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31. 发明专利

JPH0995436A PREPARATION FOR EXTERNAL USE FOR SKIN 失效
公开(公告)号：JPH0995436A
公开(公告)日：1997-04-08
申请号：JP20880596
申请日：1996-07-19
申请人： SHISEIDO CO LTD
发明人： AITSU YOKO , WADA MOTOTSUGU , INOMATA SHINJI , YANO KIICHIRO , YOKOGAWA YOSHIHIRO , TANAKA NAOMI , YAGI EIICHIRO , SAKAMOTO OKIHIKO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/18 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K7/48 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain an external preparation for skin, having an excellent melamine production-inhibiting action, an excellent tyrosinase activity-inhibiting action, an excellent esterase-inhibiting action and an antioxidizing action. SOLUTION: This preparation for skin contains the extract of a Myrtaceae Baeckea plant (e.g. jongrahab) in an amount of 0.0005-20wt.%, preferably 0.001-10wt.%, as the dry product. The extract is obtained by immersing or thermally refluxing the leaves, stems, fruits, whole body, etc., of the Baeckea plant in an extraction solvent (e.g. ethanol), filtering the product, and subsequently concentrating the filtrate. The external preparation for the skin exhibits excellent paling effects to beautifully whiten chromatosis, spots, ephelis, chloasma, etc., after sunburnt, recover and maintain the tension and elasticity of the skin to prevent the skin from aging, and maintain the young skin. The preparation can express preventing effects on the oxidation of skin lipids and curing the oxidation injuries of the skin to protect the skin. The preparation can further be applied to make-up cosmetics, foundation cosmetics, toiletry products, etc.

32. 发明专利

JPH0987163A SKIN PREPARATION FOR EXTERNAL USE 失效
公开(公告)号：JPH0987163A
公开(公告)日：1997-03-31
申请号：JP20311596
申请日：1996-07-12
申请人： SHISEIDO CO LTD
发明人： SUZUKI YUMIKO , OTA MASAHIRO , YOKOGAWA YOSHIHIRO , TANAKA NAOMI , YAGI EIICHIRO , SAKAMOTO OKIHIKO
IPC分类号： C12N9/99 , A61K8/00 , A61K8/02 , A61K8/96 , A61K8/97 , A61K36/18 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K7/48 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a skin preparation for external use suitable for lightening skin and preventing aging, excellent in inhibitory action on tyrosinase activity and promoting action on melanin production. SOLUTION: This skin preparation for external use contains 0.0005-20wt.%, preferably 0.001-10wt.% calculated as a dried substance of an extract of a plant of Mesoyi growing in a dry meadow, pasture, etc., especially in Indonesia. The extract of Mesoyi is obtained by immersing leaves, stems, flowers, bark, seeds. fruits, the whole plant of Mesoyi in an extractive solvent (e.g. solvent) or heating under reflux, filtering and concentrating. The extract is properly mixed with conventional additives and can be prepared into an ointment, cream, milky lotion, pack, bathing agent, etc. The skin preparation for external use has excellent effects on pigmentation after suntan, stain, freckles, lightening such as chloasma and lightening skin, maintains lively skin free from wrinkle and slack, etc., prevents skin aging and can retain young skin.

33. 发明专利

JPH08301756A SKIN PREPARATION FOR EXTERNAL USE 失效
公开(公告)号：JPH08301756A
公开(公告)日：1996-11-19
申请号：JP12902495
申请日：1995-04-28
申请人： SHISEIDO CO LTD
发明人： YOKOGAWA YOSHIHIRO , YAGI EIICHIRO , SHIBATA YUKI
IPC分类号： C07D311/92 , A61K8/00 , A61K8/49 , A61K31/35 , A61K31/352 , A61P17/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61Q19/02 , A61K7/00 , A61K7/48
摘要： PURPOSE: To obtain a skin preparation for external use, containing eleutherinol, exhibiting melanogenesis suppressing action and tyrosinase inhibiting action and having excellent skin-beautifying effect and safety. CONSTITUTION: This skin preparation contains eleutherinol expressed by formula in an amount of 0.005-20wt.%, preferably 0.01-10wt.% based on the total skin preparation. The compound of formula is compounded with proper amounts of conventional skin preparation components and prepared in the form of ointment, cream, milky lotion, lotion, pack, bathing agent, etc. The agent exhibits excellent effect for the fading of pigmentation caused by sunburn, spots, freckles, chloasma, etc., and skin-beautifying effect. The compound of formula can be produced by extracting a plant of the family Iridaceae, especially a plant of the genus Eleutherin with an organic solvent, partitioning with ethyl acetate and water and purifying the ethyl acetate phase by silica gel column chromatography, etc.

34. 发明专利

JPH0812559A SKIN EXTERNAL PREPARATION 失效
公开(公告)号：JPH0812559A
公开(公告)日：1996-01-16
申请号：JP16868594
申请日：1994-06-29
申请人： SHISEIDO CO LTD
发明人： YAGI EIICHIRO , KOMAZAKI HISAYUKI , SHIBATA YUKI , NAGANUMA MASAKO , FUKUDA MINORU
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/18 , A61P17/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61Q19/02 , A61K7/48 , A61K7/00 , A61K35/78
摘要： PURPOSE:To obtain a skin external preparation having suppressing actions on melanogenesis and inhibiting actions on tyrosinase activities, excellent in lightening of the color, beautifying and whitening of pigmentation, dermal stains, ephelides, chloasmata, etc., after sunburn, excellent in safety and useful as an ointment, a cream, etc., for beautifying and whitening by blending an extract of Piri-Piri therein. CONSTITUTION:This skin external preparation is obtained by blending 0.005-20.0wt.%, preferably 0.01-10.0wt.% extract of Piri-Piri [botanical name: Cyperas sphaeelatus Rottb. (Cyperas articulatas L.)] therein. Furthermore, the Pri-Pri is a plant growing in an arid grassland, a pasture, etc., in South America, especially the Andes, etc. For example, an extract prepared by immersing a leaf and a stem or a fruit, etc., of the Piri-Piri or the whole herb thereof in an extracting solvent such as ethanol or refluxing the solvent together with the leaf, etc., therein under heating, filtering the resultant extract solution, concentrating the prepared filtrate, etc., is preferably used as the extract.

35. 发明专利

JPH0563182B2 失效
公开(公告)号：JPH0563182B2
公开(公告)日：1993-09-10
申请号：JP11514385
申请日：1985-05-28
申请人： SHISEIDO CO LTD
发明人： KANDA FUJIHIRO , OOTA TADAO , YAGI EIICHIRO , FUKUDA MINORU , EBISAWA SHUNEI
IPC分类号： A61L9/01 , A61K8/00 , A61Q15/00

36. 发明专利

JPH0149327B2 失效
公开(公告)号：JPH0149327B2
公开(公告)日：1989-10-24
申请号：JP5752585
申请日：1985-03-23
申请人： SHISEIDO CO LTD
发明人： KANDA FUJIHIRO , OOTA TADAO , YAGI EIICHIRO , FUKUDA MINORU , EBISAWA SHUNEI
IPC分类号： A61L9/01 , A61K8/00 , A61Q17/04

37. 发明专利

JP2002128646A SUNSCREEN SKIN CARE PREPARATION 失效
公开(公告)号：JP2002128646A
公开(公告)日：2002-05-09
申请号：JP2000318803
申请日：2000-10-19
申请人： SHISEIDO CO LTD
发明人： YAMAGUCHI KENJI , YAGI EIICHIRO
IPC分类号： A61K8/00 , A61K8/29 , A61K8/33 , A61K8/36 , A61K8/44 , A61K8/49 , A61K31/195 , A61K31/351 , A61K31/7032 , A61K33/24 , A61P17/16 , A61Q17/04 , A61Q19/00 , A61K7/42 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To provide a sunscreen skin care preparation having both bleaching and anti-suntan effects and excellent stabilities to light and thermal. SOLUTION: This sunscreen care preparation for anti-suntan is obtained by formulating one or more kinds of bleaching ingredients selected from the group consisting of a hydroquinone glycoside and its derivatives, kojic acid and its derivatives and tranexamic acid and its salts with a titanium oxide subjected to hydrophobizing treatment with a fatty acid or its salt and an aluminum compound.

38. 发明专利

JPH1171295A IMMUNOACTIVATOR FOR PREVENTING LOWERING OF DERMAL IMMUNOFUNCTION DUE TO ULTRAVIOLET RAY 失效
公开(公告)号：JPH1171295A
公开(公告)日：1999-03-16
申请号：JP9247298
申请日：1998-03-20
申请人： SHISEIDO CO LTD
发明人： HATAO MASATO , YAMAGUCHI KENJI , NAGANUMA MASAKO , IWAI ICHIRO , YAGI EIICHIRO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/02 , A61K8/97 , A61K36/53 , A61P17/00 , A61P37/04 , A61Q1/00 , A61Q1/12 , A61Q19/00 , A61K35/78 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain the subject excellent immunoactivator which is usually usable and can prevent the lowering of dermal immunofunction due to ultraviolet rays by formulating an extract from Scutellariae radix thereto. SOLUTION: This immunoactivator is obtained by formulating an extract extracted with an organic solvent from roots of Scutellaria baicalensis Georgi of Labite, Scutellariae radix, preferably in an amount of 0.01-5.0 wt.% as the dry product based on the whole weight. As the above-stated extract from Scutellariae radix, for example, dry powders of Scutellariae radix or undried chips of Scutellariae radix are extracted with an alcohol such as ethanol and the like at 30-70 deg.C for 1-10 hrs. under stirring or at room temperature for 1-20 days, the filtrate obtained by filtrating the extract is concentrated and the yellow powder precipitated by stirring this concentrate with purified water is usable after being dried. This immunoactivator can be utilized in forms of preparations for external use for skin, e.g. ointments and creams, and is useful as an immunopotentiation cosmetic.

39. 发明专利

JPH1149696A IMMUNE ACTIVATOR FOR PREVENTING HYPOFUNCTION OF ULTRA-VIOLET SKIN IMMUNOFUNCTION 失效
公开(公告)号：JPH1149696A
公开(公告)日：1999-02-23
申请号：JP9247198
申请日：1998-03-20
申请人： SHISEIDO CO LTD
发明人： NAGANUMA MASAKO , IWAI ICHIRO , HATAO MASATO , YAMAGUCHI KENJI , YAGI EIICHIRO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/64 , A61K38/00 , A61P17/00 , A61Q1/00 , A61Q1/12 , A61K7/00 , A61K7/035
摘要： PROBLEM TO BE SOLVED: To obtain an immune activating agent for preventing the hypofunction of the skin immune functions caused by ultraviolet rays by formulating a specific SH compound as an active ingredient. SOLUTION: This immune activator is prepared by formulating glutathione. The formulation of the glutathione in this skin immune activator or in the skin immune hypofunction improving or preventing agent is 0.005-20.0 wt.% of the dry basis in the whole amount. This skin immune activating agent or skin immune hypofunction preventing agent can be used in the form of an external preparation for skin as ointment, cream, milk, lotion, pack or bath medicine.

40. 发明专利

JPH10265321A SKIN PREPARATION FOR EXTERNAL USE 失效
公开(公告)号：JPH10265321A
公开(公告)日：1998-10-06
申请号：JP8574797
申请日：1997-03-19
申请人： SHISEIDO CO LTD
发明人： YAGI EIICHIRO , NAGANUMA MASAKO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/44 , A61K8/96 , A61K8/97 , A61Q19/02 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain a skin preparation for external use having practically sufficient beautifying and whitening effects by including tranexamic acid or its derivative and a plant extract or a crude drug essence having the beautifying and whitening actions therein. SOLUTION: This skin preparation for external use is obtained by formulating (A) one or more selected from tranexamic acid and its derivative (a dimer, an ester derivative with hydroquinone, an ester derivative with gentisic acid, an amide derivative, etc.) with (B) at least one of a plant extract and a crude drug essence having beautifying and whitening actions (Gambir, Matricaria chamomilla L., Aloe, Scutellaria Radix, Saxifraga stolonifera Meerburg, Sophora angustifloria Sieb. et Zucc., Sophorae Radix, Betula platyphylla Sukatchev var. japonica Hara, birch, Phellodendri Cortex, Lithospermi Radix, etc.). The amounts of the ingredients based on the total amount of the skin preparation for external use are 0.001-20 wt.%, preferably 0.01-10 wt.%, especially preferably 0.1-7 wt.% ingredient A and 0.001-20 wt.%, preferably 0.1-5 wt.% ingredient B.

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