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31. 发明专利

ES2555154T3 Procesos para la preparación de intermedios del pemetrexed 未知
公开(公告)号：ES2555154T3
公开(公告)日：2015-12-29
申请号：ES07811336
申请日：2007-08-14
申请人： SICOR INC
发明人： DIULGHEROFF NICOLA , PIRKES MORAN , PONTIROLI ALESSANDRO , VILLA MARCO
IPC分类号： C07D487/04
摘要： Un compuesto de la siguiente fórmula X**Fórmula** en la que R es CN; e Y es un grupo saliente halógeno.

32. 发明专利

BRPI0803102A2 未知
公开(公告)号：BRPI0803102A2
公开(公告)日：2011-11-01
申请号：BRPI0803102
申请日：2008-05-01
申请人： SICOR INC
发明人： PONTIROLI ALESSANDRO , DIULGHEROFF NICOLA , SCARPITTA FRANCESCA , AROSIO ROBERTO , POGGIALI ANDREA , VILLA MARCO
IPC分类号： C07J53/00
摘要： The present invention encompasses processes for preparing drospirenone and intermediates thereof.

33. 发明专利

DE602007010894D1 TELLUNGSVERFAHREN DAFÜR 未知
公开(公告)号：DE602007010894D1
公开(公告)日：2011-01-13
申请号：DE602007010894
申请日：2007-08-14
申请人： SICOR INC
发明人： BUSOLLI JONATHAN , DIULGHEROFF NICOLA , NEMETHNE RACZ CSILLA , PIRKES MORAN , PONTIROLI ALESSANDRO , VILLA MARCO , ARONHIME JUDITH
IPC分类号： C07D487/04

34. 发明专利

MX2007006837A DIFLUORONUCLEOSIDOS Y PROCESO DE PREPARACION DE LOS MISMOS. 未知
公开(公告)号：MX2007006837A
公开(公告)日：2007-10-23
申请号：MX2007006837
申请日：2005-12-08
申请人： SICOR INC
发明人： VILLA MARCO , BORN ANNE-RUTH , MARTIN PIERRE , SPIELVOGEL DIRK
IPC分类号： C07H19/06
摘要： Se proporciona un proceso estereoselectivo de preparacion de 2??,2??-difluoronucleosido. En el proceso, se acopla el 2??,2??-difluorofuranosa con una base seleccionada del grupo que consiste en derivados de pirimidina y de purina en presencia de acido de Lewis, en donde el 2??,2??-difluorofuranosa protegido tiene una posicion 1 saliente y 3- y 5- tienen posicion de grupos protectores y, cuando la base comprende uno o mas atomos de oxigeno, la base es una base protegida, en donde cada atomo de oxigeno esta protegido con un grupo protector.

35. 发明专利

CA2620308A1 CRYSTALLINE FORMS OF DOCETAXEL AND PROCESSES FOR THEIR PREPARATION 未知
公开(公告)号：CA2620308A1
公开(公告)日：2007-04-19
申请号：CA2620308
申请日：2006-10-12
申请人： SICOR INC
发明人： ARONHIME JUDITH , VILLA MARCO , LEVI SIGALIT , PONTIROLI ALESSANDRO
IPC分类号： C07D305/14 , A61K31/337 , A61P35/00
摘要： Novel forms of crystalline docetaxel are provided, as well as pharmaceutical compositions, and methods of treatment. Novel processes for making crystalli ne docetaxel are also provided.

37. 发明专利

AU2005272647A1 Process for the preparation of 3-oximino steroids 未知
公开(公告)号：AU2005272647A1
公开(公告)日：2006-02-23
申请号：AU2005272647
申请日：2005-08-12
申请人： SICOR INC
发明人： DIULGHEROFF NICOLA , FRETTA ROBERTA , VILLA MARCO
IPC分类号： C07J41/00
摘要： The present invention provides a method of preparing norelgestromin or norgestimate by reacting the corresponding 3-oxosteroid precursor with hydroxylamine HCl and a base to obtain a reaction mixture forming norelgestromin or norgestimate; monitoring the anti/syn ratio of the norelgestromin or norgestimate produced in the reaction mixture; adding a base to the reaction mixture to neutralize acidity in the reaction mixture when a desired anti/syn ratio is detected; and isolating the norelgestromin or norgestimate. The present invention also provides a process allowing a control of the formation of the anti isomer and syn isomer of norelgestromin or norgestimate by reacting the corresponding 3-oxosteroid precursor with hydroxylamine HCl and a base to obtain a reaction mixture forming norelgestromin or norgestimate; regulating the acidity of the reaction mixture to adjust the anti/syn ratio of the norelgestromin or norgestimate produced in the reaction mixture; adding a base to the reaction mixture to neutralize acidity in the reaction mixture when a desired anti/syn ratio is detected; and isolating the norelgestromin or norgestimate.

38. 发明专利

ES2354843T3 FORMAS CRISTALINAS DE DIACIDO DE PEMETREXED Y PROCEDIMIENTOS PARA LA PREPARACION DE LAS MISMAS. 未知
公开(公告)号：ES2354843T3
公开(公告)日：2011-03-18
申请号：ES07836867
申请日：2007-08-14
申请人： SICOR INC
发明人： BUSOLLI JONATHAN , DIULGHEROFF NICOLA , NEMETHNE RACZ , PIRKES MORAN , PONTIROLI ALESSANDRO , VILLA MARCO , ARONHIME JUDITH
IPC分类号： C07D487/04
摘要： Forma cristalina de diácido de pemetrexed caracterizada porque presenta un patrón de difracción de polvo de rayos X que presenta picos a aproximadamente 5,7, 12,2, 17,2 y 18,4 grados dos theta ± 0,2 grados dos theta.

39. 发明专利

AT492547T 未知
公开(公告)号：AT492547T
公开(公告)日：2011-01-15
申请号：AT07836879
申请日：2007-08-14
申请人： SICOR INC
发明人： BUSOLLI JONATHAN , DIULGHEROFF NICOLA , NEMETHNE RACZ CSILLA , PIRKES MORAN , PONTIROLI ALESSANDRO , VILLA MARCO , HAREL ZVI
IPC分类号： C07D487/04
摘要： Provided are processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid, in particular, pemetrexed disodium salt, directly from pemetrexed diacid or salts thereof, i.e., without isolating the obtained pemetrexed salt prior to lyophilizing it.

40. 发明专利

AT490257T 未知
公开(公告)号：AT490257T
公开(公告)日：2010-12-15
申请号：AT07836867
申请日：2007-08-14
申请人： SICOR INC
发明人： BUSOLLI JONATHAN , DIULGHEROFF NICOLA , NEMETHNE RACZ , PIRKES MORAN , PONTIROLI ALESSANDRO , VILLA MARCO , ARONHIME JUDITH
IPC分类号： C07D487/04
摘要： This invention relates a crystalline form of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and to a process for the preparation thereof.

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