专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明专利

CZ20001264A3 Crystal modification against moulds 未知
公开(公告)号：CZ20001264A3
公开(公告)日：2000-08-16
申请号：CZ20001264
申请日：1998-10-05
申请人： SCHERING CORP
发明人： ANDREWS DAVID R , LEONG WILLIAM , SUDHAKAR ANANTHA R
IPC分类号： A61K31/4196 , A61K31/496 , A61K31/4965 , A61P31/10 , C07D241/00 , C07D249/00 , C07D307/00 , C07D405/14
摘要： The crystalline polymorph Form I of (-)-4-[4- [4-[4-[ [(2R-cis)-5-(2, 4-difluorophenyl) tetrahydro-5-(1H-1, 2,4-triazol- 1-ylmethyl)furan-3-yl] methoxy]phenyl] -1-piperazinyl] phenyl-2,4-dihydro-2- [(S)-1-ethyl-2(S)- hydroxylpropyl]-3H-1, 2,4-triazol-3-one represented by formula (I), pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

32. 发明专利

BR9812866A 未知
公开(公告)号：BR9812866A
公开(公告)日：2000-08-08
申请号：BR9812866
申请日：1998-10-05
申请人： SCHERING CORP
发明人： ANDREWS DAVID R , LEONG WILLIAM , SUDHAKAR ANANTHA R
IPC分类号： A61K31/4196 , A61K31/496 , A61K31/4965 , A61P31/10 , C07D241/00 , C07D249/00 , C07D307/00 , C07D405/14 , A61K31/495 , A61K31/41
摘要： The crystalline polymorph Form I of (-)-4-[4- [4-[4-[ [(2R-cis)-5-(2, 4-difluorophenyl) tetrahydro-5-(1H-1, 2,4-triazol- 1-ylmethyl)furan-3-yl] methoxy]phenyl] -1-piperazinyl] phenyl-2,4-dihydro-2- [(S)-1-ethyl-2(S)- hydroxylpropyl]-3H-1, 2,4-triazol-3-one represented by formula (I), pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

33. 发明专利

AT171186T 未知
公开(公告)号：AT171186T
公开(公告)日：1998-10-15
申请号：AT93904484
申请日：1993-01-26
申请人： SCHERING CORP
发明人： ANDREWS DAVID R , SUDHAKAR ANANTHA R
IPC分类号： A61K31/57 , A61P31/04 , C07J1/00 , C07J5/00 , C07J7/00 , C07J13/00 , C07J21/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J51/00
摘要： PCT No. PCT/US93/00211 Sec. 371 Date Jul. 25, 1994 Sec. 102(e) Date Jul. 25, 1994 PCT Filed Jan. 26, 1993 PCT Pub. No. WO93/15103 PCT Pub. Date Aug. 5, 1993.Novel steroids having a 9 alpha -hydroxy or a 9 alpha -carbonate substituent can be prepared from 9 alpha -hydroxyandrostenedione and can be utilized in the synthesis of commercially valuable corticosteroids such as betamethasone. The 9 alpha -carbonates are prepared by reaction of the corresponding 9 alpha -hydroxy steroid with a sequence of excess base, trialkylsilyl chloride, alkyl haloformate and alkanol or by using excess base, alkyl haloformate and alkoxide. 9 alpha -Carbonate-17-keto compounds can be treated with lithium acetylide and a lithium salt to afford the corresponding 17 alpha -ethynyl-17 beta -hydroxy-9 alpha -carbonate. This compound is then esterified with a novel series of reagents to give the 17-ester which can be reduced the corresponding 17-allene. Oxidation of this allene to the bis-epoxide compound, followed by treatment with an alkali metal salt of a carboxylic acid under phase transfer conditions gives the 17 alpha -hydroxy 21-ester 9 alpha -carbonate. Elimination of the 9 alpha -carbonate group affords the a 17 alpha -hydroxy, 9(11)ene, which in a few subsequent steps can be converted to a variety of commercially important corticosteroids. Novel 9 alpha -carbonate compounds are prepared in the various reaction steps.

34. 发明专利

CA2128860A1 NOVEL STEROID INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION 未知
公开(公告)号：CA2128860A1
公开(公告)日：1993-08-05
申请号：CA2128860
申请日：1993-01-26
申请人： SCHERING CORP
发明人： ANDREWS DAVID R , SUDHAKAR ANANTHA R
IPC分类号： A61K31/57 , A61P31/04 , C07J1/00 , C07J5/00 , C07J7/00 , C07J13/00 , C07J21/00 , C07J31/00 , C07J41/00 , C07J43/00 , C07J51/00
摘要： 2128860 9315103 PCTABS00024 Novel steroids having a 9.alpha.-hydroxy or a 9.alpha.-carbonate substituent can be prepared from 9.alpha.-hydroxyandrostenedione and can be utilized in the synthesis of commercially valuable corticosteroids such as betamethasone. The 9.alpha.-carbonates are prepared by reaction of the corresponding 9.alpha.-hydroxy steroid with a sequence of excess base, trialkylsilyl chloride, alkyl haloformate and alkanol or by using excess base, alkyl haloformate and alkoxide. 9.alpha.-Carbonate-17-keto compounds can be treated with lithium acetylide and a lithium salt to afford the corresponding 17.alpha.-ethynyl-17.beta.-hydroxy-9.alpha.-carbonate. This compound is then esterified with a novel series of reagents to give the 17-ester which can be reduced the corresponding 17-allene. Oxidation of this allene to the bis-epoxide compound, followed by treatment with an alkali metal salt of a carboxylic acid under phase transfer conditions gives 17.alpha.-hydroxy 21-ester 9.alpha.-carbonate. Elimination of the 9.alpha.-carbonate group affords the a 17.alpha.-hydroxy, 9(11)ene, which in a few subsequent steps can be converted to a variety of commercially important corticosteroids. Novel 9.alpha.-carbonate compounds are prepared in the various reaction steps.

35. 发明专利

MY130126A CRYSTALLINE ANTIFUNGAL POLYMORPH 未知
公开(公告)号：MY130126A
公开(公告)日：2007-06-29
申请号：MYPI9804576
申请日：1998-10-06
申请人： SCHERING CORP
发明人： ANDREWS DAVID R , LEONG WILLIAM , SUDHAKAR ANANTHA R
IPC分类号： C07D405/14 , A61K31/41 , A61K31/4196 , A61K31/495 , A61K31/496 , A61K31/4965 , A61P31/10 , C07D241/00 , C07D249/00 , C07D307/00
摘要： THE CRYSTALLINE POLYMORPH FORM I OF (-)-4-[4-[4-[4-[[(2R-CIS)-5-(2,4-DIFLUOROPHENYL) TETRAHYDRO-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)FURAN-3-YL] METHOXY]PHENYL]-1-PIPERAZINYL]PHENYL-2,4-DIHYDRO-2- [(S)-1-ETHYL 2(S)-HYDROXYLPROPYL]-3H-1,2,4-TRIAZOL-3-ONE REPRESENTED BY FORMULA (I), PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH A POLYMORPH AND METHODS OF USING SUCH A POLYMORPH TO TREAT FUNGAL INFECTIONS IN MAMMALS ARE DISCLOSED.(FIG 1)

36. 发明专利

NO320154B1 未知
公开(公告)号：NO320154B1
公开(公告)日：2005-11-07
申请号：NO982880
申请日：1998-06-19
申请人： SCHERING CORP
发明人： NIELSEN CHRISTOPHER M , SUDHAKAR ANANTHA R
IPC分类号： C12P7/62 , C21C7/10 , C07C69/63 , C07C69/65 , C12P41/00 , C21C7/068 , C21C7/072 , C12P7/22
摘要： A process for producing a crystalline chiral hydroxy ester of formula (1.0) is disclosed. The process comprises reacting a diol of formula (2.0), with an effective amount of isobutyric anhydride and an effective amount of a lipase enzyme in an effective amount of acetonitrile, said reaction being conducted at a low temperature, and wherein X and X are each independently selected from F or Cl.

37. 发明专利

NO318827B1 未知
公开(公告)号：NO318827B1
公开(公告)日：2005-05-09
申请号：NO20001779
申请日：2000-04-06
申请人： SCHERING CORP
发明人： LEONG WILLIAM , SUDHAKAR ANANTHA R , ANDREWS DAVID R
IPC分类号： C07D405/14 , A61K31/4196 , A61K31/496 , A61K31/4965 , A61P31/10 , C07D241/00 , C07D249/00 , C07D307/00
摘要： The crystalline polymorph Form I of (-)-4-[4- [4-[4-[ [(2R-cis)-5-(2, 4-difluorophenyl) tetrahydro-5-(1H-1, 2,4-triazol- 1-ylmethyl)furan-3-yl] methoxy]phenyl] -1-piperazinyl] phenyl-2,4-dihydro-2- [(S)-1-ethyl-2(S)- hydroxylpropyl]-3H-1, 2,4-triazol-3-one represented by formula (I), pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

38. 发明专利

ES2217594T3 未知
公开(公告)号：ES2217594T3
公开(公告)日：2004-11-01
申请号：ES98951994
申请日：1998-10-05
申请人： SCHERING CORP
发明人： ANDREWS DAVID R , LEONG WILLIAM , SUDHAKAR ANANTHA R
IPC分类号： A61K31/4196 , A61K31/496 , A61K31/4965 , A61P31/10 , C07D241/00 , C07D249/00 , C07D307/00 , C07D405/14 , A61K31/495 , A61K31/41
摘要： The crystalline polymorph Form I of (-)-4-[4- [4-[4-[ [(2R-cis)-5-(2, 4-difluorophenyl) tetrahydro-5-(1H-1, 2,4-triazol- 1-ylmethyl)furan-3-yl] methoxy]phenyl] -1-piperazinyl] phenyl-2,4-dihydro-2- [(S)-1-ethyl-2(S)- hydroxylpropyl]-3H-1, 2,4-triazol-3-one represented by formula (I), pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

39. 发明专利

ID29290A 未知
公开(公告)号：ID29290A
公开(公告)日：2001-08-16
申请号：ID20000632
申请日：1998-10-05
申请人： SCHERING CORP
发明人： ANDREWS DAVID R , LEONG WILLIAM , SUDHAKAR ANANTHA R
IPC分类号： A61K31/4196 , A61K31/496 , A61K31/4965 , A61P31/10 , C07D241/00 , C07D249/00 , C07D307/00 , C07D405/14 , A61K31/495 , A61K31/41
摘要： The crystalline polymorph Form I of (-)-4-[4- [4-[4-[ [(2R-cis)-5-(2, 4-difluorophenyl) tetrahydro-5-(1H-1, 2,4-triazol- 1-ylmethyl)furan-3-yl] methoxy]phenyl] -1-piperazinyl] phenyl-2,4-dihydro-2- [(S)-1-ethyl-2(S)- hydroxylpropyl]-3H-1, 2,4-triazol-3-one represented by formula (I), pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

40. 发明专利

HK1029588A1 CRYSTALLINE ANTIFUNGAL POLYMORPH 未知
公开(公告)号：HK1029588A1
公开(公告)日：2001-04-06
申请号：HK01100382
申请日：2001-01-13
申请人： SCHERING CORP
发明人： ANDREWS DAVID R , LEONG WILLIAM , SUDHAKAR ANANTHA R
IPC分类号： A61K31/4196 , A61K31/496 , A61K31/4965 , A61P31/10 , C07D241/00 , C07D249/00 , C07D307/00 , C07D405/14 , C07D , A61K
摘要： The crystalline polymorph Form I of (-)-4-[4- [4-[4-[ [(2R-cis)-5-(2, 4-difluorophenyl) tetrahydro-5-(1H-1, 2,4-triazol- 1-ylmethyl)furan-3-yl] methoxy]phenyl] -1-piperazinyl] phenyl-2,4-dihydro-2- [(S)-1-ethyl-2(S)- hydroxylpropyl]-3H-1, 2,4-triazol-3-one represented by formula (I), pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式