Jeong-Ho Lee , Seung-Pyo Hong , Ju-Ho Son , Seung-Ho Jang , Hyun-Tae Gill , Joon-Hee Lee , Yi-Ju Roh
IPC分类号： H03L5/00 , H03K19/003
CPC分类号： H03K19/00384
摘要： An electronic circuit apparatus for compensating for a process variation of a resistor in an electronic circuit is provided. The electronic circuit includes a detecting part for generating a tune voltage corresponding to a process variation value of the at least one resistor, and a compensating part for compensating for a process variation of the at least one resistor using the tune voltage.
摘要翻译：提供了用于补偿电子电路中的电阻器的工艺变化的电子电路装置。电子电路包括用于产生对应于至少一个电阻器的过程变化值的调谐电压的检测部分和用于使用调谐电压来补偿至少一个电阻器的工艺变化的补偿部分。

37. 发明授权

US08616875B2 Light guide plate stamp and method of manufacturing the same 有权
标题翻译：导光板印章及其制造方法
公开(公告)号：US08616875B2
公开(公告)日：2013-12-31
申请号：US13240982
申请日：2011-09-22
申请人： Ho-Han Ryu , Tae-Seok Kim , Seung-Pyo Hong , Seung-Yeop Lee
发明人： Ho-Han Ryu , Tae-Seok Kim , Seung-Pyo Hong , Seung-Yeop Lee
IPC分类号： B29C45/34 , F21V7/04 , B29D7/00
CPC分类号： B21D47/04
摘要： A stamp includes a metal supporting layer, a pattern forming layer and an adhesive layer. The metal supporting layer has a first thermal conductivity. The pattern forming layer is disposed on the metal supporting layer and has a surface with a molding pattern formed thereon. The adhesive layer is disposed between the metal supporting layer and the pattern forming layer to couple the pattern forming layer to the metal supporting layer, and has a second thermal conductivity lower than the first thermal conductivity. Thus, strength of the stamp may be improved, and deformation of the stamp during the process of manufacturing a light guide plate may be reduced or prevented.
摘要翻译：印模包括金属支撑层，图案形成层和粘合剂层。金属支撑层具有第一导热性。图案形成层设置在金属支撑层上，并具有在其上形成有模制图案的表面。粘合剂层设置在金属支撑层和图案形成层之间，以将图案形成层耦合到金属支撑层，并且具有比第一热导率低的第二热导率。因此，可以提高印模的强度，并且可以减少或防止在制造导光板的过程中印模的变形。

38. 发明申请

US20060140971A1 Cell surface expression vector of sars virus antigen and microorganisms transformed thereby 审中-公开
标题翻译： sars病毒抗原和微生物转化的细胞表面表达载体
公开(公告)号：US20060140971A1
公开(公告)日：2006-06-29
申请号：US10559631
申请日：2004-06-04
申请人： Moon-Hee Sung , Chul-Joong Kim , Chang-Min Jung , Seung-Pyo Hong , Jong Su Lee , Jae Choi , Kwang Kim , Kuroda Shunichi , Ha Ryoung Poo
发明人： Moon-Hee Sung , Chul-Joong Kim , Chang-Min Jung , Seung-Pyo Hong , Jong Su Lee , Jae Choi , Kwang Kim , Kuroda Shunichi , Ha Ryoung Poo
IPC分类号： A61K39/02 , C12N1/21 , C12N15/74 , C07K14/165
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/523 , C07K2319/00 , C12N9/93 , C12N15/74 , C12N2710/20022 , C12N2770/20022 , Y02A50/476
摘要： The present invention relates to a surface expression vector of SARS coronavirus antigen containing a gene encoding an antigen of SARS inducing coronavirus and any one or two or more of genes pgsB, pgsC and pgsA encoding poly-gamma-glutamic acid synthase complex, a microorganism transformed by the surface expression vector, and a SARS vaccine comprising the microorganism. According to the present invention, it is possible to economically produce a vaccine for prevention and treatment of SARS using a recombinant strain expressing an SARS coronavirus antigen on their surface.
摘要翻译：本发明涉及SARS冠状病毒抗原的表达表达载体，其含有编码SARS诱导冠状病毒抗原的基因和编码聚-γ-谷氨酸合酶复合物的pgsB，pgsC和pgsA基因中的一种或两种以上的基因，微生物转化通过表面表达载体和包含该微生物的SARS疫苗。根据本发明，可以在表面上使用表达SARS冠状病毒抗原的重组菌株经济地制备用于预防和治疗SARS的疫苗。

39. 发明授权

US06967087B1 Obligately symbiotic thermophile symbiobacterium toebii SC-1 producing thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase and a method for screening its relative bacteria 失效
标题翻译：共生共生嗜热菌共生菌toebii SC-1产生热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶及其相对细菌筛选方法
公开(公告)号：US06967087B1
公开(公告)日：2005-11-22
申请号：US10220174
申请日：2000-07-14
申请人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Ok Jeon , Joong-Jae Kim , Kwang Kim , Jae Jun Song
发明人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Ok Jeon , Joong-Jae Kim , Kwang Kim , Jae Jun Song
IPC分类号： G01N33/569 , C12N1/20 , C12N9/88 , C12P13/22 , C12Q1/06 , C12R1/01 , G01N21/77 , C12P39/00 , C12Q1/12
CPC分类号： C12R1/01 , C12N9/88 , C12P13/227
摘要： The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1(Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The present invention also relates to a pure culture method of Symbiobacterium toebii SC-1, a method of growth measurement for Symbiobacterium toebu SC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains of Symbiobacterium toebii SC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.
摘要翻译：本发明涉及一种新型的共生共生嗜热ile ile i i i i i i i i））i i i i i i i i i i i i i i i i i。。。。。。。。。。。。。。。。。。。。本发明还涉及使用硝酸盐呼吸的共生杆菌SC-1的纯培养方法，使用硝酸盐呼吸显示低生长量的共生杆菌SC-1及其相对共生菌的生长测定方法以及相对共生菌株的筛选方法的来自环境的共表达杆菌SC-1使用特异性抗体。因此，在本发明中由共生杆菌（Toibii）SC-1产生的热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶可以在酶生物转化过程中提供更稳定的催化剂，其中酶促产生有价值的羟基 - 氨基酸3,4-脱羟基 - L-苯丙氨酸（L-DOPA）和L-色氨酸。

40. 发明授权

US08080402B2 Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase 有权
标题翻译：使用编码聚-γ-谷氨酸合成酶的基因的肽P5和Anal3的表面表达方法
公开(公告)号：US08080402B2
公开(公告)日：2011-12-20
申请号：US11622158
申请日：2007-01-11
申请人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Kyung Park , Chul-Joong Kim , Ha-Ryoung Poo
发明人： Moon-Hee Sung , Seung-Pyo Hong , Jong-Su Lee , Chang-Min Jung , Kyung-Soo Hahm , Dong-Gun Lee , Yoon Kyung Park , Chul-Joong Kim , Ha-Ryoung Poo
IPC分类号： C12N15/00 , C12N1/21 , A61K48/00
CPC分类号： C07K14/32
摘要： The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63, 65, 67, 69, 71, on the microbial surface, using a vector containing outer membrane protein genes (pgsBCA) that are derived from Bacillus sp. strains and involved in the synthesis of poly-gamma-glutamate. Moreover, the present invention relates to lactic acid-forming bacteria having each of the peptide antibiotics P5 15 and Anal3 43 expressed on their surface, and the use thereof. According to the present invention, the peptide antibiotics can be expressed on the surface of various microorganisms transformed with the surface expression vectors. The inventive method for the surface expression of the peptide antibiotics allows the peptide antibiotics to be mass-produced without a purification process. Thus, the inventive method has very high industrial applicability. Further, the present invention can be applied to other peptide antibiotics besides P5 3 and Anal 3 35.
摘要翻译：本发明涉及在微生物表面上表达具有两亲性的肽抗生素P5 3和Anal335各自表现出抗菌，抗真菌，抗癌活性的方法，来自芽孢杆菌属的膜蛋白基因（pgsBCA）菌株并参与了聚-γ-谷氨酸的合成。此外，本发明涉及在其表面表达的各肽抗生素P515和Anal343各自的乳酸形成细菌及其用途。根据本发明，肽抗生素可以在用表面表达载体转化的各种微生物的表面上表达。肽抗生素表面表达的本发明方法允许肽抗生素在没有纯化过程的情况下批量生产。因此，本发明的方法具有非常高的工业实用性。此外，除了P5 3和Anal 3 35之外，本发明可以应用于其它肽抗生素。

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