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31. 发明专利

CA2724842A1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS 未知
公开(公告)号：CA2724842A1
公开(公告)日：2009-11-26
申请号：CA2724842
申请日：2009-05-19
申请人： SUNOVION PHARMACEUTICALS INC
发明人： FANG QUN KEVIN , WU FRANK XINHE , GROVER PAUL T , HOPKINS SETH C , CAMPBELL UNA , CHYTIL MILAN , SPEAR KERRY L
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5025 , A61K31/506 , A61P25/00 , C07D487/04 , C07D519/00
摘要： Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed.

32. 发明专利

BR112012013431B1 Composto e seu uso, composição farmacêutica 未知
公开(公告)号：BR112012013431B1
公开(公告)日：2022-04-12
申请号：BR112012013431
申请日：2010-12-03
申请人： PSYCHOGENICS INC , SUNOVION PHARMACEUTICALS INC
发明人： SHAO LIMING , JOHN EMMERSON CAMPBELL , MICHAEL CHARLES HEWITT , TALEEN G HANANIA , CAMPBELL UNA
IPC分类号： C07D333/56 , A61K31/381 , A61P25/00 , A61P25/18 , C07D495/04 , C07D495/20
摘要： composto, composição farmacêutica e seu uso são fornecidos aqui compostos multicíclicos, métodos para a sua síntese, composições farmacêuticas compreendendo os mesmos, e métodos para o seu uso. os compostos aqui providos são úteis no tratamento, prevenção e/ou administração de vários transtornos neurológicos, incluindo mas não limitando a psicose e/ou esquizofrenia.

33. 发明专利

AU2013369649B2 Heterocyclic compounds and methods of use thereof 未知
公开(公告)号：AU2013369649B2
公开(公告)日：2018-07-26
申请号：AU2013369649
申请日：2013-12-31
申请人： SUNOVION PHARMACEUTICALS INC
发明人： FANG QUN KEVIN , SPEAR KERRY L , CAMPBELL UNA
IPC分类号： C07D209/04 , A61K31/404 , A61P25/18
摘要： Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

34. 发明专利

AU2017254871A1 HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF 未知
公开(公告)号：AU2017254871A1
公开(公告)日：2017-11-16
申请号：AU2017254871
申请日：2017-10-31
申请人： SUNOVION PHARMACEUTICALS INC , CAMPBELL JOHN EMMERSON , CAMPBELL UNA , HANANIA TALEEN G , SHAO LIMING
发明人： CAMPBELL JOHN EMMERSON , CAMPBELL UNA , HANANIA TALEEN G , SHAO LIMING
IPC分类号： C07D405/04
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

35. 发明专利

HK1203954A1 HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF 未知
公开(公告)号：HK1203954A1
公开(公告)日：2015-11-06
申请号：HK15104580
申请日：2015-05-14
申请人： SUNOVION PHARMACEUTICALS INC
发明人： CAMPBELL JOHN EMMERSON , CAMPBELL UNA , HANANIA TALEEN G , SHAO LIMING
IPC分类号： C07D20060101
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

36. 发明专利

AU2015202379A1 Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors 未知
公开(公告)号：AU2015202379A1
公开(公告)日：2015-05-28
申请号：AU2015202379
申请日：2015-05-05
申请人： SUNOVION PHARMACEUTICALS INC
发明人： SHAO LIMING , WANG FENGJIANG , MALCOLM SCOTT CHRISTOPHER , HEWITT MICHAEL CHARLES , MA JIANGUO , RIBE SETH , VARNEY MARK A , CAMPBELL UNA , ENGEL SHARON RAE , HARDY LARRY WENDELL , KOCH PATRICK , SCHREIBER RUDY , SPEAR KERRY L
IPC分类号： C07C215/42 , A01N43/00
摘要： PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also disclosed.

37. 发明专利

NZ600008A Multicyclic compounds and methods of use thereof 未知
公开(公告)号：NZ600008A
公开(公告)日：2014-10-31
申请号：NZ60000810
申请日：2010-12-03
申请人： SUNOVION PHARMACEUTICALS INC , PSYCHOGENICS INC
发明人： HEWITT MICHAEL CHARLES , HANANIA TALEEN G , CAMPBELL UNA , CAMPBELL JOHN EMMERSON , SHAO LIMING
IPC分类号： A61K31/35 , C07D495/04 , A61K31/381 , A61P25/00 , A61P25/18 , C07D333/56 , C07D495/20
摘要： Disclosed are thieno[2,3-c]pyran derivatives represented by the structural formula depicted herein, and pharmaceutical uses thereof. These thieno[2,3-c]pyran derivatives are suitable for the treatment, prevention, or management of a neurological disorder selected from schizophrenia, schizophrenia spectrum disorder, acute schizophrenia, chronic schizophrenia, NOS schizophrenia, schizoid personality disorder, schizotypal personality disorder, delusional disorder, psychosis, psychotic disorder, brief psychotic disorder, shared psychotic disorder, psychotic disorder due to a general medical condition, drug-induced psychosis, psychoaffective disorder, aggression, delirium, Parkinson’s psychosis, excitative psychosis, Tourette’s syndrome, organic or NOS psychosis, seizure, agitation, post-traumatic stress disorder, behavior disorder, neurodegenerative disease, Alzheimer’s disease, Parkinson’s disease, dyskinesias, Huntington’s disease, dementia, mood disorder, anxiety, affective disorder, depression, major depressive disorder, dysthymia, bipolar disorder, manic disorder; seasonal affective disorder; attention deficit disorder, attention deficit hyperactivity disorder, obsessive-compulsive disorder, vertigo, epilepsy, pain, neuropathic pain, sensitization accompanying neuropathic pain, inflammatory pain, fibromyalgia, migraine, cognitive impairment, movement disorder, restless leg syndrome, multiple sclerosis, sleep disorder, sleep apnea, narcolepsy, excessive daytime sleepiness, jet lag, drowsy side effect of medications, insomnia, substance abuse or dependency, addiction, eating disorder, sexual dysfunction, hypertension, emesis, Lesche-Nyhane disease, Wilson’s disease, autism, Huntington’s chorea, and premenstrual dysphoria.

38. 发明专利

CA3132120A1 HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF 未知
公开(公告)号：CA3132120A1
公开(公告)日：2013-08-15
申请号：CA3132120
申请日：2013-02-08
申请人： SUNOVION PHARMACEUTICALS INC
发明人： CAMPBELL JOHN EMMERSON , CAMPBELL UNA , HANANIA TALEEN G , SHAO LIMING
IPC分类号： C07D409/04 , A61K31/506 , A61K31/517 , A61K31/519 , A61P25/00 , A61P25/18 , C07D405/04 , C07D491/048 , C07D495/04
摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

39. 发明专利

AU2006335174B2 Tetralone-based monoamine reuptake inhibitors 未知
公开(公告)号：AU2006335174B2
公开(公告)日：2012-09-06
申请号：AU2006335174
申请日：2006-12-21
申请人： SUNOVION PHARMACEUTICALS INC
发明人： SHAO LIMING , MA JIANGUO , BUSH LARRY R , CAMPBELL UNA , HARDY LARRY WENDELL , MALCOLM SCOTT CHRISTOPHER , KOCH PATRICK , VARNEY MARK , HEWITT MICHAEL CHARLES , WANG FENGJIANG , ENGEL SHARON RAE
IPC分类号： C07D215/12 , A01N43/42 , A61K31/47 , A61K31/4706
摘要： The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.

40. 发明专利

CA2759180A1 COMPOSITIONS COMPRISING TRANSNORSERTRALINE AND SEROTONIN RECEPTOR 1A AGONISTS/ANTAGONISTS AND USES THEREOF 未知
公开(公告)号：CA2759180A1
公开(公告)日：2010-11-18
申请号：CA2759180
申请日：2010-05-12
申请人： SUNOVION PHARMACEUTICALS INC
发明人： CAMPBELL UNA , DUNN JUDITH
IPC分类号： A61K31/135 , A61K31/44 , A61K31/496 , A61K31/505 , A61K31/535 , A61P25/00
摘要： Provided herein are methods of, and compositions for, treating, preventing and managing various neurological disorders. The methods comprise administering a transnorsertraline in combination with a serotonin receptor IA agonist, antagonist or modulator.

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