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31. 发明公开

EP2404172A1 METHODS FOR ISOLATING AGONISTS AND ANTAGONISTS OF TASTE RECEPTORS 审中-公开
标题翻译：式分离方法激动剂和味觉受体拮抗剂
公开(公告)号：EP2404172A1
公开(公告)日：2012-01-11
申请号：EP10708132.5
申请日：2010-03-08
申请人： Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke , Technische Universität München , Symrise GmbH & Co. KG
发明人： HOFMANN, Thomas , DUNKEL, Andreas , TÄUBERT, Alexander , MEYERHOF, Wolfgang , STÄHLER, Frauke , LEY, Jakob
IPC分类号： G01N33/50
CPC分类号： G01N33/74 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： The invention relates to improved methods for identifying molecules that modulate a taste response, e.g. suppress (antagonist) or enhance (agonist) taste receptor activity. The invention also relates to a pharmaceutical composition, a food stuff, precursor material or additive employed in the production of foodstuffs which comprises an antagonist or agonist identified according to a method of the invention and to a saliva co-factor component useful for the methods according to the invention.

32. 发明授权

EP1868452B1 HYDROXYDEOXYBENZOINS AND THE USE THEREOF TO MASK A BITTER TASTE 有权
标题翻译： Hydroxydeoxybenzoins和苦涩的味道掩盖的使用TO
公开(公告)号：EP1868452B1
公开(公告)日：2009-07-22
申请号：EP06724999.5
申请日：2006-03-09
申请人： Symrise GmbH & Co. KG
发明人： LEY, Jakob , KINDEL, Günter , PAETZ, Susanne , KRAMMER, Gerhard
IPC分类号： A23L1/226 , A61K47/10 , C07C49/825 , C07C49/84
CPC分类号： A61K8/35 , A23L27/204 , A23L27/86 , A61Q11/00 , C07C45/00 , C07C45/46 , C07C49/83 , C07C49/84
摘要： The use of hydroxydeoxybenzoins of formula (I) wherein R1 and R2 independently of one another represent hydrogen or lower alkyl and R3, R4, R5 and R6 independently of one another represent hydrogen, hydroxy or lower alkoxy, salts thereof and mixtures thereof to mask or reduce the unpleasant taste impression of a substance that tastes unpleasant and/or to enhance the sweet taste of a substance that tastes sweet.

33. 发明公开

EP2028955A1 USE OF DIACETYL DIMER AS AN AROMATIC AND/OR FLAVOURING SUBSTANCE 有权
标题翻译： VERWENDUNG VON DIACETYLDIMER ALS AROMA UND / ODER GESCHMACKSSTOFF
公开(公告)号：EP2028955A1
公开(公告)日：2009-03-04
申请号：EP07728854.6
申请日：2007-05-07
申请人： Symrise GmbH & Co. KG
发明人： LEY, Jakob , WEBER, Berthold , KRAMMER, Gerhard , REISS, Ingo , BERTRAM, Heinz-Jürgen , GATFIELD, Ian , HOFFMANN-LÜCKE, Petra
IPC分类号： A23L1/226
CPC分类号： A23C9/1307 , A21D2/14 , A21D13/40 , A21D13/80 , A23C9/156 , A23D7/0056 , A23D7/015 , A23G3/36 , A23G4/06 , A23G9/32 , A23L19/00 , A23L27/206 , C12C5/026 , C12G1/00 , C12G3/06
摘要： The invention relates to the use of 5-acetyl-2,5-dimethyl-2-hydroxytetrahydrofuran-3-one (diacetyl dimer of formula (I)) in the form of one of its stereoisomers or in the form of a mixture consisting of or containing two, three or four of its stereoisomers (i) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (ii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavour; and/or (iii) as an aromatic and/or flavouring substance. The invention furthermore relates to a process (i) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (ii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavour, to corresponding aromatic compositions, to formulations selected from a nutrition formulation (foodstuff), an oral hygiene formulation, a luxury product formulation, a formulation for oral pharmaceutical use or a semi-finished good formulation for the preparation of nutrition formulations or luxury product formulations, as well as preparations comprising one or more of said compositions and/or formulations.
摘要翻译：本发明涉及其一种立体异构体形式的5-乙酰基-2,5-二甲基-2-羟基 - 四氢呋喃-3-酮（式（I）的二乙酰二聚体）或混合物形式的用途包含或含有二，三或四种立体异构体（i）用于赋予，增强和/或改变口腔中的乳状和/或脂肪感觉，（ii）用于赋予，加强和/或改变甜味，奶油状和/或奶油味; 和/或（iii）作为芳香和/或调味物质。本发明还涉及一种用于赋予，增强和/或改变口腔中的乳状和/或脂肪感觉的方法（i），（ii）用于赋予，加强和/或改变甜的，黄油状的奶油状和/ 或奶油味，相应的芳族组合物，选自营养制剂（食品），口腔卫生制剂，豪华产品制剂，用于口服药物用途的制剂或用于制备营养制剂的半成品良好制剂的制剂，或豪华产品制剂，以及包含一种或多种所述组合物和/或制剂的制剂。

34. 发明公开

EP1909599A1 USE OF HESPERETIN FOR ENHANCING THE SWEET TASTE 有权转让
标题翻译：橙皮素对增强甜味的使用
公开(公告)号：EP1909599A1
公开(公告)日：2008-04-16
申请号：EP06777960.3
申请日：2006-07-25
申请人： Symrise GmbH & Co. KG
发明人： LEY, Jakob , KINDEL, Günter , PAETZ, Susanne , RIESS, Thomas , HAUG, Martin , SCHMIDTMANN, Ralph , KRAMMER, Gerhard
IPC分类号： A23L1/236 , A23L1/307 , A23L1/22
CPC分类号： A61K8/498 , A23L27/00 , A23L27/30 , A23L27/88 , A23L33/20 , A61K8/02 , A61Q11/00
摘要： The use of hesperetin of formula (I) is described wherein the hesperetin of formula (I) is in the form of a (2S)-enantiomer, (2R)-enantiomer or any desired mixture of the two enantiomers, a salt of hesperetin of formula (I), - a mixture comprising or consisting of two or more salts of the hesperetin of formula (I), or a mixture comprising or consisting of hesperetin of formula (I) and one or more salts of hesperetin of formula (I) for enhancing the sweet taste of a sweet-tasting substance or sweet olfactory impression of a flavouring which gives a sweet olfactory impression.

35. 发明公开

EP1868452A1 HYDROXYDEOXYBENZOINS AND THE USE THEREOF TO MASK A BITTER TASTE 有权
标题翻译： Hydroxydeoxybenzoins和苦涩的味道掩盖的使用TO
公开(公告)号：EP1868452A1
公开(公告)日：2007-12-26
申请号：EP06724999.5
申请日：2006-03-09
申请人： Symrise GmbH & Co. KG
发明人： LEY, Jakob , KINDEL, Günter , PAETZ, Susanne , KRAMMER, Gerhard
IPC分类号： A23L1/226 , A61K47/10 , C07C49/825 , C07C49/84
CPC分类号： A61K8/35 , A23L27/204 , A23L27/86 , A61Q11/00 , C07C45/00 , C07C45/46 , C07C49/83 , C07C49/84
摘要： The use of hydroxydeoxybenzoins of formula (I) wherein R1 and R2 independently of one another represent hydrogen or lower alkyl and R3, R4, R5 and R6 independently of one another represent hydrogen, hydroxy or lower alkoxy, salts thereof and mixtures thereof to mask or reduce the unpleasant taste impression of a substance that tastes unpleasant and/or to enhance the sweet taste of a substance that tastes sweet.

36. 发明公开

EP1784088A1 HYDROXYBENZOES[UREAMIDE UND DEREN VERWENDUNG ZUR MASKIERUNG VON BITTEREM GESCHMACK 审中-公开
标题翻译：羟基[酸酰胺及其USE IN苦味MASK
公开(公告)号：EP1784088A1
公开(公告)日：2007-05-16
申请号：EP05777921.7
申请日：2005-08-02
申请人： Symrise GmbH & Co. KG
发明人： LEY, Jakob , BERTRAM, Heinz-Jürgen , KINDEL, Günter , KRAMMER, Gerhard
IPC分类号： A23L1/226 , A61K8/40 , A61Q11/00 , C07C235/60 , C07C235/48
CPC分类号： A61Q11/00 , A61K8/42 , C07C235/48 , C07C235/60
摘要： The invention relates to hydrobenzoic acid amides of formula (I), wherein R1 to R5 are independently hydrogen, hydroxy, methoxy or ethoxy, provided that at least the groups from R1 to R5 represent hydroxy and R6 is hydrogen, methyl or ethyl and n is equal to 1 or 2 and to the salts and mixtures thereof which are used for masking and attenuating the unpleasant flavour impression of an unpleasant taste product and/or for reinforcing sweeten flavour impression of a sweet product.

37. 发明公开

EP1734835A1 VERWENDUNG VON y-AMINOBUTTERSÄURE ZUR MASKIERUNG ODER VERMINDERUNG EINES UNANGENEHMEN GESCHMACKSEINDRUCKS SOWIE ZUBEREITUNGEN ENTHALTEND y-AMINOBUTTERSÄURE 审中-公开
标题翻译： γ-氨基丁酸的使用以掩盖或减少不愉快味道的印象，而含PREPARATIONSγ-氨基丁酸
公开(公告)号：EP1734835A1
公开(公告)日：2006-12-27
申请号：EP05740177.0
申请日：2005-03-29
申请人： Symrise GmbH & Co. KG
发明人： LEY, Jakob , KINDEL, Günter , KRAMMER, Gerhard , HOFMANN, Thomas , ROTZOLL, Nina
IPC分类号： A23L1/22
CPC分类号： A61Q11/00 , A23L27/82 , A23L27/84 , A23L27/86 , A23V2002/00 , A61K8/44 , A23V2200/16 , A23V2250/038
摘要： Disclosed is the use of Ϝ-aminobutanoic acid or a physiologically acceptable salt of Ϝ-aminobutanoic acid for masking or reducing the unpleasant flavor impression of a substance that has an unpleasant taste. Also disclosed are oral pharmaceutical preparations or pharmaceutical preparations that are used for feeding, enjoyment, or oral hygiene and comprise at least one substance having an unpleasant taste and Ϝ-aminobutanoic acid.

38. 发明公开

EP1937089A1 MIXTURES HAVING A SALTY TASTE 有权转让
标题翻译：混合工咸味
公开(公告)号：EP1937089A1
公开(公告)日：2008-07-02
申请号：EP06807022.6
申请日：2006-10-06
申请人： Symrise GmbH & Co. KG
发明人： LEY, Jakob , KINDEL, Günter , MUCHE, Sylvia , FREIHERR, Kathrin , BRENNECKE, Stefan , KRAMMER, Gerhard
IPC分类号： A23L1/237
CPC分类号： A23L27/45 , A23L27/40
摘要： The present invention relates to a mixture comprising or consisting of: (a) one or more inorganic salts which are suitable for nutrition and are not sodium chloride, (b) one or more mono- or polyvalent salts of polybasic food acids, (c) one or more amino acids, or salts thereof, which are suitable for nutrition.

39. 发明公开

EP1901618A1 HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE 有权
标题翻译： HYDROXYPHENYLALKADIONE及其用途覆盖范围苦味和/或甜味加强
公开(公告)号：EP1901618A1
公开(公告)日：2008-03-26
申请号：EP06777471.1
申请日：2006-06-27
申请人： Symrise GmbH & Co. KG
发明人： LEY, Jakob , BERTRAM, Heinz-Jürgen , KRAMMER, Gerhard , KINDEL, Günter
IPC分类号： A23L1/226 , C07C49/00
CPC分类号： C07C49/258 , A23F3/405 , A23L2/56 , A23L27/20 , A23L27/84 , A23L27/86 , C07C45/62 , C07C45/74 , C07C49/245 , C07C49/248 , C07C49/255
摘要： The use of a hydroxyphenylalkadione derivative of the formula (I) wherein, for X, a and Y: X is a -CH2-, -NH- or -O- group, Y is a -CH2- group and a is a single bond or X and Y are in each case a -CH- group and a is a double bond in the Z or E configuration, wherein, for R1 , R2 and R3 R1 denotes hydrogen, an aliphatic radical having 1 to 4 C atoms or a -O-R5, -S-R5 or -NR5R6 group and R2 and R3 independently of one another denote hydrogen or an alkyl having 1, 2, 3, 4 or 5 C atoms which is optionally substituted by one or more oxo groups or R7-O- groups or R1 and R2 together form an aliphatic ring which contains a total of 4 to 10 carbon atoms and 0 or 1 oxygen atom, wherein the ring constituent represented by R1 and R2 is optionally substituted by one or more oxo groups and/or R7-O- groups and/or aliphatic radicals having 1 to 4 C atoms and R3 denotes hydrogen or an alkyl having 1, 2, 3, 4 or 5 C atoms which is optionally substituted by one or more oxo groups or R7-O- groups or R2 and R3 together form an aliphatic ring which contains a total of 4 to 10 carbon atoms and 0 or 1 oxygen atom, wherein the ring constituent represented by R2 and R3 is optionally substituted by one or more oxo groups and/or R7-O- groups and/or aliphatic radicals having 1 to 4 C atoms and R1 denotes hydrogen, an aliphatic radical having 1 to 4 C atoms or a -O-R5, -S-R5 or -NR5R6 group, wherein, for R4 and R: R4 and R independently of one another denote hydrogen, methyl or ethyl and wherein, for R5, R6 and R7: R5 R6 and R7 independently of one another denote hydrogen or an aliphatic radical having 1 to 4 C atoms, a salt of such a hydroxyphenylalkadione of the formula (I), a mixture comprising or consisting of two or more different hydroxy- phenylalkadiones of the formula (I), wherein X, a, Y, R, R1, R2, R3, R4, R5, R6 and R7 in each case have the meaning given above, a mixture comprising or consisting of salts of two or more different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R1, R2, R3, R4, R5, R6 and R7 in each case have the meaning given above, or a mixture comprising or consisting of a hydroxyphenylalkadione of the formula (I) or two or more different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R1, R2, R3, R4, R5, R6 and R7 in each case have the meaning given above, and a salt of a hydroxyphenylalkadione of the formula (I) or two or more salts of different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R1, R2, R3, R4, R5, R6 and R7 in each case have the meaning given above, for modifying, masking or reducing the unpleasant flavour impression of an unpleasantly tasting substance and/or for intensifying the sweet taste of a sweet-tasting substance and/or the sweet odour impression of an aroma substance which causes a sweet odour impression, as well as formulations and processes including a hydroxyphenylalkadione of the formula (I), are described.

40. 发明授权

EP1998636B1 USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS 有权转让
标题翻译： 4- hydroxydihydrochalcones及其盐类改善甜的感觉使用
公开(公告)号：EP1998636B1
公开(公告)日：2010-05-19
申请号：EP07727190.6
申请日：2007-03-21
申请人： Symrise GmbH & Co. KG
发明人： KRAMMER, Gerhard , LEY, Jakob , RIESS, Thomas , HAUG, Martin , PAETZ, Susanne , KINDEL, Günter , SCHMIDTMANN, Ralph
IPC分类号： A23L1/236 , C11B9/00 , C07C49/84
摘要： The use of - hesperetin of formula (I) is described wherein the hesperetin of formula (I) is in the form of a (2S)-enantiomer, (2R)-enantiomer or any desired mixture of the two enantiomers, - a salt of hesperetin of formula (I), - a mixture comprising or consisting of two or more salts of the hesperetin of formula (I), or - a mixture comprising or consisting of hesperetin of formula (I) and one or more salts of hesperetin of formula (I) for enhancing the sweet taste of a sweet-tasting substance or sweet olfactory impression of a flavouring which gives a sweet olfactory impression.

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